LOCUS       NP_034271                998 aa            linear   ROD 27-JUL-2024
DEFINITION  ephrin type-A receptor 7 isoform 1 precursor [Mus musculus].
ACCESSION   NP_034271
VERSION     NP_034271.3
DBSOURCE    REFSEQ: accession NM_010141.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 998)
  AUTHORS   Zhou,B., Feng,C., Sun,S., Chen,X., Zhuansun,D., Wang,D., Yu,X.,
            Meng,X., Xiao,J., Wu,L., Wang,J., Wang,J., Chen,K., Li,Z., You,J.,
            Mao,H., Yang,S., Zhang,J., Jiao,C., Li,Z., Yu,D., Wu,X., Zhu,T.,
            Yang,J., Xiang,L., Liu,J., Chai,T., Shen,J., Mao,C.X., Hu,J.,
            Hao,X., Xiong,B., Zheng,S., Liu,Z. and Feng,J.
  TITLE     Identification of signaling pathways that specify a subset of
            migrating enteric neural crest cells at the wavefront in mouse
            embryos
  JOURNAL   Dev Cell 59 (13), 1689-1706 (2024)
   PUBMED   38636517
REFERENCE   2  (residues 1 to 998)
  AUTHORS   Rasool,D., Burban,A., Sharanek,A., Madrigal,A., Hu,J., Yan,K.,
            Qu,D., Voss,A.K., Slack,R.S., Thomas,T., Bonni,A., Picketts,D.J.,
            Soleimani,V.D., Najafabadi,H.S. and Jahani-Asl,A.
  TITLE     PHF6-mediated transcriptional control of NSC via Ephrin receptors
            is impaired in the intellectual disability syndrome BFLS
  JOURNAL   EMBO Rep 25 (3), 1256-1281 (2024)
   PUBMED   38429579
REFERENCE   3  (residues 1 to 998)
  AUTHORS   Tran,H., Sawatari,A. and Leamey,C.A.
  TITLE     Ten-m3 plays a role in the formation of thalamostriatal projections
  JOURNAL   Dev Neurobiol 83 (7-8), 255-267 (2023)
   PUBMED   37700636
REFERENCE   4  (residues 1 to 998)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   5  (residues 1 to 998)
  AUTHORS   Lewis,A.E., Kuwahara,A., Franzosi,J. and Bush,J.O.
  TITLE     Tracheal separation is driven by NKX2-1-mediated repression of
            Efnb2 and regulation of endodermal cell sorting
  JOURNAL   Cell Rep 38 (11), 110510 (2022)
   PUBMED   35294885
REFERENCE   6  (residues 1 to 998)
  AUTHORS   Taneja,R., Thisse,B., Rijli,F.M., Thisse,C., Bouillet,P., Dolle,P.
            and Chambon,P.
  TITLE     The expression pattern of the mouse receptor tyrosine kinase gene
            MDK1 is conserved through evolution and requires Hoxa-2 for
            rhombomere-specific expression in mouse embryos
  JOURNAL   Dev Biol 177 (2), 397-412 (1996)
   PUBMED   8806819
REFERENCE   7  (residues 1 to 998)
  AUTHORS   Mori,T., Wanaka,A., Taguchi,A., Matsumoto,K. and Tohyama,M.
  TITLE     Localization of novel receptor tyrosine kinase genes of the eph
            family, MDK1 and its splicing variant, in the developing mouse
            nervous system
  JOURNAL   Brain Res Mol Brain Res 34 (1), 154-160 (1995)
   PUBMED   8750872
REFERENCE   8  (residues 1 to 998)
  AUTHORS   Ellis,J., Liu,Q., Breitman,M., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G., Tempest,H.V., Warren,S., Muir,E., Schilling,H. et
            al.
  TITLE     Embryo brain kinase: a novel gene of the eph/elk receptor tyrosine
            kinase family
  JOURNAL   Mech Dev 52 (2-3), 319-341 (1995)
   PUBMED   8541219
REFERENCE   9  (residues 1 to 998)
  AUTHORS   Ciossek,T., Millauer,B. and Ullrich,A.
  TITLE     Identification of alternatively spliced mRNAs encoding variants of
            MDK1, a novel receptor tyrosine kinase expressed in the murine
            nervous system
  JOURNAL   Oncogene 10 (1), 97-108 (1995)
   PUBMED   7824284
REFERENCE   10 (residues 1 to 998)
  AUTHORS   Jolly,K.W., Malkin,D., Douglass,E.C., Brown,T.F., Sinclair,A.E. and
            Look,A.T.
  TITLE     Splice-site mutation of the p53 gene in a family with hereditary
            breast-ovarian cancer
  JOURNAL   Oncogene 9 (1), 97-102 (1994)
   PUBMED   8302608
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX000989.10.
            
            On Apr 1, 2008 this sequence version replaced NP_034271.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030480.1, X79082.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..998
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 12.42 cM"
     Protein         1..998
                     /product="ephrin type-A receptor 7 isoform 1 precursor"
                     /EC_number="2.7.10.1"
                     /note="ephrin type-A receptor 7; EPH homology kinase 3;
                     developmental kinase 1; embryonic brain kinase"
                     /calculated_mol_wt=108726
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3153
     mat_peptide     28..998
                     /product="Ephrin type-A receptor 7. /id=PRO_0000016819"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61772.2)"
                     /calculated_mol_wt=108726
     Region          30..206
                     /region_name="EphR_LBD_A7"
                     /note="Ligand Binding Domain of Ephrin type-A Receptor 7;
                     cd10485"
                     /db_xref="CDD:198453"
     Site            order(56,58..62,69..70,72,74,105,107,112..113,155,
                     159..160,163..165,192..194,196)
                     /site_type="other"
                     /note="ephrin binding site [polypeptide binding]"
                     /db_xref="CDD:198453"
     Region          <314..>549
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            343
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61772.2)"
     Site            410
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61772.2)"
     Region          443..534
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(443,507,522)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(523..524,526..527)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            556..576
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61772.2)"
     Region          565..630
                     /region_name="EphA2_TM"
                     /note="Ephrin type-A receptor 2 transmembrane domain;
                     pfam14575"
                     /db_xref="CDD:464211"
     Site            608
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61772.2)"
     Site            614
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61772.2)"
     Region          628..894
                     /region_name="PTKc_EphR_A"
                     /note="Catalytic domain of the Protein Tyrosine Kinases,
                     Class EphA Ephrin Receptors; cd05066"
                     /db_xref="CDD:270651"
     Site            order(639,641..643,647,663,665,711..712,714,758,762..763,
                     765,776,795..799,808,842)
                     /site_type="active"
                     /db_xref="CDD:270651"
     Site            order(639..643,647,663,665,711..714,717..718,762..763,765,
                     776)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270651"
     Site            order(758,762,795..799,808,842)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270651"
     Site            775..801
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270651"
     Site            791
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q61772.2)"
     Region          919..988
                     /region_name="SAM_EPH-A7"
                     /note="SAM domain of EPH-A7 subfamily of tyrosine kinase
                     receptors; cd09548"
                     /db_xref="CDD:188947"
     Site            order(940,973)
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:188947"
     Site            940
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61772.2)"
     Region          996..998
                     /region_name="PDZ-binding. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61772.2)"
     CDS             1..998
                     /gene="Epha7"
                     /gene_synonym="Cek11; Ebk; Ehk3; Hek11; Mdk1"
                     /coded_by="NM_010141.5:222..3218"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS18013.1"
                     /db_xref="GeneID:13841"
                     /db_xref="MGI:MGI:95276"
ORIGIN      
        1 mvvqtrfpsw iilcyiwllg fahtgeaqaa kevllldska qqtelewiss ppsgweeisg
       61 ldenytpirt yqvcqvmepn qnnwlrtnwi skgnaqrifv elkftlrdcn slpgvlgtck
      121 etfnlyyyet dydtgrnire nlyvkidtia adesftqgdl gerkmklnte vreigplskk
      181 gfylafqdvg acialvsvkv yykkcwsive nlavfpdtvt gsefsslvev rgtcvssaee
      241 eaensprmhc saegewlvpi gkcickagyq qkgdtcepcg rrfyksssqd lqcsrcpths
      301 fsdregssrc ecedgyyrap sdppyvactr ppsapqnlif ninqttvsle wsppadnggr
      361 ndvtyrilck rcsweqgecv pcgsnigymp qqtglednyv tvmdllahan ytfeveavng
      421 vsdlsrsqrl faavsittgq aapsqvsgvm kervlqrsvq lswqepehpn gviteyeiky
      481 yekdqrerty stlktkstsa sinnlkpgtv yvfqiravta agygnysprl dvatleeasg
      541 kmfeatavss eqnpviiiav vavagtiilv fmvfgfiigr rhcgyskadq egdeelyfhf
      601 kfpgtktyid petyedpnra vhqfakelda scikiervig agefgevcsg rlklpgkrdv
      661 avaiktlkvg ytekqrrdfl ceasimgqfd hpnvvhlegv vtrgkpvmiv iefmengald
      721 aflrkhdgqf tviqlvgmlr giaagmryla dmgyvhrdla arnilvnsnl vckvsdfgls
      781 rvieddpeav ytttggkipv rwtapeaiqy rkftsasdvw sygivmwevm sygerpywdm
      841 snqdvikaie egyrlpapmd cpaglhqlml dcwqkdraer pkfeqivgil dkmirnpssl
      901 ktplgtcsrp lsplldqstp dftafcsvge wlqaikmery kdnftaagyn slesvarmti
      961 ddvmslgitl vghqkkimss iqtmraqmlh lhgtgiqv
//
