LOCUS       NM_172663               4358 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus enhancer of polycomb homolog 2 (Epc2), mRNA.
ACCESSION   NM_172663 XM_905350 XM_919326 XM_919335
VERSION     NM_172663.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4358)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4358)
  AUTHORS   Farini,D., Cesari,E., Weatheritt,R.J., La Sala,G., Naro,C.,
            Pagliarini,V., Bonvissuto,D., Medici,V., Guerra,M., Di Pietro,C.,
            Rizzo,F.R., Musella,A., Carola,V., Centonze,D., Blencowe,B.J.,
            Marazziti,D. and Sette,C.
  TITLE     A Dynamic Splicing Program Ensures Proper Synaptic Connections in
            the Developing Cerebellum
  JOURNAL   Cell Rep 31 (9), 107703 (2020)
   PUBMED   32492419
REFERENCE   3  (bases 1 to 4358)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4358)
  AUTHORS   Fisher,C.L., Marks,H., Cho,L.T., Andrews,R., Wormald,S.,
            Carroll,T., Iyer,V., Tate,P., Rosen,B., Stunnenberg,H.G.,
            Fisher,A.G. and Skarnes,W.C.
  TITLE     An efficient method for generation of bi-allelic null mutant mouse
            embryonic stem cells and its application for investigating
            epigenetic modifiers
  JOURNAL   Nucleic Acids Res 45 (21), e174 (2017)
   PUBMED   28981838
REFERENCE   5  (bases 1 to 4358)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 4358)
  AUTHORS   Jacquet,K., Fradet-Turcotte,A., Avvakumov,N., Lambert,J.P.,
            Roques,C., Pandita,R.K., Paquet,E., Herst,P., Gingras,A.C.,
            Pandita,T.K., Legube,G., Doyon,Y., Durocher,D. and Cote,J.
  TITLE     The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1
            through Direct H4K20me Binding and H2AK15 Acetylation
  JOURNAL   Mol Cell 62 (3), 409-421 (2016)
   PUBMED   27153538
REFERENCE   7  (bases 1 to 4358)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
REFERENCE   8  (bases 1 to 4358)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4358)
  AUTHORS   Stankunas,K., Berger,J., Ruse,C., Sinclair,D.A., Randazzo,F. and
            Brock,H.W.
  TITLE     The enhancer of polycomb gene of Drosophila encodes a chromatin
            protein conserved in yeast and mammals
  JOURNAL   Development 125 (20), 4055-4066 (1998)
   PUBMED   9735366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY253789.1, AK031025.1, BB620197.1, AK164886.1 and AK141073.1.
            
            On Sep 7, 2007 this sequence version replaced NM_172663.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031025.1, SRR1660821.107250.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BY253789.1         2-31
            31-110              AK031025.1         2-81
            111-580             BB620197.1         73-542
            581-1671            AK031025.1         554-1644
            1672-3152           AK164886.1         699-2179
            3153-3930           AK031025.1         3126-3903
            3931-4358           AK141073.1         3222-3649
FEATURES             Location/Qualifiers
     source          1..4358
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 28.62 cM"
     gene            1..4358
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /note="enhancer of polycomb homolog 2"
                     /db_xref="GeneID:227867"
                     /db_xref="MGI:MGI:1278321"
     exon            1..473
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..2747
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /codon_start=1
                     /product="enhancer of polycomb homolog 2"
                     /protein_id="NP_766251.3"
                     /db_xref="CCDS:CCDS16023.1"
                     /db_xref="GeneID:227867"
                     /db_xref="MGI:MGI:1278321"
                     /translation="MSKLSFRARALDAAKPLPIYRGKDMPDLNDCVSINRAVPQMPTG
                     MEKEEESEHHLQRAISAQQVFREKKESMVIPVPEAESNVNYYNRLYKGEFKQPKQFIH
                     IQPFNLDNEQPDYDMDSEDETLLNRLNRKMEIKPLQFEIMIDRLEKASSNQLVTLQEA
                     KLLLNEDDYLIKAVYDYWVRKRKNCRGPSLIPQIKQEKRDGSTNNDPYVAFRRRTEKM
                     QTRKNRKNDEASYEKMLKLRREFSRAITILEMIKRREKTKRELLHLTLEVVEKRYHLG
                     DYGGEILNEVKVNRSEKELYASPATLHNGNHHKVQECKTKHPHHLSLKEEASDVVRQK
                     KKYPKKPKAEAGIAPQQPTPETLPVINKSDIKQYDFQSSDEDEFPQVLSPASEAEEEN
                     DPDGSCAFRRRAGCQYYAPRLDQANNHMCENSELADLDKLRYKHCLTTLTVPRRCIGF
                     ARRRIGRGGRVIMDRISTEHDPVLKQIDPEMLNGFSSSSQTIDFSSNFSRTNASSKPC
                     ENRLSLSEILSNIRSCRLQCFQPRLLNVQDIDSEECTSRKPGQTVSSKRVSAASVALL
                     NTSKNGISVTGGITEEQFQTHQQQLVQMQRQQLAQLHQKQQSQHSSQQTHPKAQGSST
                     SDCMSKTLDSASAHFAASAVVSAPVPSRSEGSKEQNTGHNNMNGVVQPSGPSKTLYST
                     NMALSSSPGISAVQLVRTVGHTTTNHLIPALCTSSPQTLPMNNSCLTNAVHLNNVSVV
                     SPVNVHINTRTSAPSPTALKLATVAASMDRVPKVTPSSAISSIARENHEPERLGLNGL
                     AETTVAMEVT"
     exon            474..633
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /inference="alignment:Splign:2.1.0"
     exon            634..779
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /inference="alignment:Splign:2.1.0"
     exon            780..986
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1135
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1268
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1460
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1550
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1699
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..2043
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2180
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2340
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2674
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..4358
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3133..3138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /note="hexamer: AATAAA"
     polyA_site      3158
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /note="major polyA site"
     regulatory      3911..3916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /note="hexamer: AATAAA"
     polyA_site      3935
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /note="major polyA site"
     regulatory      4283..4288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
                     /note="hexamer: ATTAAA"
     polyA_site      4305
                     /gene="Epc2"
                     /gene_synonym="5830499L14; D2Ertd694e"
ORIGIN      
        1 gggggcgcgc tctcgcgcgg gctgccggga tcgctcgccg ccgctgtggt aatgtccgcc
       61 atgttggcca tggcgcaggg agcggatcgg gcgggcgagc ggcggatcta gagtgtggaa
      121 gcggccgcgg gcggcggggg gctgttctgg ggcggggtgg gcgcccatgc tggggccggg
      181 ggcactgcgg aggaggagga ggagcgggcc ggccgcgctg cactgaggaa ggaggtggag
      241 gaggcggcgg gagtgctccc cccccctccc cgcccgcccc gccgccgccg cccgggctgt
      301 tcctgtaagg cggggagaca atgagtaaac tctccttccg agcgcgggcg ctggacgccg
      361 ccaaaccgct gcccatctac cgcggcaagg acatgcctga tctcaacgac tgcgtctcca
      421 tcaaccgggc cgtgccccag atgcccaccg ggatggagaa ggaggaggaa tcggaacatc
      481 acctacagcg agctatttca gcgcagcaag tatttagaga aaaaaaagag agcatggtca
      541 ttccagttcc tgaggcagag agcaacgtca actattacaa tcgcttgtac aaaggggagt
      601 tcaaacagcc caagcagttc attcatattc agccttttaa cctagacaac gagcaaccag
      661 attatgatat ggattcagaa gatgagacat tattaaatag acttaacaga aaaatggaaa
      721 ttaaaccttt gcaatttgaa attatgattg acagacttga aaaagccagt tctaaccagc
      781 ttgtaacact tcaagaagca aaactgctgc taaatgaaga tgattatctt attaaagctg
      841 tatatgacta ctgggtgaga aaacgaaaga actgcagggg gccatccctc attccccaga
      901 ttaagcaaga gaaaagagat ggctctacca acaatgatcc ttacgttgcc tttcggagga
      961 gaacagagaa aatgcagact cggaagaacc gtaagaatga tgaagcttct tatgaaaaga
     1021 tgctgaagct gaggcgggag ttcagcagag ccataacaat tttggaaatg attaagagaa
     1081 gagaaaaaac caaacgggaa ttattgcact taacactgga agttgtggaa aaaagatatc
     1141 atttgggaga ctatgggggt gaaatcctta atgaagtgaa agttaataga tcagaaaaag
     1201 agttatatgc cagtccagca acccttcata atggaaatca tcacaaagtt caagaatgta
     1261 aaactaagca ccctcatcat ttgtctttga aagaagaggc ttctgatgtg gttcgtcaaa
     1321 agaagaagta cccaaagaag cctaaggcag aggctgggat agcccctcag cagcccactc
     1381 ctgagacatt gcctgtgatc aataagagtg acattaagca atatgacttt cagagctcag
     1441 acgaagatga atttccacag gtgctgtctc cagcttcaga ggctgaggag gagaatgacc
     1501 ctgacggttc ctgtgctttc agaagacggg caggatgcca gtattacgct ccgcgtttgg
     1561 accaagctaa taaccatatg tgtgaaaatt cagagttggc agacttggat aagttgaggt
     1621 ataagcattg tcttacgaca cttacagttc caagaagatg tataggattt gcaaggaggc
     1681 gaattggcag aggtggcagg gtcataatgg accgaatatc cacagaacat gaccccgtcc
     1741 tgaaacagat agaccctgag atgctgaacg ggttttcaag ctcttcccaa actatagact
     1801 tttcttctaa tttctctcgg accaatgctt ccagtaaacc ttgtgaaaat agactgtctc
     1861 tttctgaaat attaagcaat atcagatcat gtcgactaca gtgtttccag ccaaggctac
     1921 taaatgtaca ggacattgat agtgaagaat gtacctcaag aaaaccaggg cagactgtga
     1981 gcagtaaaag agtttctgca gcatccgtag ctttattgaa caccagcaag aacggcatat
     2041 cagtaacagg gggcatcaca gaagagcagt ttcagacaca tcaacagcag ctagttcaaa
     2101 tgcaaaggca gcaacttgcg cagcttcatc agaaacaaca atcccagcat tcctcacagc
     2161 agacacatcc aaaagcacag ggctcaagca cctctgactg tatgtctaaa acacttgact
     2221 cagccagcgc ccactttgct gcatctgcag tggtcagtgc tcctgttcca agtcgcagtg
     2281 agggatccaa ggaacagaac actggccaca acaatatgaa tggtgttgtc cagccttcag
     2341 gaccctctaa aacattatat tccaccaata tggctttatc atccagccca gggatttcag
     2401 ctgtacagct tgtaaggaca gttggccaca ctactacaaa ccacttgatc ccagcgttgt
     2461 gcacaagcag tcctcagaca cttcccatga acaattcctg cctgaccaat gcagtgcacc
     2521 tcaataacgt cagtgttgtt tctcctgtca atgtgcatat caatacacgg acttcagcac
     2581 catcgccaac agccttaaaa cttgccacag ttgctgccag catggacaga gtgccaaagg
     2641 ttactcccag cagtgccatc agcagcatag ccagagagaa ccatgaacca gaaagactgg
     2701 gtttaaatgg actagcagag acaacagtag ctatggaggt gacataacgg aaggcgcgtg
     2761 gcctgacctg tgtggatggt tgcagtcatt cctattccag cggaatacaa aggcgggtgg
     2821 cactctgtgg atcacagagc agaacaatgg acctaaatgg agtacagtat accggatgtt
     2881 aagtcgatat atgatgtata ttttgtaaaa ttgggaaaat cactaccttg taaaatagtt
     2941 tatttgtatc atcaatatta tttctgttac ttgaatagta gatattcatc atcatgcttt
     3001 tgcacttgaa tttgcaactg aatggatttt aaaaataatt ctttaatggg atcatgagca
     3061 tgaaatggga tcctgcatca cttgttttaa ctatttattt tgccatgttt acattttgta
     3121 tcttgtaaaa aaaataaatc caactttgtg tctaaaaagt taaagattca tagctaggaa
     3181 atgaaattct tgtaattttt ttctaaagga actgtaaagt tttcacttgg ttcattttgt
     3241 ttcacaattt gactagatgg actttttggt aaatacttta gtggcatttc actgtcaaat
     3301 acgacttcaa ggcaaaatag tattttctat tactgtgcag gggaagggat ggatcgatac
     3361 atgcaaattt aatgtagtaa ctcacttttc catatatttt gaatgtatat ttctatttat
     3421 aataccagtt tataaaaaat aattacacag aaaaagtgga ctaggaaatt atgcatctag
     3481 cacatttaaa ctgtgcagat atgaaaattt ttcatggatt acattttatc tgaagactgc
     3541 atattttaac tggctttaaa actgtaacac accacataaa agatatttac caggtatgta
     3601 ttgcatcata tcattgcaat aattattgga agtctatata tcgagccatc ccaggttttg
     3661 ggagggggga gggttgtggc gagattgtct tttcaatttt ggagagtttt cctgtggcta
     3721 caaggcaagt aacgggttgg aaaccgtctg actgtaagtg ttggacacct tcatagcgta
     3781 gtgtttagtg acttttttat acggttcttg taaattagat acgtgtagtg gtgtttcaga
     3841 atgtttgttt atgcactagt tcagacaact ttccctgtta cttgttcttg ataagtgaaa
     3901 actgcaggga aataaaaaat acatatcaaa acacggccat gctgcatatg tgtttatttc
     3961 accatgtgca cacagcgcaa gtgagggagg acaggaggga caggccagcc cgcacagcac
     4021 ttgtcgccca ggccttcagg catggaggag aaggtcgaag gctcgcctct gggctccatt
     4081 gggtttcaga taatccaata taaactacct ttgctatgaa agttcttaaa atattttaca
     4141 gaatgtaagt aatttgcagt atagcagtca ttgaaatctc ataaatgagc ctcattttat
     4201 aaatatatag agtatagtgt agaattatat tgcaaggggg ttttggaagt cctgggaaat
     4261 gtaaatattt ttaatgaata caattaaaaa ccatttcaaa ctgaacataa ttttatacct
     4321 tttttatatc tgcagtcctg aaagttgtaa acttattg
//
