LOCUS       NM_027497               3983 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus enhancer of polycomb homolog 1 (Epc1), transcript
            variant 2, mRNA.
ACCESSION   NM_027497
VERSION     NM_027497.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3983)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3983)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3983)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3983)
  AUTHORS   Elsen,G.E., Bedogni,F., Hodge,R.D., Bammler,T.K., MacDonald,J.W.,
            Lindtner,S., Rubenstein,J.L.R. and Hevner,R.F.
  TITLE     The Epigenetic Factor Landscape of Developing Neocortex Is
            Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1
  JOURNAL   Front Neurosci 12, 571 (2018)
   PUBMED   30186101
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3983)
  AUTHORS   Dong,Y., Isono,K.I., Ohbo,K., Endo,T.A., Ohara,O., Maekawa,M.,
            Toyama,Y., Ito,C., Toshimori,K., Helin,K., Ogonuki,N., Inoue,K.,
            Ogura,A., Yamagata,K., Kitabayashi,I. and Koseki,H.
  TITLE     EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis
            in Mice
  JOURNAL   Mol Cell Biol 37 (19), e00082-17 (2017)
   PUBMED   28694333
  REMARK    GeneRIF: Results report that EPC1 and TIP60 are co-expressed in
            male germ cells. Genetic ablation of either Epc1 or Tip60 disrupts
            hyperacetylation and impairs histone replacement, in turn causing
            aberrant spermatid development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3983)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 3983)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
REFERENCE   8  (bases 1 to 3983)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3983)
  AUTHORS   Shimono,Y., Murakami,H., Hasegawa,Y. and Takahashi,M.
  TITLE     RET finger protein is a transcriptional repressor and interacts
            with enhancer of polycomb that has dual transcriptional functions
  JOURNAL   J Biol Chem 275 (50), 39411-39419 (2000)
   PUBMED   10976108
REFERENCE   10 (bases 1 to 3983)
  AUTHORS   Stankunas,K., Berger,J., Ruse,C., Sinclair,D.A., Randazzo,F. and
            Brock,H.W.
  TITLE     The enhancer of polycomb gene of Drosophila encodes a chromatin
            protein conserved in yeast and mammals
  JOURNAL   Development 125 (20), 4055-4066 (1998)
   PUBMED   9735366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139300.4, AK040254.1 and AF079765.1.
            
            On Feb 1, 2013 this sequence version replaced NM_027497.2.
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longest isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040254.1, BC138623.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC139300.4         155695-155695       c
            2-3159              AK040254.1         2-3159
            3160-3983           AF079765.1         2988-3811
FEATURES             Location/Qualifiers
     source          1..3983
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 4.48 cM"
     gene            1..3983
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /note="enhancer of polycomb homolog 1"
                     /db_xref="GeneID:13831"
                     /db_xref="MGI:MGI:1278322"
     exon            1..395
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..2684
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="enhancer of polycomb homolog 1 isoform 2"
                     /protein_id="NP_081773.1"
                     /db_xref="CCDS:CCDS29041.1"
                     /db_xref="GeneID:13831"
                     /db_xref="MGI:MGI:1278322"
                     /translation="MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTG
                     MEKEEESEHHLQRAISAQQVYGEKRDNMVIPVPEAESNIAYYESIYPGEFRMPKQLIH
                     IQPFSLDAEQPDYDLDSEDEVFVNKLKKKMDICPLQFEEMIDRLEKGSGQQPVSLQEA
                     KLLLKEDDELIREVYEYWIKKRKTCRGSSLIPLVKQEKRDGSSTNDPYVAFRRRTEKM
                     QTRKNRKNDEASYEKMLKLRRDLSRAVTILEMIKRREKSKRELLHLTLEIMEKRYNLG
                     DYSGEIMSEVMAQRQPVKPTYAIPIIPITNSSQFKHQDATDSKEFKVNKQDKADLIRP
                     KRKYEKKPKVLPPSAAAPQQQSPAALPGFSAKDLNQYDFPSSDEEPLSQVLSGSSEAE
                     EENDPDGPFAFRRKAGCQYYAPHLDQTGNWPWTSPKDGGLGDVRYRYCLTTLTVPQRC
                     LGFARRRVGRGGRVVLDRAHSDYDSMFHHLDLDMLSSPQPSPVNQFANTSEPNTSDRS
                     SSKDLSQILVDIKSCRWRHFRPRTPSLPDSDSGELSSRKLHRSISRAGAAQPGAHTCS
                     TSTQNRSSSGSAHCAFTAEQYQQHQQQLALMQQQQLAQTQQQQQANSSSSAAAQQGFV
                     SKTLDSASAQFAASALMTSEQLLGFKVKDDVVLGLGVNGVLPASGVYKGLHLSSTTPT
                     ALVHTSPSTAGSTLLQPSNITQTSGSHSSLSHQVTAASSATTQVLFGNNIRLTVPSSV
                     PTVNSVTPINARHIPRTLSAVPPSALKLAAAANCQVSKVPSSSSVDSVPRENHESEKP
                     ALNNIADNTVAMEVT"
     exon            396..555
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            556..701
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            702..908
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1057
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1217
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1391
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1481
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1630
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1983
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2105
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2247
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2611
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..3968
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3949..3954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /note="hexamer: ATTACA"
     polyA_site      3968
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /note="major polyA site"
ORIGIN      
        1 acagtggagt tttaatgtcc gccatgttgg ccatggcgta ttgaagagag cgagtgagcg
       61 aggcgcggag cggcacagcc tcccaccctc ccggctggtg tcagggcccg gacggcgggc
      121 tttgcgctcc gcccccaagt ccccggcagc ggcaggcgag tggagaccga aactccggtt
      181 ctccatgatc ccgctggccg gggccgtttc cccagagcgg agaggtatct gctgcgcctg
      241 agatgagtaa actgtcgttt cgggcgcggg cgctggacgc ctcgaagccg ctgccggtct
      301 tccgctgtga ggatctgccc gacctgcacg aatacgcctc gataaaccgg gccgtgccgc
      361 agatgcccac cgggatggag aaggaagagg agtcggaaca ccatcttcag cgggctattt
      421 ctgcacagca ggtgtacggc gagaagcggg ataacatggt tattccagtt cctgaagcag
      481 agagtaacat cgcttactat gagtccatat accctgggga gttcaggatg ccaaagcagc
      541 tcattcacat acagcctttt agcttggacg ctgaacagcc tgattacgat ctggattctg
      601 aagatgaagt atttgtgaat aaactgaaga agaaaatgga catctgccca ttgcagtttg
      661 aggagatgat tgaccggcta gaaaaaggca gcggtcagca gccagtcagt ctgcaggaag
      721 ccaaactact tctaaaagaa gatgatgagt taattagaga agtttatgaa tactggatta
      781 aaaagaggaa aacctgccgg gggtcatcac ttatcccgtt ggtaaaacag gaaaagcgag
      841 atggttctag cacaaatgat ccttacgtgg cttttagaag acgaactgag aaaatgcaaa
      901 ctcggaaaaa ccgtaagaat gatgaagcct catatgagaa aatgctcaag ctgcgccgcg
      961 atctcagccg ggctgtcacc atcctggaaa tgatcaagag acgggagaag agtaaacggg
     1021 agctgctgca cctgaccctg gaaatcatgg agaagaggta taatttaggt gactatagtg
     1081 gagagatcat gtctgaggtc atggcacaga gacagccagt gaagcctact tatgccatcc
     1141 ccatcatccc gattactaac agcagccagt tcaaacacca ggatgccacg gactcgaagg
     1201 agttcaaagt taacaagcaa gataaggctg atcttatccg gccgaagcgc aaatatgaaa
     1261 agaagcccaa agtcttaccc ccatctgctg ccgcccctca gcagcagagt cctgctgcac
     1321 tgccaggctt cagtgctaaa gacttaaacc agtacgactt ccccagctca gatgaagagc
     1381 ctctgtcaca ggttttgtct ggctcttcgg aagctgagga agagaatgac cctgatggcc
     1441 cttttgcttt ccgtaggaaa gcaggctgtc agtactatgc tcctcattta gaccaaactg
     1501 gcaactggcc ctggactagc cctaaagatg gaggcctggg ggatgtgcga tatagatatt
     1561 gcttaactac tctcaccgta ccccagaggt gtcttggatt tgcacgaaga cgggtcggac
     1621 gtggtggaag ggtcgtgctg gacagagcgc attcagacta tgacagtatg tttcaccacc
     1681 tggatttgga catgctttcc tcaccacaac cttctccagt caatcagttt gccaatacct
     1741 cagaacccaa tacctcggac agatcttcct ctaaagacct cagtcagata ctagtcgata
     1801 tcaaatcatg tagatggcgg cactttaggc ctcggacacc atccctgcct gacagtgaca
     1861 gtggtgaact ctccagtaga aagttacaca ggagtatcag tcgagcagga gcagcacagc
     1921 ctggggccca cacgtgcagc acctccaccc agaacagaag tagcagtggc tcagcacact
     1981 gtgcattcac agccgaacag taccagcagc accagcagca gctggcactc atgcagcagc
     2041 agcagcttgc gcagactcag cagcagcagc aagcaaatag tagttcctct gccgccgcgc
     2101 aacagggttt tgtttctaag acgttggact ctgctagtgc acagtttgct gcttctgctt
     2161 tgatgacgtc ggaacagctg ctggggttca aggtgaagga tgatgtggtg ctcgggctcg
     2221 gggtgaatgg cgtccttcct gcctcaggag tatacaaggg cttacacctc agtagcacta
     2281 caccaacggc acttgtacat acgagtcctt cgacagcagg ttcaactttg ttacagcctt
     2341 caaatattac acagacttcg ggttcccaca gctcactgag tcaccaagta actgctgcca
     2401 gctctgcaac aactcaggtt ctgtttggga acaacatccg attaactgtc ccctcatctg
     2461 tccccactgt caactctgtc accccaataa acgcacggca tatacctagg actttaagtg
     2521 ctgttccgcc atctgcctta aagctggctg ctgcagcaaa ttgtcaagtt tccaaggtcc
     2581 cctcctcatc ctctgtagat tcagttccaa gggaaaatca tgaatcggaa aagccagcac
     2641 tgaacaacat agcagacaac acagtagcaa tggaggtgac gtagcttcct gggagcagga
     2701 ctgcatcctg gggacatggt caggtgctat gcatcagagc gttggaacgc agggagtatg
     2761 gagagcactt gtgcggttcc gtggcagctg tggggactcg gcagcactgc gcagctctcg
     2821 aatctctcgt gcttcaacct ttcttttctt attgttaata ggaaaaaatc aacatctgta
     2881 aattaagaat acagcaatta tctgtacagt actgcatatt tgtaataccc ttgtatatat
     2941 gttacttgaa tacagaactg ttcatttgtg atgctttgca cttgggggcg gggggtgggg
     3001 ggtaactgca acaagagtgt gagctgtgag attgtgtagc tggtgtcatc acatcatgtg
     3061 catggtgcgg aacctgctgt ctctatttat tgtgccgtgt ttacaggttt tgtacactgt
     3121 accctcattg gttcctgtgc tgtagtaaat gtgttaggta gctgtggact ccttggtatt
     3181 ttgtaaatgg tataacataa cttggttccc tctgggtcct tgagttttct gtgtatcatg
     3241 tgaaaaaaaa atggtgacat acatacagaa ttttacaaaa aaaaaaaggc atcagttttt
     3301 taaaacgggg aatgtactgt tcaatgggga tcttcctggt ctactagcat taggacgcgc
     3361 aacaagctaa aaatgaagtc tcttgaattc tcccgtcccc gcctgtctgc aagcttgggc
     3421 ggccctggta cttaaagcac taatgttatg ttgctgccct acaaacagcc cagtcgtccc
     3481 atttccttcc acaccaaaaa gtgttaaatc aagtacacaa acggagtcct tacaactgga
     3541 gtttatgttg tcttgccctt tttttttttt agcacaaaaa gatgtacttt tatattgtgg
     3601 aattgtttaa agacttcatt ctttacttgt tcttacagaa aggatatagg ggagaagaat
     3661 gcggtaattg ctgtccgtgt atcgtcattc cagtttgtaa aacagccagc cagctttttt
     3721 ccttttaaga ttctccagaa ggctgcgagg ccagaaccac aaatatcggg tgccttcctt
     3781 tggaaacatt tgacctctct tctgtgaaga gaatggtact taccagacta ctactgcttt
     3841 gttagtaccg aagtctgaat gcccagtcca atggcatacg ttatccttaa ggtttttaat
     3901 cccacctgga aacattgtga tagaattctc acaaaataaa cccagggcat tacatgttga
     3961 caaactaaaa aaaaaaaaaa aaa
//
