LOCUS       NM_173447               4686 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus Eph receptor B1 (Ephb1), transcript variant 1, mRNA.
ACCESSION   NM_173447
VERSION     NM_173447.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4686)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4686)
  AUTHORS   Liu,L., Jiang,Y., Al-Shabrawey,M., Ren,X., Wang,S. and Steinle,J.J.
  TITLE     EphB1 causes retinal damage through inflammatory pathways in the
            retina and retinal Muller cells
  JOURNAL   Mol Vis 30, 167-174 (2024)
   PUBMED   38601015
  REMARK    GeneRIF: EphB1 causes retinal damage through inflammatory pathways
            in the retina and retinal Muller cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4686)
  AUTHORS   Assali,A., Chenaux,G., Cho,J.Y., Berto,S., Ehrlich,N.A. and
            Cowan,C.W.
  TITLE     EphB1 controls long-range cortical axon guidance through a cell
            non-autonomous role in GABAergic cells
  JOURNAL   Development 151 (5) (2024)
   PUBMED   38345254
  REMARK    GeneRIF: EphB1 controls long-range cortical axon guidance through a
            cell non-autonomous role in GABAergic cells.
REFERENCE   4  (bases 1 to 4686)
  AUTHORS   Rasool,D., Burban,A., Sharanek,A., Madrigal,A., Hu,J., Yan,K.,
            Qu,D., Voss,A.K., Slack,R.S., Thomas,T., Bonni,A., Picketts,D.J.,
            Soleimani,V.D., Najafabadi,H.S. and Jahani-Asl,A.
  TITLE     PHF6-mediated transcriptional control of NSC via Ephrin receptors
            is impaired in the intellectual disability syndrome BFLS
  JOURNAL   EMBO Rep 25 (3), 1256-1281 (2024)
   PUBMED   38429579
REFERENCE   5  (bases 1 to 4686)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 4686)
  AUTHORS   Rogers,J.H., Ciossek,T., Menzel,P. and Pasquale,E.B.
  TITLE     Eph receptors and ephrins demarcate cerebellar lobules before and
            during their formation
  JOURNAL   Mech Dev 87 (1-2), 119-128 (1999)
   PUBMED   10495276
REFERENCE   7  (bases 1 to 4686)
  AUTHORS   Holder,N. and Klein,R.
  TITLE     Eph receptors and ephrins: effectors of morphogenesis
  JOURNAL   Development 126 (10), 2033-2044 (1999)
   PUBMED   10207129
  REMARK    Review article
REFERENCE   8  (bases 1 to 4686)
  AUTHORS   .
  TITLE     Unified nomenclature for Eph family receptors and their ligands,
            the ephrins. Eph Nomenclature Committee
  JOURNAL   Cell 90 (3), 403-404 (1997)
   PUBMED   9267020
REFERENCE   9  (bases 1 to 4686)
  AUTHORS   Stein,E., Cerretti,D.P. and Daniel,T.O.
  TITLE     Ligand activation of ELK receptor tyrosine kinase promotes its
            association with Grb10 and Grb2 in vascular endothelial cells
  JOURNAL   J Biol Chem 271 (38), 23588-23593 (1996)
   PUBMED   8798570
REFERENCE   10 (bases 1 to 4686)
  AUTHORS   Mori,T., Wanaka,A., Taguchi,A., Matsumoto,K. and Tohyama,M.
  TITLE     Differential expressions of the eph family of receptor tyrosine
            kinase genes (sek, elk, eck) in the developing nervous system of
            the mouse
  JOURNAL   Brain Res Mol Brain Res 29 (2), 325-335 (1995)
   PUBMED   7609620
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK039530.1, AK036148.1 and BC057301.1.
            
            On Nov 28, 2009 this sequence version replaced NM_173447.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057301.1, AK033966.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1651              AK039530.1         2-1652
            1652-4109           AK036148.1         1340-3797
            4110-4686           BC057301.1         4050-4626
FEATURES             Location/Qualifiers
     source          1..4686
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 54.15 cM"
     gene            1..4686
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /note="Eph receptor B1"
                     /db_xref="GeneID:270190"
                     /db_xref="MGI:MGI:1096337"
     exon            1..412
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..3309
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ephrin type-B receptor 1"
                     /codon_start=1
                     /product="ephrin type-B receptor 1 isoform 1 precursor"
                     /protein_id="NP_775623.3"
                     /db_xref="CCDS:CCDS40742.1"
                     /db_xref="GeneID:270190"
                     /db_xref="MGI:MGI:1096337"
                     /translation="MALDCLLLFLLASAVAAMEETLMDTRTATAELGWTANPASGWEE
                     VSGYDENLNTIRTYQVCNVFEPNQNNWLLTTFINRRGAHRIYTEMRFTVRDCSSLPNV
                     PGSCKETFNLYYYETDSVIATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNT
                     EVRSFGPLTRNGFYLAFQDYGACMSLLSVRVFFKKCPSIVQNFAVFPETMTGAESTSL
                     VIARGTCIPNAEEVDVPIKLYCNGDGEWMVPIGRCTCKPGYEPENSVACKACPAGTFK
                     ASQEAEGCSHCPSNSRSPSEASPICTCRTGYYRADFDPPEVACTSVPSGPRNVISIVN
                     ETSIILEWHPPRETGGRDDVTYNIICKKCRADRRSCSRCDDNVEFVPRQLGLTECRVS
                     ISSLWAHTPYTFDIQAINGVSSKSPFPPQHVSVNITTNQAAPSTVPIMHQVSATMRSI
                     TLSWPQPEQPNGIILDYEIRYYEKEHNEFNSSMARSQTNTARIDGLRPGMVYVVQVRA
                     RTVAGYGKFSGKMCFQTLTDDDYKSELREQLPLIAGSAAAGVVFVVSLVAISIVCSRK
                     RAYSKEAAYSDKLQHYSTGRGSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEV
                     IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIR
                     LEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNY
                     VHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAY
                     RKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQL
                     MLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFT
                     TVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLRIGVTLAGHQKKILSSIHSM
                     RVQMNQSPSVMA"
     exon            413..477
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            478..1159
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1315
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1651
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1776
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1939
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2048
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2113
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2236
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2484
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2700
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2850
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..3044
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            3045..3200
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..4667
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3809..3814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /note="hexamer: AATAAA"
     polyA_site      3834
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /note="major polyA site"
     regulatory      4632..4637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /note="hexamer: ATTAAA"
     polyA_site      4667
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /note="major polyA site"
ORIGIN      
        1 cagtctggcc cgctctgtcc tcccgtaggc tccgctgtag ctcgcaatgt gacaccagga
       61 cgcacacgct ctcgcgcgct ctcccaggct cgctctccct caccctctct cacacacgca
      121 cgcacacacc cacctctccc ataaacacac acacacacat gcacacccac atccacgcgc
      181 gcccgcaccg ccccacgcgc gcacactccc gcccacgccc acgccgcgct ccggggagtc
      241 cggtcccggc cagagcgcga aaggacacgg agaagccacc cgccgggagc gcagcggcgc
      301 cctgggacgc ggcgcgtctc cgctggggct cggcctgggg gccgctggcc ggcgatggcc
      361 ctggattgct tgctgctctt cctcctggca tctgcagtgg ccgcgatgga agagacattg
      421 atggacacaa ggacagccac tgcagagttg ggatggacgg ccaaccctgc ctctgggtgg
      481 gaagaagtca gtggctatga tgaaaacctg aacaccatcc gtacttacca agtgtgcaac
      541 gtcttcgaac ccaaccagaa caactggctg cttaccacct ttatcaacag aaggggcgcc
      601 catcgcatct atacagagat gcgcttcact gtgagggact gcagcagcct tccaaatgtc
      661 ccaggctcct gcaaggagac cttcaacttg tactactatg agactgactc tgtgattgcc
      721 accaagaagt cagccttctg gtctgaagcc ccctacctca aagtggacac cattgctgca
      781 gatgagagct tctcccaggt ggattttggg ggaaggttga tgaaagtcaa cacggaagtc
      841 aggagctttg ggcctcttac taggaacggt ttttacctcg ctttccagga ttatggagcc
      901 tgtatgtctc tcctttctgt ccgtgtcttc ttcaaaaagt gtcccagcat cgtgcagaat
      961 tttgcagtgt tcccagaaac catgacagga gcagagagca catctctggt gattgctcgg
     1021 ggcacatgca tcccaaatgc ggaagaagtg gatgtgccca taaaactcta ctgcaacgga
     1081 gatggagagt ggatggtgcc cattgggcgc tgtacctgta agcctggcta tgagcctgag
     1141 aacagcgtgg cctgcaaggc ctgtcctgcg gggaccttca aggccagcca ggaagctgaa
     1201 ggctgctccc actgcccctc caacagtcgc tccccttcag aggcgtctcc catctgcacc
     1261 tgccggactg gctattaccg agctgacttt gatccaccag aggtggcgtg tactagtgtc
     1321 ccatcgggtc ctcgaaatgt catctccatc gtgaatgaga catctatcat tctagagtgg
     1381 caccctccaa gagagactgg tgggagagat gacgtgacgt acaacatcat ctgcaagaag
     1441 tgccgagcag accgccgcag ctgctcccgc tgcgatgaca atgtggagtt tgtccccagg
     1501 caactgggct tgactgagtg tcgtgtctcc atcagtagcc tatgggccca caccccgtac
     1561 acctttgata tccaggccat caatggagtc tctagcaaga gtccctttcc cccacagcac
     1621 gtctctgtca acatcaccac aaaccaagct gccccctcca ctgttcctat catgcaccag
     1681 gtcagtgcca ccatgaggag catcaccttg tcatggcctc agccggagca acccaatggc
     1741 ataatcctgg actatgagat ccggtactat gagaaggaac acaatgagtt caactcttcc
     1801 atggccagga gccagaccaa cacagcacgt atcgatgggc tacggcctgg catggtatac
     1861 gtggtccagg tgcgagctcg aaccgtggct ggctatggca agttcagtgg caagatgtgt
     1921 ttccagactc tgacagatga tgattacaag tcggagctga gagagcagct acccctgatt
     1981 gctggctcgg cagcagctgg agtcgtattt gttgtgtctc tggtggccat ctctattgtc
     2041 tgcagcagga aacgagctta cagcaaagag gctgcgtaca gtgataagct tcaacattac
     2101 agcacaggcc gaggctcccc agggatgaag atctacattg acccattcac ttatgaggac
     2161 cccaatgaag ccgtccggga atttgccaag gagattgatg tatcttttgt gaaaattgaa
     2221 gaggtcatcg gagcagggga gttcggcgag gtgtacaagg gccgtttgaa gctgccaggc
     2281 aagagggaaa tctatgtggc catcaagacc ctgaaggctg ggtactcaga gaaacagcgt
     2341 cgggattttc tgagcgaggc gagcatcatg ggccagtttg accatcccaa catcattcgc
     2401 ctggagggtg tcgtcaccaa gagccggcct gtcatgatca ttacggagtt catggagaac
     2461 ggcgctttag actctttcct ccggcaaaat gatggacagt tcaccgtgat ccagcttgtg
     2521 gggatgctga ggggcatcgc tgctggcatg aagtacctat ctgagatgaa ttatgtgcac
     2581 cgggacctgg ctgctagaaa cattctggtc aacagcaacc tggtgtgcaa agtttctgac
     2641 tttggtctct ctcgctacct ccaggatgac acctcagacc ccacctacac cagctccttg
     2701 ggagggaaga tccctgtgag atggacagct ccagaggcca tcgcctaccg caagtttacg
     2761 tcagccagcg atgtctggag ctatgggatt gtcatgtggg aagtgatgtc atttggagag
     2821 agaccttact gggatatgtc caatcaagat gtcatcaatg ccattgagca ggattaccgg
     2881 ctgcctcctc ctatggactg cccagctgcc ctgcaccagc tcatgctgga ctgttggcag
     2941 aaggatcgca atagccggcc ccgttttgca gagatcgtca acaccctgga caagatgatc
     3001 cggaacccag ctagtctcaa gactgtggca accatcaccg ctgtgccttc ccaacccctg
     3061 cttgaccgct ctatcccaga cttcacggcc tttaccaccg tggatgactg gctaagtgcc
     3121 atcaaaatgg tccagtacag ggacagcttc ctcaccgcag gcttcacctc ccttcagctg
     3181 gtcacccaga tgacatcaga agacctcctg agaatagggg taaccttggc aggccatcag
     3241 aagaagattc tgagtagcat tcactcaatg agggtccaga tgaaccagtc accatcggta
     3301 atggcgtgag aactcggtgt tcatagggga ggagaggaat gtaaaggacc agggtcaaag
     3361 gggagccaga ggttgaccac tgtggaatgt gccagaaaga tcagcttctt ggctgagaaa
     3421 caacttccca tctgtgaaga atgaactgga cttgttgccc acgggcaacc gccgtttctc
     3481 ggcaacggaa gtccgtagat gccacgggaa accaaacacg taatgataaa gacagagaaa
     3541 ggtgatgcta aacagaagca aatctgaaac cgtatgcatt ggggaccaag gtgaactcgg
     3601 ttcccatctg agagggactg gagttacctg tctgcaggaa gaaaggaagg aggtggaagg
     3661 gaagagaccg aagccccagc tgtgccatgc tctccctcac caatgacatt cttttctttt
     3721 ctcctttctt actcctccct cagagcccct cctccctccc ccacatccat ctccctttgc
     3781 tcatgactca tgtagggaag tttcttcaaa taaagcccag ctcctgagtc tccagatgtc
     3841 gtctgtcagt tgccaaagga ctttgctgac cactactgca tggggatcca accaattcaa
     3901 ttaatgtctt catattgaag aagagatgta ccttcaattg aaaaccttgt ttttcttttg
     3961 tttgcatttt ctgcaaaaag gaaaaaaaaa aagaaaccac aaattggaaa aaaaatagaa
     4021 aaacctgttt ccgtgtgcaa acgcacacgt atgtgtgtct gcgttataaa atgactgtgc
     4081 ttgttcgtga cagatgcaaa caagaaaaaa gaattgggaa aggtttttgg ccctgggagg
     4141 tctcaagggg ctggaatatg ctgttggcct ggctctctgc ttggcccgct gggaagagaa
     4201 aagggggagg gatgatcgta aatgaaagaa aaaaaagtct ctgaagagtt tgcaaattaa
     4261 gacaggaaac aggtgagtgg tttgaattgg gtgcagagtg ggccggtcca gaatgatgct
     4321 gactgaagag gtattctttg ataagatctg aagaaaagaa gagggaaagg gtttctggag
     4381 agtgttcctc atcccagaac cagcgatttg agaggcgctg gcgagggaga actctttctt
     4441 gcctggcccg tggactggct gaagccgtgt ggcatggagg aaagtctctg tcctatctgt
     4501 gtttctcttt gcatcccttc ctgaaacctc attgttcatt gtttgattcg cttttgtaaa
     4561 ttccacctaa cattgaaata tttttaattt ctccttttac cttaaatcct cttgctaatt
     4621 ttatctgtct aattaaaaag agcagaagca tgtctgggtt tacgtaaaaa aaaaaaaaaa
     4681 aaaaaa
//
