LOCUS       NM_001355492            6940 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus erythrocyte membrane protein band 4.1 like 4b
            (Epb41l4b), transcript variant 2, mRNA.
ACCESSION   NM_001355492 XM_017320318
VERSION     NM_001355492.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6940)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6940)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 6940)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 6940)
  AUTHORS   Nakajima,H. and Tanoue,T.
  TITLE     Lulu2 regulates the circumferential actomyosin tensile system in
            epithelial cells through p114RhoGEF
  JOURNAL   J Cell Biol 195 (2), 245-261 (2011)
   PUBMED   22006950
REFERENCE   5  (bases 1 to 6940)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   6  (bases 1 to 6940)
  AUTHORS   Cuajungco,M.P., Leyne,M., Mull,J., Gill,S.P., Gusella,J.F. and
            Slaugenhaupt,S.A.
  TITLE     Cloning, characterization, and genomic structure of the mouse
            Ikbkap gene
  JOURNAL   DNA Cell Biol 20 (9), 579-586 (2001)
   PUBMED   11747609
REFERENCE   7  (bases 1 to 6940)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 6940)
  AUTHORS   Shimizu,K., Nagamachi,Y., Tani,M., Kimura,K., Shiroishi,T.,
            Wakana,S. and Yokota,J.
  TITLE     Molecular cloning of a novel NF2/ERM/4.1 superfamily gene, ehm2,
            that is expressed in high-metastatic K1735 murine melanoma cells
  JOURNAL   Genomics 65 (2), 113-120 (2000)
   PUBMED   10783258
REFERENCE   9  (bases 1 to 6940)
  AUTHORS   Hashimoto,Y., Shindo-Okada,N., Tani,M., Takeuchi,K., Toma,H. and
            Yokota,J.
  TITLE     Identification of genes differentially expressed in association
            with metastatic potential of K-1735 murine melanoma by messenger
            RNA differential display
  JOURNAL   Cancer Res 56 (22), 5266-5271 (1996)
   PUBMED   8912867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL805921.7 and AL831761.9.
            
            On Feb 25, 2022 this sequence version replaced NM_001355492.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.77600.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-906               AL805921.7         3048-3953           c
            907-1011            AL831761.9         141180-141284       c
            1012-1054           AL831761.9         126558-126600       c
            1055-1133           AL831761.9         125742-125820       c
            1134-1178           AL831761.9         123752-123796       c
            1179-1231           AL831761.9         121779-121831       c
            1232-1352           AL831761.9         116631-116751       c
            1353-1440           AL831761.9         114920-115007       c
            1441-1529           AL831761.9         114670-114758       c
            1530-1599           AL831761.9         114290-114359       c
            1600-1769           AL831761.9         114047-114216       c
            1770-1879           AL831761.9         111018-111127       c
            1880-1910           AL831761.9         108808-108838       c
            1911-1944           AL831761.9         106061-106094       c
            1945-2009           AL831761.9         102555-102619       c
            2010-2218           AL831761.9         78600-78808         c
            2219-2337           AL831761.9         76259-76377         c
            2338-2463           AL831761.9         69871-69996         c
            2464-2531           AL831761.9         65365-65432         c
            2532-2630           AL831761.9         62094-62192         c
            2631-2817           AL831761.9         57528-57714         c
            2818-2895           AL831761.9         54610-54687         c
            2896-2967           AL831761.9         45662-45733         c
            2968-3113           AL831761.9         37338-37483         c
            3114-6940           AL831761.9         29733-33559         c
FEATURES             Location/Qualifiers
     source          1..6940
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 31.66 cM"
     gene            1..6940
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /note="erythrocyte membrane protein band 4.1 like 4b"
                     /db_xref="GeneID:54357"
                     /db_xref="MGI:MGI:1859149"
     exon            1..906
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     CDS             601..3183
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     expressed in high-metastatic cells; band 4.1-like protein
                     4B; erythrocyte protein band 4.1-like 4b; erythrocyte
                     protein band 4.1-like 4b; expressed in high-metastatic
                     cells"
                     /codon_start=1
                     /product="band 4.1-like protein 4B isoform 2"
                     /protein_id="NP_001342421.1"
                     /db_xref="GeneID:54357"
                     /db_xref="MGI:MGI:1859149"
                     /translation="MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAA
                     ASSSVLPAAPGGSVFPAGGGPLLTGGAAVHISASGAAKATLYCRVFLLDGTEVSVDLP
                     KHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVTHWLDHAKPIKKQMKVGPAYALHF
                     RVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAALCLQAELGECEL
                     PEHTPELVSEFRFIPNQTEAMEFDIFQRWKEYRGKSPAQAELSYLNKAKWLEMYGVDM
                     HVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQG
                     REQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPSNSKSARSDFIRLGSRFRFSGR
                     TEYQATHGSRLRRTSTFERKPSKRYPSRRHSTFKASNPVIAAQLCSKANPEVHNYQPQ
                     YHPDVHPSQPRWRPHSPNVSYPLPSPALSPTERLPFSLEENGGTPFAPKTSGRHHHQH
                     QHQHHSNYGLSLTLENKEAPLRSPNASKALTKLSPGTPALYSEAAAHLKKLELETVKA
                     VAPWPALHININKAEEKKVSEKTLQTPLLPSPVADHVKCNILKAQLENASRVNAQIGK
                     EEPSFVNINKKSNLQDTNVRSPIPIRVEAAQPAVEKPEIKPPRVRRLTRQYSFDEDDL
                     PPDLAEAVGATTATTTTTTTTTMSATQVSVSLASPKIQKVSSPQKSEVKSPLSPGAKS
                     PSDHGGSLTLGPGDLLMDFTEATPLIKTFPAEPVMNPFPDPFTTGPQFPADFRENKLQ
                     CCPGQSSPLIPTVTLRPLTETVATVQTIYTSRKPVSLATSAETLRQELEREKMMKRLL
                     MTEL"
     exon            907..1011
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1054
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1133
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1178
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1231
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1352
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1440
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1529
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1599
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1769
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1879
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1910
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..1944
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2009
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2218
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2337
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2463
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2531
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2630
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2817
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..2895
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..2967
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3113
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     exon            3114..6940
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6909..6914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /note="hexamer: AATAAA"
     polyA_site      6940
                     /gene="Epb41l4b"
                     /gene_synonym="6430543G08Rik; D4Ertd346e; Ehm2; Epb4.1l4b;
                     Lulu2"
                     /note="major polyA site"
ORIGIN      
        1 agcacaagcc cggcgcagcc ccgggggagg agggcgtgct gcagtgccgg cggcggcggc
       61 tggaggtgca gccctcccag gtgggaggcg ggggctgcgg gcgcaggaaa aggcgccccg
      121 ggagcgggcg ctcggcgggg gcctcctcgg gccgggcgcg gcgcgagtgg gagcgagcgc
      181 gccgggagca cgcaggcgct ttgctccggc tggccctcgg ccggcgcgcg gcgcgggagc
      241 agcccgcagc cgggtccccc cgcggcgctc ttcgcggggc agcggccacg cagcagccgg
      301 caccgaccga ccgccccaag cgcgcggcag cgacagcggc gacagcagcg ggacggtccc
      361 ccgggccgcc tgtgcgcgtt ctctcccgcg cggctactct cggcgggcgc tggcccggcc
      421 gacgcgtccc gcgggcggcc ggagcgcggc ggcggcctcg gctggggcgg gagcgagccc
      481 cgggccgcag cccgcgggag gcggcgcggc gcggcgggca ctgacggcgg cgccgggcgc
      541 tcccgggcgg cggcgcggcg gcagcgcagg gggcggaggc agggggcgcc cccggccagg
      601 atgctgcggt tcctgcgccg gacctttggc cgccgctcca tgcagcgcta cgcgcggggc
      661 gcggcggggc gcggggccgc cgggctgggg gacgagcgcg acggggggcc gcgagggggc
      721 ccggctgccg ccgccagctc ctcggtgctg cccgccgcgc ccgggggcag cgtattcccg
      781 gccggcggcg ggcccctgct caccggcggc gcggctgtgc acatctccgc ctcgggagct
      841 gccaaggcca ccctttactg ccgtgtcttc ctgctcgacg gaaccgaagt gagcgtggac
      901 ctgccgaaac atgccaaagg ccaggatttg ttcgaccaga ttgtgtacca cttggacctg
      961 gtggaaacag attattttgg tctgcagttc ctcgactctg cccaggtcac gcactggctg
     1021 gatcacgcga aacccataaa gaaacagatg aaagtgggac ctgcctatgc cttgcacttt
     1081 cgagtcaaat actattcttc agaaccaaac aaccttcgag aggaatttac aaggtacctg
     1141 tttgttttac aactcaggca tgacattctt tctggaaaat tgaagtgccc ctatgaaacg
     1201 gccgtggaac tagctgccct ctgtctgcaa gcggagctag gagagtgtga gctcccggaa
     1261 cacacgcccg agcttgtgtc tgagtttcgg ttcatcccaa atcagacaga agccatggag
     1321 ttcgatatct tccagagatg gaaagagtac aggggaaaga gccctgccca ggcggaactc
     1381 tcctatctga acaaagcgaa gtggctggaa atgtatggag tggacatgca tgttgtcagg
     1441 ggaagagatg gctgtgaata ttctcttgga ctgaccccga caggcatatt aatctttgaa
     1501 ggagctaaca aaataggctt attcttttgg cctaagatca ccaaaatgga ctttaaaaag
     1561 agtaaactga ccctcgtagt agtggaagat gatgaccagg ggcgtgagca agagcacacc
     1621 ttcgtgttca ggctggacag tgcgcgtacc tgcaagcact tgtggaagtg tgcagtggag
     1681 caccatgcct tcttccgtct gcgcacaccc agcaacagca agtccgccag atctgacttc
     1741 atccggctgg gttcccgctt ccggttcagt ggacggacgg aatatcaagc tacacacggc
     1801 tccagattgc gaagaaccag cacctttgag aggaagccta gcaaacgtta cccgtcccgg
     1861 cgacattcca cattcaaagc gagcaaccca gtaattgctg ctcagctctg ctctaaagca
     1921 aatcctgaag tccacaatta ccagcctcag taccatcctg acgtccaccc cagccagccc
     1981 cggtggcgcc ctcactctcc aaatgtcagc tacccgctcc cgtcccctgc gctcagcccc
     2041 acagaaaggc tgcctttcag cctcgaagag aacgggggca caccatttgc ccccaaaact
     2101 tcggggaggc atcaccacca gcatcagcac cagcaccact ccaactacgg cctttcactg
     2161 accctggaga ataaggaggc gccgctgagg tccccgaacg ctagcaaggc cctcaccaaa
     2221 ctgagtccag gcacgccagc cctgtacagc gaagcagctg cacatctgaa gaagctggag
     2281 ctggagaccg tgaaggctgt ggcaccctgg cctgccctgc atatcaacat caacaaggct
     2341 gaggaaaaga aagtttcaga gaagaccctt cagaccccgc tgctgccttc gcccgtagca
     2401 gatcatgtga agtgcaacat tttgaaagca cagctggaga atgcctctcg tgtgaatgcc
     2461 cagattggaa aagaggagcc ctcatttgta aatatcaata agaaatcgaa tctccaggat
     2521 accaatgtca gaagccccat tcctatccgc gtggaagccg cccagccagc tgtggagaag
     2581 ccggaaatca agcctccccg tgtgaggagg ttaacaaggc agtatagttt tgatgaagat
     2641 gacctccctc cagaccttgc tgaggcagtg ggagccacca cagccacaac cacaaccacc
     2701 accaccacca cgatgtctgc cactcaagtt tcggtgtcac tggcgtcccc caaaatccag
     2761 aaagtcagct cgcctcagaa gtcagaagtc aagagcccgc tgtccccagg ggccaagagt
     2821 ccctctgacc acggaggctc cctgaccctg gggccaggcg acttgctgat ggattttaca
     2881 gaagctaccc ctctgataaa aacgttccca gcagagccag tgatgaaccc gtttcctgat
     2941 ccctttacca caggaccaca gttccctgca gactttagag agaacaaatt acagtgttgt
     3001 cctggccagt cttccccgtt gattccaaca gtgaccctgc ggccactgac agagactgtg
     3061 gccacagtac agaccatcta tacctcccgg aagcccgtct ctctggcaac cagtgcagag
     3121 acgctccggc aggaactgga aagagagaag atgatgaaaa gattgctgat gaccgaactg
     3181 tgacactcca cccttgctgc ctggagatgg catggtgcct tcgtccgctt cctttcctcg
     3241 ggctcggtgg tgtgctcact gcggcacgac atacagatgt gtgctctgtt cgcccaggtc
     3301 tccagggtta gcggaagcca gcttccggct tgactttgtt ggaaaagtta ttttacgtct
     3361 cctgagcacg agagcttttt ctactgctca atgcagtgga gacagggttt gataggaagt
     3421 ttctagatga aaggggattt ctattcagag gtacctgtgt gtatctgtta gtaaccccag
     3481 ggactaacgc agcacagagt cctccgctta cactctcaac gatgtgactt ttttaaatga
     3541 catttgcacc aagctttggc tgtttgttaa atgggtcatt ttatgagaga ataaattctt
     3601 tactgctggt tttccattta cactgaataa tacacagatc ttataaagtt atttattttt
     3661 attcagacat gaatagatga aggggggaaa gttgcatctt atacaactga aaatatttca
     3721 gcttaacctg aaatacaatt gattgtgtga actcgttgga tacaaaacaa ctttggataa
     3781 atggaattta tctttgaggc ccatatagga aattctaact tatattgtct aaaaaaaaaa
     3841 aaaaaacctt tacagggtca agatgactca ggatcagaaa gattcatttg actttccata
     3901 aagaaaaata tttctaaatt ccattcactc taaccatgtt gataggatct gacctggaag
     3961 aaacttaact ccctttttat atagtttcaa gaaatgtgtt tttaaatttt tattatgcac
     4021 ttgaataact ttgcaggagt taaggagccc ctacccacag ctcgctgtaa agttctccct
     4081 gcgcacagat aagctgtttt gacatagctg tgctcagcgc tgacatccct ttgttacatt
     4141 tctttaccta acacatctcc tcattagaca ggtactttca ctaccttaaa tgtctttata
     4201 ttcacatgac accgttaacc tcacttctcc ccactaacag atatttgagt tatatgcaaa
     4261 ttttcacact tataaatagt gctgctatga atgtctttgt aaaaaaatat ataaataaat
     4321 aaatatatct ataaaatcct tctcttggat tattccctcc ggaatatctc caaagaggga
     4381 ttacaaggtc agagagcatg aagtatttta tagctcttgt tttatattgt cagattgctt
     4441 tctagaaaga tccaatcttt gggttggaag gaccttaaag gtcatctcat ttaaacttcc
     4501 cctcctctga atgcttgaat cccctttaca atttataatt ccaccagcaa tgtataagca
     4561 tttctattta ccaatagctc tgccagtact gagttttgct attctaactt attttatttt
     4621 ttgctagttt aatagatgtg tatagttact cttgagaagc tgtctgattt gatgaactgc
     4681 tagcaaggct gaacactttt ccgtgtgatg agttatgagc tgtgttttct cgtatgtaaa
     4741 ccgtccacat ccatttctta tgactgcttg gtcaatagaa ctgatcgagt cgtacctttg
     4801 taccagaact gtatttttat gttgtattgt agtttgcctt ctccccaccc ctacaaatga
     4861 atggtgccaa taatttgata ctaatgacta taaaagttgc ctcactgact agcgttgatg
     4921 caaacgaggt atgtaaacag gtattcggtt aaccaaggag tgacccttta aggactgact
     4981 ctacaattta atattttttt tgagggaact ctttatagga tgtatggcac atttccttgc
     5041 cttagtacac agagtgtcct ggagggtgtt cagccctttc ctgatgaatc ctggttgtca
     5101 gtacacatat ccacccctcc tgtaccttgg tatggtacaa aaaatgtcag gaggagttat
     5161 cgacacttgt ggggcttgct gtgacctata taggccatga ccctcttctc atcaatagct
     5221 ctgtattgtc ctgctctttc tgtggagctg tctggggaaa gtggagtttt gggtgggtgc
     5281 tttttactca cgaagcccct agattactag caaaatggct ttggctgtcc tctatcatgt
     5341 gcacgtgaca caaaccatgt tcctatagaa cacagggttg tcacctcctg ccaacccagc
     5401 agctgcttcc tcttctgagc tgctctctgc agtgtgcact cctccccctt gctctcagat
     5461 ggaagcctcc agaacacagc agaaggtttc cggagctttc gggccacatg tgtatcccac
     5521 gagtctgact tgatttgttc ctaggtaggt gtgcatggag gttctagccg ctgcgttcag
     5581 gaggcttgca agctcctacc ttgtccccca cctctccctt gggctcacaa gagtctcagt
     5641 gggtggacat ccctgcaaac ctgagcacaa acatgctggt tgctcttgta tgtgcaaacc
     5701 cagaaccgca ggcagttcat cccaaggaga ggagtggccg cagtggccat ttatcttctg
     5761 cctacttaaa tgtatggtgg gtgctgagac agcaaagctg ccctggggga gctcacagtg
     5821 actataagga gttgtgcaat tattaccttc ttggtctgct ttagacccaa acaacagcac
     5881 tagagggtaa cacaaccacc cactgtggat tcaagaggag aggagagagt ctgctaacat
     5941 gatcattaca gagctgggac tgtacagcat ggcctcagac tcttagttgg gaagtcatgg
     6001 catgttactg caaaggtctg gtaccctcaa ctcatagagt tgacaggtta gggacagcac
     6061 agatctttgg gtgtgagaaa ggaagccttt ggtcttcaga aattcccacc agggtgcatc
     6121 aggaatgtta ttttcccaaa gagcacagga aggttctgat atcgctgtta tcattcacca
     6181 tttcaaagat cacagacctt taaagtcttg gactaaaacc caccatttta gtgattttaa
     6241 agtgtgtacc tcagtgtctt tcagcgtgtc catgatgcag ggcaaacata atctgacctg
     6301 tgactctgcc cctcccctag caactactaa ccacccccta gcaaccacta accaccccta
     6361 ccctggcctg taggtttctg attatgaatt tgcttattct ggacacttca tataactgga
     6421 atcatatagt atgtgggctt ccatgatcag cttctctcat ttaaccatgt tttcaaggtt
     6481 cctctgtgtt atcgcatgta tcaggacgtc attctgtctt tgtggttgaa taatggagat
     6541 gatgaggatg ctatgttttg tttatctatt tattcagttg gcagatgttt gggttgctcc
     6601 tgctttgggg ctattatgaa cgataatttt atgaacagtc atacacaaat ttttctgtgt
     6661 gaacatatgt tttgggtcct cttggaattg ccagatcata tggcaactct atgtttaact
     6721 ttctgaggga cttccaagat cacagctttt atatcttatg aaattcaaag tgaaaaatga
     6781 catacaccag gcggtcagag gcagggcaca tctgttcctg gttggatact gaatggtagc
     6841 actaatctgg ggatgtttta taacagaaaa aaaaggtcct tttgagaaat tattttgatg
     6901 agaagagaaa taaaggttgt ctgtctttta aaaatgaaaa
//
