LOCUS       NM_001168296            4563 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus Eph receptor B1 (Ephb1), transcript variant 2, mRNA.
ACCESSION   NM_001168296
VERSION     NM_001168296.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4563)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4563)
  AUTHORS   Liu,L., Jiang,Y., Al-Shabrawey,M., Ren,X., Wang,S. and Steinle,J.J.
  TITLE     EphB1 causes retinal damage through inflammatory pathways in the
            retina and retinal Muller cells
  JOURNAL   Mol Vis 30, 167-174 (2024)
   PUBMED   38601015
  REMARK    GeneRIF: EphB1 causes retinal damage through inflammatory pathways
            in the retina and retinal Muller cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4563)
  AUTHORS   Assali,A., Chenaux,G., Cho,J.Y., Berto,S., Ehrlich,N.A. and
            Cowan,C.W.
  TITLE     EphB1 controls long-range cortical axon guidance through a cell
            non-autonomous role in GABAergic cells
  JOURNAL   Development 151 (5) (2024)
   PUBMED   38345254
  REMARK    GeneRIF: EphB1 controls long-range cortical axon guidance through a
            cell non-autonomous role in GABAergic cells.
REFERENCE   4  (bases 1 to 4563)
  AUTHORS   Rasool,D., Burban,A., Sharanek,A., Madrigal,A., Hu,J., Yan,K.,
            Qu,D., Voss,A.K., Slack,R.S., Thomas,T., Bonni,A., Picketts,D.J.,
            Soleimani,V.D., Najafabadi,H.S. and Jahani-Asl,A.
  TITLE     PHF6-mediated transcriptional control of NSC via Ephrin receptors
            is impaired in the intellectual disability syndrome BFLS
  JOURNAL   EMBO Rep 25 (3), 1256-1281 (2024)
   PUBMED   38429579
REFERENCE   5  (bases 1 to 4563)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 4563)
  AUTHORS   Rogers,J.H., Ciossek,T., Menzel,P. and Pasquale,E.B.
  TITLE     Eph receptors and ephrins demarcate cerebellar lobules before and
            during their formation
  JOURNAL   Mech Dev 87 (1-2), 119-128 (1999)
   PUBMED   10495276
REFERENCE   7  (bases 1 to 4563)
  AUTHORS   Holder,N. and Klein,R.
  TITLE     Eph receptors and ephrins: effectors of morphogenesis
  JOURNAL   Development 126 (10), 2033-2044 (1999)
   PUBMED   10207129
  REMARK    Review article
REFERENCE   8  (bases 1 to 4563)
  AUTHORS   .
  TITLE     Unified nomenclature for Eph family receptors and their ligands,
            the ephrins. Eph Nomenclature Committee
  JOURNAL   Cell 90 (3), 403-404 (1997)
   PUBMED   9267020
REFERENCE   9  (bases 1 to 4563)
  AUTHORS   Stein,E., Cerretti,D.P. and Daniel,T.O.
  TITLE     Ligand activation of ELK receptor tyrosine kinase promotes its
            association with Grb10 and Grb2 in vascular endothelial cells
  JOURNAL   J Biol Chem 271 (38), 23588-23593 (1996)
   PUBMED   8798570
REFERENCE   10 (bases 1 to 4563)
  AUTHORS   Mori,T., Wanaka,A., Taguchi,A., Matsumoto,K. and Tohyama,M.
  TITLE     Differential expressions of the eph family of receptor tyrosine
            kinase genes (sek, elk, eck) in the developing nervous system of
            the mouse
  JOURNAL   Brain Res Mol Brain Res 29 (2), 325-335 (1995)
   PUBMED   7609620
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK039530.1, AK036211.1, CT025594.13 and BC057301.1.
            
            Transcript Variant: This variant (2) lacks a coding exon compared
            to variant 1. The resulting protein (isoform 2) is shorter but has
            the same N- and C-termini compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036211.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1651              AK039530.1         2-1652
            1652-2152           AK036211.1         1651-2151
            2153-2264           CT025594.13        159252-159363
            2265-4563           BC057301.1         2328-4626
FEATURES             Location/Qualifiers
     source          1..4563
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 54.15 cM"
     gene            1..4563
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /note="Eph receptor B1"
                     /db_xref="GeneID:270190"
                     /db_xref="MGI:MGI:1096337"
     exon            1..412
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..3186
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /EC_number="2.7.10.1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; ephrin type-B receptor 1"
                     /codon_start=1
                     /product="ephrin type-B receptor 1 isoform 2 precursor"
                     /protein_id="NP_001161768.1"
                     /db_xref="CCDS:CCDS52901.1"
                     /db_xref="GeneID:270190"
                     /db_xref="MGI:MGI:1096337"
                     /translation="MALDCLLLFLLASAVAAMEETLMDTRTATAELGWTANPASGWEE
                     VSGYDENLNTIRTYQVCNVFEPNQNNWLLTTFINRRGAHRIYTEMRFTVRDCSSLPNV
                     PGSCKETFNLYYYETDSVIATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNT
                     EVRSFGPLTRNGFYLAFQDYGACMSLLSVRVFFKKCPSIVQNFAVFPETMTGAESTSL
                     VIARGTCIPNAEEVDVPIKLYCNGDGEWMVPIGRCTCKPGYEPENSVACKACPAGTFK
                     ASQEAEGCSHCPSNSRSPSEASPICTCRTGYYRADFDPPEVACTSVPSGPRNVISIVN
                     ETSIILEWHPPRETGGRDDVTYNIICKKCRADRRSCSRCDDNVEFVPRQLGLTECRVS
                     ISSLWAHTPYTFDIQAINGVSSKSPFPPQHVSVNITTNQAAPSTVPIMHQVSATMRSI
                     TLSWPQPEQPNGIILDYEIRYYEKEHNEFNSSMARSQTNTARIDGLRPGMVYVVQVRA
                     RTVAGYGKFSGKMCFQTLTDDDYKSELREQLPLIAGSAAAGVVFVVSLVAISIVCSRK
                     RAYSKEAAYSDKLQHYSTGRGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDF
                     LSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVG
                     MLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSS
                     LGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQ
                     DYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAV
                     PSQPLLDRSIPDFTAFTTVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLRIG
                     VTLAGHQKKILSSIHSMRVQMNQSPSVMA"
     exon            413..477
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            478..1159
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1315
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1651
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1776
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1939
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2048
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2113
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2361
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2577
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            2578..2727
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2921
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..3077
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..4544
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3686..3691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /note="hexamer: AATAAA"
     polyA_site      3711
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /note="major polyA site"
     regulatory      4509..4514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /note="hexamer: ATTAAA"
     polyA_site      4544
                     /gene="Ephb1"
                     /gene_synonym="9330129L11; C130099E04Rik; Cek6; Elk; Elkh;
                     Hek6; Net"
                     /note="major polyA site"
ORIGIN      
        1 cagtctggcc cgctctgtcc tcccgtaggc tccgctgtag ctcgcaatgt gacaccagga
       61 cgcacacgct ctcgcgcgct ctcccaggct cgctctccct caccctctct cacacacgca
      121 cgcacacacc cacctctccc ataaacacac acacacacat gcacacccac atccacgcgc
      181 gcccgcaccg ccccacgcgc gcacactccc gcccacgccc acgccgcgct ccggggagtc
      241 cggtcccggc cagagcgcga aaggacacgg agaagccacc cgccgggagc gcagcggcgc
      301 cctgggacgc ggcgcgtctc cgctggggct cggcctgggg gccgctggcc ggcgatggcc
      361 ctggattgct tgctgctctt cctcctggca tctgcagtgg ccgcgatgga agagacattg
      421 atggacacaa ggacagccac tgcagagttg ggatggacgg ccaaccctgc ctctgggtgg
      481 gaagaagtca gtggctatga tgaaaacctg aacaccatcc gtacttacca agtgtgcaac
      541 gtcttcgaac ccaaccagaa caactggctg cttaccacct ttatcaacag aaggggcgcc
      601 catcgcatct atacagagat gcgcttcact gtgagggact gcagcagcct tccaaatgtc
      661 ccaggctcct gcaaggagac cttcaacttg tactactatg agactgactc tgtgattgcc
      721 accaagaagt cagccttctg gtctgaagcc ccctacctca aagtggacac cattgctgca
      781 gatgagagct tctcccaggt ggattttggg ggaaggttga tgaaagtcaa cacggaagtc
      841 aggagctttg ggcctcttac taggaacggt ttttacctcg ctttccagga ttatggagcc
      901 tgtatgtctc tcctttctgt ccgtgtcttc ttcaaaaagt gtcccagcat cgtgcagaat
      961 tttgcagtgt tcccagaaac catgacagga gcagagagca catctctggt gattgctcgg
     1021 ggcacatgca tcccaaatgc ggaagaagtg gatgtgccca taaaactcta ctgcaacgga
     1081 gatggagagt ggatggtgcc cattgggcgc tgtacctgta agcctggcta tgagcctgag
     1141 aacagcgtgg cctgcaaggc ctgtcctgcg gggaccttca aggccagcca ggaagctgaa
     1201 ggctgctccc actgcccctc caacagtcgc tccccttcag aggcgtctcc catctgcacc
     1261 tgccggactg gctattaccg agctgacttt gatccaccag aggtggcgtg tactagtgtc
     1321 ccatcgggtc ctcgaaatgt catctccatc gtgaatgaga catctatcat tctagagtgg
     1381 caccctccaa gagagactgg tgggagagat gacgtgacgt acaacatcat ctgcaagaag
     1441 tgccgagcag accgccgcag ctgctcccgc tgcgatgaca atgtggagtt tgtccccagg
     1501 caactgggct tgactgagtg tcgtgtctcc atcagtagcc tatgggccca caccccgtac
     1561 acctttgata tccaggccat caatggagtc tctagcaaga gtccctttcc cccacagcac
     1621 gtctctgtca acatcaccac aaaccaagct gccccctcca ctgttcctat catgcaccag
     1681 gtcagtgcca ccatgaggag catcaccttg tcatggcctc agccggagca acccaatggc
     1741 ataatcctgg actatgagat ccggtactat gagaaggaac acaatgagtt caactcttcc
     1801 atggccagga gccagaccaa cacagcacgt atcgatgggc tacggcctgg catggtatac
     1861 gtggtccagg tgcgagctcg aaccgtggct ggctatggca agttcagtgg caagatgtgt
     1921 ttccagactc tgacagatga tgattacaag tcggagctga gagagcagct acccctgatt
     1981 gctggctcgg cagcagctgg agtcgtattt gttgtgtctc tggtggccat ctctattgtc
     2041 tgcagcagga aacgagctta cagcaaagag gctgcgtaca gtgataagct tcaacattac
     2101 agcacaggcc gaggggagtt cggcgaggtg tacaagggcc gtttgaagct gccaggcaag
     2161 agggaaatct atgtggccat caagaccctg aaggctgggt actcagagaa acagcgtcgg
     2221 gattttctga gcgaggcgag catcatgggc cagtttgacc atcccaacat cattcgcctg
     2281 gagggtgtcg tcaccaagag ccggcctgtc atgatcatta cggagttcat ggagaacggc
     2341 gctttagact ctttcctccg gcaaaatgat ggacagttca ccgtgatcca gcttgtgggg
     2401 atgctgaggg gcatcgctgc tggcatgaag tacctatctg agatgaatta tgtgcaccgg
     2461 gacctggctg ctagaaacat tctggtcaac agcaacctgg tgtgcaaagt ttctgacttt
     2521 ggtctctctc gctacctcca ggatgacacc tcagacccca cctacaccag ctccttggga
     2581 gggaagatcc ctgtgagatg gacagctcca gaggccatcg cctaccgcaa gtttacgtca
     2641 gccagcgatg tctggagcta tgggattgtc atgtgggaag tgatgtcatt tggagagaga
     2701 ccttactggg atatgtccaa tcaagatgtc atcaatgcca ttgagcagga ttaccggctg
     2761 cctcctccta tggactgccc agctgccctg caccagctca tgctggactg ttggcagaag
     2821 gatcgcaata gccggccccg ttttgcagag atcgtcaaca ccctggacaa gatgatccgg
     2881 aacccagcta gtctcaagac tgtggcaacc atcaccgctg tgccttccca acccctgctt
     2941 gaccgctcta tcccagactt cacggccttt accaccgtgg atgactggct aagtgccatc
     3001 aaaatggtcc agtacaggga cagcttcctc accgcaggct tcacctccct tcagctggtc
     3061 acccagatga catcagaaga cctcctgaga ataggggtaa ccttggcagg ccatcagaag
     3121 aagattctga gtagcattca ctcaatgagg gtccagatga accagtcacc atcggtaatg
     3181 gcgtgagaac tcggtgttca taggggagga gaggaatgta aaggaccagg gtcaaagggg
     3241 agccagaggt tgaccactgt ggaatgtgcc agaaagatca gcttcttggc tgagaaacaa
     3301 cttcccatct gtgaagaatg aactggactt gttgcccacg ggcaaccgcc gtttctcggc
     3361 aacggaagtc cgtagatgcc acgggaaacc aaacacgtaa tgataaagac agagaaaggt
     3421 gatgctaaac agaagcaaat ctgaaaccgt atgcattggg gaccaaggtg aactcggttc
     3481 ccatctgaga gggactggag ttacctgtct gcaggaagaa aggaaggagg tggaagggaa
     3541 gagaccgaag ccccagctgt gccatgctct ccctcaccaa tgacattctt ttcttttctc
     3601 ctttcttact cctccctcag agcccctcct ccctccccca catccatctc cctttgctca
     3661 tgactcatgt agggaagttt cttcaaataa agcccagctc ctgagtctcc agatgtcgtc
     3721 tgtcagttgc caaaggactt tgctgaccac tactgcatgg ggatccaacc aattcaatta
     3781 atgtcttcat attgaagaag agatgtacct tcaattgaaa accttgtttt tcttttgttt
     3841 gcattttctg caaaaaggaa aaaaaaaaag aaaccacaaa ttggaaaaaa aatagaaaaa
     3901 cctgtttccg tgtgcaaacg cacacgtatg tgtgtctgcg ttataaaatg actgtgcttg
     3961 ttcgtgacag atgcaaacaa gaaaaaagaa ttgggaaagg tttttggccc tgggaggtct
     4021 caaggggctg gaatatgctg ttggcctggc tctctgcttg gcccgctggg aagagaaaag
     4081 ggggagggat gatcgtaaat gaaagaaaaa aaagtctctg aagagtttgc aaattaagac
     4141 aggaaacagg tgagtggttt gaattgggtg cagagtgggc cggtccagaa tgatgctgac
     4201 tgaagaggta ttctttgata agatctgaag aaaagaagag ggaaagggtt tctggagagt
     4261 gttcctcatc ccagaaccag cgatttgaga ggcgctggcg agggagaact ctttcttgcc
     4321 tggcccgtgg actggctgaa gccgtgtggc atggaggaaa gtctctgtcc tatctgtgtt
     4381 tctctttgca tcccttcctg aaacctcatt gttcattgtt tgattcgctt ttgtaaattc
     4441 cacctaacat tgaaatattt ttaatttctc cttttacctt aaatcctctt gctaatttta
     4501 tctgtctaat taaaaagagc agaagcatgt ctgggtttac gtaaaaaaaa aaaaaaaaaa
     4561 aaa
//
