LOCUS       NM_134065               2404 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ependymin related 1 (Epdr1), mRNA.
ACCESSION   NM_134065
VERSION     NM_134065.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2404)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2404)
  AUTHORS   Ahmed,T., Flores,P.C., Pan,C.C., Ortiz,H.R., Lee,Y.S.,
            Langlais,P.R., Mythreye,K. and Lee,N.Y.
  TITLE     EPDR1 is a noncanonical effector of insulin-mediated angiogenesis
            regulated by an endothelial-specific TGF-beta receptor complex
  JOURNAL   J Biol Chem 298 (9), 102297 (2022)
   PUBMED   35872017
  REMARK    GeneRIF: EPDR1 is a noncanonical effector of insulin-mediated
            angiogenesis regulated by an endothelial-specific TGF-beta receptor
            complex.
REFERENCE   3  (bases 1 to 2404)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2404)
  AUTHORS   Deshmukh,A.S., Peijs,L., Beaudry,J.L., Jespersen,N.Z.,
            Nielsen,C.H., Ma,T., Brunner,A.D., Larsen,T.J., Bayarri-Olmos,R.,
            Prabhakar,B.S., Helgstrand,C., Severinsen,M.C.K., Holst,B.,
            Kjaer,A., Tang-Christensen,M., Sanfridson,A., Garred,P.,
            Prive,G.G., Pedersen,B.K., Gerhart-Hines,Z., Nielsen,S.,
            Drucker,D.J., Mann,M. and Scheele,C.
  TITLE     Proteomics-Based Comparative Mapping of the Secretomes of Human
            Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine
  JOURNAL   Cell Metab 30 (5), 963-975 (2019)
   PUBMED   31668873
REFERENCE   5  (bases 1 to 2404)
  AUTHORS   Danyukova,T., Ariunbat,K., Thelen,M., Brocke-Ahmadinejad,N.,
            Mole,S.E. and Storch,S.
  TITLE     Loss of CLN7 results in depletion of soluble lysosomal proteins and
            impaired mTOR reactivation
  JOURNAL   Hum Mol Genet 27 (10), 1711-1722 (2018)
   PUBMED   29514215
REFERENCE   6  (bases 1 to 2404)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   7  (bases 1 to 2404)
  AUTHORS   Shimogori,T., Lee,D.A., Miranda-Angulo,A., Yang,Y., Wang,H.,
            Jiang,L., Yoshida,A.C., Kataoka,A., Mashiko,H., Avetisyan,M.,
            Qi,L., Qian,J. and Blackshaw,S.
  TITLE     A genomic atlas of mouse hypothalamic development
  JOURNAL   Nat Neurosci 13 (6), 767-775 (2010)
   PUBMED   20436479
REFERENCE   8  (bases 1 to 2404)
  AUTHORS   Della Valle,M.C., Sleat,D.E., Sohar,I., Wen,T., Pintar,J.E.,
            Jadot,M. and Lobel,P.
  TITLE     Demonstration of lysosomal localization for the mammalian
            ependymin-related protein using classical approaches combined with
            a novel density shift method
  JOURNAL   J Biol Chem 281 (46), 35436-35445 (2006)
   PUBMED   16954209
  REMARK    GeneRIF: A novel density shift method was used to demonstrate that
            EPDR resides in the lysosome.
REFERENCE   9  (bases 1 to 2404)
  AUTHORS   Apostolopoulos,J., Sparrow,R.L., McLeod,J.L., Collier,F.M.,
            Darcy,P.K., Slater,H.R., Ngu,C., Gregorio-King,C.C. and
            Kirkland,M.A.
  TITLE     Identification and characterization of a novel family of mammalian
            ependymin-related proteins (MERPs) in hematopoietic,
            nonhematopoietic, and malignant tissues
  JOURNAL   DNA Cell Biol 20 (10), 625-635 (2001)
   PUBMED   11749721
REFERENCE   10 (bases 1 to 2404)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB853470.1, AK046185.1, AK034083.1 and CD740844.1.
            
            On Dec 29, 2009 this sequence version replaced NM_134065.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.67271.1, AK038733.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BB853470.1         2-27
            27-632              AK046185.1         2-607
            633-2377            AK034083.1         602-2346
            2378-2404           CD740844.1         1-27                c
FEATURES             Location/Qualifiers
     source          1..2404
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 6.97 cM"
     gene            1..2404
                     /gene="Epdr1"
                     /gene_synonym="Epdm2; Epdr2; MERP-1; MERP-2; MERP2; Ucc1"
                     /note="ependymin related 1"
                     /db_xref="GeneID:105298"
                     /db_xref="MGI:MGI:2145369"
     exon            1..537
                     /gene="Epdr1"
                     /gene_synonym="Epdm2; Epdr2; MERP-1; MERP-2; MERP2; Ucc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..943
                     /gene="Epdr1"
                     /gene_synonym="Epdm2; Epdr2; MERP-1; MERP-2; MERP2; Ucc1"
                     /note="ependymin 2; mammalian ependymin-related protein 1;
                     upregulated in colorectal cancer gene 1; ependymin related
                     protein 2; ependymin related protein 1"
                     /codon_start=1
                     /product="mammalian ependymin-related protein 1 precursor"
                     /protein_id="NP_598826.3"
                     /db_xref="CCDS:CCDS26260.1"
                     /db_xref="GeneID:105298"
                     /db_xref="MGI:MGI:2145369"
                     /translation="MPARAPRRLVQGPRGTWLLGSLWVWVLCGLGMAGSLGTPQPCQA
                     PQQWEGRQVLYQQSSGHNNRALVSYDGLNQRVRVLDERKALIPCKRLFEYILLYKEGV
                     MFQIEQATKQCAKIPLVESWDPLDIPQNSTFEDQYSIGGPQEQILVQEWSDRRTARSY
                     ETWIGVYTAKDCYPVQETFIRNYTVVMSTRFFDVQLGIKDPSVFTPPSTCQAAQPEKM
                     SDGCSL"
     exon            538..746
                     /gene="Epdr1"
                     /gene_synonym="Epdm2; Epdr2; MERP-1; MERP-2; MERP2; Ucc1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..2387
                     /gene="Epdr1"
                     /gene_synonym="Epdm2; Epdr2; MERP-1; MERP-2; MERP2; Ucc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2242..2247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epdr1"
                     /gene_synonym="Epdm2; Epdr2; MERP-1; MERP-2; MERP2; Ucc1"
                     /note="hexamer: ATTAAA"
     polyA_site      2265
                     /gene="Epdr1"
                     /gene_synonym="Epdm2; Epdr2; MERP-1; MERP-2; MERP2; Ucc1"
                     /note="major polyA site"
     regulatory      2351..2356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epdr1"
                     /gene_synonym="Epdm2; Epdr2; MERP-1; MERP-2; MERP2; Ucc1"
                     /note="hexamer: AATAAA"
     polyA_site      2380
                     /gene="Epdr1"
                     /gene_synonym="Epdm2; Epdr2; MERP-1; MERP-2; MERP2; Ucc1"
                     /note="major polyA site"
ORIGIN      
        1 gttggcagca gagagcagga aaaacaagct ttggtaagcc tccgccagag cagaaagagc
       61 tggggcgatt cacgcggctt tcccaggccg gtgtcccggt gtccggagcc cccaagccag
      121 gagcctgtgg aacggaaaat cgagagaggc ctgaactggg tcccggagca cacctttcgc
      181 cagggcgcag agaaggctca cgcgactagt ccaacgcagg gcctcggctc tctctggagc
      241 tcggctgacc ctggggcggc agatcacgat gcccgcgcgc gctccccgcc gcctggtcca
      301 ggggcctcgg gggacctggc tgctgggaag cctctgggtc tgggtgctgt gcggcctggg
      361 gatggcgggc tccctgggaa ccccacagcc atgccaggca ccccagcagt gggagggacg
      421 ccaggttctg taccagcaga gcagcgggca caacaaccgc gccctggtgt cctacgatgg
      481 tctcaaccag cgcgtgcggg tgctggacga gaggaaagcg ctgatcccct gcaagagatt
      541 atttgaatac attttactct ataaggaggg agtgatgttt cagattgaac aagccaccaa
      601 acagtgtgca aagatcccct tggtggaatc ctgggatcct ctggacattc cccagaattc
      661 tacctttgaa gatcagtact ccatcggagg gcctcaggag cagatcctgg tccaggagtg
      721 gtctgacaga agaacagcaa gatcctatga aacttggatc ggcgtttata cagccaagga
      781 ttgttatccg gtccaggaga ccttcatcag gaactacact gtggtcatgt ccacgcggtt
      841 ctttgatgtg cagctaggca ttaaggaccc ctctgtgttc accccaccaa gcacatgcca
      901 ggcagcgcag ccagagaaga tgagtgacgg ctgctccttg tgaactcgcc gaactgaacc
      961 caacctcagc tcttagtgac cttgtatggc aatggattag agactagttt gaaagtaact
     1021 cttcactgaa aataaagcta attttaggaa gataaaccct atgtgggctt gcttgtacat
     1081 ctgactgtgg ctgctcagct ctgttttgag aaggaaaggg gccatccttt ctgtgagcag
     1141 gtgggtagtc agtgccatag agtaggaaag ggcgggggtg gggtcagcac aaggagtttg
     1201 cctctgcagg gtgagacttt tattattgcc aataagaatc gaaggtgata ataagatata
     1261 gaatgctttt gttcagttct ccccttacaa agaaagtccc ttgcttgtct gcaccaggga
     1321 agcaagagct cccagtgaca ccaccccctg cctctggtta ctataagatg agcctttaag
     1381 attctttcta gacttaaatt ttgtgccatg gcccactgga tgtagatatt ctacaaggaa
     1441 gtagaaactt ttaatacgaa gtaatgattc ctctaaaggg aaaggaagtt ttaagaggga
     1501 ggcttggaca atcttagtat ttacacgtga gatgaaatga agagtcccgt gtgctgctct
     1561 gtgtgcaaga gtactgaccg ctctgctgaa ccttcatgtc ttttctagtg ggcaaccagg
     1621 cttccaaaat agcactgacc tgggaggccc ccaagtaagg ccaagaagtc tctgctactc
     1681 taatctttta cgtattaaat gcactaggct agtagccctt gcctttcctt tcctgaaact
     1741 ctttcaacac aactgtgtct atatgactac ggctcatgct tccaaggtca gctcacatgt
     1801 gacctctgtg agctgttccc tcgcctgaat tcattgcatc ttacaccttg gcatgccttg
     1861 ctcacaatac tcattatgct gtgtgggatt tcctgattac tagaagctga cctctgctat
     1921 cctgggtaag aacgccctga gtacgggtac catgctctgt ttactttagg atctccagca
     1981 ccaagcaagt gcctggcaca tagtctgtgc ccttaacatt tgtagaaagg agctcaccag
     2041 ctctgtcagt gtttagtttc ttcatctatt aaacagggtt ggtttttctg gttgctaggg
     2101 agacttatag taatacaact tactattcta gattcttctt atcgctgtgt tttatttgcc
     2161 atgtatcatc ttttgttatc aagagaagtg tatgatgctt gctttatgcc atagccatct
     2221 atattgtaat ttatctatac aattaaacaa atttaatgaa ccctatgaat tattctttga
     2281 tgtgtttgtt tttgtaagaa atatggagga actgaattat aaagaaaata aaatccttct
     2341 gtaataatca aataaagtac ttcccataat caaaaccaaa ttggttaaaa aaaaaaaaaa
     2401 aaaa
//
