LOCUS       NM_001347341            2402 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus epoxide hydrolase 3 (Ephx3), transcript variant 2,
            mRNA.
ACCESSION   NM_001347341 XM_006524956
VERSION     NM_001347341.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2402)
  AUTHORS   Edin,M.L., Yamanashi,H., Boeglin,W.E., Graves,J.P., DeGraff,L.M.,
            Lih,F.B., Zeldin,D.C. and Brash,A.R.
  TITLE     Epoxide hydrolase 3 (Ephx3) gene disruption reduces ceramide
            linoleate epoxide hydrolysis and impairs skin barrier function
  JOURNAL   J Biol Chem 296, 100198 (2021)
   PUBMED   33334892
  REMARK    GeneRIF: Epoxide hydrolase 3 (Ephx3) gene disruption reduces
            ceramide linoleate epoxide hydrolysis and impairs skin barrier
            function.
REFERENCE   2  (bases 1 to 2402)
  AUTHORS   Hoopes,S.L., Gruzdev,A., Edin,M.L., Graves,J.P., Bradbury,J.A.,
            Flake,G.P., Lih,F.B., DeGraff,L.M. and Zeldin,D.C.
  TITLE     Generation and characterization of epoxide hydrolase 3
            (EPHX3)-deficient mice
  JOURNAL   PLoS One 12 (4), e0175348 (2017)
   PUBMED   28384353
  REMARK    GeneRIF: Generation and characterization of epoxide hydrolase 3
            (EPHX3)-deficient mice
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2402)
  AUTHORS   Sirish,P., Li,N., Liu,J.Y., Lee,K.S., Hwang,S.H., Qiu,H., Zhao,C.,
            Ma,S.M., Lopez,J.E., Hammock,B.D. and Chiamvimonvat,N.
  TITLE     Unique mechanistic insights into the beneficial effects of soluble
            epoxide hydrolase inhibitors in the prevention of cardiac fibrosis
  JOURNAL   Proc Natl Acad Sci U S A 110 (14), 5618-5623 (2013)
   PUBMED   23493561
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT033755.6.
            
            On Mar 28, 2018 this sequence version replaced NM_001347341.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010021.1, BC145797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-436               CT033755.6         70137-70572         c
            437-522             CT033755.6         69888-69973         c
            523-680             CT033755.6         69513-69670         c
            681-809             CT033755.6         69278-69406         c
            810-913             CT033755.6         66548-66651         c
            914-1050            CT033755.6         66318-66454         c
            1051-2402           CT033755.6         64872-66223         c
FEATURES             Location/Qualifiers
     source          1..2402
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.39 cM"
     gene            1..2402
                     /gene="Ephx3"
                     /gene_synonym="2310063B19Rik; Abhd9; EH3"
                     /note="epoxide hydrolase 3"
                     /db_xref="GeneID:71932"
                     /db_xref="MGI:MGI:1919182"
     exon            1..436
                     /gene="Ephx3"
                     /gene_synonym="2310063B19Rik; Abhd9; EH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1276
                     /gene="Ephx3"
                     /gene_synonym="2310063B19Rik; Abhd9; EH3"
                     /EC_number="3.3.2.10"
                     /note="isoform 2 is encoded by transcript variant 2;
                     abhydrolase domain-containing protein 9"
                     /codon_start=1
                     /product="epoxide hydrolase 3 isoform 2"
                     /protein_id="NP_001334270.1"
                     /db_xref="CCDS:CCDS84290.1"
                     /db_xref="GeneID:71932"
                     /db_xref="MGI:MGI:1919182"
                     /translation="MRGGSICPSRASVSSTGPVDSDSTVESQNKGGGLLAPAPLAQSP
                     DHGGSVVVPERKDMPEFVVTALLAPSRLSLKLLRALVMSLVYLAALVAAFVYSCIALT
                     HVMCRPRRGCCGRQRLSPPECLRDPTLGEHCFLTLRSSGLRLHYVSAGHGNGPLMLFL
                     HGFPENWFSWRYQLREFQSHFHVVAVDMRGYSPSDAPKEVDCYTIDLLLDDIKDTILG
                     LGYSKCILVSHDWGASLAWEFSIYYPSLVERMVVANGPPMSVIQEYSIHHIGQIFRSN
                     YMFLFQLPWLPEKLLSMSDFQILKDTFTHRKNGIPGLTPSELEAFLYHFSQPGCLTGP
                     INYYRNVFRNFPLEPKKLSTPTLLLWGEKDFAFQQGLVEAIGRHFVPGRLESHILPGS
                     GHWIPQSHPQEMHQYMWAFLQDLLG"
     exon            437..522
                     /gene="Ephx3"
                     /gene_synonym="2310063B19Rik; Abhd9; EH3"
                     /inference="alignment:Splign:2.1.0"
     exon            523..680
                     /gene="Ephx3"
                     /gene_synonym="2310063B19Rik; Abhd9; EH3"
                     /inference="alignment:Splign:2.1.0"
     exon            681..809
                     /gene="Ephx3"
                     /gene_synonym="2310063B19Rik; Abhd9; EH3"
                     /inference="alignment:Splign:2.1.0"
     exon            810..913
                     /gene="Ephx3"
                     /gene_synonym="2310063B19Rik; Abhd9; EH3"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1050
                     /gene="Ephx3"
                     /gene_synonym="2310063B19Rik; Abhd9; EH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..2402
                     /gene="Ephx3"
                     /gene_synonym="2310063B19Rik; Abhd9; EH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1482..1487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ephx3"
                     /gene_synonym="2310063B19Rik; Abhd9; EH3"
                     /note="hexamer: CATAAA"
     polyA_site      1513
                     /gene="Ephx3"
                     /gene_synonym="2310063B19Rik; Abhd9; EH3"
                     /note="major polyA site"
     regulatory      1554..1559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ephx3"
                     /gene_synonym="2310063B19Rik; Abhd9; EH3"
                     /note="hexamer: AATATA"
     polyA_site      1576
                     /gene="Ephx3"
                     /gene_synonym="2310063B19Rik; Abhd9; EH3"
     regulatory      2363..2368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ephx3"
                     /gene_synonym="2310063B19Rik; Abhd9; EH3"
                     /note="hexamer: AGTAAA"
     polyA_site      2384
                     /gene="Ephx3"
                     /gene_synonym="2310063B19Rik; Abhd9; EH3"
ORIGIN      
        1 agctgccact ttagagtgag tcatgagagg tggcagtatc tgtccgagcc gcgcatctgt
       61 ttcctcgacc ggtccagtgg actccgatag cacggtggaa tcccaaaaca aaggtggtgg
      121 gctgctggcg ccagcacccc tggctcagtc tcccgaccac ggcggctctg tagtcgtccc
      181 agagcgcaag gatatgccgg agtttgtggt gacagcgcta ctcgcaccct cacgcctctc
      241 gctgaagctg ctgcgagcgc tggtgatgag cctggtgtac ttggctgcct tggtggccgc
      301 gtttgtctac agctgcatcg cgctcaccca tgtgatgtgc cgtcctcgca ggggctgctg
      361 cggccgccag aggttgtctc ccccagagtg cctgagagac cccacgctgg gcgagcattg
      421 ctttctaacc ctcaggagtt ccggcctgcg tctgcactat gtctctgctg gtcatggcaa
      481 tgggccactc atgctatttc tgcatggctt cccagagaac tggttcagct ggcgctacca
      541 gctgcgagag tttcagagcc atttccatgt cgtggctgta gacatgcgtg gttatagtcc
      601 ctctgatgct ccaaaggaag tggattgtta caccattgac ttgttgttgg atgacatcaa
      661 ggataccatc ctaggcctgg ggtactccaa gtgcatcctc gtgagccacg actggggggc
      721 ctcccttgcc tgggagttct ccatctacta cccatcccta gtggagcgta tggttgtggc
      781 caatggtcct cccatgtcag tgatccaaga atactcaatc caccacatcg gccagatatt
      841 ccgatcaaac tacatgttcc tgttccagct tccctggctg ccagagaagc tgttgtctat
      901 gtctgacttc cagattctca aagacacatt cactcaccgc aagaacggca tcccaggact
      961 gactccttct gaacttgaag cattccttta tcacttctca caacctggat gcctcactgg
     1021 gcccatcaac tactacagga acgtgttcag gaacttcccc ctggagccca agaaactgtc
     1081 aacacccacg ctgttgctgt ggggggaaaa agacttcgcc ttccagcagg ggctggtgga
     1141 agccattgga agacactttg tgcccggccg gttggaaagc cacattttgc caggcagtgg
     1201 gcactggatt ccacagagcc atcctcagga gatgcatcag tacatgtggg ccttcttgca
     1261 agacctgctg ggctagaagc tcttgtttgc cagcctaaca ttgatatgtt ggagcacata
     1321 tcccctgtcc ttgtgtacct gggagtccat gcagtgtgtg cataagggtg cactcccaga
     1381 actccgagtt acacacagaa gcatctgtgg gcatcttgcc tcacctgcgt ggatgtctta
     1441 ctacttatca aaacctccct gcccccaagg gctacacaaa ccataaattc taacctttct
     1501 gtcttgtttt ccacccccgg tctgatgttt aagtcttcct taatattgca tccaatatat
     1561 ttctaacaca caggaatact tcaatttaaa tgttaatgag ctaaaacgaa ccactatgaa
     1621 aaatacaatg tctctgaagc caggaagacc gacagctgag tgactaaaag catttggtgc
     1681 tcttgtagag gatatgagtt ctattctcag cactcacatg gagtttcaca gccatccata
     1741 aatccatgtt caggggacag gacactcttt cctgctgtcc ctgagcaatg ggcatgcata
     1801 cagcatacac acagacatgc aagtcagaca ttcctacata cagaaaagtc aataaggaat
     1861 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtccctga gcaataggca tgcatgcagc
     1921 atacacacag acatgcaagt cagacattcc tacatacaga aaagtcaata aggaatgtgt
     1981 gtgtgtctcc ctgagcaata ggcatgcatg cagcatacac acagacatgc aagtcagaca
     2041 ttcctacata cagaaaagtc aataaggaat gtgtgtgtgt gtctccctga gcaataggca
     2101 tgcatgcagc atacacacag acatgcaagt cagacattcc tacatacaga aaagtcaata
     2161 aggaatgtgt gtgtgtgtgt gtgtgtgtga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     2221 ttcaagatag ggtttctctg tgtagccctg gccattcagg aactcactct gtagaccagg
     2281 ctgaccttga acttggagat ctgcctgctt ctgcctctca aatgctggaa ttaaaggcgt
     2341 gcgccgccac caccctgtaa gaagtaaatc ttctttaaaa aatacagtgt cttggtcacc
     2401 ac
//
