LOCUS       NM_008532               2061 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus epithelial cell adhesion molecule (Epcam), mRNA.
ACCESSION   NM_008532
VERSION     NM_008532.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2061)
  AUTHORS   Hrncir,H.R., Goodloe,B., Bombin,S., Hogan,C.B., Jadi,O. and
            Gracz,A.D.
  TITLE     Sox9 inhibits Activin A to promote biliary maturation and branching
            morphogenesis
  JOURNAL   Nat Commun 16 (1), 1667 (2025)
   PUBMED   39955269
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2061)
  AUTHORS   Li,K.R., Yu,P.L., Zheng,Q.Q., Wang,X., Fang,X., Li,L.C. and Xu,C.R.
  TITLE     Spatiotemporal and genetic cell lineage tracing of endodermal
            organogenesis at single-cell resolution
  JOURNAL   Cell 188 (3), 796-813 (2025)
   PUBMED   39824184
REFERENCE   3  (bases 1 to 2061)
  AUTHORS   Trinh,L.T., Finnel,R.R., Osipovich,A.B., Musselman,J.R.,
            Sampson,L.L., Wright,C.V.E. and Magnuson,M.A.
  TITLE     Positive autoregulation of Sox17 is necessary for gallbladder and
            extrahepatic bile duct formation
  JOURNAL   Development 152 (2) (2025)
   PUBMED   39745200
REFERENCE   4  (bases 1 to 2061)
  AUTHORS   Defamie,V., Aliar,K., Sarkar,S., Vyas,F., Shetty,R., Reddy
            Narala,S., Fang,H., Saw,S., Tharmapalan,P., Sanchez,O., Knox,J.J.,
            Waterhouse,P.D. and Khokha,R.
  TITLE     Metalloproteinase inhibitors regulate biliary progenitor cells
            through sDLK1 in organoid models of liver injury
  JOURNAL   J Clin Invest 135 (3), e164997 (2024)
   PUBMED   39699962
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2061)
  AUTHORS   Cai,S. and Yin,N.
  TITLE     Single-cell transcriptome and chromatin accessibility mapping of
            upper lip and primary palate fusion
  JOURNAL   J Cell Mol Med 28 (19), e70128 (2024)
   PUBMED   39392189
REFERENCE   6  (bases 1 to 2061)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   7  (bases 1 to 2061)
  AUTHORS   Nelson,A.J., Dunn,R.J., Peach,R., Aruffo,A. and Farr,A.G.
  TITLE     The murine homolog of human Ep-CAM, a homotypic adhesion molecule,
            is expressed by thymocytes and thymic epithelial cells
  JOURNAL   Eur J Immunol 26 (2), 401-408 (1996)
   PUBMED   8617310
REFERENCE   8  (bases 1 to 2061)
  AUTHORS   Borkowski,T.A., Nelson,A.J., Farr,A.G. and Udey,M.C.
  TITLE     Expression of gp40, the murine homologue of human epithelial cell
            adhesion molecule (Ep-CAM), by murine dendritic cells
  JOURNAL   Eur J Immunol 26 (1), 110-114 (1996)
   PUBMED   8566052
REFERENCE   9  (bases 1 to 2061)
  AUTHORS   Bergsagel,P.L., Victor-Kobrin,C., Timblin,C.R., Trepel,J. and
            Kuehl,W.M.
  TITLE     A murine cDNA encodes a pan-epithelial glycoprotein that is also
            expressed on plasma cells
  JOURNAL   J Immunol 148 (2), 590-596 (1992)
   PUBMED   1729376
REFERENCE   10 (bases 1 to 2061)
  AUTHORS   Timblin,C., Battey,J. and Kuehl,W.M.
  TITLE     Application for PCR technology to subtractive cDNA cloning:
            identification of genes expressed specifically in murine
            plasmacytoma cells
  JOURNAL   Nucleic Acids Res 18 (6), 1587-1593 (1990)
   PUBMED   2326198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI986346.1, AK167182.1 and AK133510.1.
            
            On Aug 15, 2006 this sequence version replaced NM_008532.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK133510.1, BC094465.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849376, SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-357               BI986346.1         1-357
            358-1755            AK167182.1         3-1400
            1756-2061           AK133510.1         1438-1743
FEATURES             Location/Qualifiers
     source          1..2061
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 57.87 cM"
     gene            1..2061
                     /gene="Epcam"
                     /gene_synonym="CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1;
                     GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1"
                     /note="epithelial cell adhesion molecule"
                     /db_xref="GeneID:17075"
                     /db_xref="MGI:MGI:106653"
     exon            1..94
                     /gene="Epcam"
                     /gene_synonym="CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1;
                     GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1"
                     /inference="alignment:Splign:2.1.0"
     exon            95..531
                     /gene="Epcam"
                     /gene_synonym="CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1;
                     GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             456..1403
                     /gene="Epcam"
                     /gene_synonym="CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1;
                     GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1"
                     /note="lymphocyte antigen 74; Trop-1 protein; mEGP314;
                     protein 289A; epithelial glycoprotein 314; panepithelial
                     glycoprotein 314; tumor-associated calcium signal
                     transducer 1"
                     /codon_start=1
                     /product="epithelial cell adhesion molecule precursor"
                     /protein_id="NP_032558.2"
                     /db_xref="CCDS:CCDS29018.1"
                     /db_xref="GeneID:17075"
                     /db_xref="MGI:MGI:106653"
                     /translation="MAGPQALAFGLLLAVVTATLAAAQRDCVCDNYKLATSCSLNEYG
                     ECQCTSYGTQNTVICSKLASKCLAMKAEMTHSKSGRRIKPEGAIQNNDGLYDPDCDEQ
                     GLFKAKQCNGTATCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKERESPYDHQ
                     SLQTALQEAFTSRYKLNQKFIKNIMYENNVITIDLMQNSSQKTQDDVDIADVAYYFEK
                     DVKGESLFHSSKSMDLRVNGEPLDLDPGQTLIYYVDEKAPEFSMQGLTAGIIAVIVVV
                     SLAVIAGIVVLVISTRKKSAKYEKAEIKEMGEIHRELNA"
     exon            532..639
                     /gene="Epcam"
                     /gene_synonym="CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1;
                     GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..880
                     /gene="Epcam"
                     /gene_synonym="CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1;
                     GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1"
                     /inference="alignment:Splign:2.1.0"
     exon            881..946
                     /gene="Epcam"
                     /gene_synonym="CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1;
                     GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1010
                     /gene="Epcam"
                     /gene_synonym="CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1;
                     GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1112
                     /gene="Epcam"
                     /gene_synonym="CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1;
                     GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1316
                     /gene="Epcam"
                     /gene_synonym="CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1;
                     GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1361
                     /gene="Epcam"
                     /gene_synonym="CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1;
                     GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..2061
                     /gene="Epcam"
                     /gene_synonym="CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1;
                     GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1799..1804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epcam"
                     /gene_synonym="CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1;
                     GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1"
                     /note="hexamer: AATAAA"
     regulatory      1819..1824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epcam"
                     /gene_synonym="CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1;
                     GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1"
                     /note="hexamer: AATAAA"
     polyA_site      1825
                     /gene="Epcam"
                     /gene_synonym="CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1;
                     GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1"
                     /note="major polyA site"
     polyA_site      1838
                     /gene="Epcam"
                     /gene_synonym="CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1;
                     GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1"
                     /note="major polyA site"
     regulatory      2042..2047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epcam"
                     /gene_synonym="CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1;
                     GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1"
                     /note="hexamer: AAGAAA"
     polyA_site      2060
                     /gene="Epcam"
                     /gene_synonym="CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1;
                     GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1"
ORIGIN      
        1 gcacttcttc cctctgatgg actgattctg cacgtgagac ctgcggcggc ggcggcggcg
       61 gctgctgcag ctgcagctgc atgtttcact agaggaagtt ctcggtttga cttggtatcc
      121 ctttcggctt tcacgtccag tctcgtccgt gtgtccgcga catccggtcc ttccggggta
      181 ctggaatccc cgcctctggt ccgggacagc gcacacctgg agagggggcg aggtggggcg
      241 ggtgagtcac cgcgggcgag cgggcgggtg ggcgggcgag cggaggtgag ggcggggagg
      301 ggcgtggccg gccgccgggg cagcagatcc gcaggtccgc tcccgcctcg ccgcgcgcac
      361 agcgctcagt ccgtccgccg ccgcgcagcg cgactgtcct ccgagccgtc ccgcgccgca
      421 cctccgcgag tcgccctcgc cgctccgcgc gcagcatggc gggtccccag gccctcgcgt
      481 tcgggctcct gctcgcggtg gtcacagcga cgctggccgc ggctcagaga gactgtgtct
      541 gtgacaacta caagctggca acaagttgct ctctgaatga atatggtgaa tgccagtgta
      601 cttcctatgg tacacagaat actgtcattt gctccaaact ggcgtctaaa tgcttggcga
      661 tgaaagcaga aatgactcac agcaagtctg ggaggaggat aaagcccgaa ggggcgatcc
      721 agaacaacga tgggctgtac gaccccgact gcgacgagca ggggctcttc aaagccaagc
      781 agtgcaacgg caccgccacg tgctggtgtg tcaacaccgc cggagtccga agaaccgaca
      841 aggacacgga gatcacgtgc tccgagcgcg tgaggaccta ctggatcatc attgaactaa
      901 aacacaaaga aagagaaagc ccctacgacc atcagagctt gcagactgcg cttcaagagg
      961 cgttcacatc tcgatataag ctgaatcaga aatttatcaa aaacattatg tatgagaata
     1021 atgttatcac cattgatctg atgcaaaact cttctcagaa aacacaagac gacgtggaca
     1081 tagctgatgt ggcttactat tttgaaaaag atgtgaaggg ggagtccctg ttccattctt
     1141 ctaagagcat ggacctgaga gtgaacggag agccgctcga tctggacccc gggcagactc
     1201 tgatttacta cgttgatgaa aaggcacccg agttctccat gcagggcctc acggccggga
     1261 tcatcgctgt cattgtggtg gtgtcattag cagtcatcgc ggggattgtt gtcctggtta
     1321 tatctacaag gaagaaatca gcaaaatatg agaaggctga gataaaggag atgggtgaga
     1381 tccacagaga gcttaatgcc tagccgtgct gagtgctgaa ctgaggaggg gccgcccgac
     1441 cggaagtggc agaagagctc ggactgcaga tgtataaacc tggggaagat gaagacctgc
     1501 gaagggttac tgctttgata gttactttgt tagtttcaca tttgtaacag tgaaatttgt
     1561 actcgtaaat acaagcagct ggacaccggc attaccgatc gtaaaattag acgaacgtct
     1621 tataggtgca ggtccagtgt ggtactcaga acttagcctg caaagttaag agagttgatg
     1681 cttattatga cagagtgtgc gtcgcaaaca ttccaacagt agaatgcggt gactagtctc
     1741 attttttttt tttttttgtg attaaggctg cccttctata tacctgagtc ttgtacataa
     1801 taaacttttt tttaatgaaa taaaacattt taaagtgagt ttctaagttt gtttgaatca
     1861 aattttccta gcatgtgcat aattaagata atagatgtct aaatgctctg gcactgctaa
     1921 ctggtacaaa cctgtaattc tgtacttggg aggtagaggt aggagggtta gcgcttccga
     1981 ggtagctgct gtgtatctgc tctgccactg actggccttg actatccaac accctatctg
     2041 aaagaaataa aaatcaaact t
//
