LOCUS       NM_175266               7273 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus EPM2A interacting protein 1 (Epm2aip1), mRNA.
ACCESSION   NM_175266
VERSION     NM_175266.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7273)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7273)
  AUTHORS   Nitschke,F., Sullivan,M.A., Wang,P., Zhao,X., Chown,E.E.,
            Perri,A.M., Israelian,L., Juana-Lopez,L., Bovolenta,P., Rodriguez
            de Cordoba,S., Steup,M. and Minassian,B.A.
  TITLE     Abnormal glycogen chain length pattern, not hyperphosphorylation,
            is critical in Lafora disease
  JOURNAL   EMBO Mol Med 9 (7), 906-917 (2017)
   PUBMED   28536304
  REMARK    GeneRIF: The authors conclude that laforin's principle function is
            to control glycogen chain lengths, in a malin-dependent fashion,
            and that loss of this control underlies Lafora disease.
REFERENCE   3  (bases 1 to 7273)
  AUTHORS   Turnbull,J., Tiberia,E., Pereira,S., Zhao,X., Pencea,N.,
            Wheeler,A.L., Yu,W.Q., Ivovic,A., Naranian,T., Israelian,N.,
            Draginov,A., Piliguian,M., Frankland,P.W., Wang,P., Ackerley,C.A.,
            Giacca,A. and Minassian,B.A.
  TITLE     Deficiency of a glycogen synthase-associated protein, Epm2aip1,
            causes decreased glycogen synthesis and hepatic insulin resistance
  JOURNAL   J Biol Chem 288 (48), 34627-34637 (2013)
   PUBMED   24142699
  REMARK    GeneRIF: We show that the absence of Epm2aip1 in mice impairs
            allosteric activation of GS by glucose 6-phosphate, decreases
            hepatic glycogen synthesis, increases liver fat, causes hepatic
            insulin resistance, and protects against age-related obesity
REFERENCE   4  (bases 1 to 7273)
  AUTHORS   Pei,L., Leblanc,M., Barish,G., Atkins,A., Nofsinger,R., Whyte,J.,
            Gold,D., He,M., Kawamura,K., Li,H.R., Downes,M., Yu,R.T.,
            Powell,H.C., Lingrel,J.B. and Evans,R.M.
  TITLE     Thyroid hormone receptor repression is linked to type I
            pneumocyte-associated respiratory distress syndrome
  JOURNAL   Nat Med 17 (11), 1466-1472 (2011)
   PUBMED   22001906
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7273)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7273)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   7  (bases 1 to 7273)
  AUTHORS   Chan,E.M., Ackerley,C.A., Lohi,H., Ianzano,L., Cortez,M.A.,
            Shannon,P., Scherer,S.W. and Minassian,B.A.
  TITLE     Laforin preferentially binds the neurotoxic starch-like
            polyglucosans, which form in its absence in progressive myoclonus
            epilepsy
  JOURNAL   Hum Mol Genet 13 (11), 1117-1129 (2004)
   PUBMED   15102711
REFERENCE   8  (bases 1 to 7273)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ125214.1, AK043518.1, AK033908.1, CD807865.1, AK122366.1 and
            CN530473.1.
            
            On May 23, 2007 this sequence version replaced NM_175266.3.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-456               CJ125214.1         2-457
            457-4284            AK043518.1         416-4243
            4285-5697           AK033908.1         376-1788
            5698-6137           CD807865.1         302-741
            6138-7113           AK122366.1         5228-6203
            7114-7273           CN530473.1         34-193              c
FEATURES             Location/Qualifiers
     source          1..7273
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 60.92 cM"
     gene            1..7273
                     /gene="Epm2aip1"
                     /gene_synonym="A930003G21Rik; mKIAA0766"
                     /note="EPM2A interacting protein 1"
                     /db_xref="GeneID:77781"
                     /db_xref="MGI:MGI:1925031"
     exon            1..7249
                     /gene="Epm2aip1"
                     /gene_synonym="A930003G21Rik; mKIAA0766"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1937
                     /gene="Epm2aip1"
                     /gene_synonym="A930003G21Rik; mKIAA0766"
                     /note="laforin-interacting protein; EPM2A (laforin)
                     interacting protein 1"
                     /codon_start=1
                     /product="EPM2A-interacting protein 1"
                     /protein_id="NP_780475.1"
                     /db_xref="CCDS:CCDS40785.1"
                     /db_xref="GeneID:77781"
                     /db_xref="MGI:MGI:1925031"
                     /translation="MWMTPKRIRMEVDEALVFRPEWTQRYLVVEPAEGDGALCLVCRR
                     LVASTRERDVRRHYEAEHEFYERFVGDEERAALVERLRQGDMSLAAVLTPEERATRAG
                     LGLCRFLALKGRGWGEGDFVHQCMEVLLREVLPDHVGVLEGIDLSPEITRQRILSIDS
                     NLRSQLFNRARDFKAYSLALDDQAFVAYENYLLVFIRGVGRDLEVQEDLLTIINLTHH
                     FSVGALMSAILEALQTAGLSLQRMVGLTTTHTLRMIGENSGLVSYMREKAVSPNCWNV
                     IHYSGFLHLELLSSYDVDINQIINTISEWVVMIKTRGVRRPEFQPLLTESESEHGERV
                     NGRCLNNWLRRGKTLKLIFSLRKEIEAFLVSVGATTVHFSDKQWLCDFGFLVDIMDYL
                     REISEELQISKVFAAAAFERICTFEGKLSSLQRHMEEVNLTDFPAFSIIVDELKQQFK
                     EDQKIFDPDRYQMVISRLQKDFERHFKDLRFIKKDLELFSNPFSFKPEYAPISVRVEL
                     TKLQANTDLWNEYRVKDLGQFYAGLSGEAYPIIKGVAYKVASLFDSNQICDKAFAYLT
                     RNQHTLSQPLTDEHLQALFRVATTEMDPRWDDLVRERNDS"
     regulatory      7231..7236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epm2aip1"
                     /gene_synonym="A930003G21Rik; mKIAA0766"
                     /note="hexamer: AATAAA"
     polyA_site      7249
                     /gene="Epm2aip1"
                     /gene_synonym="A930003G21Rik; mKIAA0766"
                     /note="major polyA site"
ORIGIN      
        1 ggtgcacccc tgctcgggtg atctggcgca gaacccaggg ggtgcttggc gttcgtcggg
       61 ctcctccccg tttgctgcgg cctcagagct cggcgttctc ctgtggcctc cgcagaatgt
      121 ggatgacgcc caagaggatt aggatggaag tcgacgaggc tctggtgttc cggcccgagt
      181 ggacccagcg atacctggtg gtggagcctg cggagggtga cggggccctg tgcctggtgt
      241 gtcgccgcct ggtcgcctct actcgggaac gcgacgtgag gcgccactac gaggccgagc
      301 acgaattcta cgagcggttt gtaggggacg aggaacgcgc ggccctggtc gagcgtctgc
      361 ggcagggtga catgtctttg gccgccgtgc tcactccgga ggagagagcg acccgggcag
      421 gcctcggcct ctgccgcttc ttggccttga agggtcgcgg ctggggtgag ggtgacttcg
      481 tacaccagtg catggaggtg ttgctgagag aggtgctgcc ggatcacgtc ggcgtcctgg
      541 aaggcattga cttgtctcca gagatcacac ggcagaggat tctgagcatt gacagcaacc
      601 tccgcagcca gctgtttaac cgagccaggg actttaaggc ctattccctt gctttggatg
      661 accaggcttt tgtggcctat gagaactacc tgctggtctt catccgtggc gtcggccgcg
      721 acctggaggt gcaagaagat cttctgacga ttatcaacct gactcatcac ttcagtgttg
      781 gggctctcat gtcggcaatt ctggaagccc tgcagacagc agggctcagc ttacagcgaa
      841 tggttggact gaccacgacc cacactttaa ggatgatcgg cgagaactcc ggactggtct
      901 cctacatgag agagaaggcc gtgagtccca actgttggaa cgtaatccac tattcgggat
      961 ttcttcactt ggaactgttg agttcttatg atgttgatat taatcagatc ataaatacca
     1021 tatctgaatg ggtagttatg attaagacca gaggtgttag gcgaccggag tttcagcctc
     1081 tactaactga gtctgagtca gagcatggtg aaagagttaa cggacggtgt ttgaacaact
     1141 ggctgagaag aggcaaaacg ttaaaactaa tattttcact aagaaaagaa atcgaggcgt
     1201 tcttggtctc agtgggggca acaacagttc atttctcaga caagcagtgg ctttgtgatt
     1261 ttggtttctt ggtagatatt atggactatc ttcgagagat cagtgaagaa ctgcagatca
     1321 gtaaagtctt tgctgctgct gcctttgaac gcatctgcac ctttgagggt aagctgagtt
     1381 cacttcagag acatatggag gaagtaaatc taacagactt tcctgccttc agtataatcg
     1441 ttgatgaact taaacagcag tttaaggaag atcaaaaaat atttgatcct gacaggtatc
     1501 aaatggtgat ctcccgccta cagaaagatt ttgagagaca ttttaaggac ctcaggttca
     1561 ttaaaaagga cttagaactt ttctcaaatc catttagctt taaaccggaa tatgcgccta
     1621 tttctgtaag agtggagcta acaaaacttc aggccaacac tgacctgtgg aatgagtaca
     1681 gagtcaaaga cttgggacag ttttatgcag gactgtctgg tgaagcttac ccaattatca
     1741 aaggggttgc ctataaggtg gcatccttat ttgatagtaa ccagatctgt gataaggctt
     1801 ttgcatattt aactcgaaac cagcacacat tgagccagcc actgacggat gagcatctcc
     1861 aagcactgtt tcgagttgcc acaactgaaa tggatcctcg ttgggatgat cttgtgagag
     1921 aaagaaatga ttcgtaagcc gttgtggtcc aagaagttga tttgaaaagg gaaaattaat
     1981 ttgatttttc tttcacattt cctcatttgg atggttggaa agcattgaac ttactacaga
     2041 tgttcaaatt gataagcatt gaaatctttc tgacaagttg cctttctcca tctcatttgg
     2101 caacatggga ctgactgaag cataagaata ccacctttaa aaaacttagt ttaatggaaa
     2161 agtcattgtt ctttcctttt attattactg attttcaaca aatttagtat tgatattgtc
     2221 agttgaacta gaagtctggt tttaaaatgg tttaaagata tatgccaaaa gtttcagctc
     2281 ttattttgac acagtggaaa gtgtgacacg tggtttgaaa tgaccaactc cttaaaagtg
     2341 tatttgagcc agtttacaga aactcacata tcaaattaag tttctgaaaa ggaatagcat
     2401 aaacacagtg gaggtatttt atctagataa cagaatttaa gattattttt taaagcatat
     2461 ttctaagtaa atacaatccc cccatcccca cctacccagt tgatggtgac attacggatg
     2521 gaggaagtaa tcaatttggt gttggagcag caagaattat tttaaattcc tgatttagga
     2581 gtttcttact atcaggagtt aagaataacc aattattggt ggtttgctcc ttattttttc
     2641 acagctggag caattttttc agctcatcta tcaaaggacc atggtaagta tggaatcttg
     2701 atcactgcca gtcagtaatt tttttttccc tgctctagac agaactttgg ccctatccaa
     2761 acagtaaagg ggaaagactt ttacacttca agatcaggag ttctgaaggt tttagctcgt
     2821 ttgtcttatc tgcatgggta ttcatgtttt ataaggaaac catgcttaag ggagacactt
     2881 tattttgaag tgatgagtca gattttgtta ggtgtaggaa atggatttat tctagaattt
     2941 agaactgtct cgcacattga gtagttaaga cagtgcacaa gtaaaaatat ttaaatctca
     3001 agaagcaacc ttatccacag actgtaataa ttcctatttc tggagacatt ggttttgtgc
     3061 tatgatgtta tcagactttc taactgtgga gaagacaatc ttaaggtaaa gctcaacctg
     3121 aagcctgatc taaaagcagc actgatttgt aactcctcct cgtgcagttt acaagctgat
     3181 gtgctccgtt ctgtcttaaa tacggcagca cactgtcgtg ttgcacattc gaggaacctt
     3241 attacaacca agcgtttgga aggaactgat gcttaagcca cacgagtcta agagccaaag
     3301 ttagatcagt ggttctaaac caaaggtaga agcccttcct tccagagagt gctggaaagg
     3361 gttagggcac ctttgtagtc ctggagggtt gtgctggcag gtaagccaag aagagctctc
     3421 cttcctatgg tggtcagaca gcctgatgcc atgaagagtc atccattact cccaaagtgc
     3481 cagcacctcc ccctccccca ccaagcatac atcatcttac ttcaaaggac aggaaacaat
     3541 ctccagcgga agctgatggt gtatacttga tagggaagcc tagttccagc agttcagagg
     3601 agaaaagcta gtgtcagatt gacattttcc ttatcaaaga atgagcttaa gtacctggaa
     3661 aatgagtcta ctggtagttt cccaggagct ttgtggatta cctttcacaa taaatacgta
     3721 aaatactttt attatttgag agaatgattg gaagtcctga aagctgcttc tactttctat
     3781 tttagtcccc taaatattaa tatcttgtgc attctatcaa gttcttgtgt tttgcttaag
     3841 gtgataataa agctagtttg catcatgtaa ccactgtgtg aatatggggg agatataaat
     3901 aagctaaggg atttttttaa attaatcctt agcaagtttg ctgtaactag tcttattttt
     3961 tgtttttttc ttcgtttaag gcagtggttc ttaaccttcc tagtgctgcg accctttaat
     4021 atagttcctc atgttgtggt aacccccagc cataaaatta tttctttgct atttcataac
     4081 tgtaattttg ctactgttat gaattgtaaa tatccaatat gcaggataga tatctgatat
     4141 tcgacccccc agaggggcga gactcatggg ttgagaactt ctggtttaag gtgttttgct
     4201 gttttttgta tttctggaag taactctagc tgcatggcag ttttttcttt cctttttccg
     4261 ttttaaatat atagttgtta ctggtcctgt ggtatcagtg aatatagttc aaataagtgc
     4321 catttaaagc aacaacaatt ctgtgtcctt aactgtcctt tcccatttct ctcattccca
     4381 ctagttcaaa tatttgcttg cccaggctcc catattgccc atcagatcac tcaagttcag
     4441 tgtgttttgt cagtattttt gccttcttga aatcattgta gcattgcaga gacaccaact
     4501 ccagtaattg tagtcacctc ttccttaagt atgtctgtct ggttgttttg tttgctgttc
     4561 tgttttgttt tcttttaaga ctcccttacc tcatattcct acattacttc cttagttgat
     4621 ctctttctat gactttagtt atcacctgta tgcagatact tccaaatttt tgtctcctga
     4681 gatttccctg taaatcatag ttgctaatat tgctaactct ttgctctttc acatcttggc
     4741 tctttctccc agacctgctc ttcctctcac tttcccttca gcagatggct ttacagtcag
     4801 atcactcata ccactcccct gccttcattg ctatcaaggt agatagaaga caaacttctg
     4861 ttcatcttgc agaacttggc ttacatatca tctaagaagc ttcaggggta tcctctaggc
     4921 caggtaccca actacacgtg ctgaacaccc tgtcctttct acttagcatc tcttactgtg
     4981 cgttggtcat tgctagactg gaccagaggg acgtttaatc cattgtttca tctctagtgc
     5041 ctggcatttg aacaaatgct tgggcaaata aatacttgtg tggttttttt tgttttttat
     5101 gaaaccttca cagtcttttt tgaccgtcac ggacattttg cctgttctct gaatagttct
     5161 tagccatgta ttgcaaatta agaaatgaaa ttcaccttac ttgcgactag taatctcatt
     5221 gttgtgtttc ttgaatttag tgcagtgctt agcatgtggt tcaaatatta tgtgaatgtt
     5281 gttaagaaaa cagactgtaa tttaccctag taaactagta gtaatgtcaa gattcaaacc
     5341 taggtgtact caaaaatcag ctctctagtg ttaagtccat aatacagagc ctttattttg
     5401 ttttaatttc caaaggaacc tacatataga gggaaaacat tggataactg cttagattga
     5461 actgagttca gtaatctaaa aatcaccttc agtattggag aaagacaaga ctgcaaaaag
     5521 ttaatgtcca tttttccttt tgtaggcatc aaccctagga gaaagtggca tgctatttag
     5581 tacttacttt cctttacaga tgatttctgg ctctcctgga acttaaaagt aagtaaactt
     5641 gtttctgaga aagatgtctt agtcagccct tctgactaca agatcttcag ctcatttaaa
     5701 aaaaaaaaaa atgtggaatt cccacatcat ctcccagaga gaaaaccccc agatgacatc
     5761 cagttaacat ggacttttag atttgctgta ttttcttgct ttcttgtttc atgcttctga
     5821 atttcatttc taggtaaatg agacatttca gtcttaagtt ggaaagccag atgcttatta
     5881 gtctctttca ttaagccatt ttgctcaact taagagataa actagtatca ttctcttagt
     5941 tggacttaca gttttaggaa gtcacactaa ttagttcact ctgaggtctt ggtagtaggt
     6001 acaacagtca tccagagatt tgatcctgtt gcaaaactag gtttttgtca accttcaggt
     6061 taagggtttc tcatttttat ctcgtattta aaaagttgtt tcatcctaca gtgtaagaac
     6121 gttataaata ctctatcatt tctgccttga aactgaccaa atactgaatt catgtatact
     6181 ttgtctaaag cagccaatgg ccaccacaaa gtattttttt ttcttcttta ataaagggta
     6241 gatgtcccat ctcccagctc atctcaaggg gcacctctct agaacataac ttgtccctgt
     6301 gtcgttattt tgttctatct tccagtagcg tctccctgat gcctcccaaa taatcactaa
     6361 gcaaactgtt tagtgtttta gttctgcatc aggattgctg aagttgccgg aagcagacaa
     6421 aagtttagtt gtttgtgaca ggttgtctga gctgtcagac tccaacccct acaggccaag
     6481 tctgtcctgg cccatccttc tctgaggaaa ttattacagg agttagagcc gtgtctgtct
     6541 aggaactgtc atggctgctc ccctctacag ttgcagactt gagtagttgt gacactgtgt
     6601 gcaacacaag ctaaaatact ttttggaaaa gttcactgtt tcctgcttta aattgtccct
     6661 acctaccctg gggactaagc agatatactc aataggagtc gacagcccac tctgggcaaa
     6721 gagaaaagaa agtttggctc tgtaagccca tagccacacc agatctcaag tgcaaattcc
     6781 tccatacagg tgggaggaag gtgaactatt tggaagataa cactactggt cctagttaca
     6841 tcactctaaa tatgtctttg ctttttcatt gagataaaag tttacaaata ttcagtgtcc
     6901 acttcttttt atattcacct gtgaatgcac ctctcagatc aaggtaggaa atatttctgt
     6961 tactccagta ggtgcccttt gcctctcaca gatagagaac tgctggtctg acttgtattg
     7021 cctgtcagtt agttttgcct gttttaaatg tatatcaaga ggaattaaat acactgttgt
     7081 atcctctgtt ctctgtgtct gctatagtag tccatgttgt ggagtgtaac acctcatttt
     7141 tcacttctgt gtcacagtcc attcattgta caagttgatc cattcaatgt tgatgaatat
     7201 ttggattgtt tccagtttat gatcattatg aataaaattg ctgttaaaaa aaaaaaaaaa
     7261 aaaaaaaaaa aaa
//
