LOCUS       NM_001001804            1262 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus epoxide hydrolase 4 (Ephx4), transcript variant 1,
            mRNA.
ACCESSION   NM_001001804 XM_357493
VERSION     NM_001001804.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1262)
  AUTHORS   Shen,Y., Zheng,L.L., Fang,C.Y., Xu,Y.Y., Wang,C., Li,J.T.,
            Lei,M.Z., Yin,M., Lu,H.J., Lei,Q.Y. and Qu,J.
  TITLE     ABHD7-mediated depalmitoylation of lamin A promotes myoblast
            differentiation
  JOURNAL   Cell Rep 43 (2), 113720 (2024)
   PUBMED   38308845
  REMARK    GeneRIF: ABHD7-mediated depalmitoylation of lamin A promotes
            myoblast differentiation.
REFERENCE   2  (bases 1 to 1262)
  AUTHORS   Sirish,P., Li,N., Liu,J.Y., Lee,K.S., Hwang,S.H., Qiu,H., Zhao,C.,
            Ma,S.M., Lopez,J.E., Hammock,B.D. and Chiamvimonvat,N.
  TITLE     Unique mechanistic insights into the beneficial effects of soluble
            epoxide hydrolase inhibitors in the prevention of cardiac fibrosis
  JOURNAL   Proc Natl Acad Sci U S A 110 (14), 5618-5623 (2013)
   PUBMED   23493561
REFERENCE   3  (bases 1 to 1262)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126598.13 and BN000367.1.
            
            On Mar 31, 2007 this sequence version replaced NM_001001804.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3764887.1,
                                           SRR5189670.110399.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AC126598.13        103727-103764
            39-741              BN000367.1         1-703
            742-889             AC126598.13        127015-127162
            890-1118            BN000367.1         852-1080
            1119-1262           AC126598.13        130106-130249
FEATURES             Location/Qualifiers
     source          1..1262
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 52.23 cM"
     gene            1..1262
                     /gene="Ephx4"
                     /gene_synonym="Abhd7; Ephxrp; Gm1382"
                     /note="epoxide hydrolase 4"
                     /db_xref="GeneID:384214"
                     /db_xref="MGI:MGI:2686228"
     exon            1..263
                     /gene="Ephx4"
                     /gene_synonym="Abhd7; Ephxrp; Gm1382"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1118
                     /gene="Ephx4"
                     /gene_synonym="Abhd7; Ephxrp; Gm1382"
                     /note="isoform 1 is encoded by transcript variant 1;
                     abhydrolase domain containing 7; epoxide hydrolase-related
                     protein; abhydrolase domain-containing protein 7"
                     /codon_start=1
                     /product="epoxide hydrolase 4 isoform 1"
                     /protein_id="NP_001001804.2"
                     /db_xref="CCDS:CCDS19501.1"
                     /db_xref="GeneID:384214"
                     /db_xref="MGI:MGI:2686228"
                     /translation="MAPPRPPRLLPALRALLYWSLVYGYCGLCASVHLLKLLWSIGRA
                     PAQTFRRAARANPPACLNDPSLGTHCYVRIKDSGLRFHYVAAGERGKPLMLLLHGFPE
                     FWYSWRHQLREFKSEYRVVALDLRGYGESDAPAHQESYKLDCLIADIKDILDSLGYSK
                     CVLIGHDWGGMIAWLIAVCYPEMIMKLIVINFPHPSVFTEYILRHPAQLFRSSFYYFF
                     QIPRFPEFMFSINDFKALKHLFTSQSTGIGRKGRQLTTEDLEAYVYVFSQPGALSGPI
                     NHYRNIFSCLPLKHHMVTTPTLLLWGEEDAFMEVEMAEVTKIYVKNYFRLTILSEGSH
                     WLQQDQPDIVNGLIWAFLKEETRRD"
     exon            264..349
                     /gene="Ephx4"
                     /gene_synonym="Abhd7; Ephxrp; Gm1382"
                     /inference="alignment:Splign:2.1.0"
     exon            350..507
                     /gene="Ephx4"
                     /gene_synonym="Abhd7; Ephxrp; Gm1382"
                     /inference="alignment:Splign:2.1.0"
     exon            508..636
                     /gene="Ephx4"
                     /gene_synonym="Abhd7; Ephxrp; Gm1382"
                     /inference="alignment:Splign:2.1.0"
     exon            637..740
                     /gene="Ephx4"
                     /gene_synonym="Abhd7; Ephxrp; Gm1382"
                     /inference="alignment:Splign:2.1.0"
     exon            741..889
                     /gene="Ephx4"
                     /gene_synonym="Abhd7; Ephxrp; Gm1382"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1262
                     /gene="Ephx4"
                     /gene_synonym="Abhd7; Ephxrp; Gm1382"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1235..1240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ephx4"
                     /gene_synonym="Abhd7; Ephxrp; Gm1382"
                     /note="hexamer: AATATA"
     polyA_site      1262
                     /gene="Ephx4"
                     /gene_synonym="Abhd7; Ephxrp; Gm1382"
                     /note="major polyA site"
ORIGIN      
        1 gcgggaggga cgccgcagct cggctcccgc aggcgcccat ggccccgccg cgcccgcccc
       61 gcctgctgcc cgcgctgcgc gccctgctct actggtccct ggtgtacggc tactgcgggc
      121 tgtgcgcctc cgtccacctg ctcaaacttt tgtggagcat cggtagggcg ccggcgcaga
      181 ccttccgccg ggcggcccgg gccaaccctc cggcgtgcct gaacgacccc tccttaggga
      241 ctcactgcta cgtgcgcatc aaggactccg ggttaagatt tcactatgtt gctgctggag
      301 aaaggggcaa accgctcatg ctgctgcttc atggatttcc agaattctgg tattcttggc
      361 gccatcaact gagagaattt aaaagcgaat acagggttgt tgcattggat ttgagaggtt
      421 atggagagtc tgatgcacct gctcatcaag agagttacaa actggactgt ctaattgcag
      481 acataaagga tattttggac tccttagggt atagcaaatg tgtcctgatc ggccatgact
      541 ggggaggcat gattgcctgg ctgattgctg tctgctaccc tgagatgata atgaagctca
      601 ttgttattaa cttcccacat ccaagtgtat ttacagagta tatactgcgg catcctgccc
      661 agctgttcag atccagcttt tattacttct tccaaatacc acgcttccca gaatttatgt
      721 tctcaattaa tgattttaag gctttgaaac atctgtttac cagtcagagt actggcattg
      781 gaaggaaagg acgccagctg acaacagaag atctagaagc ttacgtttat gtcttttctc
      841 agcctggagc actaagtggt ccaattaacc attatcgaaa cattttcagc tgcctgcctc
      901 tcaaacatca catggtgacc accccaacac tgcttctgtg gggagaggaa gatgcgttta
      961 tggaggtaga gatggccgag gtcacaaaga tttatgttaa aaactatttc agactcacca
     1021 ttttgtcaga aggtagccac tggcttcagc aagaccagcc tgacatagtg aatggactga
     1081 tatgggcatt cctgaaggaa gaaacaagga gagactgact ttatctccta cagggagtct
     1141 ttcatggaat ttcaaaaaaa actcttaaaa acttgttctt caacttatgt tttattagaa
     1201 aaaatacctg ttttaatatg cttgattata aataaatata gtgatacatg gtactgaaaa
     1261 aa
//
