LOCUS       NM_145506               6510 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus erythrocyte membrane protein band 4.1 like 5
            (Epb41l5), transcript variant 1, mRNA.
ACCESSION   NM_145506
VERSION     NM_145506.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6510)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6510)
  AUTHORS   Maier,J.I., Rogg,M., Helmstadter,M., Sammarco,A., Schilling,O.,
            Sabass,B., Miner,J.H., Dengjel,J., Walz,G., Werner,M., Huber,T.B.
            and Schell,C.
  TITLE     EPB41L5 controls podocyte extracellular matrix assembly by
            adhesome-dependent force transmission
  JOURNAL   Cell Rep 34 (12), 108883 (2021)
   PUBMED   33761352
  REMARK    GeneRIF: EPB41L5 controls podocyte extracellular matrix assembly by
            adhesome-dependent force transmission.
REFERENCE   3  (bases 1 to 6510)
  AUTHORS   Lu,X., Zhao,Z.A., Wang,X., Zhang,X., Zhai,Y., Deng,W., Yi,Z. and
            Li,L.
  TITLE     Whole-transcriptome splicing profiling of E7.5 mouse primary germ
            layers reveals frequent alternative promoter usage during mouse
            early embryogenesis
  JOURNAL   Biol Open 7 (3) (2018)
   PUBMED   29592913
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6510)
  AUTHORS   Schell,C., Rogg,M., Suhm,M., Helmstadter,M., Sellung,D.,
            Yasuda-Yamahara,M., Kretz,O., Kuttner,V., Suleiman,H.,
            Kollipara,L., Zahedi,R.P., Sickmann,A., Eimer,S., Shaw,A.S.,
            Kramer-Zucker,A., Hirano-Kobayashi,M., Abe,T., Aizawa,S.,
            Grahammer,F., Hartleben,B., Dengjel,J. and Huber,T.B.
  TITLE     The FERM protein EPB41L5 regulates actomyosin contractility and
            focal adhesion formation to maintain the kidney filtration barrier
  JOURNAL   Proc Natl Acad Sci U S A 114 (23), E4621-E4630 (2017)
   PUBMED   28536193
  REMARK    GeneRIF: Genetic deletion of Epb41l5 resulted in severe
            proteinuria, detachment of podocytes, and development of focal
            segmental glomerulosclerosis. Remarkably, by binding and recruiting
            the RhoGEF ARGHEF18 to the leading edge, EPB41L5 directly controls
            actomyosin contractility and subsequent maturation of focal
            adhesions, cell spreading, and migration.
REFERENCE   5  (bases 1 to 6510)
  AUTHORS   Nakajima,H. and Tanoue,T.
  TITLE     Lulu2 regulates the circumferential actomyosin tensile system in
            epithelial cells through p114RhoGEF
  JOURNAL   J Cell Biol 195 (2), 245-261 (2011)
   PUBMED   22006950
REFERENCE   6  (bases 1 to 6510)
  AUTHORS   Lee,J.D., Silva-Gagliardi,N.F., Tepass,U., McGlade,C.J. and
            Anderson,K.V.
  TITLE     The FERM protein Epb4.1l5 is required for organization of the
            neural plate and for the epithelial-mesenchymal transition at the
            primitive streak of the mouse embryo
  JOURNAL   Development 134 (11), 2007-2016 (2007)
   PUBMED   17507402
  REMARK    GeneRIF: Lulu mutation in Epb4.1l5 helps anchor the actin-myosin
            contractile machinery to the membrane to allow the dynamic
            rearrangements of epithelia that mediate embryonic morphogenesis.
REFERENCE   7  (bases 1 to 6510)
  AUTHORS   Garcia-Garcia,M.J., Eggenschwiler,J.T., Caspary,T., Alcorn,H.L.,
            Wyler,M.R., Huangfu,D., Rakeman,A.S., Lee,J.D., Feinberg,E.H.,
            Timmer,J.R. and Anderson,K.V.
  TITLE     Analysis of mouse embryonic patterning and morphogenesis by forward
            genetics
  JOURNAL   Proc Natl Acad Sci U S A 102 (17), 5913-5919 (2005)
   PUBMED   15755804
REFERENCE   8  (bases 1 to 6510)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 6510)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 6510)
  AUTHORS   Takeuchi,K., Kawashima,A., Nagafuchi,A. and Tsukita,S.
  TITLE     Structural diversity of band 4.1 superfamily members
  JOURNAL   J Cell Sci 107 (Pt 7), 1921-1928 (1994)
   PUBMED   7983158
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY737035.1, AK044959.1, AC132393.4 and AK054177.1.
            
            On Jan 12, 2008 this sequence version replaced NM_145506.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044959.1, AK047523.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                BY737035.1         1-64
            65-3412             AK044959.1         3-3350
            3413-6004           AC132393.4         111333-113924       c
            6005-6510           AK054177.1         1817-2322
FEATURES             Location/Qualifiers
     source          1..6510
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 52.32 cM"
     gene            1..6510
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /note="erythrocyte membrane protein band 4.1 like 5"
                     /db_xref="GeneID:226352"
                     /db_xref="MGI:MGI:103006"
     exon            1..216
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            217..398
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..2414
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /note="isoform 1 is encoded by transcript variant 1; band
                     4.1-like protein 5; erythrocyte protein band 4.1-like 5"
                     /codon_start=1
                     /product="band 4.1-like protein 5 isoform 1"
                     /protein_id="NP_663481.2"
                     /db_xref="CCDS:CCDS15226.1"
                     /db_xref="GeneID:226352"
                     /db_xref="MGI:MGI:103006"
                     /translation="MLSFLRRTLGRRSMRKHAEKERLREAQRAATHIPAAGDAKSIIT
                     CRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTK
                     SIKKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLECPFDTAV
                     QLAAYNLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYRGQTPAQAET
                     NYLNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGETKIGLFFWPKITRLDF
                     KKNKLTLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQKSSH
                     RSGFIRLGSRFRYSGKTEYQTTKTNKARRSTSFERRPSKRYSRRTLQMKASTTQPEDL
                     GVLNASAQKSDSQQAWGVMSPVPVTSSSSCGAVQVEIENLPQTSATEQHDRKCLPLSV
                     DLLNSPDLLETTIGDVTRTSETSAPFPAPDTINVATRSNELEEFKAECETLKDDTEKL
                     KQLETEQTILPSLRPTIDINVNSQEEVVKLTEKCLNNAIENPALNAVKVPPDFKSNIL
                     KAQVEAVHKVTREDSLLTHKNASVQDAATNSTAFNENDVPVCKDSLTPVHGTAADSAS
                     VLKDATDELDALLLSLTENLMDHTVTPQVSSPSMITPRWIIPQSATISNGLAGYGASL
                     AGTDECSQKDGFSLISPPAPFLVDAVTSSAPPLPEDSTLKQKCLLTTEL"
     exon            399..503
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            504..546
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            547..625
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            626..670
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            671..723
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            724..844
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            845..932
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1021
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1091
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1261
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1368
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1396
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1436
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1552
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1716
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1814
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1943
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2008
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2099
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2174
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2216
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2347
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..6510
                     /gene="Epb41l5"
                     /gene_synonym="1700030C16Rik; BE37; E230025E14Rik;
                     Epb4.1l5; Lulu1; NBL5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcggacc ttggatgggg ctttaagggg cgtgccctcg ggcggccggg gtcctccggg
       61 gattagcgca gggtgggctc gcgccttgcg ccgccatttc tcggtgtctc tggagacccg
      121 tcctctcctc tagccggctg ggcatctctc tccgagggtc gcgcgtccca gtcgcagtgg
      181 tctccgtcgc ttcacggtgt tcacccccga gtacagaaat gctgagcttc ctgagacgaa
      241 cgcttggccg caggtctatg cgcaagcatg ctgaaaagga gcggctccga gaggcacagc
      301 gtgcggccac acacattcct gccgctgggg atgccaagtc catcatcaca tgcagggtgt
      361 cccttctgga cggtacagat gtcagtgtgg acttgccgaa aaaagccaaa ggacaggagc
      421 tgtttgacca aatcatgtat cacctggact tgattgaaag tgactatttt ggtttgagat
      481 tcatggattc agcccaagta gcccattggt tggatggtac aaaaagcatc aaaaagcaag
      541 taaaaattgg ttcaccctat tgtcttcatc ttcgagttaa gttttattcc tcggaaccaa
      601 ataatcttcg tgaggagcta acccggtatt tatttgttct tcagctaaaa caagatattc
      661 tcagtgggaa gttagagtgt ccctttgata cagcagttca gttggcagct tataatctgc
      721 aagctgaact tggcgactat gatcttgctg aacatagtcc tgaactggtc tctgagttca
      781 ggtttgtgcc catccagact gaagagatgg aactggctat ttttgagaaa tggaaggaat
      841 acagaggtca gacaccagca caagcagaaa ccaattacct gaataaagcc aaatggctag
      901 aaatgtatgg tgttgatatg cacgtggtca aggctagaga tggcaatgac tatagtttgg
      961 gactgactcc aacaggagtc cttgtttttg aaggagagac caaaattggc ttgtttttct
     1021 ggcccaagat aaccagattg gattttaaga agaataagtt aactctagtg gttgtggaag
     1081 atgatgatca gggcaaagaa caagagcata cctttgtctt tagattggat caccctaaag
     1141 cctgcaaaca cttatggaaa tgtgctgtgg agcaccatgc cttcttccgc ctccgaggac
     1201 ctgtccaaaa gagttcccat cgatcaggat tcattcgact aggatcccga tttagataca
     1261 gtggaaaaac agaatatcag accacaaaaa ctaataaagc aagaagatca acctcctttg
     1321 aaagaaggcc tagcaagcgg tattcccgac ggacgctgca aatgaaagcc agcacaacac
     1381 aacctgaaga tcttggtgtt cttaatgctt ccgctcagaa aagtgactcc caacaggctt
     1441 ggggtgtgat gtctcctgtg cctgtcactt cttcctcatc ctgtggcgct gtgcaggtgg
     1501 agatagagaa tctcccacag acctctgcga cagagcagca cgacaggaaa tgcttgcccc
     1561 taagcgttga tttgctcaac agcccagact tactagaaac aaccattggt gatgtaacaa
     1621 ggacgtcaga gacttcggca ccattcccag caccagatac cattaatgtt gccaccaggt
     1681 caaatgaatt agaggaattc aaagctgaat gtgagacatt aaaggatgac acagagaagc
     1741 ttaaacagct tgaaacagag cagactatct tgccatctct tcgacctacc attgacatta
     1801 atgtcaacag ccaggaagaa gtggtaaagt tgactgagaa atgtcttaat aatgccattg
     1861 agaacccagc attgaatgca gtaaaggttc ctcctgactt caagagtaat attttgaaag
     1921 ctcaagtaga agctgtgcat aaggttacaa gagaagatag tttattaact cataaaaatg
     1981 ccagcgttca ggatgctgcc acaaacagta ctgcattcaa tgaaaatgat gtgcccgtct
     2041 gtaaagattc cctcactccg gtgcatggca cagctgcaga cagtgcctct gtactaaagg
     2101 atgctactga tgaactggac gccttacttc tttctctgac agagaatctg atggaccaca
     2161 cagtaacacc tcaggtgtct tcaccatcca tgatcacacc ccggtggatt attccacaga
     2221 gtgctaccat ctccaatggg cttgcaggat atggagcatc tttggcaggg acagatgaat
     2281 gtagtcagaa agatggattc tcactgattt cccccccagc accattcttg gtagatgctg
     2341 tgaccagctc tgcccctccc ttgcctgaag actcaacctt gaagcagaag tgcttgctga
     2401 ctactgagct ctgagggctg ctgctcccca cctgtaactg gattgcccca caccgtcccc
     2461 agtcagccct ggatccatgt gtcctttact tggggaaaac cttctaccag gatttgactt
     2521 caactccata atgagagtag ctacattttc cgtccaactg gaagtctacc ccatataact
     2581 gcttaactga agatacctcc tcctcctcct gtaactgtat ttgcattgcc aattcctgaa
     2641 gcaatgaagg taactagttt cctgcaaact gatggctcca cctagcggtt gcaactgttt
     2701 atagcttaga gcaaggcttg ctgtccagag cctttcattg ctgtttccct gggttgtcag
     2761 gggagcacac ctgaactgag agcctgctgg agaaatgcgt ggcactttcc tgtgcattcc
     2821 ctggaaatga gaattagaaa atggatggaa acactatgtg gctagatccc aggccagctc
     2881 ctgcacagtt gctaggattc ttggagaagc tgagaacata gaggggtgag gctgtcaccc
     2941 agactttgaa ttctgagcag taatgacctt acatcaaagg taaatgttat ctttggataa
     3001 ctagagagag gttcagtctc taggcgtgaa ctcctcagac cactttccta ttggaagcac
     3061 ctaaacccct cgcctgtttt taactttgca gcctgggagg gagcaagtgt cagctcagag
     3121 acccgaggcc tgtgctcttc ttcctgagcc agtggggaat tcggccctac taggcttacc
     3181 agttggaaag tcaggacctg tttaggcata gcctccagtt cctttcggtg tacactgcgt
     3241 gagcttacag cttccaagct aaaaggaaaa gaaaaatact tggcagaaat ggggaatgcc
     3301 tgtgagaggg cttgggttct tgaatgggta taacaaatga agtcagttta cataggggtt
     3361 ttgtattcat tttaaagtcc tctagaatcc cccattcctt tagcctgtac ccaaaaaaaa
     3421 aaaaagataa tgttaaagta gtacccaccc atcatagaaa agtgtatgga tatgaaccta
     3481 tcatcccaaa acagaaatga cactgaatag ctttacctgc ttaggctgaa ggatcaggcc
     3541 tcagttgctg tggagacaag ggtgatgtgc agacggtggt ggtgccagta gtgttgcact
     3601 gatgctaagc tgctaagctg tgtcccctgg agtttgttct gcccaccatg tgatgtgtac
     3661 tcattcttgc ttctcagtta agaagacacc cagctcgtgg tctaaggagc tgtgatttga
     3721 actaccctgg cttccttgtg catagtttgt gctcaggcaa acactaatgt cttgattggg
     3781 aagcccaggg ggttcagttt cacagtgtcc agaggagctg gacagtttag aaacactttc
     3841 taaacagtct gctaaggagt tgctcttctt gctggctgtc tccccttagc cagtagtgta
     3901 tcttgtgtga tcgtccgcag tgttttttcc agtcctgagt gataagacat ttcttacagg
     3961 atgacactta gaattggggc ttgacccagg cacactgcac tgggtttcag atttctggtg
     4021 tctggaagtc ctggatggcc tgcaaggcta gctgttctgc taacacacac ccaagacacg
     4081 gcggcttaga gggcctaaat gtcctgttct gcttagaagc aagcactgtc ccttcaagat
     4141 tgagtccata tgagtatccc ataacatttt tgtctccagg taactgaatt cttactagtc
     4201 agaatatttg ctagtgactt ggttaggatt cacttgaatc ccagtaaaaa gaaatcctat
     4261 gtcctactgt caagtcctaa gcttagaagt acatattgag tgacatattt tccctgacag
     4321 attagacact gttacatgtt tcctgtgctg ttacagtagc agtactctgc tcctttgaga
     4381 atggtagtgt ctaatgagac aggcctgagg gcgcctgtgg aagcagtaga ggcagggcaa
     4441 gtccatgaga cagtgagaat gctgacagag tgaggctggg taagaaggca acaggcagag
     4501 ttaggccaag tcaggaagat gggtagctgc cggccgtgtg ggtttatggc acaatggaga
     4561 tagggccaaa agactggcct gctacaaacc tagggaggga gagagggatc cgggcaaggt
     4621 tcgtattgtg tccctggctg gggtagggac ttggcatggc agtttccagt aagatgaaga
     4681 ttcagttagg agtcctaggc tccacctcag cacttagaaa gtacatgtga gggaggaatc
     4741 tggatactga cagcttctgg gtagcagctc ctttcaacac agaggactca cagttatctc
     4801 acccctctcc tcagcagatg gtctccttct cattccactt tgctttgaga aatactcttt
     4861 acagtcctgc tggcggacta gggtacttgc tttgcacagg cttagctgtc ctgggcatgt
     4921 caggggctga gatctccgag ttgttactag catctactgc ttgtttttct cagttctggc
     4981 taaagcttgg gcctctcttc tcttaactga gccccagaaa actgctgtcc cttgctcgat
     5041 tgctaggcac tcaactgatg aaaaagttta tttttttctt tccttccttc tttctttgtt
     5101 tctttccttt ttttctgtgt agctctggct gtcctggaac ttactctata gaccaggctg
     5161 gtctcaaaat cagagatcct cctgcctctg cctcctgagt gcttcattaa aggctatgcc
     5221 actacacctg ggaacatagt ttctaagaaa gcttcttgtc ttttcatttg gcaggtatca
     5281 tgttcatttg ttgttttgtg ttgttttact ttggttgtgt agacagggtc tcgctgtgga
     5341 gcccaggatg gtcataactc ccagcagtct tcctgccgca gctttccagg ggctggattt
     5401 tcagtcatga accattgagt ctggcataga cttgttctga caggttttct gtttggttgg
     5461 ctttggtttt gagttgctag gggtcataac cagaaccttg gactgggaat ggtggcatgt
     5521 ctttaatccc atcactctct gagctgcagg caaactaagg ctacatggtg aggcccgtgt
     5581 ctcactcagc cactgagcta tgtccccaag acccactaag tttgttctat agagaccccg
     5641 agataacaga tacttcacca atcagttctg ctggtgctgc gcagcatcat cagaggcagc
     5701 actcagcatc gttgcattca ctgcagctga ttcacagtgc tgcttcccag ctctgagcac
     5761 aggagagtgc tgcctgcagt ccatggtctg cagcactagc agccactcag gcagccagca
     5821 cttgaggaca ttgtgtcaag ttgtccacag ggctgcaagg agattgtggg tctcagctgt
     5881 gaaagacttg gacctattat ttgatccatc tcttgaccat ccagttgact ggaaatttgc
     5941 atacatgtat gtaataaaga atgtgggttt atagatcact gatgcttttt tttttttttt
     6001 ttttctggaa aaaaatgaaa cttgggtttg gatggtcagg atgaactgga aacattccta
     6061 ttccaggata gggaacttgg tttgcactgt ggagacttgg cctgagctgt gttctgctgt
     6121 gtgcacttct ggtgggactg cttatcttct tctttatggc gttgttgggg gtgatagcca
     6181 ctaattctca ggattccttc ttatctctct ctgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     6241 gtggtttcat ggaactctgt gctctttctg tgctcacatc tggatacaat agacgattat
     6301 gaggattcac cagctctttt gtgtttacct tttctacatg ttaagctctg cagtagcttt
     6361 gaaactgtaa tttatttttg tatcacatgc actatattca gtgacttcct gttgtatgta
     6421 ttagaagcac tgcagtgaac tgtgagttgt ctgtacactg aacaagaact ctaggtatga
     6481 cccattgcaa taaaacttcc atgagagttc
//
