LOCUS       NM_010140               5682 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus Eph receptor A3 (Epha3), transcript variant 1, mRNA.
ACCESSION   NM_010140
VERSION     NM_010140.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5682)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   2  (bases 1 to 5682)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5682)
  AUTHORS   Alderman,P.J., Saxon,D., Torrijos-Saiz,L.I., Sharief,M., Page,C.E.,
            Baroudi,J.K., Biagiotti,S.W., Butyrkin,V.A., Melamed,A., Kuo,C.T.,
            Vicini,S., Garcia-Verdugo,J.M., Herranz-Perez,V., Corbin,J.G. and
            Sorrells,S.F.
  TITLE     Delayed maturation and migration of excitatory neurons in the
            juvenile mouse paralaminar amygdala
  JOURNAL   Neuron 112 (4), 574-592 (2024)
   PUBMED   38086370
REFERENCE   4  (bases 1 to 5682)
  AUTHORS   Lee,Y., Yeo,I.S., Kim,N., Lee,D.K., Kim,K.T., Yoon,J., Yi,J.,
            Hong,Y.B., Choi,B.O., Kosodo,Y., Kim,D., Park,J. and Song,M.R.
  TITLE     Transcriptional control of motor pool formation and motor circuit
            connectivity by the LIM-HD protein Isl2
  JOURNAL   Elife 12, e84596 (2023)
   PUBMED   37869988
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5682)
  AUTHORS   Ozekin,Y.H., O'Rourke,R. and Bates,E.A.
  TITLE     Single cell sequencing of the mouse anterior palate reveals
            mesenchymal heterogeneity
  JOURNAL   Dev Dyn 252 (6), 713-727 (2023)
   PUBMED   36734036
REFERENCE   6  (bases 1 to 5682)
  AUTHORS   Cheng,H.J. and Flanagan,J.G.
  TITLE     Identification and cloning of ELF-1, a developmentally expressed
            ligand for the Mek4 and Sek receptor tyrosine kinases
  JOURNAL   Cell 79 (1), 157-168 (1994)
   PUBMED   7522971
REFERENCE   7  (bases 1 to 5682)
  AUTHORS   Fujimoto,J. and Yamamoto,T.
  TITLE     brt, a mouse gene encoding a novel receptor-type protein-tyrosine
            kinase, is preferentially expressed in the brain
  JOURNAL   Oncogene 9 (3), 693-698 (1994)
   PUBMED   8108111
REFERENCE   8  (bases 1 to 5682)
  AUTHORS   Gilardi-Hebenstreit,P., Nieto,M.A., Frain,M., Mattei,M.G.,
            Chestier,A., Wilkinson,D.G. and Charnay,P.
  TITLE     An Eph-related receptor protein tyrosine kinase gene segmentally
            expressed in the developing mouse hindbrain
  JOURNAL   Oncogene 7 (12), 2499-2506 (1992)
   PUBMED   1281307
  REMARK    Erratum:[Oncogene. 1993 Apr;8(4):1103.. PMID: 8455939]
REFERENCE   9  (bases 1 to 5682)
  AUTHORS   Sajjadi,F.G., Pasquale,E.B. and Subramani,S.
  TITLE     Identification of a new eph-related receptor tyrosine kinase gene
            from mouse and chicken that is developmentally regulated and
            encodes at least two forms of the receptor
  JOURNAL   New Biol 3 (8), 769-778 (1991)
   PUBMED   1657122
REFERENCE   10 (bases 1 to 5682)
  AUTHORS   Lai,C. and Lemke,G.
  TITLE     An extended family of protein-tyrosine kinase genes differentially
            expressed in the vertebrate nervous system
  JOURNAL   Neuron 6 (5), 691-704 (1991)
   PUBMED   2025425
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154844.2, AC155275.1 and AC154568.2.
            
            On Apr 18, 2018 this sequence version replaced NM_010140.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093483.1, AK132335.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               AC154844.2         126815-127030       c
            217-281             AC154844.2         106958-107022       c
            282-942             AC155275.1         190210-190870       c
            943-1098            AC155275.1         70723-70878         c
            1099-1434           AC155275.1         69515-69850         c
            1435-1559           AC154568.2         5629-5753
            1560-1722           AC154568.2         7495-7657
            1723-1825           AC154568.2         14970-15072
            1826-1893           AC154568.2         16275-16342
            1894-2019           AC154568.2         20288-20413
            2020-2205           AC154568.2         22860-23045
            2206-2267           AC154568.2         33585-33646
            2268-2477           AC154568.2         35006-35215
            2478-2627           AC154568.2         50066-50215
            2628-2821           AC154568.2         51831-52024
            2822-2977           AC154568.2         65958-66113
            2978-5682           AC154568.2         72367-75071
FEATURES             Location/Qualifiers
     source          1..5682
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 36.49 cM"
     gene            1..5682
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /note="Eph receptor A3"
                     /db_xref="GeneID:13837"
                     /db_xref="MGI:MGI:99612"
     exon            1..216
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..3083
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ephrin type-A receptor 3; EPH-like kinase 4;
                     tyrosine-protein kinase TYRO4; tyrosine-protein kinase
                     receptor ETK1"
                     /codon_start=1
                     /product="ephrin type-A receptor 3 isoform 1 precursor"
                     /protein_id="NP_034270.1"
                     /db_xref="CCDS:CCDS28264.1"
                     /db_xref="GeneID:13837"
                     /db_xref="MGI:MGI:99612"
                     /translation="MDCHLSILVLLGCCVLSCSGELSPQPSNEVNLLDSKTIQGELGW
                     ISYPSHGWEEISGVDEHYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFT
                     LRDCNSIPLVLGTCKETFNLYYMESDDDHGVKFREHQFTKIDTIAADESFTQMDLGDR
                     ILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPDTVPM
                     DSQSLVEVRGSCVNNSKEEDPPRMYCSTEGEWLVPIGKCTCNAGYEERGFICQACRPG
                     FYKASDGAAKCAKCPPHSSTQEDGSMNCRCENNYFRAEKDPPSMACTRPPSAPRNVIS
                     NINETSVILDWSWPLDTGGRKDITFNIICKKCGWNVRQCEPCSPNVRFLPRQLGLTNT
                     TVTVTDLLAHTNYTFEIDAVNGVSELSSPPRQYAAVSITTNQAAPSPVMTIKKDRTSR
                     NSISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRARGTNVTISSLKPDTTYVFQ
                     IRARTAAGYGTNSRKFEFETSPDSFSISGENSHVVMIAISAAVAIIVLTVVTYVLVGR
                     FCGYHKSKHSAEEKRLHFGNGHLKLPGLRTYVDPHTYEDPTQAVHEFAKELDATNISI
                     DKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPN
                     IIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSD
                     MGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIA
                     YRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQ
                     LMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDIATF
                     HTTGDWLNGMRTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVGPQKKIISTIKA
                     LETQSKNGPVPV"
     exon            217..281
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /inference="alignment:Splign:2.1.0"
     exon            282..942
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1098
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1434
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1559
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1722
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1825
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1893
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2019
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2205
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2267
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2477
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2627
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2821
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..2977
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..5682
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3381..3386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /note="hexamer: AATAAA"
     polyA_site      3404
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /note="major polyA site"
     regulatory      5646..5651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /note="hexamer: AATAAA"
     regulatory      5655..5660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
                     /note="hexamer: AATGAA"
     polyA_site      5677
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
     polyA_site      5680
                     /gene="Epha3"
                     /gene_synonym="Cek4; EK4; End3; ETK1; Hek; Hek4; Mek4;
                     Tyro4"
ORIGIN      
        1 agtgtcaaac ttgacatcag actgcgagcg gagcatggta acttctccag caatcagagc
       61 gctccccctc acatcagtgg tatgcttcgc ggagatatgc tcctctcact gcccggtgca
      121 ccagcaacat ggattgtcac ctctccatcc tcgtcctgct cggctgctgc gtcctcagct
      181 gctccggaga actgagccca cagccttcca acgaagttaa tctactagat tcgaaaacaa
      241 ttcaaggaga gctgggctgg atctcctacc catcccatgg gtgggaagag atcagtggtg
      301 ttgatgaaca ttacacacca atcaggactt accaggtgtg caatgtcatg gatcacagcc
      361 aaaataattg gctgaggaca aactgggtac ccagaaactc agctcagaag atctatgtgg
      421 agctaaagtt cacactgcgg gactgtaaca gcattccatt ggttttgggg acttgcaagg
      481 agacctttaa cctgtactac atggagtctg atgatgatca tggcgtcaaa ttccgagagc
      541 atcagttcac gaagattgac accattgccg ctgatgaaag tttcactcag atggatctcg
      601 gggatcgcat tctgaaactc aacactgaga ttagagaagt gggaccagtc aacaaaaagg
      661 ggttttattt ggcctttcaa gatgttggtg cttgtgttgc cttggtgtct gtgagagtgt
      721 acttcaaaaa gtgcccgttt acagtgaaga atctggctat gtttccagac acagtgccca
      781 tggactccca gtctttggtg gaggttaggg gctcttgtgt caataattcc aaagaggagg
      841 accctcccag gatgtactgc agcacagaag gggaatggct ggtccccatt ggcaaatgca
      901 cttgcaatgc tgggtatgaa gaacgaggtt tcatatgcca agcttgtcga ccaggcttct
      961 acaaggcttc cgatggtgct gctaagtgtg ctaagtgccc accacacagc tcaacacaag
     1021 aagatggttc aatgaactgc aggtgtgaga ataattattt ccgggcagaa aaagaccctc
     1081 catccatggc ttgtacccga cctccatccg caccaagaaa tgttatctca aacataaacg
     1141 agacctcggt tatcctggac tggagttggc ccctggacac aggaggccgg aaggatatta
     1201 ccttcaacat catatgtaaa aagtgtgggt ggaatgtcag gcagtgtgag ccgtgcagcc
     1261 ccaacgtccg cttccttcct cggcagcttg gactcaccaa caccacggtg acagtgacag
     1321 acctcctagc tcacaccaac tacacctttg agatcgatgc tgttaatggg gtgtcagagc
     1381 tgagctcgcc accgagacag tatgccgcag tcagcatcac aactaatcag gctgctccat
     1441 caccagttat gacaattaag aaagatcgga cttccagaaa cagtatctct ttatcttggc
     1501 aagaaccgga acatccaaat ggaattatcc tggactatga ggtcaaatac tatgaaaagc
     1561 aggagcaaga gacgagttat accattttga gagcaagagg cacaaatgtt actatcagta
     1621 gcctcaagcc agatactact tatgtcttcc aaatccgagc tcggacagca gcgggatatg
     1681 gaaccaacag ccgcaaattt gaatttgaaa ctagcccaga ctctttctcc atctccggtg
     1741 aaaacagtca tgtggtgatg attgctattt ccgcagctgt ggccatcatt gtcctcacgg
     1801 tggtcaccta tgttctggtc gggaggtttt gtggctatca caagtcaaaa cacagtgcag
     1861 aggagaagcg ccttcacttt gggaatggcc acttaaaact tccaggtctc aggacctatg
     1921 ttgatccaca tacatatgaa gaccctactc aagcagttca tgagttcgcg aaggagttgg
     1981 atgccaccaa tatatccatc gacaaagttg ttggagcagg tgaatttgga gaagtttgca
     2041 gcggccgctt aaaacttcct tcaaaaaaag agatttcggt ggccataaag accctgaaag
     2101 tagggtatac cgagaaacag aggagagact tcctcggtga agcgagcatc atgggacagt
     2161 ttgaccatcc caacatcatc cgactggaag gcgttgtcac taagagtaag ccagtgatga
     2221 ttgtcacgga atacatggag aatggctcct tggacagttt cttacgtaag cacgatgccc
     2281 agttcacagt catccagctt gtgggaatgc tccgtgggat agcatcaggt atgaaatacc
     2341 tctcagatat gggctacgtc caccgggacc ttgctgctcg caacatcttg atcaacagta
     2401 acttagtgtg taaagtttct gactttggac tctctcgggt acttgaagat gacccagaag
     2461 ctgcttacac aaccagggga ggaaagatac caataaggtg gacatcacca gaagcaattg
     2521 cctaccgcaa gttcacctca gccagcgatg tatggagtta cgggattgtt ctctgggaag
     2581 tgatgtctta cggagaaagg ccatactggg agatgtccaa tcaggatgta attaaggctg
     2641 tggatgaggg ctatcgcctg ccacctccca tggattgccc agctgccttg tatcagttga
     2701 tgttggactg ctggcagaaa gacaggaaca acagacccaa gttcgagcag atcgtcagca
     2761 ttctggacaa actcatccgg aatccaggca gtctgaagat catcaccagc gcggctgcaa
     2821 ggccatcaaa ccttcttctg gaccaaagca atgtcgatat cgctaccttc cacacaactg
     2881 gtgattggct taacggcatg aggacagcac actgtaagga aatcttcaca ggcgtcgaat
     2941 acagctcctg tgacaccatt gccaagatct ccacagatga catgaaaaag gttggtgtca
     3001 ctgtggttgg gccacagaag aagatcatca gcaccattaa agctctagaa acacaatcta
     3061 agaatggtcc agttccagtg taaagtcctg gagggatgtg agaaacggga agatgcagca
     3121 gcatcctgca gacagatgga aatgataaat aagatgctgc agaaagctcc aagtctaata
     3181 agacactcag ttataagtcc aaatgcctta aaatggaatt gaaaaatctc tttattttcc
     3241 cctatcattt tacagatggg tgggtgggtg cattttgctt tgtaattgct ttttaaatgt
     3301 taattgatgg ggttagttaa aattcttcag tatgaagtgg aagaactagt gtagagccat
     3361 tgatcattaa ctatcatgga aataaaccaa gtaaactagc aaaacagacc tgaaggcttt
     3421 gttgtgaatg gccacagagg aaaagacttg tcgtattttt atacacagaa aaaaatctgt
     3481 aacaggtatt ttgtttcttt taaaaacaag caaaatggag gcatttatac ctcaaactat
     3541 ctggccatac ttactacctt atcacgttag tattctcttt atctgtttga agcatataga
     3601 gataaagttt gtagttgttt taaatactat acatttttaa ttgttacctt ccttaagtag
     3661 accatgtaaa aacacgtctt aatttggggg caagtgcgta tttattttct tttggatttt
     3721 taaattgttt tatatttatg ccttgatgat ttaatttggg ttttgttaca gccaagtgcc
     3781 aaatgctatt gcaaattgtc agcagtaaga aacatgttta actataccca gagaattata
     3841 tgttcttttc tacaactgtt gaacaatcca cttacatgta ccaacaaaat gaaatgcttt
     3901 ccctgttcct actgtcacca aatcactcac agtctgaata tcccattcat ttttgtctct
     3961 tcatttatca gtaaatgtat gctcctaatt tagtgtaata tactggcttg tatgtaatag
     4021 atttttacca agatgtcata ccttccctac tctggtgctt agaggatatc aactcctttc
     4081 attcatgaaa gaagcttgtt agaactcctt agatttgcaa actggaaaga tcaaaatgag
     4141 gttaaatggt tacagtaatt gacagcagca tataggtaaa tgcatgagcc aaaaaaaaaa
     4201 aaaatgataa gaaagaaaaa ttgcttgttt tgaaaagtct taatatcatt gcttaaacat
     4261 gtagagaatg atgataacta agctactcat ctgcatcact ggggtgtacg tcaattaatt
     4321 gcacactttc atgatcaata tcaggtataa ctatctttga gtcttccact tcaatgtacc
     4381 tattgtgagt taggtgcatg attagaagcc ttggccttct aaacatatta ttaagcataa
     4441 catttttgaa aaagcaactc atcgaaccaa taaatccaca tccacagaca atggaggaat
     4501 gagatgtctc attatgggga tgtagtcttg ctgttccgga aaggccaatt gtaagcatat
     4561 tcttgaatat taagaaggat gtgcctaacg ggcatcctga tgatgacaca tgctgaagca
     4621 atattttaga ttctggattt tcttgctgat agtatcattc cataggatca agggatgtgt
     4681 gtgtcacaga acaagatggt tcaaacagtg ctgtacgaaa tacgtctcta tgcaaaaagg
     4741 gacactaaag aaatacagct tccaatcata gaggcagatt tccaaatgta atctgttgta
     4801 ggtttagtat actagagctt aggtgagttc tttcagatgt gaaattgttt cccaaatgtt
     4861 gacaatactc cgtatcatgc tgctagaatt tgtactgaac ttataagagc atgaatattt
     4921 tggaaatgag ctgatgaaac taataataaa ttttatatgt cctgaaagca ggtagaaaag
     4981 actctaatca agtaatttaa aatttggaat accaggtcaa aattcaaatc cagcatctga
     5041 accaattcgc ctatgacagc attgattctc ttaggcaata ttctgaacat gctaaaaaaa
     5101 tgaatttcaa aataattagg tattcaaaac ttgttgaatc tgttgcattt attttgactg
     5161 agaattttgt ttgaaattag aggtggttta agcagtatat tgcttttcat ttgtcagtat
     5221 ttttctatct caccgtttat ggatttcctt tgcataaccc cttccctgta catatgtaaa
     5281 cataacagtg tacgattctg gactggggag tagaggtact agatcgctta tggccatctc
     5341 tttgtacagg aactacattg ccttcccata tcaatgaggc taccgctccc ttgccatgtt
     5401 atgtaccata ttacctgatt tgtatcttaa atttgattta tagatattat ttatttctcg
     5461 caacacaccc agtctaggct gtactgagta tctatcaagc catgtataaa tatgatatga
     5521 ttggcagtat gtgtttactt taaacttgca ttttaaaaac atggttcatt tagtttatgt
     5581 tgcacaatgt agatggcctc ttactaatgt aaaatgattt ctagtgggaa catttatatt
     5641 tttataataa acataatgaa aatattttta cagatcagaa ta
//
