LOCUS       NM_010139               3948 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus Eph receptor A2 (Epha2), mRNA.
ACCESSION   NM_010139 XM_982454
VERSION     NM_010139.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3948)
  AUTHORS   Horner,J.L., Vu,M.P., Clark,J.T., Innis,I.J. and Cheng,C.
  TITLE     Canonical ligand-dependent and non-canonical ligand-independent
            EphA2 signaling in the eye lens of wild-type, knockout, and aging
            mice
  JOURNAL   Aging (Albany NY) 16 (20), 13039-13075 (2024)
   PUBMED   39466050
REFERENCE   2  (bases 1 to 3948)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3948)
  AUTHORS   Liu,X., Li,Y., Chen,C., Dong,J., Zhou,J., Tong,D., Wang,L., Gao,X.
            and Kang,X.
  TITLE     Exosomal EphA2 promotes tumor metastasis of triple-negative breast
            cancer by damaging endothelial barrier
  JOURNAL   Clin Exp Metastasis 40 (1), 105-116 (2023)
   PUBMED   36380015
  REMARK    GeneRIF: Exosomal EphA2 promotes tumor metastasis of
            triple-negative breast cancer by damaging endothelial barrier.
REFERENCE   4  (bases 1 to 3948)
  AUTHORS   Xu,Z., Ye,Y., Huang,G., Li,Y., Guo,X., Li,L., Wu,Y., Xu,W., Nian,S.
            and Yuan,Q.
  TITLE     EphA2 recognizes Dermatophagoidespteronyssinus to mediate airway
            inflammation in asthma
  JOURNAL   Int Immunopharmacol 111, 109106 (2022)
   PUBMED   35969898
  REMARK    GeneRIF: EphA2 recognizes Dermatophagoidespteronyssinus to mediate
            airway inflammation in asthma.
REFERENCE   5  (bases 1 to 3948)
  AUTHORS   Chanda,K., Jana,N.R. and Mukhopadhyay,D.
  TITLE     Long non-coding RNA MALAT1 protects against Abeta1-42 induced
            toxicity by regulating the expression of receptor tyrosine kinase
            EPHA2 via quenching miR-200a/26a/26b in Alzheimer's disease
  JOURNAL   Life Sci 302, 120652 (2022)
   PUBMED   35598655
  REMARK    GeneRIF: Long non-coding RNA MALAT1 protects against Abeta1-42
            induced toxicity by regulating the expression of receptor tyrosine
            kinase EPHA2 via quenching miR-200a/26a/26b in Alzheimer's disease.
REFERENCE   6  (bases 1 to 3948)
  AUTHORS   Pandey,A., Duan,H. and Dixit,V.M.
  TITLE     Characterization of a novel Src-like adapter protein that
            associates with the Eck receptor tyrosine kinase
  JOURNAL   J Biol Chem 270 (33), 19201-19204 (1995)
   PUBMED   7543898
REFERENCE   7  (bases 1 to 3948)
  AUTHORS   Mark,M.R., Scadden,D.T., Wang,Z., Gu,Q., Goddard,A. and
            Godowski,P.J.
  TITLE     rse, a novel receptor-type tyrosine kinase with homology to
            Axl/Ufo, is expressed at high levels in the brain
  JOURNAL   J Biol Chem 269 (14), 10720-10728 (1994)
   PUBMED   7511603
REFERENCE   8  (bases 1 to 3948)
  AUTHORS   Nieto,M.A., Gilardi-Hebenstreit,P., Charnay,P. and Wilkinson,D.G.
  TITLE     A receptor protein tyrosine kinase implicated in the segmental
            patterning of the hindbrain and mesoderm
  JOURNAL   Development 116 (4), 1137-1150 (1992)
   PUBMED   1295734
REFERENCE   9  (bases 1 to 3948)
  AUTHORS   Gilardi-Hebenstreit,P., Nieto,M.A., Frain,M., Mattei,M.G.,
            Chestier,A., Wilkinson,D.G. and Charnay,P.
  TITLE     An Eph-related receptor protein tyrosine kinase gene segmentally
            expressed in the developing mouse hindbrain
  JOURNAL   Oncogene 7 (12), 2499-2506 (1992)
   PUBMED   1281307
  REMARK    Erratum:[Oncogene. 1993 Apr;8(4):1103.. PMID: 8455939]
REFERENCE   10 (bases 1 to 3948)
  AUTHORS   Lindberg,R.A. and Hunter,T.
  TITLE     cDNA cloning and characterization of eck, an epithelial cell
            receptor protein-tyrosine kinase in the eph/elk family of protein
            kinases
  JOURNAL   Mol Cell Biol 10 (12), 6316-6324 (1990)
   PUBMED   2174105
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ088701.1, AK144202.1 and AW457468.1.
            
            On Jul 30, 2011 this sequence version replaced NM_010139.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137704.1, AK144202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                CJ088701.1         5-23
            20-3924             AK144202.1         4-3908
            3925-3948           AW457468.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..3948
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 73.67 cM"
     gene            1..3948
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /note="Eph receptor A2"
                     /db_xref="GeneID:13836"
                     /db_xref="MGI:MGI:95278"
     exon            1..214
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..3066
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /EC_number="2.7.10.1"
                     /note="ephrin type-A receptor 2; epithelial cell kinase;
                     tyrosine-protein kinase receptor ECK; tyrosine-protein
                     kinase receptor MPK-5; tyrosine-protein kinase receptor
                     SEK-2"
                     /codon_start=1
                     /product="ephrin type-A receptor 2 precursor"
                     /protein_id="NP_034269.2"
                     /db_xref="CCDS:CCDS18869.1"
                     /db_xref="GeneID:13836"
                     /db_xref="MGI:MGI:95278"
                     /translation="MELRAVGFCLALLWGCALAAAAAQGKEVVLLDFAAMKGELGWLT
                     HPYGKGWDLMQNIMDDMPIYMYSVCNVVSGDQDNWLRTNWVYREEAERIFIELKFTVR
                     DCNSFPGGASSCKETFNLYYAESDVDYGTNFQKRQFTKIDTIAPDEITVSSDFEARNV
                     KLNVEERMVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPEMLQSLARFPETIAVAV
                     SDTQPLATVAGTCVDHAVVPYGGEGPLMHCTVDGEWLVPIGQCLCQEGYEKVEDACRA
                     CSPGFFKSEASESPCLECPEHTLPSTEGATSCQCEEGYFRAPEDPLSMSCTRPPSAPN
                     YLTAIGMGAKVELRWTAPKDTGGRQDIVYSVTCEQCWPESGECGPCEASVRYSEPPHA
                     LTRTSVTVSDLEPHMNYTFAVEARNGVSGLVTSRSFRTASVSINQTEPPKVRLEDRST
                     TSLSVTWSIPVSQQSRVWKYEVTYRKKGDANSYNVRRTEGFSVTLDDLAPDTTYLVQV
                     QALTQEGQGAGSKVHEFQTLSTEGSANMAVIGGVAVGVVLLLVLAGVGLFIHRRRRNL
                     RARQSSEDVRFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVARQKVIGAGE
                     FGEVYKGTLKASSGKKEIPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHNIIRLEGV
                     VSKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIASGMKYLANMNYVHRD
                     LAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSA
                     SDVWSYGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQ
                     QERSRRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWL
                     ESIKMQQYTEHFMVAGYTAIEKVVQMSNEDIKRIGVRLPGHQKRIAYSLLGLKDQVNT
                     VGIPI"
     exon            215..282
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /inference="alignment:Splign:2.1.0"
     exon            283..958
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1114
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1447
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1563
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1717
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1817
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1873
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1999
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2188
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2250
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2460
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2610
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2804
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2960
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /inference="alignment:Splign:2.1.0"
     exon            2961..3932
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3906..3911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /note="hexamer: AATAAA"
     polyA_site      3932
                     /gene="Epha2"
                     /gene_synonym="Eck; Myk2; Sek-2; Sek2"
                     /note="major polyA site"
ORIGIN      
        1 gggttctcac ccaacttcca ttaaggactt ggagcaggag ggtagaagtt gtctctgtcg
       61 gcgggcgggc aggattgggg caccgagacc ggcgtgcgga cagcagggat cgcggggagc
      121 gaggggtgcg gcatggagct ccgggcagtc ggtttctgcc tggcgctgct gtggggttgc
      181 gcgctggcgg ccgcggcggc acagggaaag gaagttgttt tgttggactt cgcagcaatg
      241 aagggagagc tcggctggct cacgcacccc tatggcaaag ggtgggacct gatgcagaac
      301 atcatggacg acatgcctat ctacatgtac tcggtgtgca acgtggtatc cggcgaccag
      361 gacaactggc tccgcaccaa ctgggtgtac cgggaggagg ccgagcgcat ctttattgag
      421 ctcaagttca cggtgcgaga ctgtaacagc ttcccgggtg gcgccagctc atgcaaagag
      481 accttcaacc tctactatgc agagtcagat gtggactatg gcaccaactt ccagaagcgc
      541 cagttcacca agattgacac catcgcccct gacgagatca cggtcagcag tgacttcgag
      601 gctcgcaatg tcaagctgaa cgtagaggag cgcatggtgg ggccccttac ccggaagggc
      661 ttctacctgg ccttccagga catcggcgcc tgcgtggcgc tgctctccgt tcgcgtctac
      721 tacaagaagt gtcccgagat gctgcagagc ttggctcgct tccccgagac cattgctgtc
      781 gctgtctccg atacacaacc cctggccacg gtggccggta cctgcgtgga ccatgccgtg
      841 gtgccttatg ggggcgaggg gcctctcatg cactgcacgg tggatggcga gtggctggtg
      901 cccatcgggc agtgcctgtg ccaggaaggc tacgagaagg tcgaggatgc ctgccgagcc
      961 tgttctccag gattcttcaa gtctgaggca tctgagagcc cttgcctgga gtgtccagag
     1021 cataccctgc catccacaga gggtgccacc tcctgccagt gtgaagaagg ctatttcagg
     1081 gcacctgagg acccactgtc catgtcttgc acacgtccac cctctgcccc caactacctc
     1141 acggccattg gcatgggtgc caaagtagaa ctgcgttgga cagctcccaa ggacactggt
     1201 ggccgccagg acattgtcta cagtgtcact tgcgaacagt gctggccaga gtctggcgag
     1261 tgtgggccct gtgaggcgag cgtgcgctat tcagaacctc ctcacgccct gacccgcacg
     1321 agtgtgacag tcagtgacct ggagccccac atgaactata ccttcgctgt cgaagcacgc
     1381 aatggtgtct caggcctggt gactagccga agcttccgga ctgccagcgt cagtattaac
     1441 caaacagagc cccccaaagt gaggctggag gaccgaagca ccacctccct gagtgtcacc
     1501 tggagcatcc cggtgtcaca gcagagccgt gtgtggaagt acgaagtcac ctaccgcaag
     1561 aagggggatg ccaacagcta taatgtgcgc cgcacggaag gcttctccgt gaccctggat
     1621 gaccttgctc cggataccac gtacctggtg caggtgcagg cgctgacgca ggagggccag
     1681 ggagccggca gcaaagtgca cgagttccag acactgtcca cggaaggatc tgccaacatg
     1741 gcggtgatcg gcggtgtggc tgtaggtgtt gttttgcttc tggtactggc aggagttggc
     1801 ctcttcatcc atcgaaggag gaggaacctg cgggctcgcc agtcctctga ggatgtccgt
     1861 ttttccaagt cagaacaact aaagcccctg aagacctatg tggatcctca cacttacgaa
     1921 gaccccaacc aggctgtact caagtttacc accgagatcc acccatcctg tgtggcaagg
     1981 cagaaggtca ttggagcagg agagtttgga gaggtctata aagggacgct gaaggcatcc
     2041 tcggggaaga aggagatacc ggtggccatc aagacactga aagcgggcta cactgagaag
     2101 cagcgggtgg acttcctgag cgaggccagc atcatgggcc agtttagcca ccacaatatc
     2161 atccgcctgg agggcgtggt ctctaaatac aaacccatga tgattatcac agagtacatg
     2221 gagaatggag cgctagacaa gttccttagg gagaaggatg gtgagttcag tgtacttcag
     2281 ttggtgggca tgctgagggg tatcgcatcc ggcatgaagt acctggccaa catgaactac
     2341 gtgcaccggg acctggccgc ccgcaacatc ctcgtcaaca gcaacctggt gtgcaaggtg
     2401 tccgattttg gcctgtcgcg tgtgctggaa gatgaccccg aggccaccta caccacaagt
     2461 ggcggcaaga tccctattcg atggacagcc ccagaggcca tttcctaccg caagttcacc
     2521 tcagccagcg atgtgtggag ctacggcatt gtcatgtggg aagtgatgac ttatggcgaa
     2581 cggccctact gggaactgtc aaaccacgag gtcatgaaag ccatcaacga cggcttccgg
     2641 ctccctacgc ccatggactg cccttcagcc atttaccagc tcatgatgca gtgctggcag
     2701 caagagcgct cccgccgacc caagtttgcc gacatcgtta gcatcctgga caagctcatc
     2761 cgagcccccg actccctcaa gacgctggct gactttgatc cccgagtgtc catccggctg
     2821 cccagcacca gcggctcgga gggagtcccc ttccgtacgg tgtccgagtg gctggagagc
     2881 atcaagatgc aacagtacac ggaacacttc atggtggctg gctacacggc catcgagaag
     2941 gtggtacaga tgtccaacga agacatcaaa aggatcggag tgcgtcttcc tggccaccag
     3001 aagcgtattg cctacagcct gctgggactc aaggaccagg tcaacacagt ggggattcct
     3061 atctgagtcc attggggccg tgcccaacaa tacttgaaga gccacagtgg tctccctgcc
     3121 gacctggtgc tggcccactg gaactttatt tatttctgtt tcctcgtcta tgcctccctg
     3181 aggactctgc agggggcttt tgaatgacac cctggcctga gcctgggaaa cttggatgct
     3241 ggtcagggct ctctttcccc tgcaaaggac ccagctaagc acttagcagt ttgccatggc
     3301 cttcccagca tcccctgagg ctaaagttcc accaagaccg tcgatatcga cgagggacat
     3361 ttccaaacgg acctccccat cttcatttgg cctcctgaga agccacctca ggagctgagg
     3421 ctaagcacta agcccaggac catatgacta gggcactgta cgccccgccc ctagttagag
     3481 ggtaggtttt ggacttggct gggtgtggtc acagcaatct cccagtgcct tttacagacc
     3541 cagggctctg ccctccgccc tcgagggcca gcttcttgct ttcctagggc cctctcagga
     3601 tgcttggctg tgctgaggtt tttattaaat atatatttta tacttgtgga aagaatgagt
     3661 gtgtggcagg gaccttgcca gggctggaga cagaggatcc cctgcaacag acattcccgg
     3721 gctgggggct ggcggacctg caggagactt tccgccagcc acccagtctc cagccccttt
     3781 ggacaaatgt cgctgtcagt gttacagatt tcttttattg ggttgttttt ttgttgtatt
     3841 ttttgaacct taacttatta ttttttttat atttattgtt agaaaatgac ttatttctgc
     3901 tctggaataa agttgcagat ggttcaaact gaaaaaaaaa aaaaaaaa
//
