LOCUS       NM_007938               4213 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus Eph receptor A6 (Epha6), mRNA.
ACCESSION   NM_007938 XM_358870
VERSION     NM_007938.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4213)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 4213)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4213)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4213)
  AUTHORS   Farini,D., Cesari,E., Weatheritt,R.J., La Sala,G., Naro,C.,
            Pagliarini,V., Bonvissuto,D., Medici,V., Guerra,M., Di Pietro,C.,
            Rizzo,F.R., Musella,A., Carola,V., Centonze,D., Blencowe,B.J.,
            Marazziti,D. and Sette,C.
  TITLE     A Dynamic Splicing Program Ensures Proper Synaptic Connections in
            the Developing Cerebellum
  JOURNAL   Cell Rep 31 (9), 107703 (2020)
   PUBMED   32492419
REFERENCE   5  (bases 1 to 4213)
  AUTHORS   Zhang,L., Song,N.N., Zhang,Q., Mei,W.Y., He,C.H., Ma,P., Huang,Y.,
            Chen,J.Y., Mao,B., Lang,B. and Ding,Y.Q.
  TITLE     Satb2 is required for the regionalization of retrosplenial cortex
  JOURNAL   Cell Death Differ 27 (5), 1604-1617 (2020)
   PUBMED   31666685
REFERENCE   6  (bases 1 to 4213)
  AUTHORS   Feldheim,D.A., Kim,Y.I., Bergemann,A.D., Frisen,J., Barbacid,M. and
            Flanagan,J.G.
  TITLE     Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement
            in multiple aspects of retinocollicular mapping
  JOURNAL   Neuron 25 (3), 563-574 (2000)
   PUBMED   10774725
REFERENCE   7  (bases 1 to 4213)
  AUTHORS   Yue,Y., Su,J., Cerretti,D.P., Fox,G.M., Jing,S. and Zhou,R.
  TITLE     Selective inhibition of spinal cord neurite outgrowth and cell
            survival by the Eph family ligand ephrin-A5
  JOURNAL   J Neurosci 19 (22), 10026-10035 (1999)
   PUBMED   10559410
REFERENCE   8  (bases 1 to 4213)
  AUTHORS   Rogers,J.H., Ciossek,T., Menzel,P. and Pasquale,E.B.
  TITLE     Eph receptors and ephrins demarcate cerebellar lobules before and
            during their formation
  JOURNAL   Mech Dev 87 (1-2), 119-128 (1999)
   PUBMED   10495276
REFERENCE   9  (bases 1 to 4213)
  AUTHORS   .
  TITLE     Unified nomenclature for Eph family receptors and their ligands,
            the ephrins. Eph Nomenclature Committee
  JOURNAL   Cell 90 (3), 403-404 (1997)
   PUBMED   9267020
REFERENCE   10 (bases 1 to 4213)
  AUTHORS   Lee,A.M., Navaratnam,D., Ichimiya,S., Greene,M.I. and Davis,J.G.
  TITLE     Cloning of m-ehk2 from the murine inner ear, an eph family receptor
            tyrosine kinase expressed in the developing and adult cochlea
  JOURNAL   DNA Cell Biol 15 (10), 817-825 (1996)
   PUBMED   8892754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134526.4, AC133940.4, AC118603.9, CT009682.6, AC154632.2,
            AC122318.4, AC131707.3, AC154212.2 and AC154473.2.
            
            On Apr 18, 2007 this sequence version replaced NM_007938.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U58332.1, BC141090.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-668               AC134526.4         82011-82678
            669-733             AC133940.4         117611-117675       c
            734-1397            AC118603.9         14711-15374
            1398-1553           CT009682.6         142943-143098
            1554-1889           CT009682.6         158272-158607
            1890-2014           AC154632.2         123213-123337
            2015-2177           AC122318.4         35094-35256
            2178-2286           AC122318.4         80351-80459
            2287-2357           AC122318.4         83854-83924
            2358-2483           AC122318.4         86016-86141
            2484-2669           AC122318.4         124824-125009
            2670-2795           AC131707.3         28001-28126
            2796-2857           AC131707.3         48371-48432
            2858-3067           AC154212.2         130781-130990       c
            3068-3217           AC154212.2         37847-37996         c
            3218-3411           AC154473.2         14685-14878
            3412-3561           AC154473.2         25560-25709
            3562-4213           AC154473.2         27299-27950
FEATURES             Location/Qualifiers
     source          1..4213
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 34.83 cM"
     gene            1..4213
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /note="Eph receptor A6"
                     /db_xref="GeneID:13840"
                     /db_xref="MGI:MGI:108034"
     exon            1..668
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..3676
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /EC_number="2.7.10.1"
                     /note="EPH homology kinase 2"
                     /codon_start=1
                     /product="ephrin type-A receptor 6"
                     /protein_id="NP_031964.2"
                     /db_xref="CCDS:CCDS28260.2"
                     /db_xref="GeneID:13840"
                     /db_xref="MGI:MGI:108034"
                     /translation="MQFPSPPAARSSPAAQAASSPQAAAPAPGQPGPSCPAHRASRGG
                     RPGTSPADRVEEEEEEEEEEESLVQDPHATRNTWLRCCHFFLRRRREPTRAMGGCEVR
                     EFLLQFGFFLPLLTAWTGDCSHVSNQVVLLDTTTVMGELGWKTYPLNGWDAITEMDEH
                     NRPIHTYQVCNVMEPNQNNWLRTNWISRDAAQKIYVEMKFTLRDCNSIPWVLGTCKET
                     FNLYYIESDESHGTKFKPSQYIKIDTIAADESFTQMDLGDRILKLNTEIREVGPIERK
                     GFYLAFQDIGACIALVSVRVFYKKCPFTVRNLAMFPDTIPRVDSSSLVEVRGSCVKSA
                     EERDTPKLYCGADGDWLVPLGRCICSTGYEEIEGSCHACRPGFYKAFAGNTKCSKCPP
                     HSSTYVEATSVCHCEKGYFRAEKDPPSMACTRPPSAPRNVAFNINETALILEWSPPSD
                     TGGRKDLTYSVICKKCGLDTTQCEDCGGGLRFIPRHTGLINNSVVVLDFVSHVNYTFE
                     IEAMNGVSELSISPKPFTAITVTTDHDAPSLIGMMRKDWASQNSLALSWQAPAFSNGA
                     ILDYEIKYYEKEHEQLTYSSTRSKAPSVIVTGLKPATTYIFHIRVRTATGYSGYSQKF
                     EFETGDETSDMAAEQGQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSEEK
                     RRTHLQNGHLRFPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVC
                     SGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSF
                     PAIGVEAFCPSFLRAGFLNGIQAPHPVTAGGSLPPRIPAGRPVMIVVEYMENGSLDSF
                     LRKHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLS
                     RVLEDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSSASDAWSYGIVMWEVMSYGERPYW
                     EMSNQDVILSIEEGYRLPAPMGCPPSLHQLMLHCWQKERNHRPKFTDIVSFLDKLIRN
                     PSALHTLVEDILVMPESPGDVPEYPLFVTVGDWLDSIKMGQYKSNFMAAGFTTFDLIS
                     RMSIDDIRRIGVILIGHQRRIVSSIQTLRLHMMHIQEKGFHV"
     exon            669..733
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /inference="alignment:Splign:2.1.0"
     exon            734..1397
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1553
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1889
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2014
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2177
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2286
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2357
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2483
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2669
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2795
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..2857
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..3067
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..3217
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3411
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3561
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3562..4213
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4213
                     /gene="Epha6"
                     /gene_synonym="EHK-2; Ehk2; Hek12; m-ehk2"
                     /note="major polyA site"
ORIGIN      
        1 agacacatga aagttctgga tgcccagact acccttacta tctgctgtgc ctcctctgct
       61 ctggggtctg taagtgccca cttggatgca gagagcactt gggtccccag aactgcacct
      121 tcactacccg tccaaacgtc cctacccatc cccagtaccg gcctagagcc accctccccc
      181 gtccaccatc ccctccccca aactagagcc tgagctcgct cttgcgcgcg cgctctcctg
      241 ggcccaagtg aatagtcctc gctcgagcgg gacacggtgg tggatgcaat tcccctcgcc
      301 tccagccgcc aggagctccc cggcggcgca ggcagcatcg tccccgcaag cagctgctcc
      361 agcacctggg cagcctggac cctcgtgccc tgcgcaccgg gcctcgcgcg gggggcgccc
      421 cgggacttcc cctgcggacc gggtggagga ggaagaggag gaggaggaag aagaagagag
      481 cttggttcag gacccccacg ctactaggaa cacctggctg cgctgctgcc acttcttttt
      541 aaggaggaga agagaaccaa ccagagccat ggggggctgc gaagtccggg aatttctttt
      601 gcaatttggt ttcttcttgc ccctgctaac ggcttggacc ggcgactgca gtcacgtctc
      661 caaccaagtt gtgttgcttg atacaaccac agtgatggga gaactaggat ggaaaacata
      721 tccattaaat gggtgggatg ccattactga aatggatgaa cacaataggc ccatacatac
      781 ataccaggta tgcaatgtca tggaaccaaa ccagaacaac tggcttcgta ctaactggat
      841 ctctcgtgat gctgcacaga aaatttatgt ggaaatgaag ttcacactga gggattgtaa
      901 cagcatccca tgggtcttgg ggacttgtaa agaaaccttt aacctgtatt atatagaatc
      961 cgatgaatcc catgggacaa aattcaagcc aagccaatat ataaagatcg acacaattgc
     1021 tgctgatgag agttttactc agatggattt gggtgaccgc atccttaaac tcaacactga
     1081 aatccgtgag gtggggccta tagaaaggaa aggattttat ttggcttttc aagatattgg
     1141 agcatgcatc gctctggtct cagtccgagt tttctacaaa aaatgcccct tcaccgtgcg
     1201 gaacttggct atgtttcctg ataccatccc aagggttgat tcttcctctt tggttgaagt
     1261 gcggggctca tgtgtaaaga gtgctgagga gcgagatact cctaaactct actgtggagc
     1321 tgatggggat tggcttgttc ctcttggaag gtgtatctgc agtacagggt atgaagaaat
     1381 cgagggttct tgccatgctt gcagaccagg attctacaaa gcatttgctg ggaacacaaa
     1441 atgttccaaa tgccctccac acagctcaac ctacgtggaa gcaacgtcag tctgtcattg
     1501 tgaaaagggt tacttccggg cagaaaaaga cccaccttct atggcatgca ctagaccacc
     1561 ttcagctcct agaaatgtgg cttttaacat caatgaaaca gcccttattt tggaatggag
     1621 cccacccagt gacacaggag ggagaaaaga tctcacatac agtgtaatct gtaagaaatg
     1681 tggtttagac actacccagt gtgaggactg tggtggagga ctccgcttca tcccaagaca
     1741 cactggactg atcaacaatt ctgtggtagt actggacttt gtgtctcacg tcaattatac
     1801 ctttgaaata gaagccatga atggagtttc tgagttgagc atctctccca agccattcac
     1861 agctattaca gtgactacag atcacgatgc accttctctg attggtatga tgagaaagga
     1921 ctgggcatct cagaacagcc ttgctctatc gtggcaagca cctgcatttt ccaatggagc
     1981 tattctggac tatgagatca agtactacga gaaagagcat gagcagctca cctattcctc
     2041 cacgaggtcc aaggccccaa gcgtcatcgt cacgggcctc aagcccgcca ccacgtacat
     2101 atttcacatc cgagtgagga cggcgacagg ctacagtggc tacagtcaga agtttgaatt
     2161 tgaaacagga gatgaaactt ctgacatggc ggcagaacaa gggcagattc tggtcatagc
     2221 cactgcagcc gtcgggggat tcactctctt agtcatcctc accctgttct tcctcatcac
     2281 tgggaggtgt caatggtaca taaaggccaa aatgaagtca gaagagaaga gaagaactca
     2341 cttacagaac ggccacctgc gcttcccggg aattaaaaca tacattgatc cagacaccta
     2401 tgaagaccca tccctagcag tccacgaatt tgcaaaagag attgatcctt caagaattcg
     2461 cattgagaga gtgattggag caggtgaatt tggagaagtc tgcagtgggc gtttgaagac
     2521 accagggaaa agggagatcc cagttgcaat taaaacattg aaaggtggcc acatggaccg
     2581 acaaagaaga gattttctaa gagaagctag catcatgggt cagtttgacc acccaaacat
     2641 cattcgccta gaaggtgttg tcactaaaag atccttcccg gcgattgggg tggaagcctt
     2701 ctgccccagc ttcctaaggg ctgggttttt aaatggcatc caagcgccac atccagtgac
     2761 tgcaggaggc tctctgcccc ccaggattcc tgcaggtcgg ccagtaatga tcgtagtaga
     2821 gtatatggag aatggatcac tggactcctt tttgcggaag catgatggcc acttcaccgt
     2881 catccagttg gtcggcatgc tgaggggcat cgcgtcaggc atgaagtatc tttctgacat
     2941 gggatatgtt catcgagatc ttgccgcgag gaacatactg gtgaacagca acttagtatg
     3001 caaggtctct gattttggtc tctcccgagt gctggaagat gatccagaag cagcttatac
     3061 aacaacggga gggaaaatcc ctatacggtg gacagcccca gaagctattg cttacagaaa
     3121 gttctcctca gccagtgacg cgtggagcta cgggattgtc atgtgggagg tgatgtccta
     3181 tggagagaga ccgtactggg aaatgtccaa ccaggatgtt atcttgtcca ttgaagaagg
     3241 ttaccgactt cctgctccga tgggctgccc accgtctctg caccagctga tgctccactg
     3301 ctggcagaag gagagaaacc acaggccaaa attcactgac atcgtcagct tccttgacaa
     3361 actgatccgc aaccccagtg cccttcacac gctggtggag gacatccttg taatgccaga
     3421 atcccctggt gatgttcctg aatatccatt gtttgtcaca gtaggtgact ggctggattc
     3481 tataaagatg gggcaataca agagtaactt catggcagcg ggttttacaa cgtttgatct
     3541 gatttcacga atgagcatcg atgatattag gcgaattgga gtcattctca ttggacatca
     3601 gagacgaata gtcagcagca tacaaacttt acgtttacat atgatgcaca tacaggaaaa
     3661 aggatttcat gtatgaaagt actataaaca cctgtatctt gtgcctcagc atttctacaa
     3721 agaaagatat tccctctacg actcattctt ctgattctcc agccttccct tcaccaccca
     3781 ccgtctcctg ttccgactat ggctgcacac cttacgttta tgcttccacc ctggatttca
     3841 ataccacgct acacaggtcc tctctgaata gcctgcaaac gaaactctgg cccactgcag
     3901 atcatcactg cagaacgata aataactcag catgaatgtg taactttgta cagaaatgtt
     3961 tgggaagtgt tcatggactt cacctaaagg aatttgtcct taagtgtggc atcttcagag
     4021 acgtgtgtgg agtttgatga tagataagaa gaaaatagct gatcattctt ccatgttttg
     4081 tgatcgagta gctcccgagt tcacatgctt ttttttcaat agctctactc aacgctgcag
     4141 gttttgctgt tggtttattt ttaatgactt aactgttggt gcctgatgtt gatacaatga
     4201 tttgcagaaa taa
//
