LOCUS       NM_010142              10926 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus Eph receptor B2 (Ephb2), transcript variant 2, mRNA.
ACCESSION   NM_010142 XM_204072
VERSION     NM_010142.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10926)
  AUTHORS   David,E.T., Yousuf,M.S., Mei,H.R., Jain,A., Krishnagiri,S.,
            Elahi,H., Venkatesan,R., Srikanth,K.D., Dussor,G., Dalva,M.B. and
            Price,T.J.
  TITLE     ephrin-B2 promotes nociceptive plasticity and hyperalgesic priming
            through EphB2-MNK-eIF4E signaling in both mice and humans
  JOURNAL   Pharmacol Res 206, 107284 (2024)
   PUBMED   38925462
  REMARK    GeneRIF: ephrin-B2 promotes nociceptive plasticity and hyperalgesic
            priming through EphB2-MNK-eIF4E signaling in both mice and humans.
REFERENCE   2  (bases 1 to 10926)
  AUTHORS   Agarwal,K. and Lamprecht,R.
  TITLE     EphB2 activation in neural stem cells in the basolateral amygdala
            facilitates neurogenesis and enhances long-term memory
  JOURNAL   Cell Mol Life Sci 81 (1), 277 (2024)
   PUBMED   38913115
  REMARK    GeneRIF: EphB2 activation in neural stem cells in the basolateral
            amygdala facilitates neurogenesis and enhances long-term memory.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10926)
  AUTHORS   Zhang,H., Lei,M., Zhang,Y., Li,H., He,Z., Xie,S., Zhu,L., Wang,S.,
            Liu,J., Li,Y., Lu,Y. and Ma,C.
  TITLE     Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE
            complex assembly and neurotransmitter release
  JOURNAL   Sci Adv 10 (20), eadi7024 (2024)
   PUBMED   38758791
  REMARK    GeneRIF: Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated
            SNARE complex assembly and neurotransmitter release.
REFERENCE   4  (bases 1 to 10926)
  AUTHORS   Montero-Herradon,S., Garcia-Ceca,J., Villarejo-Torres,M. and
            Zapata,A.G.
  TITLE     Peripheral T-cell responses of EphB2- and EphB3-deficient mice in a
            model of collagen-induced arthritis
  JOURNAL   Cell Mol Life Sci 81 (1), 159 (2024)
   PUBMED   38558087
  REMARK    GeneRIF: Peripheral T-cell responses of EphB2- and EphB3-deficient
            mice in a model of collagen-induced arthritis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10926)
  AUTHORS   Rasool,D., Burban,A., Sharanek,A., Madrigal,A., Hu,J., Yan,K.,
            Qu,D., Voss,A.K., Slack,R.S., Thomas,T., Bonni,A., Picketts,D.J.,
            Soleimani,V.D., Najafabadi,H.S. and Jahani-Asl,A.
  TITLE     PHF6-mediated transcriptional control of NSC via Ephrin receptors
            is impaired in the intellectual disability syndrome BFLS
  JOURNAL   EMBO Rep 25 (3), 1256-1281 (2024)
   PUBMED   38429579
REFERENCE   6  (bases 1 to 10926)
  AUTHORS   Singh,A., Winterbottom,E. and Daar,I.O.
  TITLE     Eph/ephrin signaling in cell-cell and cell-substrate adhesion
  JOURNAL   Front Biosci (Landmark Ed) 17 (2), 473-497 (2012)
   PUBMED   22201756
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 10926)
  AUTHORS   Bergemann,A.D., Cheng,H.J., Brambilla,R., Klein,R. and
            Flanagan,J.G.
  TITLE     ELF-2, a new member of the Eph ligand family, is segmentally
            expressed in mouse embryos in the region of the hindbrain and newly
            forming somites
  JOURNAL   Mol Cell Biol 15 (9), 4921-4929 (1995)
   PUBMED   7651410
REFERENCE   8  (bases 1 to 10926)
  AUTHORS   Sommers,C.L., Huang,K., Shores,E.W., Grinberg,A., Charlick,D.A.,
            Kozak,C.A. and Love,P.E.
  TITLE     Murine txk: a protein tyrosine kinase gene regulated by T cell
            activation
  JOURNAL   Oncogene 11 (2), 245-251 (1995)
   PUBMED   7542761
REFERENCE   9  (bases 1 to 10926)
  AUTHORS   Saito,T., Seki,N., Matsuda,Y., Kitahara,M., Murata,M., Kanda,N.,
            Nomura,N., Yamamoto,T. and Hori,T.A.
  TITLE     Identification of the human ERK gene as a putative receptor
            tyrosine kinase and its chromosomal localization to 1p36.1: a
            comparative mapping of human, mouse, and rat chromosomes
  JOURNAL   Genomics 26 (2), 382-384 (1995)
   PUBMED   7601466
REFERENCE   10 (bases 1 to 10926)
  AUTHORS   Ben-David,Y., Letwin,K., Tannock,L., Bernstein,A. and Pawson,T.
  TITLE     A mammalian protein kinase with potential for serine/threonine and
            tyrosine phosphorylation is related to cell cycle regulators
  JOURNAL   EMBO J 10 (2), 317-325 (1991)
   PUBMED   1825055
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ180821.1, BC043088.1 and
            AL671173.12.
            
            On Aug 18, 2015 this sequence version replaced NM_010142.3.
            
            Summary: This gene encodes a member of the Eph receptor family of
            receptor tyrosine kinase transmembrane glycoproteins. These
            receptors consist of an N-terminal glycosylated ligand-binding
            domain, a transmembrane region and an intracellular kinase domain.
            The encoded receptor preferentially binds membrane-bound ephrin-B
            ligands and is involved in nervous system and vascular development.
            This gene is used as a marker of intestinal stem cells. Homozygous
            knockout mice for this gene exhibit impaired axon guidance and
            vestibular function. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. It
            encodes isoform 2, which is shorter by an amino acid, compared to
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043088.1, SRR7974084.22998.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                CJ180821.1         2-78
            78-4851             BC043088.1         1-4774
            4852-10926          AL671173.12        110288-116362       c
FEATURES             Location/Qualifiers
     source          1..10926
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 69.0 cM"
     gene            1..10926
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
                     /note="Eph receptor B2"
                     /db_xref="GeneID:13844"
                     /db_xref="MGI:MGI:99611"
     exon            1..243
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            244..308
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            309..993
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1149
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1485
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1610
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1773
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1882
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..1947
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2070
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2318
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2534
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2684
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2878
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..3034
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..10926
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4154..4159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
                     /note="hexamer: AATACA"
     polyA_site      4182
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
                     /note="major polyA site"
     regulatory      4836..4841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
                     /note="hexamer: AATAAA"
     polyA_site      4860
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
     polyA_site      9689
                     /gene="Ephb2"
                     /gene_synonym="Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5;
                     Qek5; Sek3; Tyro5"
ORIGIN      
        1 ggagcccggg tccccgttct gcccgggctg gatggctcat tctgctggct gcgcggcggc
       61 ggcggctcgt gtgtgtgtgc gccgcgcccc gccgctcccc gccggccccc cgagcccggg
      121 gcgcgcgctc cagcccgggg gtccccgcgg cgccgcggcc ggaggctccg ggcagcgcag
      181 caatggccgt gcgcaggctg ggggccgcgc tgctgctgct gccgctgcta gccgccgtgg
      241 aagaaaccct gatggactct acgacagcaa cggctgagct gggctggatg gtacatcccc
      301 catcagggtg ggaagaggtg agcggctacg acgagaacat gaacactatc cgtacctacc
      361 aggtgtgcaa tgtctttgag tcaagccaga acaactggct gcggaccaaa ttcatccggc
      421 gccgcggcgc ccaccgcatc cacgtggaga tgaagttctc ggtgcgtgac tgcagcagca
      481 ttcccagcgt gccgggctcc tgcaaggaga ccttcaacct ctactactat gaggctgatt
      541 ttgacttagc caccaaaacc tttcccaact ggatggagaa tccgtgggtg aaggtggaca
      601 ccatcgcggc cgatgagagc ttctctcagg tggacctggg tggccgcgtc atgaaaatca
      661 acactgaggt gcgaagcttc ggtcccgtgt cccgcaatgg tttctacctg gccttccagg
      721 actatggcgg ctgtatgtcc ctcattgctg tgcgcgtctt ctaccggaag tgcccccgaa
      781 tcatccagaa tggtgccatc ttccaggaga cactgtcggg ggctgagagc acttcgctgg
      841 tggcagctcg gggcagctgc atcgccaatg ctgaagaagt ggatgtgccc atcaaactct
      901 actgtaacgg ggacggcgaa tggctggtgc ccataggtcg ctgcatgtgc aaggcgggct
      961 tcgaggctgt ggagaacggc accgtctgcc gaggttgtcc atcaggaacc ttcaaggcca
     1021 accaagggga cgaagcctgc acccactgtc ccatcaacag ccgcaccacc tccgagggtg
     1081 ccaccaactg tgtatgccgc aacggctact acagggccga cctggacccc ttagacatgc
     1141 cttgcacaac catcccctct gcgccccagg ctgtgatctc cagcgtcaac gagacgtccc
     1201 tcatgctaga gtggacccca ccccgagact cggggggtcg cgaggatctt gtttacaaca
     1261 tcatctgcaa gagctgtggc tccggccggg gcgcatgcac gcgctgcggg gacaacgtgc
     1321 agtacgcgcc ccgccagctg ggcctgactg agccgcgcat ctacatcagt gacctgctgg
     1381 cacacacgca gtacaccttc gagatccagg ccgtgaacgg tgtgactgac cagagtccct
     1441 tctcacctca gttcgcctct gtgaacatca ccaccaacca agcagcacca tcggccgtgt
     1501 ccatcatgca ccaggtgagc cgcactgtgg acagcatcac cctgtcgtgg tcccagccag
     1561 accagcccaa cggtgtgatc ctggactacg agctgcagta ctatgagaag gagctcagtg
     1621 agtacaacgc cacggccata aaaagcccca ccaacacagt cactgtgcag ggcctcaaag
     1681 ccggcgccat ctatgtcttc caggtgcggg cacgcaccgt tgcaggctat gggcgctaca
     1741 gtggcaagat gtacttccaa accatgacag aagccgagta ccagaccagc atcaaggaaa
     1801 agctacccct catcgttggc tcctccgccg ccggcttagt cttcctcatc gctgtggtcg
     1861 tcattgccat cgtatgtaac agacgggggt ttgagcgtgc cgactcagag tacacggaca
     1921 agctacaaca ctacaccagc ggacacatga ccccaggcat gaagatctat atagaccctt
     1981 tcacctatga agatcctaat gaggcagtgc gggagtttgc caaggaaatt gacatctcct
     2041 gtgtcaagat tgagcaggtg atcggagcag gggaatttgg tgaggtctgc agtggccatt
     2101 tgaagctgcc aggcaagaga gagatctttg tagccatcaa gaccctcaag tcaggataca
     2161 cggagaaaca gcgccgggac ttcctgagtg aggcatccat catgggccag ttcgaccacc
     2221 ccaatgtcat ccatctggaa ggggttgtca ccaagagcac acctgtcatg atcatcactg
     2281 aattcatgga gaacggatct ctggactcct tcctccggca aaacgatggg cagttcacag
     2341 tcatccaact ggtgggcatg ctgaggggca ttgcagccgg catgaagtac ctggcggaca
     2401 tgaactacgt gcaccgtgac cttgctgctc gaaacatcct cgtcaacagc aacctggtgt
     2461 gtaaggtgtc tgattttggg ctctcacgct tcctggagga tgacacgtct gaccccacct
     2521 ataccagcgc tctgggtggg aagatcccca tccgttggac ggcaccggaa gccatccagt
     2581 accggaaatt cacctcggcc agtgatgtgt ggagctatgg catcgtcatg tgggaggtga
     2641 tgtcctacgg ggaacgaccc tactgggaca tgaccaatca agacgtaatc aacgccattg
     2701 aacaggacta cagactacct ccgcccatgg actgccctag tgccctgcac cagctcatgc
     2761 tggactgctg gcagaaggac cgcaaccacc ggcccaagtt cggccagatt gtcaacacgc
     2821 tggacaagat gatccgaaac cccaacagcc tcaaagccat ggcacccctg tcctctggca
     2881 tcaacctgcc actgctggac cgcacgatac cggactacac cagctttaac acggtggatg
     2941 agtggctaga ggccatcaag atgggccagt acaaggagag ctttgccaac gccggcttta
     3001 cctctttcga cgttgtatct cagatgatga tggaggacat tctccgcgtt ggggtcactc
     3061 tagctggcca ccagaaaaaa atcctgaaca gtatccaggt gatgcgggcc cagatgaacc
     3121 agatccagtc tgtagaggtt tgacattcgc ctgcctcggt tctcctcttc ctccacgccg
     3181 ccccctgagc ccccctacat cggtccccct gctgctctgt ccactacaag gtcagccacc
     3241 tgccaggagg ccacagacaa caggaagaac caagcagcac tccagccaag ccgtcaccaa
     3301 gagcccatgc aagtcaaagg aaggaaaagg ggattgggtg ggggggacac gcacctagat
     3361 ctgggagggg gcgggacagg caagagacgt tcgttccaag aggattctca taagggaagt
     3421 gacggttctt agaggagaaa agcaaaaggc ttgggagatc cacatggcct gtccccgtga
     3481 aggccaaaaa gcattttctc tccaactcct tctgggaagg ttgagctggc cagagccaag
     3541 aaacacttcc aggaacatta acatgaaggg aagaggtgag ccaccctcct tgcctggcct
     3601 tagccgtttc ttggagcatc actaatggcc cagcccccag gcacaagggg cagagagaca
     3661 ggcagtcgcc ccagataggc tccggggaag tccattccag ctgccaccgg cagacaggag
     3721 gatagttgtt ctgtcttggg agacggtttc caaaaactcc gagagacttt ctgctaatgg
     3781 ttcaggaggc ggaagaggag ctcctggcct cccaggtcac gccaaacagg ctagatcttc
     3841 ctgaggacag ccacccaggt ctgcagcccc acaaggccct gctcctgatc agcctcagcc
     3901 agaggacgag gaggcaggtg actgtcatca gcctcgactg ccacagagaa gcatactctt
     3961 gcatctgggt ttgtttacag cgattccgtg gaccgggggt attttgatca ggggtggttt
     4021 tggtctggga gggttttgtt tgttgggttt ttttaaaaaa aaatgacaat gaagagacac
     4081 tttgacattt cctacctttt gaggacttga tccttctcca ggaagaaggt gctttctgct
     4141 tactgactta ggcaatacac caagggcgag attttatatg cacatttctg gattttttta
     4201 tatgcttttc attgataccc ttccctcctc ccacctgctg ccaggcctca ccaaagccaa
     4261 ctgtcacagg gccacctggg ccactcagag acctcagtgg gactgggaga gtggagggaa
     4321 ctacatcagc gcccacactg gaccacagac ggaggcagat gagggctcca aggccggaag
     4381 tcctcccttc ctccctgtct gctctcatgc tctccgccct gttctatctg gcacttccca
     4441 ggcacagagg ccccttcagg ttcctgggtg ctcttcaatg gccaaaactc gatttcatgt
     4501 ctgggagcct ggaccaggct acccgggaag tcaggaccct gatcattcac tgtgacaccc
     4561 cagccctcca agggtacccc gggagaccac gtgactctct ctctctctct gtctctctct
     4621 ctctctgtct ctctctctct ctctctctct ctgtctctct ctctctctgt ctctctctgt
     4681 ctctctccca ctccttcttt ccccgaggcc tttgcctggg tctgaaggtc ttggccagag
     4741 gaacaccatc atcagtcaag gggtctggcc gcaggctccc ctgtgagcaa atgcagggaa
     4801 tccgagcaga acaatcggtt agtgaattga atggaaataa atgctttagt tataaaatga
     4861 cccctgtact ctgtaagttc caagaaaaag atcctggcac ctttgggacc tgccaaatga
     4921 ctttaatgct cttgcaaggg actcttcccc ctgcccctca ggatccaaaa ggcccaggct
     4981 gaggaaactc atggaggcaa tcaaacaaac aaacaaagaa gctcatgtag ccttcttagc
     5041 ctagggtcat cagaagcaca ggcagagaag cgtaggcact gggttggctc agctctgcgt
     5101 tgcgtgtaca gtgcctggct aagtaagcca cgttagaagt ggtggcccgt ggaccccatt
     5161 cagccacaaa tgtaaccccc tcccccacac aatgctgtct cctgtgctaa gggctcggac
     5221 ttactgtgag tagttctttt gtgtggagga ggagaaggag gaagagaagg aagaggagga
     5281 gaaggaggca ggaagtgtgt gtgctgcaga taagactgtt agaagaggaa ggggtatccc
     5341 agagacagct catctcagga ccatttcctt tgtctggtga gcatctttga ggagcctatc
     5401 catgggggaa gattgaggcc acaggccacc agcaaaagac cctgcagtga gcaaaaccat
     5461 cgtggctcag cctgtcatct gtccttcacc tattctcaac ccgggagcag agggaaggaa
     5521 gggattagag aggaagcttg tccctggggt agggacagcg ggcctggaca cagggcaagt
     5581 attggcaagt ttcccacaaa gcagcaaaca gcggcccgtt ggccatccct taatggccca
     5641 aagacaccca gcgcggatgg cagctgtccc agcacacaag gtcaccttct ggtgggagct
     5701 tctctgatgc tctgcagatt aactgtctcc ccagcccacc tcccaccacc ccagagcccc
     5761 acgaggcctg gcagtcagtg tttccgtcag atggcttcct gccttaagcc actaggctgg
     5821 cgtcttctag ccagctcatc tgcccatcca ccctctagtg cccaaagtat tcgtgtaaag
     5881 ccgtaggact ctacatgtct acttccagaa tacgggtgct atccagacct tctgtctcct
     5941 cttcagggta ccaaacagac accgtcactg tggcagtcct gagtgtaggc cctgctcact
     6001 tctcaactac aagacatcgt cctcccccca ctcctcaatg ctcagcaggg agtggtaggc
     6061 cctgctgcca agcgccttcc acttaggctg cccgctcaca tgggcacaca gcttggagct
     6121 atctgctgcc tagttactaa tcccttcctg gctccacccc ccatccatct ccccactccc
     6181 agccccccca agcactagct cccacctgcc cagcatcagg aaccgcttcc ggctgttcag
     6241 cccaagcttg tttcttgagg aaagaaagct gttttgtgaa cctgggccag ggcaccatgg
     6301 aagtggggcc agctgctctg ggagagtgtg cctggaagag ccactcgggg ccaagttaag
     6361 tatgacggag ctgtgccacc caccccagaa gtctcacaat gggctgttag tggcaatcaa
     6421 caggcctgtt cctgagccgg tattgaaggt gtcttgctgg taggttggta gcacgcttgc
     6481 ctggcatgca caaagcactc ggttccaccc cccagcactg cataaaccgg atatggtaat
     6541 atatgactgt aaactcggta ctcaagaaat ggaggcagga gggttagaag atcagtggca
     6601 tccttagcta cttagtgagt tcaaagccag cctgggccac ataagacctt atctctagga
     6661 aagaagttat ggtcaatagt gacatcctta gtgctagacc cactgcttct gagcagacac
     6721 aagagtagca gagaacactt atacaatcta cttaccagct gggcctcaag tccacccttt
     6781 ccagtatcca gagcgcccac cttctctatg gctgagaggt ctatgctgcc cccttgtggg
     6841 cactcactaa cattgcaccc cctcatagat cccacccctt gctgaaggac tcccaccgga
     6901 gaccaccacc caccccaatg ccacccttgc ttctccaggt gcctgtcatt tccagggaca
     6961 gttcccagag gaagaccttt ggcagggaga ggtgcaaatg cactcaaaag acaagatgta
     7021 acctacttct gtcactaact agggccacgg gccccaggag agactgttcc tcactgggcc
     7081 atagcttctc atctataaaa caggagcatt aggctgggtg ctgcaggcct ggaaaaccct
     7141 ttgtccacct cggtcccgca aagtaaaaca ctggttcagg gccacggctc cagaaagggc
     7201 cacaagcctt ggcttccccg caccagggtc cacccgaaca tggtcactta ggcgcagaaa
     7261 acaaaggaat ccagctctgg cgtatgaggc aagagaaaac cagatgggat gggctatcag
     7321 ggtgggcttt cagggggagg ctacaggctg agagaaaggt cactccaaaa cgtagcagct
     7381 tcaacagtgc agcgcaaaaa catctggagg tgttgtgggg catgagttgg tgtgagtgta
     7441 gggcatggaa ttaaggtcca gccacagagg ctaccaagca gagattagta ggactaccat
     7501 tagattatag agcagtggtt ctcaaccttc ccaatgctgc aaccctttaa cacaattcct
     7561 cacggtgtgg tgacccccaa ccatttgttg tggtttgatt tggctttttg agacagggtt
     7621 tctctgtgta gccctggctg ttctggaact cactctgtag accaggctgg ccttgaactc
     7681 acagagatcc acctccctct gccttctagg tgctggggtt aaaggggtgc gccactacca
     7741 cctagctcat aaaaatgttt tcattgctac tttataactg taacttggct attgttatga
     7801 atcatgatgt aaatatctgt gttttccagt ggacttagac aacccctgag aatggagtca
     7861 ttcaactccc aaagtggtca cgacccacag gttgagaacc agtgttctag aaaaaaaaaa
     7921 gagtcagttt cagccatcaa atcaaaagag gagcttccag caagcccctg gaagagccct
     7981 cgggactcca agagagccca gactctgcca tttactttcc aacacggaca aacccgactc
     8041 cacttccgca gcctgggaga gaggagcttg gctttgtgtt ccctgattca tctcttttta
     8101 ttttgaaaga gtctcatata tcccagtctg accccaaact cactgtgcag tcagggatga
     8161 ccactattga acgtccgatc ctcctcgctc tacctcccaa gggctgggat tacaggcgca
     8221 caccaccacg tctggttttg cagtgctagg gtcgggaagc cggggtcttt gtgcttggga
     8281 agcaagcgct ctaccaactg agctacaccc tcagcccatc tgcttctggt tgtagctatg
     8341 atgtccacac atgggcatac accaccagcc agccagcctt gcctcagatt cccagccagt
     8401 gactgttacc acaaaactgg ctggagagcg agcttggccc cagtcagctt ttcccacaga
     8461 gaaaccagtg ttggggtgtt ggcctcaaga aaggacttgg gccaaagtgg gttcagagag
     8521 tccccgaccc ccacccagca agctggcctc aggcgattga agcctcaagg actaatatct
     8581 gaacagatta ccctatgcca agtgccaaaa tctccctgcc ccctcttcgc tagtgaggaa
     8641 catggctctc aaggggggtg gggggaaccc agccaatcct aacacctaca gcctgctgac
     8701 tgaacgtgtg tttgcaagtg cttgtaatca cccataggat aagcacctta cccactactg
     8761 catgtcgaat tgaggattcc agggctccac catgcctccc tgagtcagaa ttccccatct
     8821 gaacagtggg agattcctgc ccgccccgga gggccccctg ctccgcctcc tcccgcctcc
     8881 cacccacaac cctgtaacaa tctgcaccga gtgtactgag cagcgcttag ggtggagcct
     8941 catatcagat aagatgccca aagcccagac acaaactaag accctgacag tggagaaggc
     9001 aggacgaacc ctcaggaatg tgcccagact gggttagggt ttcagaaaaa tcaaaaagac
     9061 ccccgaagcc ccagagtcca gctgagttaa gttcacagca ggacgactgc ttcgggaaag
     9121 ctgatccggg aagaatcagg aacctaatac ttcacagggg ccctgcgtcc cagccgggac
     9181 caccctgtgg agaccccaac gccccaacac cacagcgcag acatgctcgc tcaatacctg
     9241 gcctggtggg ccaaactagg gctgggtgga ccttctaggt aaacctgacc ctcaagtctc
     9301 ctgagcctac ccactaccca aactgaggtg acagcagatg agcaaaggca cctggggctc
     9361 cctgttcctc gagggcctgg ctccccctgc tggaaaaagg gggtatggca tagggaaggg
     9421 aaggcaagca acaaggaaag gccagaaacc atctaagagc tagcacatat actctgggcc
     9481 ctgctgagcc aagaattgta gcattccaag ggctaaaaga ccccaagatt ttatgactca
     9541 ccaaacgcaa tctcctaaga ggccagtgga aagaatttgt gtttgtgaga gtccatcact
     9601 aggcaaatct gtgctaattc ttgacatcat aagccccatg gttcgacgct acccaaactc
     9661 aggggcccta gcagggagaa aaaaagaaag aaagaaaagg gggaaaaaag cacaaagaga
     9721 gagggggaga gaaagagaag agggggagac agtaatgcaa gctggggaat ctggttacag
     9781 atggatgatg gggaatataa aacctccctt ggagtgaccc tcaccaggtc tgattggaga
     9841 aggctggccc atctgcttct tcaaaaccct cttgcaggct gcagtaccca cttgcttggg
     9901 gggctctgac agcccactgt ggggctccgc ctggacagag agaactggag caagatcacc
     9961 ccataccagc gaggaagcag tggggtggag aggcaccaca ctgcctttcc tatgatggtc
    10021 tccatacaag gtttctttcc tgggacacat ggatgcatta tctcatggct gccaacacgt
    10081 cctccctcca aggagcactc tcatcccttc cactgcctcc caaaatgaga cctgccccaa
    10141 ggagagctgt gaagggccca gagctctgtg gtggtctctc tctgtcctcc tttctatgga
    10201 cagaaactct gacgcctcca ccactgaccc caggtggact tcacaggaac ccacactcac
    10261 gagcagtctc ttcagcctcc agggaagaac gacggctgct tggttttaat cccagctgct
    10321 atttcttcag tgccaaccat ggacagggct cctcgtgtct tctagacaca gccctgcaac
    10381 tccacaagag ccgtgcaata atgacaacca cactgtgggc tgggacactc agagacagca
    10441 tgctggctcc cccaggtcac acagccagcc agcggtcttg gaccccagca cagcacactt
    10501 ttctcacaat acgccactac cattggtcct cactcagctc accatggtca gatcccaggt
    10561 ccccagggtc actgctctct ttgcatggcc ccccagccca gctgctatca gagccagagg
    10621 gggtgcctgc ctagacccac tctgacagtc ccccgccccc acctccacca gcctgagctg
    10681 tcccagcaat agctctcaac cagggatatc tggcagattt cataggactg ccctttcctc
    10741 tggtcaatgt tgggagtcag aaaggggtgg ggccggggcc cctctagacc ccggtgttgt
    10801 gaccaagaaa atctcatcag ctgcatccag tggcaacctt gaccctgtgg gttactctga
    10861 tgtgtttgta ggagtatttt tagctgaatc tctttttttt ttccaaaata aatgtgaatt
    10921 gtaaaa
//
