LOCUS       NM_007939               4732 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus Eph receptor A8 (Epha8), mRNA.
ACCESSION   NM_007939
VERSION     NM_007939.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4732)
  AUTHORS   Shibata M, Pattabiraman K, Lorente-Galdos B, Andrijevic D, Kim SK,
            Kaur N, Muchnik SK, Xing X, Santpere G, Sousa AMM and Sestan N.
  TITLE     Regulation of prefrontal patterning and connectivity by retinoic
            acid
  JOURNAL   Nature 598 (7881), 483-488 (2021)
   PUBMED   34599305
REFERENCE   2  (bases 1 to 4732)
  AUTHORS   Weiss AC, Bohnenpoll T, Kurz J, Blank P, Airik R, Ludtke TH, Kleppa
            MJ, Deuper L, Kaiser M, Mamo TM, Costa R, von Hahn T, Trowe MO and
            Kispert A.
  TITLE     Delayed onset of smooth muscle cell differentiation leads to
            hydroureter formation in mice with conditional loss of the zinc
            finger transcription factor gene Gata2 in the ureteric mesenchyme
  JOURNAL   J Pathol 248 (4), 452-463 (2019)
   PUBMED   30916783
REFERENCE   3  (bases 1 to 4732)
  AUTHORS   Buenaventura DF, Corseri A and Emerson MM.
  TITLE     Identification of Genes With Enriched Expression in Early
            Developing Mouse Cone Photoreceptors
  JOURNAL   Invest Ophthalmol Vis Sci 60 (8), 2787-2799 (2019)
   PUBMED   31260032
REFERENCE   4  (bases 1 to 4732)
  AUTHORS   Bibollet-Bahena O, Okafuji T, Hokamp K, Tear G and Mitchell KJ.
  TITLE     A dual-strategy expression screen for candidate connectivity labels
            in the developing thalamus
  JOURNAL   PLoS One 12 (5), e0177977 (2017)
   PUBMED   28558017
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4732)
  AUTHORS   Teng T, Gaillard A, Muzerelle A and Gaspar P.
  TITLE     EphrinA5 Signaling Is Required for the Distinctive Targeting of
            Raphe Serotonin Neurons in the Forebrain
  JOURNAL   eNeuro 4 (1) (2017)
   PUBMED   28197551
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4732)
  AUTHORS   Choi S and Park S.
  TITLE     Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates
            Fyn binding to the Tyr-615 site by enhancing tyrosine kinase
            activity
  JOURNAL   Oncogene 18 (39), 5413-5422 (1999)
   PUBMED   10498895
REFERENCE   7  (bases 1 to 4732)
  AUTHORS   Rogers JH, Ciossek T, Menzel P and Pasquale EB.
  TITLE     Eph receptors and ephrins demarcate cerebellar lobules before and
            during their formation
  JOURNAL   Mech Dev 87 (1-2), 119-128 (1999)
   PUBMED   10495276
REFERENCE   8  (bases 1 to 4732)
  AUTHORS   Frisen J and Barbacid M.
  TITLE     Genetic analysis of the role of Eph receptors in the development of
            the mammalian nervous system
  JOURNAL   Cell Tissue Res 290 (2), 209-215 (1997)
   PUBMED   9321682
  REMARK    Review article
REFERENCE   9  (bases 1 to 4732)
  AUTHORS   Park S, Frisen J and Barbacid M.
  TITLE     Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine
            protein kinase receptors
  JOURNAL   EMBO J 16 (11), 3106-3114 (1997)
   PUBMED   9214628
REFERENCE   10 (bases 1 to 4732)
  AUTHORS   Park S and Sanchez MP.
  TITLE     The Eek receptor, a member of the Eph family of tyrosine protein
            kinases, can be activated by three different Eph family ligands
  JOURNAL   Oncogene 14 (5), 533-542 (1997)
   PUBMED   9053851
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U72207.1 and AL627214.15.
            
            [WARNING] On May 9, 2023 this sequence was replaced by NM_007939.3.
            
            On Jul 31, 2007 this sequence version replaced NM_007939.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U72207.1, SRR17784649.97055.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               U72207.1           10-197
            189-189             AL627214.15        143244-143244       c
            190-587             U72207.1           199-596
            588-702             AL627214.15        137282-137396       c
            703-1523            U72207.1           712-1532
            1524-1545           AL627214.15        127603-127624       c
            1546-1826           U72207.1           1555-1835
            1827-1827           AL627214.15        125968-125968       c
            1828-2045           U72207.1           1837-2054
            2046-2088           AL627214.15        124830-124872       c
            2089-2204           U72207.1           2098-2213
            2205-2229           AL627214.15        124434-124458       c
            2230-2486           U72207.1           2239-2495
            2487-2487           AL627214.15        123452-123452       c
            2488-2666           U72207.1           2497-2675
            2667-2763           AL627214.15        123091-123187       c
            2764-2843           U72207.1           2773-2852
            2844-2943           AL627214.15        122765-122864       c
            2944-3067           U72207.1           2953-3076
            3068-4626           AL627214.15        120949-122507       c
            4627-4732           U72207.1           4632-4737
FEATURES             Location/Qualifiers
     source          1..4732
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4"
     gene            1..4732
                     /gene="Epha8"
                     /gene_synonym="Eek; Hek3; mKIAA1459"
                     /note="Eph receptor A8"
                     /db_xref="GeneID:13842"
                     /db_xref="MGI:MGI:109378"
     exon            1..160
                     /gene="Epha8"
                     /gene_synonym="Eek; Hek3; mKIAA1459"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..3084
                     /gene="Epha8"
                     /gene_synonym="Eek; Hek3; mKIAA1459"
                     /EC_number="2.7.10.1"
                     /note="EPH- and ELK-related kinase; tyrosine-protein
                     kinase receptor EEK; Ephrin type-A receptor 8 precursor
                     (Tyrosine-protein kinase receptor EEK) (EPH-and
                     ELK-related kinase)"
                     /codon_start=1
                     /product="ephrin type-A receptor 8 precursor"
                     /protein_id="NP_031965.2"
                     /db_xref="CCDS:CCDS18813.1"
                     /db_xref="GeneID:13842"
                     /db_xref="MGI:MGI:109378"
                     /translation="MAPARARLSPALWVVTAAAAATCVSAGRGEVNLLDTSTIHGDWG
                     WLTYPAHGWDSINEVDESFRPIHTYQVCNVMSPNQNNWLRTNWVPRDGARRVYAEIKF
                     TLRDCNSIPGVLGTCKETFNLHYLESDRDLGASTQESQFLKIDTIAADESFTGADLGV
                     RRLKLNTEVRGVGPLSKRGFYLAFQDIGACLAILSLRIYYKKCPAMVRNLAAFSEAVT
                     GADSSSLVEVRGQCVRHSEERDTPKMYCSAEGEWLVPIGKCVCSAGYEERRDACMACE
                     LGFYKSAPGDQLCARCPPHSHSATPAAQTCRCDLSYYRAALDPPSAACTRPPSAPVNL
                     ISSVNGTSVTLEWAPPLDPGGRSDITYNAVCRRCPWALSHCEACGSGTRFVPQQTSLA
                     QASLLVANLLAHMNYSFWIEAVNGVSNLSPEPRSAAVVNITTNQAAPSQVVVIRQERA
                     GQTSVSLLWQEPEQPNGIILEYEIKYYEKDKEMQSYSTLKAVTTRATVSGLKPGTRYV
                     FQVRARTSAGCGRFSQAMEVETGKPRPRYDTRTIVWICLTLITGLVVLLLLLICKKRH
                     CGYSKAFQDSDEEKMHYQNGQAPPPVFLPLNHPPGKFPETQFSAEPHTYEEPGRAGRS
                     FTREIEASRIHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLS
                     EAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTIVQLVGML
                     RGVGAGMRYLSDLGYIHRDLAARNVLVDGRLVCKVSDFGLSRALEDDPEAAYTTAGGK
                     IPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNQDVISSVEEGYRL
                     PAPMGCPRALHQLMLDCWHKDRAQRPRFAHVVSVLDALVHSPESLRATATVSRCPPPA
                     FARSCFDLRAGGSGNGDLTVGDWLDSIRMGRYRDHFAAGGYSSLGMVLRMNAQDVRAL
                     GITLMGHQKKILGSIQTMRAQLSSTQGPRRHL"
     exon            161..225
                     /gene="Epha8"
                     /gene_synonym="Eek; Hek3; mKIAA1459"
                     /inference="alignment:Splign:2.1.0"
     exon            226..889
                     /gene="Epha8"
                     /gene_synonym="Eek; Hek3; mKIAA1459"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1045
                     /gene="Epha8"
                     /gene_synonym="Eek; Hek3; mKIAA1459"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1381
                     /gene="Epha8"
                     /gene_synonym="Eek; Hek3; mKIAA1459"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1506
                     /gene="Epha8"
                     /gene_synonym="Eek; Hek3; mKIAA1459"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1669
                     /gene="Epha8"
                     /gene_synonym="Eek; Hek3; mKIAA1459"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1763
                     /gene="Epha8"
                     /gene_synonym="Eek; Hek3; mKIAA1459"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1831
                     /gene="Epha8"
                     /gene_synonym="Eek; Hek3; mKIAA1459"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1996
                     /gene="Epha8"
                     /gene_synonym="Eek; Hek3; mKIAA1459"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2182
                     /gene="Epha8"
                     /gene_synonym="Eek; Hek3; mKIAA1459"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2244
                     /gene="Epha8"
                     /gene_synonym="Eek; Hek3; mKIAA1459"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2454
                     /gene="Epha8"
                     /gene_synonym="Eek; Hek3; mKIAA1459"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2604
                     /gene="Epha8"
                     /gene_synonym="Eek; Hek3; mKIAA1459"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2795
                     /gene="Epha8"
                     /gene_synonym="Eek; Hek3; mKIAA1459"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..2969
                     /gene="Epha8"
                     /gene_synonym="Eek; Hek3; mKIAA1459"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..4713
                     /gene="Epha8"
                     /gene_synonym="Eek; Hek3; mKIAA1459"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggagagg caggagcgcg ccacgcgcgg ccgccgggcc gagcccgagg agcgcggcgc
       61 cgcccggcca tggcccccgc ccgggcccgc ctgtcccccg ctctctgggt cgtcacggcc
      121 gcggcggcgg ccacctgcgt gtccgcgggg cgcggcgaag tgaacttgtt ggatacatca
      181 accatccacg gagactgggg ctggctcacg tatcccgctc atgggtggga ctccatcaac
      241 gaggtagacg agtccttccg gcccatccac acgtaccaag tatgcaacgt catgagcccc
      301 aaccagaaca actggctgcg cacgaactgg gtgccccgcg acggcgccag gcgtgtctac
      361 gccgagatca aattcaccct gcgtgactgc aatagcatcc caggggtgtt aggtacctgc
      421 aaggagacct tcaaccttca ctacctggag tctgaccgcg acctgggggc cagcacacaa
      481 gagagccagt tcctcaagat tgacaccatc gcggcggatg agagcttcac gggcgcagac
      541 ctgggtgtgc ggaggctcaa gctgaacacg gaggtgcgtg gcgtgggccc gctcagcaag
      601 cgcggcttct acctggcctt ccaggacata ggtgcctgcc tcgccatcct ctcactccga
      661 atctactaca agaagtgccc cgccatggta cgcaacctgg cagccttctc ggaggcggtt
      721 actggggccg actcgtcctc gctggttgag gttcgaggcc agtgtgtgcg gcactcggaa
      781 gagcgcgaca cacccaagat gtactgcagt gctgagggcg aatggctggt gcccatcggc
      841 aagtgcgtgt gcagtgctgg ctatgaggag cggcgggatg cctgcatggc ctgtgagctg
      901 ggcttctaca agtcagcccc cggggaccag ctgtgcgccc gatgcccacc ccacagccac
      961 tctgccaccc ctgcggccca gacctgccgt tgtgacctca gctactaccg cgcggccttg
     1021 gacccaccat cggcagcctg cacccggcca ccctcagcac cagtgaacct gatctccagc
     1081 gtaaatggaa cgtctgtgac cctcgagtgg gcccctcctc tggacccagg tggtcgcagc
     1141 gacatcacct acaacgcagt gtgccgccgc tgcccctggg ccctgagcca ctgtgaggct
     1201 tgtgggagtg gaactcgctt cgtcccgcag cagacaagcc tggcacaggc cagcctgctg
     1261 gtggccaacc tgctagccca catgaactac tccttctgga tcgaggcagt caacggtgtc
     1321 tccaacctga gccctgagcc ccgcagcgct gctgtggtca acatcaccac gaaccaggca
     1381 gccccgtccc aggtggtggt gatccggcag gagcgggctg ggcagaccag cgtgtcactc
     1441 ctgtggcagg aaccagagca gcccaacggc atcattctgg agtacgagat caagtactac
     1501 gagaaggata aggagatgca aagttactct accctcaagg ctgtcaccac ccgcgccacc
     1561 gtgtcaggcc tcaaaccagg cactcgctac gtgttccagg tccgagcccg cacctcagca
     1621 ggctgtggcc gcttcagcca ggccatggag gtggagaccg ggaaacccag gccccgctac
     1681 gacactcgga ccatcgtctg gatctgcctg acactcatca cgggcctggt ggtgctcctc
     1741 ttgcttctca tctgcaagaa gaggcactgt ggctacagca aggcgttcca ggactcggat
     1801 gaagagaaga tgcattacca gaacgggcag gcacccccac ctgtcttctt gcccttgaac
     1861 caccccccgg ggaagttccc agaaacccag ttctctgcag agccccacac ctatgaggaa
     1921 ccaggtcggg caggccggag ctttacccga gagatcgagg catccaggat ccacattgag
     1981 aagatcatag gctcggggga gtcaggagaa gtgtgctatg ggaggctgca ggtgccagga
     2041 cagcgcgatg tgcctgtggc catcaaggct ctcaaagctg gctacacgga gagacagcga
     2101 caagacttct tgagcgaggc agccatcatg ggccaatttg atcaccctaa catcatccgc
     2161 cttgagggtg tggtcacccg tggtcgcctg gcaatgattg tgacggagta catggaaaat
     2221 ggctctctgg atgccttcct caggacccac gatgggcagt tcaccatcgt gcagctagtg
     2281 ggcatgctca gaggggtggg cgctggcatg cgctacctct cagacctggg ctacattcac
     2341 cgtgacctgg ctgcccgcaa tgtcctggtg gatggccgtc tggtgtgcaa agtgtcagac
     2401 tttgggctct caagggctct ggaggatgac cccgaagctg cctacaccac tgcgggaggg
     2461 aagatcccta tccgatggac agcgccggag gccattgctt tccgcacgtt ctcctcagcc
     2521 agtgatgtgt ggagctttgg tgtggtcatg tgggaggttc tagcctatgg tgaacgaccc
     2581 tactggaaca tgaccaacca ggatgtcatc agctctgtgg aggagggtta taggctgcca
     2641 gcacccatgg gttgcccacg tgccctacac cagctcatgc tggactgctg gcacaaggac
     2701 cgtgcccagc ggcctcgctt cgctcatgtc gtgagcgttc tggatgccct ggtccacagt
     2761 cctgagagcc tcagggccac agccacagtc agcaggtgcc caccccctgc cttcgccagg
     2821 agctgctttg acctccgagc aggcggaagt gggaacgggg acctcacagt gggggactgg
     2881 ctggactcca tccgaatggg gcgctaccgg gaccacttcg cggctggcgg gtactcctcc
     2941 ctcggcatgg tgcttcggat gaacgcccag gatgtgcgcg ccctcggcat cactctcatg
     3001 ggtcaccaga agaagatact tggaagcatc cagaccatga gggcccagct gagcagcacc
     3061 cagggacccc gccggcacct ctgacccatg gccacttggc actggttata ccagctgtca
     3121 ggggctccac gcccccccca tcagtcaggg tagcccccag agcaatacca caggacctag
     3181 agtgacagag gtcaggcacc tgggacaagg accttggtgc tccaggtaga gaggacacct
     3241 gccctctgga agcaggcaca ggaccttgtg tcttctagag cctggggcct ccaacaccag
     3301 aagccgatgg tgacatcact cacctagctg tgggtgcatg cgtgcatgca tagggttgat
     3361 ggtaggtatg ggggtgcccc acaaggtcct ggcagctgat ggaaacaatg tgtaatcatg
     3421 tctctgttcc ccgtcaggcc ccagcacaga cgtgtgcagg tcaccatgag tgtgcttatc
     3481 tgctaagggc aggagccaca cgtgtgtgac cgcagataac acgtcatgaa tgaggaggca
     3541 tgacagagtg tgagcagggg atctgagctg acactgccca gttcccagga cctgtgggga
     3601 tcagacagtg cctgcaggct ggagcccagg ctgcttccga atcacaccag caccaggccc
     3661 actgcccagc ctgggtgaac ccaccatggc aatacctcag gtccgggact ccttcctact
     3721 ttggagggca gggccacctg cagcctctgc ctggctcctc ctgctactca acaggaaaac
     3781 agggttcctg gccagtccct ctggccacct tccgtagagg atcacagcag agcgtgagat
     3841 gccctcggtg gggcatgact gcctggccat ctgctctcat ggctgtgatg cctctgccca
     3901 acgtcccact acccatccct gccacccctg cccatgctgg gaacaggagc atggggcaga
     3961 ctctcaagcc ccaaacccac cccttcctat accatatagg taatgcccag agacgaggat
     4021 gccttgcctg aggtcacatg acagccaaat ttcagcgttg gggccctcat acccccagcc
     4081 atggtctgtt cttcccaacc tcccctcccc agactgctag gatgggaggg gcctgggaag
     4141 ctcaccgcca caggctgata acccccttac ggcccaccag ggtatgtaaa tatctttttt
     4201 tctaccatgt cagaatattt ttttctcctc acttctgaca atgcaaaaat ggtcttcaaa
     4261 gcacatgcaa agctccctgg gtgagagagc cccatcctgg gggaggcagg gcccaaggag
     4321 ccccggccca gaggacaggg tggccccctt ccctgcccat ccctgcccac agccagcaca
     4381 gcaccctgtg agacaccagc actgagcccc ctcccttctg caataattca ggggcttcag
     4441 ccccacccag gtgccgtgcg ctgccagctc ctgcgcttct atatattata gtactatgta
     4501 gccgagctgc ccttccttcc tatggaagtg ggaaacatgg tcaggacacg aggggtgggg
     4561 acaccttgtc ttccacccca ccccactcac ccagtgtctg ggcttaggat cctcaggcaa
     4621 ggcccctggg gtggggctcc tgggggcctc tctgtggttc ccatcctgag tctggaatca
     4681 cttgtgatga gaataaatac tgtctcatct tcaaaaaaaa aaaaaaaaaa aa
//
