LOCUS       NM_007935               3832 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus enhancer of polycomb homolog 1 (Epc1), transcript
            variant 1, mRNA.
ACCESSION   NM_007935
VERSION     NM_007935.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3832)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3832)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3832)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3832)
  AUTHORS   Elsen,G.E., Bedogni,F., Hodge,R.D., Bammler,T.K., MacDonald,J.W.,
            Lindtner,S., Rubenstein,J.L.R. and Hevner,R.F.
  TITLE     The Epigenetic Factor Landscape of Developing Neocortex Is
            Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1
  JOURNAL   Front Neurosci 12, 571 (2018)
   PUBMED   30186101
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3832)
  AUTHORS   Dong,Y., Isono,K.I., Ohbo,K., Endo,T.A., Ohara,O., Maekawa,M.,
            Toyama,Y., Ito,C., Toshimori,K., Helin,K., Ogonuki,N., Inoue,K.,
            Ogura,A., Yamagata,K., Kitabayashi,I. and Koseki,H.
  TITLE     EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis
            in Mice
  JOURNAL   Mol Cell Biol 37 (19), e00082-17 (2017)
   PUBMED   28694333
  REMARK    GeneRIF: Results report that EPC1 and TIP60 are co-expressed in
            male germ cells. Genetic ablation of either Epc1 or Tip60 disrupts
            hyperacetylation and impairs histone replacement, in turn causing
            aberrant spermatid development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3832)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 3832)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
REFERENCE   8  (bases 1 to 3832)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3832)
  AUTHORS   Shimono,Y., Murakami,H., Hasegawa,Y. and Takahashi,M.
  TITLE     RET finger protein is a transcriptional repressor and interacts
            with enhancer of polycomb that has dual transcriptional functions
  JOURNAL   J Biol Chem 275 (50), 39411-39419 (2000)
   PUBMED   10976108
REFERENCE   10 (bases 1 to 3832)
  AUTHORS   Stankunas,K., Berger,J., Ruse,C., Sinclair,D.A., Randazzo,F. and
            Brock,H.W.
  TITLE     The enhancer of polycomb gene of Drosophila encodes a chromatin
            protein conserved in yeast and mammals
  JOURNAL   Development 125 (20), 4055-4066 (1998)
   PUBMED   9735366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM936825.1, AK148194.1, AK149317.1, BB207261.2, AI849475.1 and
            DV652878.1.
            
            On Feb 1, 2013 this sequence version replaced NM_007935.1.
            
            Transcript Variant: This variant (1) differs in the 5' UTR and in
            the 5' coding region, compared to variant 2. It encodes isoform 1
            which is shorter and has a distinct N-terminus, compared to isoform
            2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF079765.1, AK148194.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BM936825.1         1-32
            33-1330             AK148194.1         2-1299
            1331-2837           AK149317.1         682-2188
            2838-2844           BB207261.2         438-444
            2845-3418           AK149317.1         2189-2762
            3419-3420           AI849475.1         413-414             c
            3421-3808           AK149317.1         2766-3153
            3809-3832           DV652878.1         183-206
FEATURES             Location/Qualifiers
     source          1..3832
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 4.48 cM"
     gene            1..3832
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /note="enhancer of polycomb homolog 1"
                     /db_xref="GeneID:13831"
                     /db_xref="MGI:MGI:1278322"
     exon            1..244
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..2533
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="enhancer of polycomb homolog 1 isoform 1"
                     /protein_id="NP_031961.1"
                     /db_xref="CCDS:CCDS37726.1"
                     /db_xref="GeneID:13831"
                     /db_xref="MGI:MGI:1278322"
                     /translation="MEHHLQRAISAQQVYGEKRDNMVIPVPEAESNIAYYESIYPGEF
                     RMPKQLIHIQPFSLDAEQPDYDLDSEDEVFVNKLKKKMDICPLQFEEMIDRLEKGSGQ
                     QPVSLQEAKLLLKEDDELIREVYEYWIKKRKTCRGSSLIPLVKQEKRDGSSTNDPYVA
                     FRRRTEKMQTRKNRKNDEASYEKMLKLRRDLSRAVTILEMIKRREKSKRELLHLTLEI
                     MEKRYNLGDYSGEIMSEVMAQRQPVKPTYAIPIIPITNSSQFKHQDATDSKEFKVNKQ
                     DKADLIRPKRKYEKKPKVLPPSAAAPQQQSPAALPGFSAKDLNQYDFPSSDEEPLSQV
                     LSGSSEAEEENDPDGPFAFRRKAGCQYYAPHLDQTGNWPWTSPKDGGLGDVRYRYCLT
                     TLTVPQRCLGFARRRVGRGGRVVLDRAHSDYDSMFHHLDLDMLSSPQPSPVNQFANTS
                     EPNTSDRSSSKDLSQILVDIKSCRWRHFRPRTPSLPDSDSGELSSRKLHRSISRAGAA
                     QPGAHTCSTSTQNRSSSGSAHCAFTAEQYQQHQQQLALMQQQQLAQTQQQQQANSSSS
                     AAAQQGFVSKTLDSASAQFAASALMTSEQLLGFKVKDDVVLGLGVNGVLPASGVYKGL
                     HLSSTTPTALVHTSPSTAGSTLLQPSNITQTSGSHSSLSHQVTAASSATTQVLFGNNI
                     RLTVPSSVPTVNSVTPINARHIPRTLSAVPPSALKLAAAANCQVSKVPSSSSVDSVPR
                     ENHESEKPALNNIADNTVAMEVT"
     exon            245..404
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            405..550
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            551..757
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            758..906
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1066
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1240
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1330
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1479
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1832
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1954
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2096
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2460
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..3817
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3798..3803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /note="hexamer: ATTACA"
     polyA_site      3817
                     /gene="Epc1"
                     /gene_synonym="2400007E14Rik; 5730566F07Rik;
                     A930032N02Rik; mir-1893"
                     /note="major polyA site"
ORIGIN      
        1 cgccgcccgc tccgcagcct ccagcctgct tcattccccc ggacgccctc ggatcctgcg
       61 gctgcccgcc ccgctccgcc gccctccatg gacgaaagtc tcacttttga tttaccaaat
      121 attttcagga tgtttgaaga tccgtacgct gcccggaggc tgttttttct gaacaaccca
      181 gaccccaacc tatattgtta caattttttt ttgagagctg gctgctgctt tgccttcacc
      241 gatggaacac catcttcagc gggctatttc tgcacagcag gtgtacggcg agaagcggga
      301 taacatggtt attccagttc ctgaagcaga gagtaacatc gcttactatg agtccatata
      361 ccctggggag ttcaggatgc caaagcagct cattcacata cagcctttta gcttggacgc
      421 tgaacagcct gattacgatc tggattctga agatgaagta tttgtgaata aactgaagaa
      481 gaaaatggac atctgcccat tgcagtttga ggagatgatt gaccggctag aaaaaggcag
      541 cggtcagcag ccagtcagtc tgcaggaagc caaactactt ctaaaagaag atgatgagtt
      601 aattagagaa gtttatgaat actggattaa aaagaggaaa acctgccggg ggtcatcact
      661 tatcccgttg gtaaaacagg aaaagcgaga tggttctagc acaaatgatc cttacgtggc
      721 ttttagaaga cgaactgaga aaatgcaaac tcggaaaaac cgtaagaatg atgaagcctc
      781 atatgagaaa atgctcaagc tgcgccgcga tctcagccgg gctgtcacca tcctggaaat
      841 gatcaagaga cgggagaaga gtaaacggga gctgctgcac ctgaccctgg aaatcatgga
      901 gaagaggtat aatttaggtg actatagtgg agagatcatg tctgaggtca tggcacagag
      961 acagccagtg aagcctactt atgccatccc catcatcccg attactaaca gcagccagtt
     1021 caaacaccag gatgccacgg actcgaagga gttcaaagtt aacaagcaag ataaggctga
     1081 tcttatccgg ccgaagcgca aatatgaaaa gaagcccaaa gtcttacccc catctgctgc
     1141 cgcccctcag cagcagagtc ctgctgcact gccaggcttc agtgctaaag acttaaacca
     1201 gtacgacttc cccagctcag atgaagagcc tctgtcacag gttttgtctg gctcttcgga
     1261 agctgaggaa gagaatgacc ctgatggccc ttttgctttc cgtaggaaag caggctgtca
     1321 gtactatgct cctcatttag accaaactgg caactggccc tggactagcc ctaaagatgg
     1381 aggcctgggg gatgtgcgat atagatattg cttaactact ctcaccgtac cccagaggtg
     1441 tcttggattt gcacgaagac gggtcggacg tggtggaagg gtcgtgctgg acagagcgca
     1501 ttcagactat gacagtatgt ttcaccacct ggatttggac atgctttcct caccacaacc
     1561 ttctccagtc aatcagtttg ccaatacctc agaacccaat acctcggaca gatcttcctc
     1621 taaagacctc agtcagatac tagtcgatat caaatcatgt agatggcggc actttaggcc
     1681 tcggacacca tccctgcctg acagtgacag tggtgaactc tccagtagaa agttacacag
     1741 gagtatcagt cgagcaggag cagcacagcc tggggcccac acgtgcagca cctccaccca
     1801 gaacagaagt agcagtggct cagcacactg tgcattcaca gccgaacagt accagcagca
     1861 ccagcagcag ctggcactca tgcagcagca gcagcttgcg cagactcagc agcagcagca
     1921 agcaaatagt agttcctctg ccgccgcgca acagggtttt gtttctaaga cgttggactc
     1981 tgctagtgca cagtttgctg cttctgcttt gatgacgtcg gaacagctgc tggggttcaa
     2041 ggtgaaggat gatgtggtgc tcgggctcgg ggtgaatggc gtccttcctg cctcaggagt
     2101 atacaagggc ttacacctca gtagcactac accaacggca cttgtacata cgagtccttc
     2161 gacagcaggt tcaactttgt tacagccttc aaatattaca cagacttcgg gttcccacag
     2221 ctcactgagt caccaagtaa ctgctgccag ctctgcaaca actcaggttc tgtttgggaa
     2281 caacatccga ttaactgtcc cctcatctgt ccccactgtc aactctgtca ccccaataaa
     2341 cgcacggcat atacctagga ctttaagtgc tgttccgcca tctgccttaa agctggctgc
     2401 tgcagcaaat tgtcaagttt ccaaggtccc ctcctcatcc tctgtagatt cagttccaag
     2461 ggaaaatcat gaatcggaaa agccagcact gaacaacata gcagacaaca cagtagcaat
     2521 ggaggtgacg tagcttcctg ggagcaggac tgcatcctgg ggacatggtc aggtgctatg
     2581 catcagagcg ttggaacgca gggagtatgg agagcacttg tgcggttccg tggcagctgt
     2641 ggggactcgg cagcactgcg cagctctcga atctctcgtg cttcaacctt tcttttctta
     2701 ttgttaatag gaaaaaatca acatctgtaa attaagaata cagcaattat ctgtacagta
     2761 ctgcatattt gtaataccct tgtatatatg ttacttgaat acagaactgt tcatttgtga
     2821 tgctttgcac ttgggggcgg ggggtggggg gtaactgcaa caagagtgtg agctgtgaga
     2881 ttgtgtagct ggtgtcatca catcatgtgc atggtgcgga acctgctgtc tctatttatt
     2941 gtgccgtgtt tacaggtttt gtacactgta ccctcattgg ttcctgtgct gtagtaaatg
     3001 tgttaggtag ctgtggactc cttggtattt tgtaaatggt ataacataac ttggttccct
     3061 ctgggtcctt gagttttctg tgtatcatgt gaaaaaaaaa tggtgacata catacagaat
     3121 tttacaaaaa aaaaaaggca tcagtttttt aaaacgggga atgtactgtt caatggggat
     3181 cttcctggtc tactagcatt aggacgcgca acaagctaaa aatgaagtct cttgaattct
     3241 cccgtccccg cctgtctgca agcttgggcg gccctggtac ttaaagcact aatgttatgt
     3301 tgctgcccta caaacagccc agtcgtccca tttccttcca caccaaaaag tgttaaatca
     3361 agtacacaaa cggagtcctt acaactggag tttatgttgt cttgcccttt ttttttttta
     3421 gcacaaaaag atgtactttt atattgtgga attgtttaaa gacttcattc tttacttgtt
     3481 cttacagaaa ggatataggg gagaagaatg cggtaattgc tgtccgtgta tcgtcattcc
     3541 agtttgtaaa acagccagcc agcttttttc cttttaagat tctccagaag gctgcgaggc
     3601 cagaaccaca aatatcgggt gccttccttt ggaaacattt gacctctctt ctgtgaagag
     3661 aatggtactt accagactac tactgctttg ttagtaccga agtctgaatg cccagtccaa
     3721 tggcatacgt tatccttaag gtttttaatc ccacctggaa acattgtgat agaattctca
     3781 caaaataaac ccagggcatt acatgttgac aaactaaaaa aaaaaaaaaa aa
//
