LOCUS       NM_023580               3273 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus Eph receptor A1 (Epha1), mRNA.
ACCESSION   NM_023580
VERSION     NM_023580.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3273)
  AUTHORS   Li,Q., Li,R., Zhu,X., Chu,X., An,X., Chen,M., Zhang,L., Gao,M. and
            Chen,L.
  TITLE     EphA1 aggravates neuropathic pain by activating CXCR4/RhoA/ROCK2
            pathway in mice
  JOURNAL   Hum Cell 36 (4), 1416-1428 (2023)
   PUBMED   37162645
  REMARK    GeneRIF: EphA1 aggravates neuropathic pain by activating
            CXCR4/RhoA/ROCK2 pathway in mice.
REFERENCE   2  (bases 1 to 3273)
  AUTHORS   LaCombe,R., Cecchini,A., Seibert,M. and Cornelison,D.
  TITLE     EphA1 receptor tyrosine kinase is localized to the nucleus in
            rhabdomyosarcoma from multiple species
  JOURNAL   Biol Open 11 (10) (2022)
   PUBMED   36214254
  REMARK    GeneRIF: EphA1 receptor tyrosine kinase is localized to the nucleus
            in rhabdomyosarcoma from multiple species.
REFERENCE   3  (bases 1 to 3273)
  AUTHORS   Yang,K.Y., Zhao,S., Feng,H., Shen,J., Chen,Y., Wang,S.T.,
            Wang,S.J., Zhang,Y.X., Wang,Y., Guo,C., Liu,H. and Tang,T.S.
  TITLE     Ca2+ homeostasis maintained by TMCO1 underlies corpus callosum
            development via ERK signaling
  JOURNAL   Cell Death Dis 13 (8), 674 (2022)
   PUBMED   35927240
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3273)
  AUTHORS   de Lemos,L., Dias,A., Novoa,A. and Mallo,M.
  TITLE     Epha1 is a cell-surface marker for the neuromesodermal competent
            population
  JOURNAL   Development 149 (6) (2022)
   PUBMED   35299237
REFERENCE   5  (bases 1 to 3273)
  AUTHORS   Ma,J., Wang,Z., Chen,S., Sun,W., Gu,Q., Li,D., Zheng,J., Yang,H.
            and Li,X.
  TITLE     EphA1 Activation Induces Neuropathological Changes in a Mouse Model
            of Parkinson's Disease Through the CXCL12/CXCR4 Signaling Pathway
  JOURNAL   Mol Neurobiol 58 (3), 913-925 (2021)
   PUBMED   33057926
  REMARK    GeneRIF: EphA1 Activation Induces Neuropathological Changes in a
            Mouse Model of Parkinson's Disease Through the CXCL12/CXCR4
            Signaling Pathway.
REFERENCE   6  (bases 1 to 3273)
  AUTHORS   Holder,N. and Klein,R.
  TITLE     Eph receptors and ephrins: effectors of morphogenesis
  JOURNAL   Development 126 (10), 2033-2044 (1999)
   PUBMED   10207129
  REMARK    Review article
REFERENCE   7  (bases 1 to 3273)
  AUTHORS   Orioli,D. and Klein,R.
  TITLE     The Eph receptor family: axonal guidance by contact repulsion
  JOURNAL   Trends Genet 13 (9), 354-359 (1997)
   PUBMED   9287490
  REMARK    Review article
REFERENCE   8  (bases 1 to 3273)
  AUTHORS   .
  TITLE     Unified nomenclature for Eph family receptors and their ligands,
            the ephrins. Eph Nomenclature Committee
  JOURNAL   Cell 90 (3), 403-404 (1997)
   PUBMED   9267020
REFERENCE   9  (bases 1 to 3273)
  AUTHORS   Lickliter,J.D., Smith,F.M., Olsson,J.E., Mackwell,K.L. and
            Boyd,A.W.
  TITLE     Embryonic stem cells express multiple Eph-subfamily receptor
            tyrosine kinases
  JOURNAL   Proc Natl Acad Sci U S A 93 (1), 145-150 (1996)
   PUBMED   8552593
REFERENCE   10 (bases 1 to 3273)
  AUTHORS   Tuzi,N.L. and Gullick,W.J.
  TITLE     eph, the largest known family of putative growth factor receptors
  JOURNAL   Br J Cancer 69 (3), 417-421 (1994)
   PUBMED   8123468
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC153915.5.
            
            On Apr 30, 2007 this sequence version replaced NM_023580.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028478.1, BC071215.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AC153915.5         11998-12140
            144-211             AC153915.5         13024-13091
            212-493             AC153915.5         17399-17680
            494-896             AC153915.5         19088-19490
            897-1052            AC153915.5         19692-19847
            1053-1397           AC153915.5         20146-20490
            1398-1525           AC153915.5         20602-20729
            1526-1676           AC153915.5         20955-21105
            1677-1773           AC153915.5         21360-21456
            1774-1832           AC153915.5         21646-21704
            1833-1958           AC153915.5         22484-22609
            1959-2144           AC153915.5         23304-23489
            2145-2206           AC153915.5         23611-23672
            2207-2413           AC153915.5         23774-23980
            2414-2563           AC153915.5         24112-24261
            2564-2757           AC153915.5         24528-24721
            2758-2913           AC153915.5         26175-26330
            2914-3273           AC153915.5         26420-26779
FEATURES             Location/Qualifiers
     source          1..3273
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 20.65 cM"
     gene            1..3273
                     /gene="Epha1"
                     /gene_synonym="5730453L17Rik; Eph; Esk"
                     /note="Eph receptor A1"
                     /db_xref="GeneID:13835"
                     /db_xref="MGI:MGI:107381"
     exon            1..143
                     /gene="Epha1"
                     /gene_synonym="5730453L17Rik; Eph; Esk"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..2992
                     /gene="Epha1"
                     /gene_synonym="5730453L17Rik; Eph; Esk"
                     /EC_number="2.7.10.1"
                     /note="ephrin type-A receptor 1; tyrosine-protein kinase
                     receptor ESK; mEpha1; embryonic stem cell kinase"
                     /codon_start=1
                     /product="ephrin type-A receptor 1 precursor"
                     /protein_id="NP_076069.2"
                     /db_xref="CCDS:CCDS20067.1"
                     /db_xref="GeneID:13835"
                     /db_xref="MGI:MGI:107381"
                     /translation="MERRWPLGLALLLLLLCAPLPPGARAEEVTLMDTSTAQGELGWL
                     LDPPETGWSEVQQMLNGTPLYMYQDCPIQEGGDTDHWLRSNWIYRGEEASRIYVELQF
                     TVRDCKSFPGGAGPLGCKETFNLFYMESDQDVGIQLRRPLFQKVTTVAADQSFTIRDL
                     ASGSVKLNVERCSLGHLTRRGLYLAFHNPGSCVALVSVRVFYQRCAETVHGLAHFPDT
                     LPGPGGLVEVAGTCLSHAQISLGSSGTPRMHCSPDGEWLVPVGQCQCEPGYEESSGNV
                     GCTACPTGFYRVDMNTLRCLKCPQHSIAESEGSTICTCENGHYRAPGEGPQVACTRPP
                     SAPQNLSFSTSGTQLSLRWEPPRDTGGRHDIRYSVECLQCRGIAQDGGPCQPCGKGVH
                     FSPAASGLTTSTVQVQGLEPYANYTFTVKSQNRVSGLDSSSPSSASLSINMGHAESLS
                     GLSLKLVKKEPRQLELTWAGSRPRNPGGNLSYELHVLNQDEEWHQMVLEPRVLLTKLQ
                     PDTTYIVRVRTLTPLGPGPFSPDHEFRTSPPVSRSLTGGEIVAVIFGLLLGIALLIGI
                     YVFRSRRGQRQRQQRQRERTTNVDREDKLWLKPYVDLQAYEDPAQGALDFAQELDPAW
                     LIVDTVIGEGEFGEVYRGALRLPSQDCKTVAIKTLKDTSPDGYWWNFLREATIMGQFN
                     HPHILRLEGVITKRKPIMIITEFMENGALDAFLKEREDQLAPGQLVAMLLGIASGMNC
                     LSGHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEA
                     IAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPL
                     YELMKNCWAYDRARRPHFLQLQAHLEQLLTDPHSLRTIANFDPRVTLRLPSLSGSDGI
                     PYRSVSEWLESIRMKRYILHFRSAGLDTMECVLELTAEDLTQMGITLPGHQKRILCSI
                     QGFKD"
     exon            144..211
                     /gene="Epha1"
                     /gene_synonym="5730453L17Rik; Eph; Esk"
                     /inference="alignment:Splign:2.1.0"
     exon            212..493
                     /gene="Epha1"
                     /gene_synonym="5730453L17Rik; Eph; Esk"
                     /inference="alignment:Splign:2.1.0"
     exon            494..896
                     /gene="Epha1"
                     /gene_synonym="5730453L17Rik; Eph; Esk"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1052
                     /gene="Epha1"
                     /gene_synonym="5730453L17Rik; Eph; Esk"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1397
                     /gene="Epha1"
                     /gene_synonym="5730453L17Rik; Eph; Esk"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1525
                     /gene="Epha1"
                     /gene_synonym="5730453L17Rik; Eph; Esk"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1676
                     /gene="Epha1"
                     /gene_synonym="5730453L17Rik; Eph; Esk"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1773
                     /gene="Epha1"
                     /gene_synonym="5730453L17Rik; Eph; Esk"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1832
                     /gene="Epha1"
                     /gene_synonym="5730453L17Rik; Eph; Esk"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1958
                     /gene="Epha1"
                     /gene_synonym="5730453L17Rik; Eph; Esk"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2144
                     /gene="Epha1"
                     /gene_synonym="5730453L17Rik; Eph; Esk"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2206
                     /gene="Epha1"
                     /gene_synonym="5730453L17Rik; Eph; Esk"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2413
                     /gene="Epha1"
                     /gene_synonym="5730453L17Rik; Eph; Esk"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2563
                     /gene="Epha1"
                     /gene_synonym="5730453L17Rik; Eph; Esk"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2757
                     /gene="Epha1"
                     /gene_synonym="5730453L17Rik; Eph; Esk"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..2913
                     /gene="Epha1"
                     /gene_synonym="5730453L17Rik; Eph; Esk"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3273
                     /gene="Epha1"
                     /gene_synonym="5730453L17Rik; Eph; Esk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccctcgc gacctggccc agccgtaggg gccgtggtcc caggtcccgg ccggcgccat
       61 ggagcggcgc tggcccctgg ggcttgcatt gctgctgctg ctgctctgcg ccccgctgcc
      121 cccgggggcg cgcgccgagg aagtcactct aatggacaca agcacagcac aaggagagct
      181 gggctggctt ctggatcccc cagagactgg gtggagtgag gtgcaacaaa tgctaaacgg
      241 gacacccctg tacatgtacc aagactgccc aatacaggaa ggtggggaca ctgaccactg
      301 gcttcgctcc aattggatct accgcggaga ggaagcttca cgcatctacg tggagctgca
      361 gttcaccgtg cgggactgta agagtttccc agggggagct gggcctctgg gatgcaaaga
      421 gaccttcaac cttttctaca tggagagtga ccaggatgtg ggcattcagc tccgacgacc
      481 tttgttccaa aaggtaacaa ctgtggcagc agaccagagc ttcaccatca gagacctggc
      541 atctggctct gtaaagctga atgtagaacg ctgctcgttg ggccacctca cccgccgtgg
      601 cctctactta gctttccaca acccgggttc ctgtgtggcg ctagtgtctg taagggtgtt
      661 ctaccagcgc tgtgccgaga ccgtgcatgg cttggcccac ttccctgaca ctctccctgg
      721 acctggaggg ttggttgaag tagctggaac gtgcctctcc catgcacaga tcagcttggg
      781 gtcctcaggt acaccacgaa tgcactgcag ccctgatggc gagtggctgg tgcctgtggg
      841 tcagtgccag tgcgagcctg gctatgaaga aagcagtgga aatgtgggat gcactgcctg
      901 tcctactggt ttctatcgag tggacatgaa tacactccgt tgtctcaagt gcccccaaca
      961 tagcatagca gagtctgagg ggtctaccat ctgtacctgt gagaatggac attatcgagc
     1021 ccctggggag ggtccccagg tagcatgcac acgtccccca tcggctcccc aaaatctgag
     1081 cttctccaca tcagggactc aactctccct gcgctgggag ccccccagag atacaggggg
     1141 acgccatgat atcagataca gcgtggagtg cttgcagtgt cggggcattg cacaggatgg
     1201 gggtccctgc caaccctgtg gaaaaggtgt gcacttttcc ccggctgctt ccgggctcac
     1261 cacatctacc gtgcaagtgc aaggcctcga gccttacgcc aactacacat ttaccgtcaa
     1321 atcccaaaac agagtgtcag gactggacag ttccagccct agcagcgcct ccctcagtat
     1381 caacatgggg cacgcagagt cactctctgg cctgtcactg aagctggtga agaaagaacc
     1441 gaggcagctg gagctgactt gggcagggtc ccgaccccga aatcctggag ggaatctgag
     1501 ctatgagctg cacgtgctga atcaggacga agaatggcac cagatggtgt tggaacccag
     1561 ggtcttgctg acaaaacttc agccagatac cacatacatt gtcagagtgc gaacactgac
     1621 cccactgggg cctggccctt tctcccctga ccatgagttt cggacaagcc caccagtttc
     1681 cagaagcctg accggaggag agattgtggc cgtcatcttt ggattgctgc ttggaatagc
     1741 tctgctgatc gggatttatg tcttccgttc aaggagaggc cagagacaga gacagcagag
     1801 gcagcgtgaa cgcaccacca atgtcgatcg agaggacaag ctgtggctaa aaccctatgt
     1861 ggacctccag gcctatgagg accctgcaca gggagcctta gactttgccc aggaactgga
     1921 cccagcctgg ctgattgtgg acactgtcat aggagaaggg gagtttggtg aagtgtatcg
     1981 gggagccctg agactcccca gccaagattg caagactgtg gccattaaga ccttgaaaga
     2041 tacatcccca gatggctact ggtggaattt ccttcgagag gcaactatca tgggccagtt
     2101 caaccaccca cacattctac gcctagaagg tgtcatcaca aaaagaaagc ccatcatgat
     2161 catcacagaa tttatggaaa atggagccct ggatgccttt ctgaaggaac gggaggacca
     2221 actagctcct ggtcagctag tggctatgct actgggcata gcatcaggca tgaactgcct
     2281 cagtggccac aattatgtcc atagagacct ggctgccagg aacatcttgg tgaatcagaa
     2341 cctgtgctgc aaggtgtctg actttggctt gacccgcctc ctggatgact ttgacggcac
     2401 ctatgaaacc cagggaggaa agatccccat ccgatggaca gccccagaag ctattgccca
     2461 tcggatcttc accacagcca gtgatgtgtg gagctttggg attgtaatgt gggaggtgtt
     2521 gagttttggc gacaaaccct atggggagat gagcaaccaa gaggtaatga aaagcattga
     2581 agatgggtac cggttgcccc ctcctgtgga ctgtcctgcc cctctctatg aactcatgaa
     2641 gaactgctgg gcttacgatc gtgcccgtcg accccacttc ctccagctgc aggcacatct
     2701 ggaacagttg cttactgacc cccattccct aaggacaatt gccaactttg accctagggt
     2761 gaccttacgc ctgcccagcc tgagtggctc tgatgggatc ccttatcgaa gtgtctctga
     2821 gtggcttgaa tccatacgca tgaagcgcta catcctgcac ttccgttcgg ctgggctgga
     2881 caccatggag tgtgtgctgg agctgacggc tgaggacctg acgcagatgg gaataacgtt
     2941 gccagggcac cagaaacgaa ttctctgcag tattcaagga tttaaggact gagcatccac
     3001 tgaaaagatg ctccagccct ctgcctgcct ccattagcaa ggacggggct acagtcaact
     3061 ccctgggcct ttcctcagcc tacgaaatgt aggctattgg tgctgctcct gcccagtcaa
     3121 tcagaactct gcctttgaac caaggagcct ttgtttataa agggggtgga tgggtacaag
     3181 tgaaggggac tgtgggtggg ttctggggga gggtttaata tatacactta catatgcatt
     3241 atctattttt gtaaataaac aagagttgag ttt
//
