LOCUS       NM_001195633           11967 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ectopic P-granules 5 autophagy tethering factor
            (Epg5), mRNA.
ACCESSION   NM_001195633 XM_916282 XM_973419
VERSION     NM_001195633.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11967)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 11967)
  AUTHORS   Liu,W., Chen,M., Liu,C., Wang,L., Wei,H., Zhang,R., Ren,Z.,
            Chen,Y., Luo,M., Zhao,J., Jiang,H., Gao,F. and Li,W.
  TITLE     Epg5 deficiency leads to primary ovarian insufficiency due to WT1
            accumulation in mouse granulosa cells
  JOURNAL   Autophagy 19 (2), 644-659 (2023)
   PUBMED   35786405
  REMARK    GeneRIF: Epg5 deficiency leads to primary ovarian insufficiency due
            to WT1 accumulation in mouse granulosa cells.
REFERENCE   3  (bases 1 to 11967)
  AUTHORS   Lee,S., Kalugotla,G., Ingle,H., Rodgers,R., Wu,C., Wang,Y., Li,Y.,
            Yang,X., Zhang,J., Borella,N.R., Deng,H., Droit,L., Hill,R.,
            Peterson,S.T., Desai,C., Lawrence,D., Lu,Q. and Baldridge,M.T.
  TITLE     Intestinal antiviral signaling is controlled by autophagy gene Epg5
            independent of the microbiota
  JOURNAL   Autophagy 18 (5), 1062-1077 (2022)
   PUBMED   34520306
  REMARK    GeneRIF: Intestinal antiviral signaling is controlled by autophagy
            gene Epg5 independent of the microbiota.
REFERENCE   4  (bases 1 to 11967)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11967)
  AUTHORS   Li,W., Feng,Y., Chen,A., Li,T., Huang,S., Liu,J., Liu,X., Liu,Y.,
            Gao,J., Yan,D., Sun,J., Mei,L., Liu,X. and Ling,J.
  TITLE     Elmod3 knockout leads to progressive hearing loss and abnormalities
            in cochlear hair cell stereocilia
  JOURNAL   Hum Mol Genet 28 (24), 4103-4112 (2019)
   PUBMED   31628468
REFERENCE   6  (bases 1 to 11967)
  AUTHORS   Miao,G., Zhao,Y.G., Zhao,H., Ji,C., Sun,H., Chen,Y. and Zhang,H.
  TITLE     Mice deficient in the Vici syndrome gene Epg5 exhibit features of
            retinitis pigmentosa
  JOURNAL   Autophagy 12 (12), 2263-2270 (2016)
   PUBMED   27715390
  REMARK    GeneRIF: apoptotic photoreceptor cell death in epg5(-/-) retinas
            may result from the elevated unfolded protein response.
REFERENCE   7  (bases 1 to 11967)
  AUTHORS   Lu,Q., Yokoyama,C.C., Williams,J.W., Baldridge,M.T., Jin,X.,
            DesRochers,B., Bricker,T., Wilen,C.B., Bagaitkar,J.,
            Loginicheva,E., Sergushichev,A., Kreamalmeyer,D., Keller,B.C.,
            Zhao,Y., Kambal,A., Green,D.R., Martinez,J., Dinauer,M.C.,
            Holtzman,M.J., Crouch,E.C., Beatty,W., Boon,A.C., Zhang,H.,
            Randolph,G.J., Artyomov,M.N. and Virgin,H.W.
  TITLE     Homeostatic Control of Innate Lung Inflammation by Vici Syndrome
            Gene Epg5 and Additional Autophagy Genes Promotes Influenza
            Pathogenesis
  JOURNAL   Cell Host Microbe 19 (1), 102-113 (2016)
   PUBMED   26764600
REFERENCE   8  (bases 1 to 11967)
  AUTHORS   Zhao,H., Zhao,Y.G., Wang,X., Xu,L., Miao,L., Feng,D., Chen,Q.,
            Kovacs,A.L., Fan,D. and Zhang,H.
  TITLE     Mice deficient in Epg5 exhibit selective neuronal vulnerability to
            degeneration
  JOURNAL   J Cell Biol 200 (6), 731-741 (2013)
   PUBMED   23479740
  REMARK    GeneRIF: Epg5-deficient mice as a model for investigating the
            pathogenesis of ALS and indicates that dysfunction of the
            autophagic-endolysosomal system causes selective damage of neurons
            associated with neurodegenerative diseases.
REFERENCE   9  (bases 1 to 11967)
  AUTHORS   Church,D.M., Goodstadt,L., Hillier,L.W., Zody,M.C., Goldstein,S.,
            She,X., Bult,C.J., Agarwala,R., Cherry,J.L., DiCuccio,M.,
            Hlavina,W., Kapustin,Y., Meric,P., Maglott,D., Birtle,Z.,
            Marques,A.C., Graves,T., Zhou,S., Teague,B., Potamousis,K.,
            Churas,C., Place,M., Herschleb,J., Runnheim,R., Forrest,D.,
            Amos-Landgraf,J., Schwartz,D.C., Cheng,Z., Lindblad-Toh,K.,
            Eichler,E.E. and Ponting,C.P.
  CONSRTM   Mouse Genome Sequencing Consortium
  TITLE     Lineage-specific biology revealed by a finished genome assembly of
            the mouse
  JOURNAL   PLoS Biol 7 (5), e1000112 (2009)
   PUBMED   19468303
REFERENCE   10 (bases 1 to 11967)
  AUTHORS   Halama,N., Grauling-Halama,S.A., Beder,A. and Jager,D.
  TITLE     Comparative integromics on the breast cancer-associated gene
            KIAA1632: clues to a cancer antigen domain
  JOURNAL   Int J Oncol 31 (1), 205-210 (2007)
   PUBMED   17549423
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126553.4.
            
            On Jul 21, 2018 this sequence version replaced NM_001195633.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AC126553.4         178784-178877       c
            95-1027             AC126553.4         168261-169193       c
            1028-1271           AC126553.4         165951-166194       c
            1272-1408           AC126553.4         163046-163182       c
            1409-1516           AC126553.4         162503-162610       c
            1517-1590           AC126553.4         161363-161436       c
            1591-1696           AC126553.4         159831-159936       c
            1697-1811           AC126553.4         158199-158313       c
            1812-1962           AC126553.4         157713-157863       c
            1963-2118           AC126553.4         156481-156636       c
            2119-2276           AC126553.4         154805-154962       c
            2277-2431           AC126553.4         152288-152442       c
            2432-2572           AC126553.4         148666-148806       c
            2573-2737           AC126553.4         144684-144848       c
            2738-2857           AC126553.4         142245-142364       c
            2858-3114           AC126553.4         141250-141506       c
            3115-3255           AC126553.4         138079-138219       c
            3256-3400           AC126553.4         136258-136402       c
            3401-3598           AC126553.4         135848-136045       c
            3599-3709           AC126553.4         134925-135035       c
            3710-3829           AC126553.4         133753-133872       c
            3830-3996           AC126553.4         132136-132302       c
            3997-4218           AC126553.4         130736-130957       c
            4219-4342           AC126553.4         128956-129079       c
            4343-4487           AC126553.4         125853-125997       c
            4488-4659           AC126553.4         121660-121831       c
            4660-4822           AC126553.4         119974-120136       c
            4823-4965           AC126553.4         107631-107773       c
            4966-5122           AC126553.4         106353-106509       c
            5123-5317           AC126553.4         104448-104642       c
            5318-5531           AC126553.4         103139-103352       c
            5532-5680           AC126553.4         102456-102604       c
            5681-5882           AC126553.4         101463-101664       c
            5883-5955           AC126553.4         99619-99691         c
            5956-6062           AC126553.4         98022-98128         c
            6063-6238           AC126553.4         96430-96605         c
            6239-6424           AC126553.4         94507-94692         c
            6425-6634           AC126553.4         93857-94066         c
            6635-6779           AC126553.4         93273-93417         c
            6780-7022           AC126553.4         89844-90086         c
            7023-7239           AC126553.4         88364-88580         c
            7240-7455           AC126553.4         87159-87374         c
            7456-7570           AC126553.4         86888-87002         c
            7571-11967          AC126553.4         80022-84418         c
FEATURES             Location/Qualifiers
     source          1..11967
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 52.38 cM"
     gene            1..11967
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /note="ectopic P-granules 5 autophagy tethering factor"
                     /db_xref="GeneID:100502841"
                     /db_xref="MGI:MGI:1918673"
     exon            1..94
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..7753
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /note="ectopic P-granules autophagy protein 5 homolog"
                     /codon_start=1
                     /product="ectopic P granules protein 5 homolog"
                     /protein_id="NP_001182562.1"
                     /db_xref="CCDS:CCDS57126.1"
                     /db_xref="GeneID:100502841"
                     /db_xref="MGI:MGI:1918673"
                     /translation="MAEAVKPRRAKAKASRTKGKEKKKHEALQTCDAGPLPETCREQE
                     SPCPASELKGDDLKSSADPQLHSDVCGWNESEMFDIPLTSLTIGDEGPPVQDTEDLKE
                     RGEVTAGDGDDEMELKVDPGDNVIAKGEPCKNFPEVEDHTLIQCGPPESTLQPDFPCT
                     QQAVEGSHAREHPTRKQDEAALGCSKVFQNVSLHSSYEAKEVSQPPRVKKLYPELPAE
                     IAEVPALVAVKPLLRSERLYPELPSQPEVTPFTKEQLKLLEPGSWLENVASYVEEFDN
                     IAHQDRHEFYELLLNYSRCRKQLLLAEAELLTLMSDCHSAKSRLWHFKDEQMAVQGIC
                     ADQVKVYGHHHYQRVEMNENVLGELKKLFDAKSEHLHQTLTLHSYTSVLSRLQVESYI
                     FTLLNSSAALRSLAVYQADQVPKLTESIPSDVCQLKECISVLFMFTRRVSEDAQFHED
                     ILLWLQKLVSVLQRVGCPGDHFFLLNHVLRCPAGIRKWAVPFIQIKVLNNPSGVFHFM
                     QSLALLMSPVKNRAEFMCHMKPSEWKPSSSGPASGNWTLVDEAGEEDEDPETSWILLN
                     EDDLVTLLSQFPFQELFQHLLGFKAKGDYLPETTRPQEMMKIFAFANSLVELLAVGLD
                     TFNRARYRQFVKRIGYLIRMTLGYVSDHWAQYVSHSTGAGLTPQPYSMEKLQVEFDEL
                     FLRAVLHVLKAKRLGIWLFMSEMPFGTLSVQMLWKLLYLMHQVESGDLQQLCASLQPA
                     ECKRRLQDPEHFASFEKCLSSINSSEEICLLTAFAQMARARRTNVDEDFIKIIVLEIY
                     EVSYVTLSTRETFSKVGRELLGAIAAVHPEIISVLLDRVQETIDQVGMVSLYLFKELP
                     LYLWRPSAPEIAVIRDWLLNNNLTAVKNKLACVILEGLNWGFTEQGTLHLDQALHTEV
                     ALLVLEAYQKYLAQKPYTGLISESMKQVSYLASIVRYGETPETSFNQWAWNLILRLKL
                     HKNDFGRQNFPVIPFCSTVPDMTESSMFHPLLKAVKSGLPIGCYLALAVTAVGHSLEK
                     FCAEGIPLLGVLVQSRHLRAVVHALDKILPVFYPYQCYLLKNEQFLSNLLLFLQLDSG
                     VPQGVTQQVTHRVAQHLTGAVHGDNVKLLSSMIQAHICVSTQPDGVGPVAVLEFWVQA
                     LISQHLWYREQPILFLMDHLCKTAFHLMQEDCVQKLLYQQHKNALGYHCDRSLLSSLV
                     NWIVAGNITPSFVEGLSTSTQVWFAWTVLNMESIFEEDSQLRRVVERELVINAFSPDQ
                     ALKKAQVQLKLPIVPSLQRLLIYRWAHQALVTPSDHPLLPLIWQKFFLLYLHRPGPQY
                     GLPVDGCIGRRFFQSPSHVNLLKDMKRRLTEVADFHYAASKALRVPAEGSEGTPEGQA
                     GTPGFLTSPELHRELVRLFNVYVLWLEDENFQKGDTYIPSLPKHYDVHRLAKVMQNQQ
                     DLWMEYVNMERIQHEFQETVALWTQAKLESHAAPCSSSAQLDFTDPLLAKARVLSNLE
                     KHEAPHPPLLLHPVRPPVPLIPSAALLTQKDSTQLMCTDLNLLQQQARSATLRESQQV
                     ALDGELLETMPKQYVNREDQATLHLECRGSSGKKCQGAAVVTVQFEGMNKNEAVSQQI
                     HVLQKEVRQLQAEAAQPPALNVVEAAVHAENLITALVNTYKLQPTPGVQKLGISLFFT
                     VVDHVSDETQRHPPTRQFFTSCIEILGQVFVSGTKSECRKLLQTILKNRRLCSLLAPF
                     FTPNAAPAEFIQLYERVVTCLREDNSDVIFMLLTKFDIQQWLNSTKPPLSDRTRLLES
                     IHLALTAWGLEPEEDILMPFNLFCKHWTHLLLYQFPDQYSDVLRLLVQSSAEQLLSPE
                     CWKATLRALGCYAPSSQQGAASVESSGLHSASRVLLSDKQVMETVQWLSDFFYKLRLS
                     KLDFKSFGLFSKWSPYMADVKTFLGYLVKRLTDLEIASLSQDPTASSKEVLRSLHAQI
                     IQLFKPWILVLEDAESSHQRHYPWLESDTAVASSIVQLFSDCVGSLHTSFKDRLLPGD
                     EGALRLHLLHYCETCTAPKMPEFILYAFHSAYQRLEWKDLHPDQRLMEAFFKVERGSP
                     KSCFLFLGSVLCRVNWVSVLSDAWNPSPLPETQSMAVCLLFMMVLLAKEAQLVDEPDS
                     PLLSLLGQTSSLSWHLVDLVSYQSVLGYFSSHYPPSVVLANDCSSELIVKLLKVSAGL
                     SAHADGRKHVDIVPKCQAFTHQMVQFLSALEQTGKITFPALEREISKLLDDIIIFNPP
                     DMDSQTRHMALSSFFVEVLMMMNNAAVPTAEFLAVSIRTWIGQRVHGLIVLPLLTAAC
                     QSLASVRHMAEITEACIMAYFKESSLDQNLGWGPVLVSLQVPQLTARDFLEECLALGS
                     CLTLYVYLLQCLNSEQTVKNDMKMLLVVSGWLEQVYPSSAQEEAKLFLWWHQILQLSL
                     IQLEQNDSVLTESVIRILLMLQSRQSLMAEERLSSGILGAIGLGRRSPLSNRFRVAAR
                     SMAAFLLVQVPAEDQIRLKPSSELHLAPKAQQVLTALESMTLSKQYVEYQDQILHALQ
                     FIRHPGHCLQNGKSFLALLVNRLYPEVHYLDNIR"
     exon            95..1027
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1271
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1408
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1516
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1590
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1696
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1811
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1962
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2118
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2276
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2431
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2572
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2737
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2857
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..3114
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3255
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..3400
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3401..3598
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3599..3709
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3710..3829
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3830..3996
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3997..4218
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4219..4342
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4343..4487
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4488..4659
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4660..4822
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4823..4965
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4966..5122
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5123..5317
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5318..5531
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5532..5680
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5681..5882
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5883..5955
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5956..6062
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6063..6238
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6239..6424
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6425..6634
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6635..6779
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6780..7022
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7023..7239
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7240..7455
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7456..7570
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7571..11967
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9636..9641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      9673
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /note="major polyA site"
     regulatory      9705..9710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /note="hexamer: AATACA"
     polyA_site      9727
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
     regulatory      11944..11949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      11967
                     /gene="Epg5"
                     /gene_synonym="4732475F16; 5430411K18Rik"
ORIGIN      
        1 agaaacagac cgcgacgtcg cggaggtagg gtgtatggcc gaggctgtga agccccgccg
       61 ggccaaggcc aaggccagcc gcaccaaagg caaggaaaag aagaagcatg aagcccttca
      121 gacttgtgat gcaggtcccc tgccagagac ctgtcgcgag caggagagcc cgtgtccagc
      181 ttctgaactc aaaggagatg acctgaagtc gtctgctgac ccccagctcc acagtgatgt
      241 gtgtggatgg aatgaaagtg agatgtttga tataccactc acctccttga ctatagggga
      301 tgaaggtccc ccggtacagg acacagagga cctaaaagaa aggggagagg tcacagccgg
      361 tgatggagat gatgaaatgg agttgaaggt ggaccctggg gacaacgtta tagctaaagg
      421 tgaaccttgt aagaacttcc cggaagtaga ggaccacaca ctcatccagt gtgggcctcc
      481 agagagcaca ctgcagcctg actttccctg cactcagcag gcagtggagg gctcacatgc
      541 cagagaacat ccgactagga agcaagatga agccgccctc ggctgttcaa aggtgtttca
      601 gaatgttagc ttgcacagtt cttatgaagc caaagaagtt tctcagccac cgagagtgaa
      661 gaaactatat cctgagttgc cagctgaaat tgctgaagta ccagctctgg tggcagtgaa
      721 gccattgctc cgtagtgagc gactctaccc agaactcccg tctcaaccag aagtgacacc
      781 cttcactaaa gaacagctca aactcttgga gcctggctca tggctggaaa atgttgcatc
      841 atatgtagaa gaattcgata acattgctca tcaggacaga cacgagtttt atgagctgct
      901 tttgaattac tcacggtgca ggaagcagtt gctgttggct gaagctgagc tgctcactct
      961 gatgtctgac tgccacagtg ccaaaagtcg actgtggcac tttaaggatg agcagatggc
     1021 cgtacagggc atctgtgcag atcaagtgaa agtctacggg catcaccact accagcgagt
     1081 agagatgaat gaaaatgtcc tgggcgagct gaagaagctg tttgatgcca aatctgagca
     1141 cctccaccag accctgaccc tccactcgta cacttctgtg ctctcgaggt tgcaagtgga
     1201 gtcctacatc ttcacactgc tcaatagctc agctgctctg agatctttag cagtttatca
     1261 ggcagaccaa gttcctaaac tgacagaaag catcccctct gatgtgtgtc agctgaagga
     1321 gtgcattagt gtcttgttca tgttcaccag gagagtgagt gaggatgccc agttccatga
     1381 ggacatcctg ctctggctgc agaagctggt gtccgtgtta caacgagtcg gctgtcctgg
     1441 ggatcacttc tttctcctga accacgttct ccgctgccca gctggcattc gtaaatgggc
     1501 tgttcctttt atacagatca aagtgttgaa taacccttca ggggtctttc attttatgca
     1561 gtcccttgcc ctgctgatgt ctcctgtcaa aaaccgagcg gagtttatgt gccacatgaa
     1621 gcccagtgag tggaagccat catcttcagg gccagcatct gggaactgga cacttgtaga
     1681 tgaagcgggg gaagaggatg aagaccctga gaccagttgg attctcctta atgaagacga
     1741 cttggtcacc cttttgtccc agtttccctt tcaggagctc tttcagcatc ttcttgggtt
     1801 taaagccaaa ggtgattatt tacctgaaac aacaaggccc caagagatga tgaaaatttt
     1861 tgcctttgcc aactcattag tggagcttct ggctgtggga ctagacacct ttaacagagc
     1921 ccgctacagg cagtttgtga agcgcattgg atacctgatc aggatgaccc ttggctatgt
     1981 cagtgaccac tgggctcagt atgtgagcca cagcacaggc gcggggctaa caccgcagcc
     2041 ctactccatg gagaaactgc aggtggaatt tgatgagctg tttctcaggg ctgtcctcca
     2101 tgtcctgaaa gccaaaagac ttggcatttg gctgttcatg tctgagatgc ccttcggcac
     2161 gctgtcggtc cagatgctct ggaagctctt gtacctcatg caccaggtgg agagtgggga
     2221 cctgcagcaa ctctgtgcct ccctgcagcc ggccgagtgc aagaggcgac tccaagaccc
     2281 agaacatttt gcgagctttg agaagtgtct ttcttccatc aacagctcag aggagatctg
     2341 tctcctcacg gcctttgctc agatggctcg agccagaaga accaatgtgg atgaagactt
     2401 cataaaaatc attgtcctgg agatctatga ggtatcttat gtcacactgt ctaccagaga
     2461 gactttctca aaggttggtc gagagcttct gggagccatt gcagctgttc accctgagat
     2521 tatctctgtc cttttggaca gagtgcagga gaccattgac caagttggaa tggtttcttt
     2581 atacttgttt aaagaactgc ctttgtatct ttggcgacct tctgccccag agatagctgt
     2641 gattcgggac tggttattga ataataatct gacagcagtg aagaacaagt tggcctgtgt
     2701 gatcctagaa ggactgaatt ggggatttac tgaacagggt acccttcatt tggatcaagc
     2761 attgcacacg gaagtggcct tactggttct cgaggcttat cagaaatacc tggcacagaa
     2821 accttatact gggcttattt ctgaaagtat gaaacaggtt tcctatttgg ccagtattgt
     2881 tcgatatgga gagactcctg agacctcatt taaccagtgg gcctggaatt taatcttgag
     2941 gttaaaattg cacaaaaatg attttggaag acagaacttt ccagtcattc ccttctgcag
     3001 cacagtacct gacatgacag aatcgtccat gtttcaccct ctcttgaagg ctgtgaaatc
     3061 aggcttgccc attggctgct atctcgcttt agctgtgaca gctgttggcc acagccttga
     3121 gaagttctgt gcagaaggca tcccactgct gggcgtgctg gtccagtcac ggcatctgag
     3181 agcagtggtc catgccctag ataagatcct gcctgtgttc tacccttacc agtgctacct
     3241 tctgaagaac gagcagtttt tgtcgaacct tctcctcttc ctacaattgg acagcggtgt
     3301 tccccagggg gtcacacagc aggtcaccca cagggtggcc cagcatctga caggagccgt
     3361 ccatggagac aatgtgaaac ttctcagcag catgatccag gcacacatat gtgtaagcac
     3421 tcagccggat ggagtgggtc ctgtggctgt gttggagttc tgggtccagg ctctcataag
     3481 ccagcatctg tggtaccgag aacagcccat tctcttcctc atggaccact tgtgtaagac
     3541 agcgtttcac ctgatgcagg aagattgtgt gcaaaaattg ctctaccaac agcacaagaa
     3601 tgctttgggt taccactgtg accggagtct gctctcttcc ttggtgaact ggattgtggc
     3661 agggaacatc acgccttcct tcgtggaggg cttgtccacg tccacacagg tttggtttgc
     3721 atggactgtg ttgaacatgg aatccatctt tgaagaggac tctcagctcc gaagagttgt
     3781 tgaaagggaa ttggttataa atgcgtttag ccctgaccaa gctctaaaga aagcccaggt
     3841 ccagctgaag ctgcccatcg tcccgtccct gcagcggctg ttgatttatc gctgggccca
     3901 ccaggctctg gtcacacctt ctgatcatcc ccttttgcca ctcatttggc agaagttctt
     3961 cctcctgtat cttcatcgcc caggaccaca atatgggtta cctgtggatg gttgtattgg
     4021 aagaaggttt tttcaaagtc cctcgcacgt taatttgttg aaagacatga agagacgcct
     4081 gacggaggtg gctgacttcc actatgctgc cagcaaggcc ctccgtgttc cagcagaggg
     4141 cagtgaaggg acaccagaag ggcaggctgg cacccctggc ttcctgactt ccccagaact
     4201 gcacagggaa ctagtgaggc tctttaatgt atatgtatta tggctagaag atgaaaattt
     4261 tcagaaagga gatacctata ttccttcttt accaaagcac tacgatgttc acaggctagc
     4321 aaaagtgatg cagaatcagc aggacctgtg gatggagtat gtgaatatgg agcgcataca
     4381 gcacgagttc caggagacag ttgctctgtg gacacaggcc aagcttgagt cccatgccgc
     4441 accctgcagc tcttcagcac agctggattt cacggacccc ttgctggcta aagcaagggt
     4501 tctgagtaac ttagagaagc acgaggctcc acatcctcct cttcttctgc accccgtgag
     4561 gcctcccgtg ccactcattc cctctgctgc gctgttgaca cagaaggaca gcacccagct
     4621 catgtgcaca gacctgaatc tgctgcagca gcaggccagg agtgccactc tgcgggagtc
     4681 gcagcaggtt gccttggatg gcgagctgtt ggagaccatg cccaaacagt acgttaaccg
     4741 ggaagatcag gccaccctgc atctggagtg cagaggcagc agtggcaaga agtgccaagg
     4801 agcagcagtt gtaacggtcc agtttgaagg catgaacaag aatgaagccg taagccagca
     4861 gatccatgtt ctgcagaaag aagtgaggca gctccaagcg gaagctgctc agcccccggc
     4921 actgaatgtt gtggaggccg ctgtgcatgc agaaaacctg atcacggcct tagtgaacac
     4981 ttataagtta cagcctacac ctggagttca gaaacttggc attagccttt tctttactgt
     5041 tgtggaccat gtcagcgatg agacccagcg ccatcctcct acaaggcagt tcttcacttc
     5101 atgcatcgag atcttgggac aggtgtttgt tagcggcact aagtccgagt gcaggaagct
     5161 gctccagacc atcctgaaga acaggcggct ctgctcgctg ctggctcctt tcttcacgcc
     5221 caatgctgcg cccgccgagt tcatccagct gtatgagaga gtggtgactt gtctgcgcga
     5281 ggacaacagc gacgtgatct tcatgctgct caccaagttt gatattcagc agtggttaaa
     5341 cagcactaag ccccctctgt ctgaccgcac caggctcctg gagtccattc acttggcact
     5401 cactgcctgg ggccttgaac cagaggaaga tattctgatg ccatttaatc ttttctgcaa
     5461 gcactggact cacctcctac tctaccagtt ccctgaccag tacagtgatg tcctcaggct
     5521 gctggtgcag agctctgccg agcagctgct gagtcccgag tgctggaaag ccactttgag
     5581 agccctgggc tgttatgccc caagcagcca gcagggggcg gcgtctgtgg agagctctgg
     5641 gcttcacagt gcctcccgtg ttctcctgtc agacaagcag gtaatggaga cggtacagtg
     5701 gctttctgac ttcttttata agttgcggct ctccaagttg gactttaaaa gctttggatt
     5761 attctcaaag tggagtcctt acatggctga tgtgaagaca tttctgggat accttgtgaa
     5821 aaggctgact gacttagaaa tagcctcctt gtctcaggac ccaaccgcca gcagcaaaga
     5881 agtgctgagg tccctgcacg cgcagatcat ccagctcttt aagccctgga tcctggtttt
     5941 agaggacgcg gaaagtagcc accagcgaca ttacccgtgg ctggagagtg acactgcggt
     6001 ggcctccagc atcgtgcagc tcttctctga ctgtgtcggc tcattgcaca cgagttttaa
     6061 agacaggctg ttgccaggcg atgagggagc cctgcggttg cacctgctgc actactgtga
     6121 aacatgcaca gcacccaaga tgccggagtt cattctctat gccttccaca gtgcatacca
     6181 gagactggag tggaaggact tgcaccctga ccagaggctc atggaggcct tctttaaggt
     6241 ggaacgtgga agccccaaga gttgtttctt gtttttgggg tctgtacttt gcagagtcaa
     6301 ctgggttagt gtgctgtctg acgcctggaa tcccagcccc cttccggaaa cccagagcat
     6361 ggctgtctgc ctccttttca tgatggtttt actagcaaag gaggctcagc tcgttgacga
     6421 gccagattca cctttactga gtctccttgg acagacaagc tcactctcat ggcatcttgt
     6481 ggaccttgtg tcataccaga gtgtgttggg ttatttcagc agtcattacc caccatccgt
     6541 cgtcctggca aatgactgtt cctcggaact gatagtgaag ctgttaaaag tgtctgcagg
     6601 gctttctgct catgctgacg gccggaagca cgtggacata gttccaaaat gccaggcttt
     6661 cactcatcag atggttcagt ttctcagtgc cttggaacag actggaaaaa tcaccttccc
     6721 agcactggag cgggaaatat ctaagctgtt ggatgacatc attatcttta acccacccga
     6781 catggacagc cagacccgcc acatggccct cagcagcttc tttgtggaag tcctgatgat
     6841 gatgaacaat gcggctgttc caacagcaga gttccttgct gtcagtattc ggacctggat
     6901 tggccaaaga gtgcatggct tgatagtgct gcccctctta acagcagcct gccaaagcct
     6961 ggcgtctgtc cgccacatgg cggagatcac cgaagcctgc atcatggcct acttcaagga
     7021 aagctccctc gatcagaact taggatgggg ccccgttctg gtgtcccttc aagttcccca
     7081 gctcaccgcg cgagactttc tggaggagtg cttagccctc ggtagttgtt tgactctcta
     7141 tgtctacctg cttcagtgtc tgaacagtga gcagacggtg aagaacgaca tgaaaatgct
     7201 cctcgtcgtc agcggctggc tggagcaggt gtacccgagc tctgcacagg aagaggcaaa
     7261 gctgtttctg tggtggcatc aaatcctgca gctgtctctg attcagttgg agcagaacga
     7321 ctccgtcctg acagagtccg tcatccggat cctgctcatg ctgcagagca ggcagagcct
     7381 tatggccgag gagaggctca gctctgggat tctgggggca atcgggttgg gccggagatc
     7441 acccttgtcc aacaggttcc gagtggctgc ccgaagcatg gctgccttcc tgttggttca
     7501 ggtccctgca gaagaccaga ttcgtctgaa acccagctct gagttacatc tggctccaaa
     7561 agctcagcag gtgctgacag ctctggagtc catgacgctc agtaagcagt atgtggagta
     7621 ccaggaccag atactgcatg ctcttcagtt tataaggcat cctggccact gccttcagaa
     7681 tgggaaaagc ttcctggccc ttcttgtcaa ccgcctctat ccagaagtgc attacctgga
     7741 caacatccgg tagtgaggcc gaagccctcg gagcaccgtg tcggccctga gtttacatta
     7801 gccgtgctgt tgtgcatgta tctttcctca gtttcgccac agagctcagt tctgcctgga
     7861 atcgactgag gtgcagttgg gaggcatcag ctcgtcctgg ttgcacttac ctcttctgtc
     7921 cagtggccat cttagtgtga atgctcttcc acaagtcaac tgagttcccg agtacagacc
     7981 actcacattt ggggaatgtg cctgtcagct ccctaagaac aacagataga gtttttggta
     8041 tgtctgcacc tctgtctccc tgccttgttt aaaggtcaag actcctaatg ccagatctga
     8101 ccactttggg aggcgtgaag agccctcttt tggaactcca ttgtattctt ccgatgtaaa
     8161 aattctgtat ttctgaaatg tagggaaaca caccagcttt aaagtgttat gttacagctc
     8221 tttgagtgga gagactacac tggattaatt caggagtggt agctgggcag tggtggcaca
     8281 cacctttaat cccagtactt gggaggcaga agcaggcaga tttctgagtt cgaggacagc
     8341 ctggtctaca aagtgagttc caggacagcc agggctacag agaaaccctg tctcaaaaaa
     8401 agccaaataa tttattaatt aagaaattcg ggagtggtgg cccacacctg tcctctgagc
     8461 acatcggctg actgaaacag gaggatcaca aggttgaggc agcgtgaggt gtgtatcaag
     8521 aacatctcag caaacagagc aaaggagctg aattaaaatg agtcctgtgc agacatgtca
     8581 cttaaccctg accacagtgg ccagcacaga tggtgacaca tcctctggaa gtgagcttgt
     8641 ctgaagtgat gtgacagtgt gccctatgcc agctgtgttg tgcacaggtg tgtcgtcttt
     8701 gggagcacag aagccctgac cacagccgcc agggcactgg aaccctttgg gtctcctcag
     8761 tcacaacgtt ttattagccc tgtctatgtg gaattcccag ctcttgttat aagtcagggc
     8821 ttctgcaggc cctactgtca gggacaccgg ggactttgta cttcttcctt aggtaaatca
     8881 gatggcgctc agggactcgc tggagcatat gtccagagag aagggccagg tcacggcaat
     8941 ctgagaagtt tgactttttg tgagtagctc cgtgccttct gtcattgctg agtccccgtt
     9001 acctgtctgg cacagtgctc tgctcccttt agatctcctg ctcatgtcgc tccctgtaga
     9061 gttcctaatt tgacttctgt cagaatagtc ctacttctca aaaatgcccc caaatgggtt
     9121 ttgcaggttc agcttaaaat acgtcttttt tatgggttta ggtctagaaa tatctgtgta
     9181 aaatctatga gtggccacca agagccttga ctaaagatgg gatatacagc tagtgggtcc
     9241 cttccctgca tttggaagct tgcaggaact tcttattgga cagaacaagt ctgcctggta
     9301 gacatgtctt agaacactga taaaggacga tcctattcag tggcacaaag tatcattgtc
     9361 caggaatctg tctcagccat ctttatttct gcttctctct gctttccagg tctgtcatcc
     9421 cctctccaat agaagaaaac tttagaagct gtagacagtt gaaccagtgg ttctgtggtc
     9481 aggaaacact gtttttgtgt gctttctcca aggagaacca agttaccaat atcctagaat
     9541 gtgaaatgtt tgagtcatag tgtgtacagt ttagagaatc aattaatttt gaaagtttat
     9601 aatatttgta aattttatct gtaaaaagta taaacaataa aatcaacctt tgattgtaac
     9661 tgatgaatcc gaattgaagg ctaatgtaga tttttatgac tgataataca tttatttggc
     9721 tttgtaactg gtcggtaaaa ttgccactat tttcatccct gcttaacatc tgagagttat
     9781 ttgcctcaga ttctatgaga agcactgggc taagtcttta aaactatgta ataattcaga
     9841 acaaagaagg ctgcctgtgg acaggctggc tggctggctg gctaccggaa gacaaacctg
     9901 gctttgctag gaaaatggtt cactttgaga atgcaagtca tgacatcagg gacagtgatg
     9961 ggcacttgat gtccttgtca ccaagcaagg ccgtggctga gcagtatgga aggtggccat
    10021 cgcagactcc agagccttct gcagcttccc aggaacagat gagagtgttg gcctcagcgg
    10081 aagtgcctct gcctctccag gcattgccca cctccttgga gtgcacatgt ggggcatggg
    10141 ggtaggggat agaggttgct ctggccttcc ttgctctaca gccccactgg aacaggtgac
    10201 ggcaggtcct gtaggatggt ggctgtaaag gccagcgccc accatacaca tctctaaagc
    10261 tcctgcacac ttgaccttgt ctctaaacat gacgggcagg tgtcttgctg gttaggcctc
    10321 caccgctcat gtgtcttttg ttttttggtg tcagtgaaca tgacgtgtag actctccctg
    10381 taactagcca gcagtctttc tcctccaagg ccagccagtc tatgctctgg tgagtttaag
    10441 cgctttgtct gaatcaagcc aacaacactg gttttcaaag gtattttcta aaaattgttt
    10501 cttctacgcc cccccccccc aaacccacaa aattgattct tctgaagcag gaagccagtg
    10561 tctaggatcg tgggcagagt tgaggcacat ataaatacct ccgttccctt agtggcagtc
    10621 ctcaacctct ccccaaccct ggccactccc agcccaggct tggctatgcc agggtcctct
    10681 agttctgagt atcttgagcg agaatggtcc cttataacct tgcctattga ttgtggatct
    10741 gcctggagca cccaggaagg acctgttctc agctacctca agacattcct cctgtcccat
    10801 ctccttagtc ctctctaagt agccagagtc cttagtcatc tttaaacgtg gcgtcgcgtc
    10861 gcgtccgata aagctgcttt tgtgggcaaa gtgcccaagt cagtccacac tactgtgcca
    10921 agggttagca gtgccagaac tgtgcatgct cagccctcac agatcctcac aaggagagag
    10981 agcatccttg ccagttttat ccctggtgct ttgtcgcctt atcctggacc ctgccctaga
    11041 gctgttacct cctttgggct aagcagatcg aatcgctcta gcactcactt gggcggcatc
    11101 ggttcccatt gtcctatgta gttggcacgt taacctagca ttgagttaaa ccacaggcct
    11161 ctttaatagc ggtcactgcc cgagttccac tgagcatcta cttggtcagc ccagtggtca
    11221 ggccctttga acttcgtctc tgattgcacc tgctctttag ttagctaaac ttcacagtcc
    11281 attttaaggt gctagctgat catgttaggt gaggctctta gagccagggc cctaaacaga
    11341 ctgttgtgta ggagtcatgt ggccaggagc aggtcatgtg cttatccata gtctccttcg
    11401 ctctgcacag gcttctgatt cctcacgagg ataacgggaa aagaaaactt acactgctca
    11461 tattttacta atgaaagtgc tggtgttggt tataactcat ttttcagtgt gtcatgcaat
    11521 atggctgagc actgaagaga ggcttgcttt cagtggtttg aggtcattta tatcggagat
    11581 cagtagtgtg gcgtgctcac ctcagctagt gtgaccttta cagccacagt tttactcttg
    11641 ctccatcctc ttgccccccc cccccacgtg ctcatggctg gcctctactt ctctactcct
    11701 tctctctcta ctaccctctc aacttccctc cccatgccct gagtaaactc tatactatac
    11761 taaacaaaac caaaacaaac aaacaaaaga ccagtcttat tttggccatt taactgtgca
    11821 atacttactt cttattcgct gtttagtatt ttccatgctc atacaaagga cgcttttttt
    11881 tttttttttg taatgatggt gagaaattgg aagccgtgag aattagttaa gtgaaattct
    11941 gcaaataaag gacattgtga tttctca
//
