LOCUS       NP_001389678            1018 aa            linear   ROD 31-DEC-2024
DEFINITION  ephrin type-A receptor 5 isoform 1 precursor [Mus musculus].
ACCESSION   NP_001389678 XP_006534834
VERSION     NP_001389678.1
DBSOURCE    REFSEQ: accession NM_001402749.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1018)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1018)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   3  (residues 1 to 1018)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 1018)
  AUTHORS   Xu,M., Li,S., Xie,X., Guo,L., Yu,D., Zhuo,J., Lin,J., Kol,L. and
            Gan,L.
  TITLE     ISL1 and POU4F1 Directly Interact to Regulate the Differentiation
            and Survival of Inner Ear Sensory Neurons
  JOURNAL   J Neurosci 44 (8), e1718232024 (2024)
   PUBMED   38267260
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1018)
  AUTHORS   Vetrivel,S., Truong,D.J., Wurst,W., Graw,J. and Giesert,F.
  TITLE     Identification of ocular regulatory functions of core histone
            variant H3.2
  JOURNAL   Exp Eye Res 226, 109346 (2023)
   PUBMED   36529279
REFERENCE   6  (residues 1 to 1018)
  AUTHORS   Bentley,E., Inglis,J.D., Gossler,A., Stephenson,D.A. and
            Darling,S.M.
  TITLE     D5Ucl1 and Els1 are closely linked to W on mouse chromosome 5 but
            lie distal to the W19H deletion
  JOURNAL   Mamm Genome 7 (9), 691-693 (1996)
   PUBMED   8703124
REFERENCE   7  (residues 1 to 1018)
  AUTHORS   Gale,N.W., Holland,S.J., Valenzuela,D.M., Flenniken,A., Pan,L.,
            Ryan,T.E., Henkemeyer,M., Strebhardt,K., Hirai,H., Wilkinson,D.G.,
            Pawson,T., Davis,S. and Yancopoulos,G.D.
  TITLE     Eph receptors and ligands comprise two major specificity subclasses
            and are reciprocally compartmentalized during embryogenesis
  JOURNAL   Neuron 17 (1), 9-19 (1996)
   PUBMED   8755474
REFERENCE   8  (residues 1 to 1018)
  AUTHORS   Andres,A.C., Reid,H.H., Zurcher,G., Blaschke,R.J., Albrecht,D. and
            Ziemiecki,A.
  TITLE     Expression of two novel eph-related receptor protein tyrosine
            kinases in mammary gland development and carcinogenesis
  JOURNAL   Oncogene 9 (5), 1461-1467 (1994)
   PUBMED   8152808
  REMARK    Erratum:[Oncogene 1994 Aug;9(8):2431]
REFERENCE   9  (residues 1 to 1018)
  AUTHORS   Zhou,R., Copeland,T.D., Kromer,L.F. and Schulz,N.T.
  TITLE     Isolation and characterization of Bsk, a growth factor
            receptor-like tyrosine kinase associated with the limbic system
  JOURNAL   J Neurosci Res 37 (1), 129-143 (1994)
   PUBMED   8145300
REFERENCE   10 (residues 1 to 1018)
  AUTHORS   Inglis,J.D. and Lee,M.
  TITLE     A novel tyrosine kinase-related sequence on mouse chromosome 5
  JOURNAL   Mamm Genome 4 (5), 285-287 (1993)
   PUBMED   8507985
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101956.5, AC132597.3, AC129220.3 and AC114638.16.
            
            On Mar 21, 2022 this sequence version replaced XP_006534834.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164139
                              [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1018
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.0 cM"
     Protein         1..1018
                     /product="ephrin type-A receptor 5 isoform 1 precursor"
                     /EC_number="2.7.10.1"
                     /note="ephrin type-A receptor 5; EPH homology kinase 1;
                     brain-specific kinase; eck-like sequence 1"
                     /calculated_mol_wt=110182
     sig_peptide     1..26
                     /note="/evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q60629.2)"
                     /calculated_mol_wt=2692
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60629.2)"
     Region          62..234
                     /region_name="EphR_LBD"
                     /note="Ligand Binding Domain of Ephrin Receptors; cl02704"
                     /db_xref="CDD:470656"
     Site            order(74,86..89,91..92,97,99,102,135,137,185,193..195,
                     222..224,226)
                     /site_type="other"
                     /note="ephrin binding site [polypeptide binding]"
                     /db_xref="CDD:198439"
     Site            266
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60629.2)"
     Site            301
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60629.2)"
     Region          <357..>586
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Region          471..561
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(471,534,549)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(550..551,553..554)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          578..653
                     /region_name="EphA2_TM"
                     /note="Ephrin type-A receptor 2 transmembrane domain;
                     pfam14575"
                     /db_xref="CDD:464211"
     Region          651..917
                     /region_name="PTKc_EphR_A"
                     /note="Catalytic domain of the Protein Tyrosine Kinases,
                     Class EphA Ephrin Receptors; cd05066"
                     /db_xref="CDD:270651"
     Site            order(662,664..666,670,686,688,734..735,737,781,785..786,
                     788,799,818..822,831,865)
                     /site_type="active"
                     /db_xref="CDD:270651"
     Site            order(662..666,670,686,688,734..737,740..741,785..786,788,
                     799)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270651"
     Site            order(781,785,818..822,831,865)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270651"
     Site            798..824
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270651"
     Region          946..1011
                     /region_name="SAM_EPH-A5"
                     /note="SAM domain of EPH-A5 subfamily of tyrosine kinase
                     receptors; cd09546"
                     /db_xref="CDD:188945"
     Site            order(963,996)
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:188945"
     CDS             1..1018
                     /gene="Epha5"
                     /gene_synonym="bsk; Cek7; Ehk1; Els1; Hek7; Rek7"
                     /coded_by="NM_001402749.1:878..3934"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="GeneID:13839"
                     /db_xref="MGI:MGI:99654"
ORIGIN      
        1 mrgsgprgag hrrtqgrggg ddtprvpasl agcysaplkg plwtclllca alrtllasps
       61 nevnlldsrt vmgdlgwiaf pkngweeige vdenyapiht yqvckvmeqn qnnwlltswi
      121 snegasrifi elkftlrdcn slpgglgtck etfnmyyfes ddengrsike nqyikidtia
      181 adesfteldl gdrvmklnte vrdvgplskk gfylafqdvg acialvsvrv yykkcpsvvr
      241 hlaifpdtit gadssqllev sgscvnhsvt ddppkmhcsa egewlvpigk cmckagyeek
      301 ngtcqvcrpg ffkasphsqt cskcpphsyt heeastscvc ekdyfrkdsd pptmactrpp
      361 saprnaisnv netsvflewi ppadtggrkd vsyyiackkc nshagvceec gghvrylpqq
      421 iglkntsvmm vdllahtnyt feieavngvs dlspgtrqyv svnvttnqaa pspvtnvkkg
      481 kiaknsisls wqepdrpngi ileyeikyfe kdqetsytii ksketsitae glkpasvyvf
      541 qirartaagy gvfsrrfefe ttpvsvaasn dqsqipiiav svtvgvilla vmigfllsgr
      601 rcgyskakqd peeekmhfhn ghiklpgvrt yidphtyedp nqavhefake ieascitier
      661 vigagefgev csgrlklpgk relpvaiktl kvgytekqrr dflgeasimg qfdhpniihl
      721 egvvtkskpv mivteymeng sldtflkknd gqftviqlvg mlrgiaagmk ylsdmgyvhr
      781 dlaarnilin snlvckvsdf glsrvleddp eaayttrggk ipirwtapea iafrkftsss
      841 dvwsygivmw evvsygerpy wemtnqdvik aveegyrlps pmdcpaalyq lmldcwqkdr
      901 nsrpkfdeiv nmldklirnp sslktlvnas srvstllaeh gslgsgayrs vgewleaikm
      961 gryteifmen gyssmdavaq vtledlrrlg vtlvghqkki msslqemkvq mvngmvpv
//
