LOCUS       NM_001146351            3727 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus Eph receptor B6 (Ephb6), transcript variant 1, mRNA.
ACCESSION   NM_001146351
VERSION     NM_001146351.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3727)
  AUTHORS   Yu,H., Qin,X.K., Yin,K.W., Li,Z.M., Ni,E.D., Yang,J.M., Liu,X.H.,
            Zhou,A.J., Li,S.J., Gao,T.M., Li,Y. and Li,J.M.
  TITLE     EphB6 deficiency in intestinal neurons promotes tumor growth in
            colorectal cancer by neurotransmitter GABA signaling
  JOURNAL   Carcinogenesis 44 (8-9), 682-694 (2023)
   PUBMED   37294054
REFERENCE   2  (bases 1 to 3727)
  AUTHORS   Beggs,M.R., Young,K., Plain,A., O'Neill,D.D., Raza,A.,
            Flockerzi,V., Dimke,H. and Alexander,R.T.
  TITLE     Maternal Epidermal Growth Factor Promotes Neonatal Claudin-2
            Dependent Increases in Small Intestinal Calcium Permeability
  JOURNAL   Function (Oxf) 4 (5), zqad033 (2023)
   PUBMED   37575484
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3727)
  AUTHORS   He,C.H., Song,N.N., Xie,P.X., Wang,Y.B., Chen,J.Y., Huang,Y.,
            Hu,L., Li,Z., Su,J.H., Zhang,X.Q., Zhang,L. and Ding,Y.Q.
  TITLE     Overexpression of EphB6 and EphrinB2 controls soma spacing of
            cortical neurons in a mutual inhibitory way
  JOURNAL   Cell Death Dis 14 (5), 309 (2023)
   PUBMED   37149633
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3727)
  AUTHORS   Shibata,M., Pattabiraman,K., Lorente-Galdos,B., Andrijevic,D.,
            Kim,S.K., Kaur,N., Muchnik,S.K., Xing,X., Santpere,G., Sousa,A.M.M.
            and Sestan,N.
  TITLE     Regulation of prefrontal patterning and connectivity by retinoic
            acid
  JOURNAL   Nature 598 (7881), 483-488 (2021)
   PUBMED   34599305
REFERENCE   5  (bases 1 to 3727)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3727)
  AUTHORS   Robinson,D.R., Wu,Y.M. and Lin,S.F.
  TITLE     The protein tyrosine kinase family of the human genome
  JOURNAL   Oncogene 19 (49), 5548-5557 (2000)
   PUBMED   11114734
  REMARK    Review article
REFERENCE   7  (bases 1 to 3727)
  AUTHORS   Cowan,C.A., Yokoyama,N., Bianchi,L.M., Henkemeyer,M. and
            Fritzsch,B.
  TITLE     EphB2 guides axons at the midline and is necessary for normal
            vestibular function
  JOURNAL   Neuron 26 (2), 417-430 (2000)
   PUBMED   10839360
REFERENCE   8  (bases 1 to 3727)
  AUTHORS   Rogers,J.H., Ciossek,T., Menzel,P. and Pasquale,E.B.
  TITLE     Eph receptors and ephrins demarcate cerebellar lobules before and
            during their formation
  JOURNAL   Mech Dev 87 (1-2), 119-128 (1999)
   PUBMED   10495276
REFERENCE   9  (bases 1 to 3727)
  AUTHORS   .
  TITLE     Unified nomenclature for Eph family receptors and their ligands,
            the ephrins. Eph Nomenclature Committee
  JOURNAL   Cell 90 (3), 403-404 (1997)
   PUBMED   9267020
REFERENCE   10 (bases 1 to 3727)
  AUTHORS   Gurniak,C.B. and Berg,L.J.
  TITLE     A new member of the Eph family of receptors that lacks protein
            tyrosine kinase activity
  JOURNAL   Oncogene 13 (4), 777-786 (1996)
   PUBMED   8761299
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117678.16.
            
            On Mar 23, 2020 this sequence version replaced NM_001146351.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L77867.1, AK076442.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               AC117678.16        127680-127989
            311-382             AC117678.16        134813-134884
            383-586             AC117678.16        135384-135587
            587-651             AC117678.16        135921-135985
            652-1414            AC117678.16        136248-137010
            1415-1570           AC117678.16        137658-137813
            1571-1921           AC117678.16        138086-138436
            1922-2046           AC117678.16        138629-138753
            2047-2209           AC117678.16        138917-139079
            2210-2324           AC117678.16        139433-139547
            2325-2377           AC117678.16        139796-139848
            2378-2497           AC117678.16        140016-140135
            2498-2745           AC117678.16        140237-140484
            2746-2919           AC117678.16        140740-140913
            2920-3069           AC117678.16        141400-141549
            3070-3263           AC117678.16        141776-141969
            3264-3419           AC117678.16        142092-142247
            3420-3727           AC117678.16        142365-142672
FEATURES             Location/Qualifiers
     source          1..3727
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 19.77 cM"
     gene            1..3727
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /note="Eph receptor B6"
                     /db_xref="GeneID:13848"
                     /db_xref="MGI:MGI:1096338"
     exon            1..310
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /inference="alignment:Splign:2.1.0"
     exon            311..382
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /inference="alignment:Splign:2.1.0"
     exon            383..586
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /inference="alignment:Splign:2.1.0"
     CDS             484..3528
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /EC_number="2.7.10.1"
                     /note="ephrin type-B receptor 6; ephrin type A receptor;
                     tyrosine-protein kinase-defective receptor EPH-6; chicken
                     eph/elk receptor-like protein"
                     /codon_start=1
                     /product="ephrin type-B receptor 6 precursor"
                     /protein_id="NP_001139823.1"
                     /db_xref="CCDS:CCDS20051.1"
                     /db_xref="GeneID:13848"
                     /db_xref="MGI:MGI:1096338"
                     /translation="MATEGTTGSGSRVVAGMVCSLWLLVLGSSVLALEEVLLDTTGET
                     SEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGLPPGSGQDNWLQTHFVERRGAQ
                     RAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQADEPDGPDSIAAWHLKRWTKVDTIA
                     ADESFPASSSSSSWAVGPHRTGQRVGLQLNVKERSFGPLTQRGFYVAFQDTGACLALV
                     AVKLFSYTCPSVLRAFASFPETQASGAGGASLVAAVGTCVAHAEPEEDGVGGQAGGSP
                     PRLHCNGEGRWMVAVGGCRCQPGHQPARGDKLCQACPEGSYKALAGNVPCSPCPARSH
                     SPDPAAPVCPCLQGFYRASSDPPEAPCTGPPSAPRELWFEVQGSALMLHWRLPQELGG
                     RGDLLFNVVCKECGGHGEPSSGGMCRRCRDEVHFDPRQRGLTESRVLVGGLRAHVPYI
                     LEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVMHQVSRAANSITVSWPQPEQTN
                     GNILDYQLRYYDQAEDESHSFTMTSETNTATVTRLSPGHIYGFQVRARTAAGHGPYGG
                     KVYFQTLPQGELSSQLPEKLSLVIGSILGALAFLLLAAITVLAVIFQRKRRGTGYTEQ
                     LQQYSSPGLGVKYYIDPSTYDDPCQAIRELAREVDPTYIKIEEVIGAGSFGEVRRGRL
                     QPRGRREQAVAIQALWAGGAESLKMTFLGRAALLGQFQHPNILRLEGVVTKSRPVMVL
                     TELMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRALSARSVLVNS
                     HLVCKVARLGHSPQGSSSLLRWAAPEVITHGKYTTSSDVWSFGILMWEVMSYGERPYW
                     DMNEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRK
                     PDTLQAEGGSGDRPSQALLNPVALDFPCLDSPQAWLSAIGLECYQDNFSKFGLSTFSD
                     VAQLSLEDLPGLGITLAGHQKKLLHNIQLLQQHLRQPGSVEV"
     exon            587..651
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /inference="alignment:Splign:2.1.0"
     exon            652..1414
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1570
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1921
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2046
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2209
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2324
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2377
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2497
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2745
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2919
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3069
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /inference="alignment:Splign:2.1.0"
     exon            3070..3263
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..3419
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..3727
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3704..3709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /note="hexamer: ATTAAA"
     polyA_site      3727
                     /gene="Ephb6"
                     /gene_synonym="Cekl; Mep"
                     /note="major polyA site"
ORIGIN      
        1 gcgttcgccc agctagcgct ggggagcagc gggcgtccga acccgagacc acagctcagc
       61 gactccgatc gtgacaccgg cccccgcacg attccccagg gccccgccta gggagcagtc
      121 cctgcttgca gccttgggtc ctctcccaga atcccagaga ctctaagctg cgagcagacg
      181 cgggcccctg ggaagcgagg tccccagacc agagaggaca cgcgcgacgc taggaaagat
      241 ctgcgaggtg cagatccacc gcgggggcct cggggggcgc agacctgcag agctggaggc
      301 cggcgggaag gttggctgct ggaggaacgg tgcagagtaa atgaagagag caaactggaa
      361 taactcctac cagacaagaa gggaagcaag cctggctgta gacaccaggt cttctgaaag
      421 ccatagcagt gcctcagaac agggcagtgg ccgaggcaat ggtgggagtg ccgaagagac
      481 cgcatggcta ctgagggcac gactggctca gggagcagag tggtggcggg catggtgtgc
      541 agtctgtggc tcctggttct agggtcatca gttctagctc tggaagaggt gctgctggat
      601 accacaggag agacctctga gattggctgg ctcacctacc cgccaggtgg gtgggatgag
      661 gtgagtgttc tagatgacca gcgccgtctg actcggacct tcgaagcatg ccacgttgca
      721 gggctccctc ctggttctgg ccaggacaat tggctgcaga cacactttgt ggaacggcga
      781 ggggcccaga gggcacacat ccgccttcac ttctctgtac gagcctgttc cagcctgggt
      841 gtgagtgggg gtacctgccg agagaccttc accctttact accggcaggc tgatgagcca
      901 gacggccccg acagtattgc ggcctggcac ctcaaacgct ggaccaaagt ggacacaatt
      961 gccgcagatg agagcttccc tgcctcctct tcctcttcct catgggctgt gggaccccac
     1021 aggaccggtc agcgggtggg actgcagctg aatgtcaaag agcgcagctt tggtcctctc
     1081 actcagcgtg gcttctatgt ggccttccag gacacagggg cctgcctggc ccttgtggca
     1141 gtcaagctct tctcctacac ctgtccctcc gtcctgcgtg cctttgcctc ttttcctgag
     1201 acacaggcca gtggagctgg aggggcttcc ttagtggcag ctgtgggcac ctgtgtagct
     1261 catgcagaac cagaggagga tggagtagga ggccaggcag ggggcagccc cccaaggtta
     1321 cactgtaatg gcgaaggcag gtggatggta gctgtgggag gctgccgctg ccagcctgga
     1381 caccagcctg ctcgtggaga caagctctgc caagcctgcc ctgagggatc ctataaggcc
     1441 ctggctggga atgttccctg ttcaccgtgt ccagcccgca gccactcccc tgaccctgca
     1501 gccccagttt gcccatgtct ccaaggcttc tacagggcca gttcggaccc accagaggct
     1561 ccctgcactg gtcctccatc ggctccccgg gagctatggt ttgaggtgca aggctcggca
     1621 ctcatgctgc actggcgtct gcctcaggag ctgggtggac gaggggatct gctcttcaat
     1681 gttgtgtgca aggagtgtgg aggtcacgga gagcccagca gtggggggat gtgtcgccgc
     1741 tgcagggacg aggtgcattt cgacccccgc cagaggggac tgactgagag tcgagtgtta
     1801 gttggggggc tccgagcaca cgtgccatac atcttggaag tgcaggctgt caatggggtg
     1861 tctgagctca gccctgaccc tccccaggca gcagccatca atgtcagcac cagccacgaa
     1921 gtcccttctg cagtccctgt gatgcaccag gtgagccggg cagccaacag catcacagta
     1981 tcctggccac agcctgagca aacaaatggg aacatcctcg actaccagct gcgctactat
     2041 gaccaggcag aagatgaatc ccactccttc accatgacca gtgagaccaa cactgccact
     2101 gtgacacggt tgagccctgg ccacatctat ggcttccagg tgcgggcacg gactgcagct
     2161 ggccacggcc cctatggggg caaagtctat tttcagacat tgcctcaagg tgagctgtcc
     2221 tcccagcttc cagagaagct gtccttggtg attggttcca tcctgggggc cttggccttc
     2281 cttctactgg cagccatcac tgtactggct gtcatcttcc agcggaagcg ccgtgggacc
     2341 ggctacacag aacaactgca acaatacagc agcccaggac ttggagtgaa gtattacatt
     2401 gacccttcta catacgatga cccctgccag gccatcagag agcttgctcg agaggttgac
     2461 cctacatata tcaagattga agaagtcatt ggggcaggtt cctttggaga agtgcgtcgg
     2521 ggccgactgc aaccccgggg aaggagggaa caagctgtgg ctatccaggc cttgtgggca
     2581 gggggtgctg agagcctgaa gatgaccttt ctgggtcggg cagcactgct gggccagttc
     2641 cagcacccca atatcctgcg gctggaaggt gtagtcacta agagtcggcc tgtcatggtg
     2701 ctgacagaac tcatggaact tggtcccctg gacagctttc ttaggcagcg agagggccag
     2761 ttcagtagcc tgcagctggt ggccatgcag cggggtgtgg ctgctgccat gcagtacttg
     2821 tccagctttg cctttgttca ccgagcactc tcggcccgaa gtgtgctagt gaatagccac
     2881 ctggtgtgta aggtggcacg tctcggccac agtcctcagg gttcaagttc cttgcttcgc
     2941 tgggcagccc cagaggtcat tacacatgga aagtatacaa catctagcga tgtctggagc
     3001 tttggcatac tcatgtggga agtgatgagc tatggagaac ggccctactg ggacatgaac
     3061 gagcaggagg tactaaatgc aatagagcaa gagttccggc tgcccccacc tccagggtgc
     3121 ccccctggac tacatctact gatgctagac acttggcaga aggaccgtgc ccgtcggcct
     3181 cattttgacc agctggtagc tgcatttgac aagatgattc gcaagcctga tactctccag
     3241 gctgaagggg gctccgggga caggccttcc caggctcttc tgaaccctgt ggccttggac
     3301 ttcccttgcc tggactctcc ccaggcctgg ctttcagcca ttggactaga gtgctaccag
     3361 gacaacttct ccaagtttgg tctttccacc ttcagtgatg tggctcagct cagcctggaa
     3421 gacctgccag gcctgggcat caccctagct ggccaccaga agaaacttct gcacaacatt
     3481 cagctcctcc agcagcacct gaggcagcca ggctcagtgg aagtgtaaag cctgctcagg
     3541 agtctgtgag ccgccgatgc cccaacccag tcctggccat agggtggaga aggggcgtgt
     3601 gagactgagt caggctctac tccagcttcc atgcctgtca cattaaaccc agccctctgg
     3661 acattgcacc cccaaatcct gctcttccaa cagcctcccc catattaaag ggaaagaagg
     3721 gaattta
//
