LOCUS       NM_010143               4160 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Mus musculus Eph receptor B3 (Ephb3), mRNA.
ACCESSION   NM_010143
VERSION     NM_010143.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4160)
  AUTHORS   Thowfeequ,S., Fiorentino,J., Hu,D., Solovey,M., Ruane,S.,
            Whitehead,M., Zhou,F., Godwin,J., Mateo-Otero,Y.,
            Vanhaesebroeck,B., Scialdone,A. and Srinivas,S.
  TITLE     An integrated approach identifies the molecular underpinnings of
            murine anterior visceral endoderm migration
  JOURNAL   Dev Cell 59 (17), 2347-2363 (2024)
   PUBMED   38843837
REFERENCE   2  (bases 1 to 4160)
  AUTHORS   Rodriguez-Sosa,M.R., Del Castillo,L.M., Belarra,A., Zapata,A.G. and
            Alfaro,D.
  TITLE     The lack of EphB3 receptor prevents bone loss in mouse models of
            osteoporosis
  JOURNAL   J Bone Miner Res 39 (7), 1008-1024 (2024)
   PUBMED   38739682
  REMARK    GeneRIF: The lack of EphB3 receptor prevents bone loss in mouse
            models of osteoporosis.
REFERENCE   3  (bases 1 to 4160)
  AUTHORS   Montero-Herradon,S., Garcia-Ceca,J., Villarejo-Torres,M. and
            Zapata,A.G.
  TITLE     Peripheral T-cell responses of EphB2- and EphB3-deficient mice in a
            model of collagen-induced arthritis
  JOURNAL   Cell Mol Life Sci 81 (1), 159 (2024)
   PUBMED   38558087
  REMARK    GeneRIF: Peripheral T-cell responses of EphB2- and EphB3-deficient
            mice in a model of collagen-induced arthritis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4160)
  AUTHORS   Yang,K.Y., Zhao,S., Feng,H., Shen,J., Chen,Y., Wang,S.T.,
            Wang,S.J., Zhang,Y.X., Wang,Y., Guo,C., Liu,H. and Tang,T.S.
  TITLE     Ca2+ homeostasis maintained by TMCO1 underlies corpus callosum
            development via ERK signaling
  JOURNAL   Cell Death Dis 13 (8), 674 (2022)
   PUBMED   35927240
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4160)
  AUTHORS   Lewis,A.E., Kuwahara,A., Franzosi,J. and Bush,J.O.
  TITLE     Tracheal separation is driven by NKX2-1-mediated repression of
            Efnb2 and regulation of endodermal cell sorting
  JOURNAL   Cell Rep 38 (11), 110510 (2022)
   PUBMED   35294885
REFERENCE   6  (bases 1 to 4160)
  AUTHORS   Ciossek,T., Lerch,M.M. and Ullrich,A.
  TITLE     Cloning, characterization, and differential expression of MDK2 and
            MDK5, two novel receptor tyrosine kinases of the eck/eph family
  JOURNAL   Oncogene 11 (10), 2085-2095 (1995)
   PUBMED   7478528
REFERENCE   7  (bases 1 to 4160)
  AUTHORS   Bergemann,A.D., Cheng,H.J., Brambilla,R., Klein,R. and
            Flanagan,J.G.
  TITLE     ELF-2, a new member of the Eph ligand family, is segmentally
            expressed in mouse embryos in the region of the hindbrain and newly
            forming somites
  JOURNAL   Mol Cell Biol 15 (9), 4921-4929 (1995)
   PUBMED   7651410
REFERENCE   8  (bases 1 to 4160)
  AUTHORS   Sommers,C.L., Huang,K., Shores,E.W., Grinberg,A., Charlick,D.A.,
            Kozak,C.A. and Love,P.E.
  TITLE     Murine txk: a protein tyrosine kinase gene regulated by T cell
            activation
  JOURNAL   Oncogene 11 (2), 245-251 (1995)
   PUBMED   7542761
REFERENCE   9  (bases 1 to 4160)
  AUTHORS   Biesecker,L.G., Giannola,D.M. and Emerson,S.G.
  TITLE     Identification of alternative exons, including a novel exon, in the
            tyrosine kinase receptor gene Etk2/tyro3 that explain differences
            in 5' cDNA sequences
  JOURNAL   Oncogene 10 (11), 2239-2242 (1995)
   PUBMED   7784069
REFERENCE   10 (bases 1 to 4160)
  AUTHORS   Ruiz,J.C., Conlon,F.L. and Robertson,E.J.
  TITLE     Identification of novel protein kinases expressed in the myocardium
            of the developing mouse heart
  JOURNAL   Mech Dev 48 (3), 153-164 (1994)
   PUBMED   7893599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC168061.3.
            
            On Dec 20, 2022 this sequence version replaced NM_010143.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014822.1, AK144414.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-484               AC168061.3         40548-41031         c
            485-549             AC168061.3         32857-32921         c
            550-1222            AC168061.3         30814-31486         c
            1223-1378           AC168061.3         28460-28615         c
            1379-1729           AC168061.3         27446-27796         c
            1730-1854           AC168061.3         27192-27316         c
            1855-2014           AC168061.3         26858-27017         c
            2015-2123           AC168061.3         26664-26772         c
            2124-2176           AC168061.3         26304-26356         c
            2177-2299           AC168061.3         25269-25391         c
            2300-2547           AC168061.3         24917-25164         c
            2548-2763           AC168061.3         24311-24526         c
            2764-2913           AC168061.3         24035-24184         c
            2914-3107           AC168061.3         23753-23946         c
            3108-3263           AC168061.3         23507-23662         c
            3264-4160           AC168061.3         22507-23403         c
FEATURES             Location/Qualifiers
     source          1..4160
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 12.62 cM"
     gene            1..4160
                     /gene="Ephb3"
                     /gene_synonym="Cek10; Etk2; HEK2; mDK-5; MDK5; Sek4;
                     Tyro6"
                     /note="Eph receptor B3"
                     /db_xref="GeneID:13845"
                     /db_xref="MGI:MGI:104770"
     exon            1..484
                     /gene="Ephb3"
                     /gene_synonym="Cek10; Etk2; HEK2; mDK-5; MDK5; Sek4;
                     Tyro6"
                     /inference="alignment:Splign:2.1.0"
     CDS             391..3372
                     /gene="Ephb3"
                     /gene_synonym="Cek10; Etk2; HEK2; mDK-5; MDK5; Sek4;
                     Tyro6"
                     /EC_number="2.7.10.1"
                     /note="ephrin type-B receptor 3; tyrosine-protein kinase
                     receptor SEK-4; developmental kinase 5"
                     /codon_start=1
                     /product="ephrin type-B receptor 3 precursor"
                     /protein_id="NP_034273.1"
                     /db_xref="CCDS:CCDS28060.1"
                     /db_xref="GeneID:13845"
                     /db_xref="MGI:MGI:104770"
                     /translation="MAGARPPPGLLPLLAPLLLPLLLPAGCWALEETLMDTKWVTSEL
                     AWTSHPESGWEEVSGYDEAMNPIRTYQVCNVRESSQNNWLRTGFIWRREVQRVYVELK
                     FTVRDCNSIPNIPGSCKETFNLFYYEADSDVASASSPFWMENPYVKVDTIAPDESFSR
                     LDAGRVNTKVRSFGPLSKAGFYLAFQDQGACMSLISVRAFYKKCASTTAGFALFPETL
                     TGAEPTSLVIAPGTCIANAVEVSVPLKLYCNGDGEWMVPVGACTCATGHEPAAKESQC
                     RACPPGSYKAKQGEGPCLPCPPNSRTTSPAASICTCHNNFYRADSDSADSACTTVPSP
                     PRGVISNVNETSLILEWSEPRDLGGRDDLLYNVICKKCRGSSGAGGPATCSRCDDNVE
                     FVPRQLGLTERRVHISHLLAHTRYTFEVQAVNGVSGKSPLPPRYAAVNITTNQAAPSE
                     VPTLHLHSSSGSSLTLSWAPPERPNGVILDYEMKYFEKSKGIASTVTSQKNSVQLDGL
                     QPDARYVVQVRARTVAGYGQYSHPAEFETTSERGSGAQQLQEQLPLIVGSTVAGFVFM
                     VVVVVIALVCLRKQRHGPDAEYTEKLQQYIAPGMKVYIDPFTYEDPNEAVREFAKEID
                     VSCVKIEEVIGAGEFGEVCRGRLKLPGRREVFVAIKTLKVGYTERQRRDFLSEASIMG
                     QFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAG
                     MKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIR
                     WTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPM
                     DCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNAASLKVTASAPSGMSQPLLDR
                     TVPDYTTFTTVGDWLDAIKMGRYKESFVGAGFASFDLVAQMTAEDLLRIGVTLAGHQK
                     KILCSIQDMRLQMNQTLPVQV"
     exon            485..549
                     /gene="Ephb3"
                     /gene_synonym="Cek10; Etk2; HEK2; mDK-5; MDK5; Sek4;
                     Tyro6"
                     /inference="alignment:Splign:2.1.0"
     exon            550..1222
                     /gene="Ephb3"
                     /gene_synonym="Cek10; Etk2; HEK2; mDK-5; MDK5; Sek4;
                     Tyro6"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1378
                     /gene="Ephb3"
                     /gene_synonym="Cek10; Etk2; HEK2; mDK-5; MDK5; Sek4;
                     Tyro6"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1729
                     /gene="Ephb3"
                     /gene_synonym="Cek10; Etk2; HEK2; mDK-5; MDK5; Sek4;
                     Tyro6"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1854
                     /gene="Ephb3"
                     /gene_synonym="Cek10; Etk2; HEK2; mDK-5; MDK5; Sek4;
                     Tyro6"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2014
                     /gene="Ephb3"
                     /gene_synonym="Cek10; Etk2; HEK2; mDK-5; MDK5; Sek4;
                     Tyro6"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2123
                     /gene="Ephb3"
                     /gene_synonym="Cek10; Etk2; HEK2; mDK-5; MDK5; Sek4;
                     Tyro6"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2176
                     /gene="Ephb3"
                     /gene_synonym="Cek10; Etk2; HEK2; mDK-5; MDK5; Sek4;
                     Tyro6"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2299
                     /gene="Ephb3"
                     /gene_synonym="Cek10; Etk2; HEK2; mDK-5; MDK5; Sek4;
                     Tyro6"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2547
                     /gene="Ephb3"
                     /gene_synonym="Cek10; Etk2; HEK2; mDK-5; MDK5; Sek4;
                     Tyro6"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2763
                     /gene="Ephb3"
                     /gene_synonym="Cek10; Etk2; HEK2; mDK-5; MDK5; Sek4;
                     Tyro6"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2913
                     /gene="Ephb3"
                     /gene_synonym="Cek10; Etk2; HEK2; mDK-5; MDK5; Sek4;
                     Tyro6"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3107
                     /gene="Ephb3"
                     /gene_synonym="Cek10; Etk2; HEK2; mDK-5; MDK5; Sek4;
                     Tyro6"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3263
                     /gene="Ephb3"
                     /gene_synonym="Cek10; Etk2; HEK2; mDK-5; MDK5; Sek4;
                     Tyro6"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..4160
                     /gene="Ephb3"
                     /gene_synonym="Cek10; Etk2; HEK2; mDK-5; MDK5; Sek4;
                     Tyro6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4142..4147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ephb3"
                     /gene_synonym="Cek10; Etk2; HEK2; mDK-5; MDK5; Sek4;
                     Tyro6"
                     /note="hexamer: AATAAA"
     polyA_site      4160
                     /gene="Ephb3"
                     /gene_synonym="Cek10; Etk2; HEK2; mDK-5; MDK5; Sek4;
                     Tyro6"
                     /note="major polyA site"
ORIGIN      
        1 agaagtgagt acgtgagcgg cgcagccaga taccggctcc taccccggac ggcgagcgca
       61 caaggatccc gggatctgag ctcggcctca gtggactgtg ccccgagaac ctgcgaccac
      121 ctgcgccctc cgcttcccga gtcattgggc atcaagccac ccagcgcccc ggatcctcct
      181 ggaccggtcc gtccagattc ccgcgggaac gacctgccgg catctacccg gagtcccggg
      241 ttgggcgaca cctcggttac agagcagccc gtctgctttg ctccccctcc ctgacgggat
      301 ctcttggact gtgcgcgagc cttcttcctc gggcgtcccc agccccgccg gcgcggcccg
      361 gctcggcccc ccaaccgagc gccccgggct atggccggag cccgcccgcc gccggggctt
      421 ctgccgctgc tcgctccgct gctgctgccg ctgctgcttc ccgccggctg ctgggcgctg
      481 gaagagactc tcatggacac gaaatgggtg acgtctgagc tggcatggac atctcatcca
      541 gagagtgggt gggaagaagt aagcggctat gatgaagcca tgaatcctat ccgcacgtat
      601 caggtgtgta atgtgcgtga gtcgagccag aacaactggc tgcggacggg tttcatctgg
      661 cggcgggaag tccagcgcgt ctacgtggag ctgaagttca ccgtaagaga ctgtaacagc
      721 attcccaaca tccctggctc ctgcaaggaa accttcaacc ttttctacta cgaggctgat
      781 agcgatgtgg cctcagcctc ctctcccttc tggatggaga acccctacgt gaaagtggac
      841 accattgcgc cagatgagag cttctcgcgg ctcgatgccg ggcgtgtcaa caccaaggtg
      901 cgcagcttcg ggccgctttc caaggctggc ttctacttgg ccttccagga ccaaggtgcc
      961 tgcatgtcac tcatctctgt gcgtgccttc tacaagaagt gtgcatccac cactgcaggc
     1021 ttcgcactct tccccgagac cctcacgggg gctgagccca cttcgctggt cattgccccc
     1081 ggcacctgca tcgctaacgc tgtggaggtc tctgtaccac tcaagctcta ctgcaatggc
     1141 gacggggagt ggatggtgcc cgtcggtgcc tgcacctgcg ctactggcca tgagccagcc
     1201 gccaaggagt cccagtgccg tgcctgtcct cctgggagtt acaaagcaaa gcaaggagaa
     1261 gggccctgcc tcccctgtcc ccccaatagc cgcaccacct cgccggctgc cagcatctgc
     1321 acctgccata ataacttcta ccgtgcagac tcagactcgg ccgacagcgc ctgcaccacg
     1381 gtgccatctc caccccgggg tgtgatctcc aatgtgaatg agacctcgct aatcctcgaa
     1441 tggagtgagc cccgggacct tggcggacga gatgacctcc tttataatgt tatctgcaag
     1501 aagtgccgtg ggagctctgg ggctgggggt ccggcaacct gttcacgctg cgatgacaac
     1561 gtagagtttg tacctcggca gctgggcctg acagagcgcc gggtccacat tagccacctg
     1621 ttggcccaca cacgctacac ctttgaggtg caggctgtca acggtgtctc aggcaaaagc
     1681 cctttgccac cccgctatgc agctgtgaat atcaccacca accaggctgc tccatcagaa
     1741 gtgcctacac tccacctgca cagcagctcg gggagcagcc tgaccctgtc ctgggcaccc
     1801 ccagagcggc ctaatggagt catcttggac tatgagatga agtactttga gaagagtaaa
     1861 ggcatcgcct ccactgtaac cagccagaag aactccgtac aactggacgg gctgcagcct
     1921 gatgcccgct acgtagttca ggtccgggct cgcacagtag cgggttacgg acagtatagc
     1981 cacccggctg agtttgagac cacaagtgaa agaggttcag gtgcccagca gcttcaagaa
     2041 cagcttcccc tgattgtggg atccaccgta gccgggtttg tcttcatggt ggtcgtcgtg
     2101 gtcatcgctc ttgtctgcct caggaagcag cgccatggcc ccgatgcaga atacacagag
     2161 aagctgcagc aatacattgc tcctgggatg aaagtttaca ttgacccctt tacctatgag
     2221 gatcccaatg aggccgtccg agagttcgcc aaggagatcg atgtgtcctg tgtcaagatc
     2281 gaggaggtga ttggagctgg ggagtttggg gaagtgtgcc ggggtcgact gaaactgccc
     2341 ggccgccggg aggtgttcgt ggctatcaag acgctgaagg tgggatacac ggagaggcag
     2401 cggcgggact tcctaagtga ggcttccatt atgggtcagt ttgaccatcc caatataatc
     2461 cgtctagagg gtgtggtcac caaaagtcgt ccagtcatga tcctcactga gttcatggag
     2521 aactgtgccc tggactcctt tctacggctc aatgacggac agttcacggt catccagctt
     2581 gtgggcatgt tacgaggcat tgctgctggc atgaagtact tgtctgagat gaactacgtg
     2641 caccgtgacc ttgctgcccg aaacatcctt gtcaacagca acttggtctg caaagtctct
     2701 gactttggcc tctcccgctt cctggaggat gacccatcag accccaccta caccagctcc
     2761 ctgggtggga agatccctat ccgctggacc gccccggagg ccatagccta tcggaagttt
     2821 acgtctgcca gcgatgtctg gagctatggg attgtcatgt gggaggtcat gagctacgga
     2881 gagcgaccct actgggatat gagcaaccag gatgtcatta atgctgtaga gcaagactat
     2941 cggttaccac cccccatgga ctgccccacc gcgctgcacc agctcatgct ggactgttgg
     3001 gtgcgggacc ggaacctcag gcccaagttc tctcaaatcg tcaacacact agacaaactt
     3061 atccgcaatg ctgccagcct caaggtcacc gccagtgccc catctggcat gtcccagccc
     3121 ctcctggacc gcacagtccc agattatacg accttcacga cagtgggtga ctggctagat
     3181 gccatcaaga tggggaggta taaagagagc tttgtcggtg ctgggtttgc atcctttgac
     3241 ctggtggccc agatgactgc agaagatctg ctaaggattg gggtcacttt ggctgggcac
     3301 cagaagaaga tcctctgcag tatccaggac atgcggctgc agatgaacca gaccctgcct
     3361 gtgcaggtct gacactcagc tccaacgagg ggggggtgcc cccccaggac tgcacaagga
     3421 ttctgaccag ccagctggac ttttggatgc ctggcctctg gctgtggccc agaagatgga
     3481 agtttggggg aggaccctag ctgtgacttc tccaggcctg tgctccctcc caggaagtgt
     3541 gccccaaacc tcttcatatt gaagatggat tagaagaggg ggtgatgtcc cctccccaga
     3601 tgccttgggg cccaggcctg cctgctctcc agtggggagt cttcacaact cagattgggc
     3661 tgcgcttcag taatggacgt cctggtaggg tcaggtgggg ataagcctgg gttcttcagg
     3721 ccccagccct ggcaggggtc tgaccccacc aggtaagcag agagtactcc ctcccccagg
     3781 aagtggagga ggagactctg gggatgggga gatatggtgc cccatcctga agccagctgg
     3841 tacctccagt ttgcacaggg acttgatggg ggctgagggc cctgcctacc cttggtgctg
     3901 tcataaaagg gcaggcagga gcaggctgag aagcagcctg tgcctcccag agactgactc
     3961 agagagccag agactgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     4021 tgaaagacgg gggtgggggt atgtatgtgt gtgttgtgca catgcttgcc tgcacagaga
     4081 gcatgagtgt gtacaagctt ggccctgtgc cctgtagtgg ggccagctgg gcagacagca
     4141 aaataaaggc aataagatga
//
