LOCUS       NM_001404797            4367 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus erythrocyte membrane protein band 4.1 like 2
            (Epb41l2), transcript variant 7, mRNA.
ACCESSION   NM_001404797 XM_006512511
VERSION     NM_001404797.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4367)
  AUTHORS   Saito,M., Hirano,M., Izumi,T., Mori,Y., Ito,K., Saitoh,Y.,
            Terada,N., Sato,T. and Sukegawa,J.
  TITLE     Cytoskeletal Protein 4.1G Is Essential for the Primary Ciliogenesis
            and Osteoblast Differentiation in Bone Formation
  JOURNAL   Int J Mol Sci 23 (4), 2094 (2022)
   PUBMED   35216233
  REMARK    GeneRIF: Cytoskeletal Protein 4.1G Is Essential for the Primary
            Ciliogenesis and Osteoblast Differentiation in Bone Formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4367)
  AUTHORS   Sugita,Y., Yamamoto,H., Maeda,Y. and Furukawa,T.
  TITLE     Influence of Aging on the Retina and Visual Motion Processing for
            Optokinetic Responses in Mice
  JOURNAL   Front Neurosci 14, 586013 (2020)
   PUBMED   33335469
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4367)
  AUTHORS   Saitoh,Y., Ohno,N., Yamauchi,J., Sakamoto,T. and Terada,N.
  TITLE     Deficiency of a membrane skeletal protein, 4.1G, results in myelin
            abnormalities in the peripheral nervous system
  JOURNAL   Histochem Cell Biol 148 (6), 597-606 (2017)
   PUBMED   28755316
  REMARK    GeneRIF: The 4.1G functions as a signal for proper formation of
            myelin in peripheral nervous system.
REFERENCE   4  (bases 1 to 4367)
  AUTHORS   Kurogi,S., Sekimoto,T., Funamoto,T., Ota,T., Nakamura,S., Nagai,T.,
            Nakahara,M., Yoshinobu,K., Araki,K., Araki,M. and Chosa,E.
  TITLE     Development of an efficient screening system to identify novel bone
            metabolism-related genes using the exchangeable gene trap
            mutagenesis mouse models
  JOURNAL   Sci Rep 7, 40692 (2017)
   PUBMED   28106071
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4367)
  AUTHORS   Chen,L., Wang,T., Wang,Y., Zhang,J., Qi,Y., Weng,H., Kang,Q.,
            Guo,X., Baines,A.J., Mohandas,N. and An,X.
  TITLE     Protein 4.1G Regulates Cell Adhesion, Spreading, and Migration of
            Mouse Embryonic Fibroblasts through the beta1 Integrin Pathway
  JOURNAL   J Biol Chem 291 (5), 2170-2180 (2016)
   PUBMED   26644476
  REMARK    GeneRIF: 4.1G has a role in cell adhesion, spreading, and migration
            in MEF cells by modulating the surface expression of beta1 integrin
            and subsequent downstream signal transduction
REFERENCE   6  (bases 1 to 4367)
  AUTHORS   Kontrogianni-Konstantopoulos,A., Frye,C.S., Benz,E.J. Jr. and
            Huang,S.C.
  TITLE     The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog
            mediate fodrin-actin complex formation
  JOURNAL   J Biol Chem 276 (23), 20679-20687 (2001)
   PUBMED   11274145
REFERENCE   7  (bases 1 to 4367)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   8  (bases 1 to 4367)
  AUTHORS   Peters,L.L., Weier,H.U., Walensky,L.D., Snyder,S.H., Parra,M.,
            Mohandas,N. and Conboy,J.G.
  TITLE     Four paralogous protein 4.1 genes map to distinct chromosomes in
            mouse and human
  JOURNAL   Genomics 54 (2), 348-350 (1998)
   PUBMED   9828140
REFERENCE   9  (bases 1 to 4367)
  AUTHORS   Walensky,L.D., Gascard,P., Fields,M.E., Blackshaw,S., Conboy,J.G.,
            Mohandas,N. and Snyder,S.H.
  TITLE     The 13-kD FK506 binding protein, FKBP13, interacts with a novel
            homologue of the erythrocyte membrane cytoskeletal protein 4.1
  JOURNAL   J Cell Biol 141 (1), 143-153 (1998)
   PUBMED   9531554
REFERENCE   10 (bases 1 to 4367)
  AUTHORS   Takeuchi,K., Kawashima,A., Nagafuchi,A. and Tsukita,S.
  TITLE     Structural diversity of band 4.1 superfamily members
  JOURNAL   J Cell Sci 107 (Pt 7), 1921-1928 (1994)
   PUBMED   7983158
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153550.10, AC156274.8 and AC153547.3.
            
            On Apr 14, 2022 this sequence version replaced XM_006512511.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.39257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC153550.10        30514-30625         c
            113-597             AC156274.8         163957-164441
            598-810             AC156274.8         166126-166338
            811-915             AC153547.3         163522-163626       c
            916-958             AC153547.3         156280-156322       c
            959-1034            AC153547.3         155147-155222       c
            1035-1253           AC153547.3         152781-152999       c
            1254-1341           AC153547.3         151255-151342       c
            1342-1494           AC153547.3         145257-145409       c
            1495-1592           AC153547.3         144653-144750       c
            1593-1765           AC153547.3         140038-140210       c
            1766-1908           AC153547.3         135325-135467       c
            1909-1971           AC153547.3         130789-130851       c
            1972-2118           AC153547.3         128827-128973       c
            2119-2172           AC153547.3         122787-122840       c
            2173-2736           AC153547.3         122031-122594       c
            2737-2859           AC153547.3         120159-120281       c
            2860-2958           AC153547.3         118145-118243       c
            2959-3039           AC153547.3         116561-116641       c
            3040-3148           AC153547.3         111337-111445       c
            3149-4367           AC153547.3         100903-102121       c
FEATURES             Location/Qualifiers
     source          1..4367
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 12.26 cM"
     gene            1..4367
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /note="erythrocyte membrane protein band 4.1 like 2"
                     /db_xref="GeneID:13822"
                     /db_xref="MGI:MGI:103009"
     exon            1..112
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            113..597
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..3147
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /note="isoform 6 is encoded by transcript variant 7;
                     generally expressed protein 4.1; band 4.1-like protein 2;
                     erythrocyte membrane protein band 4.1-like 2 retinal;
                     erythrocyte protein band 4.1l2 long; erythrocyte protein
                     band 4.1l2 middle; erythrocyte protein band 4.1 like 2"
                     /codon_start=1
                     /product="band 4.1-like protein 2 isoform 6"
                     /protein_id="NP_001391726.1"
                     /db_xref="GeneID:13822"
                     /db_xref="MGI:MGI:103009"
                     /translation="MTTEVGSASEVKKGSDQAGADASKEKAKEVENEQTPVSEPEEEK
                     GSQPGPPVERQSTPRLRKRGKDPSENRGISRFIPPWLKKQRSYNLVVAKDGGDKKEPT
                     QADVEDQILGKEESLPEEESRAKGDAEEMAQRKHLEVQVEVREAKPALKSSVETQPAE
                     EVRKDKEETIQDTQEEKLEGGAAKRETKEVQTSELKAEVASQKATKKTKTVLAKVTLL
                     DGTEYSCDLEKRAKGQVLFDRVCEHLNLLEKDYFGLLFQDHPEQKNWLDPAKEIKRQL
                     KNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTL
                     QAEHGDYDPEEYDSIDLGDFQFAPAHTKELEEKVSELHKTHRGLSPAQADSQFLENAK
                     RLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYI
                     KVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKTKFLTLGSKF
                     RYSGRTQAQTREASTLIDRPAPQFERASSKRVSRSLDGAPIGVVDQSPPGEGSVPGPG
                     VISYTTIQDGRRDSKSPTKATPLPAEGKKNTLRVDGDNIYVRHSNLMLEDLDKAQEAI
                     LKHQASISELKRNFMASTPEPRPSEWEKRRVTPLPFQPQATRPPTSEGPCTGPRDAVK
                     SSHETLNVVEEKKRAEVGKDESVITEEMNGKEMSPGHGPGETRKVEPVAHKDSTSLSS
                     ESSSSSSESEEDVGEYQPHHRVTEGTIREEQEECDEELEEEPGQGAKVVEREAAVPDA
                     VPDRQAGASVLPVETEAQEHVVAQKLPGEKGAHGGTAEQDPREEAEEDPHRVNGEVPH
                     LDLDGLPEIICCSEPPVVKTEMVTISDASQRTEISTKEVPIVQTETKTITYESPQIDG
                     GAGGDSGVLLTAQTITSESASTTTTTHITKTVKGGISETRIEKRIVITGDAALDHDQA
                     LAQAIREAREQHPDMSVTRVVVHKETELAEEGEE"
     exon            598..810
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            811..915
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            916..958
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1034
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1253
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1341
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1494
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1592
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1765
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1908
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..1971
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2118
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2172
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2736
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2859
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..2958
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3039
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3148
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3149..4367
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4347..4352
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /note="hexamer: AATAAA"
     polyA_site      4367
                     /gene="Epb41l2"
                     /gene_synonym="4.1G; D10Ertd398e; Epb4.1l2; NBL2"
                     /note="major polyA site"
ORIGIN      
        1 aatttgaaac ccagaggagg gtggaggcgg cgggtgcgga gggccggcgg cgtccgaggc
       61 tggaacggga cgcgttcccg gggcgagcaa gctcgagagg ggcggtgtcc ggtgtaagcg
      121 gtaaccatga ctactgaagt tggctctgca tctgaagtga agaagggctc tgaccaggct
      181 ggagcagatg cctccaagga gaaagctaaa gaagtagaaa atgagcagac tccagtatct
      241 gagccagagg aagaaaaggg ttcccagcca ggtcctccgg ttgagaggca aagcactccc
      301 cgcctgcgga aacgagggaa ggatccgtct gagaacaggg gcatctctcg attcataccc
      361 ccgtggctta agaagcagag gtcttacaat ttagtagtag ccaaagatgg aggagataaa
      421 aaagagccta ctcaagctga cgtggaagac cagatcttag gcaaagagga atcccttcct
      481 gaagaagaga gtcgggccaa gggtgacgca gaagaaatgg ctcagaggaa gcacctggag
      541 gttcaggtgg aggtcaggga agcaaaacca gccttgaaaa gcagcgtgga gacccagcct
      601 gctgaagaag tgaggaagga caaggaggaa acgatacaag acacacagga agagaaactg
      661 gaaggaggtg cagccaaaag ggagacaaag gaagtacaga caagtgagct gaaggcagag
      721 gtggcctctc agaaagctac caagaagacc aagactgtcc tggccaaagt gacccttcta
      781 gatggcacgg aatacagctg tgaccttgag aaacgtgcca agggacaagt gttgtttgac
      841 cgagtgtgcg agcacctgaa cctcttggag aaggactact ttggacttct atttcaggat
      901 catcctgagc agaaaaactg gctagatcct gcaaaggaaa taaagagaca gctgaaaaat
      961 cttccctggc tgttcacttt caatgtgaaa ttttatcctc cagatccttc tcagctgact
     1021 gaagatatca ccagatactt cttgtgcctt cagctaaggc aggacatcgc ctctggccgc
     1081 ctgccctgct cctttgtgac tcacgccctc ttgggatcct acaccttgca ggccgagcat
     1141 ggggactatg acccagaaga atatgacagt attgatcttg gtgacttcca gtttgccccg
     1201 gcccacacca aggagttgga ggaaaaggtg tcagaactgc ataaaactca caggggctta
     1261 tctccagcac aagccgactc tcagttctta gagaacgcaa agaggctttc catgtacggt
     1321 gttgacctgc accatgccaa ggactctgaa ggtgtggaca tcaagctggg tgtgtgtgcc
     1381 aatggccttc tcatttacaa agacagacta aggatcaatc gttttgcttg gccgaagatt
     1441 ttgaaaattt cctataagcg cagtaatttc tacattaaag ttagaccagc agagctggaa
     1501 cagtttgaga gtaccattgg attcaaattg ccaaaccacc gggcagctaa acggctatgg
     1561 aaggtgtgtg tggaacatca cactttctac aggcttgtgt ctccagagca gccaccaaag
     1621 accaagttct tgaccctggg gtccaaattc cgctacagcg gccgcacgca ggcacagacc
     1681 agagaagcaa gtaccctcat agacaggccg gcaccacaat ttgagcgtgc ctctagtaaa
     1741 cgtgtctcga ggagcctaga cggagccccg attggtgttg tggaccaaag ccctcctgga
     1801 gagggctcag tgcctggccc tggagttatc agctatacta ccatccagga tggccggagg
     1861 gacagcaaaa gcccaacaaa agctacaccc ctgcccgctg agggaaagaa aaataccttg
     1921 agagtagacg gggataatat ttatgtcaga catagcaatt taatgttgga ggacctggat
     1981 aaggcccagg aggccattct gaaacatcag gctagcatta gtgaactcaa gcgcaatttc
     2041 atggcgtcca cacctgagcc tcgccccagt gaatgggaga agcggcgggt cacacctctg
     2101 cctttccaac cacaagcgac tcgtcctccc acgtcggaag ggccttgcac tggacccagg
     2161 gacgctgtta agagttcaca tgagactctg aatgtagtgg aggagaagaa gcgggcagag
     2221 gttgggaaag acgaaagcgt aatcacagaa gaaatgaatg gtaaagagat gtcaccgggg
     2281 catggtcctg gggagactcg taaggtggag cctgtggcac acaaagactc cacctccctg
     2341 tcttctgaga gcagcagcag cagcagtgag agtgaggagg acgtgggaga gtaccagccc
     2401 caccaccgag tgaccgaggg caccataagg gaagagcagg aggagtgtga tgaagagctg
     2461 gaggaagagc ccggccaagg agccaaggta gtagagaggg aggcagcagt gcccgacgcc
     2521 gtcccagaca gacaagcagg ggccagtgtg ctcccagtag aaacagaggc ccaggaacat
     2581 gtagttgccc aaaagttacc tggagaaaag ggtgcacacg gaggcactgc tgagcaggac
     2641 ccgagagaag aagcagagga agacccgcac agagttaatg gagaggtgcc ccatcttgac
     2701 cttgatggtt tgccagagat tatttgttgt tcagagccac cagtggtaaa aacagagatg
     2761 gtaacaattt ctgatgcctc acaaaggaca gaaatctcca ccaaggaagt ccccattgtt
     2821 caaactgaga ccaaaaccat cacatatgag tctccacaga ttgacggcgg ggctggtggt
     2881 gattcgggcg tgttactgac cgcacaaacc atcacatctg agtccgcgtc aacaacgaca
     2941 accacacaca tcaccaagac tgtgaaaggt gggatctctg aaacacgaat tgagaaacgc
     3001 attgtgatca caggagacgc agctctggat catgatcagg cgctggctca ggccatacgg
     3061 gaagcgagag agcagcaccc tgatatgtcg gtcacaaggg tggtagtgca caaagaaaca
     3121 gagttggcgg aggaaggaga agaataagaa agtctttttt aaacaacatt taacttcatg
     3181 aatctgaaga actttgacca ttccaagtct taacgccgta ccactactcc agcaaaactg
     3241 tgctccgact ggtaacagtg accagaagcc tgaagaatta aaatgccaac agcaaaccat
     3301 accttaacag ctctggtctc tactattccc atacacttct aatatattgt ttgttatata
     3361 accacttcta gacaccctgc tcccctgttc tttctttccc tacctttttt taattctttg
     3421 ttttttatta gggtttgtgt ttgtttcctt tccctacctg cttttttgac tcatttgctc
     3481 aaatgacagt gaacaaagcc agccgggctg gtaaggcgct gttcacctga acaggtgctg
     3541 ttatgtggaa aggaaactcg tgactaattt agatagcaat tttcattctt caagattgtc
     3601 tccattcaac tcttacagtc aatatttaca gctttcagac tgcagtaggg atactgcatg
     3661 agaacatatt aataccaatt aaaagcattt tttacatctt gaaatttttc taatattagg
     3721 gaatttcact acggatgatt tttatataga tctttgacct tccagtcctt tgactttgta
     3781 cttcagtaga gtcagacaga gactctctgg actggagaat taagaagctc actgaccagg
     3841 tactgtgttg agagaccctc ggcccacagt gcagtacttc tcagacatgc gctttgccac
     3901 agcattccag aacaggagga gaaccacacc gtgtgccctt cccttttact aagagaaaac
     3961 caggcagctt ccagccttag agatttcttt cttaaccttc ccagttccag ttcttcccac
     4021 tgtctgaaca cttgctttgt atgaaacttg tctgtctcca tgtacacgga ccctttgcta
     4081 ctgagcaggt aatctctgac atagtttgat gacttgcagc tttgaagaca ctgggaagaa
     4141 gaggttgggg acagtcggtc gggggtttgg ttggttgtaa gaagccatac catgtaaaac
     4201 taacatcaga gaagctgata ggagtttaac tgtattgaac attcttctca tttgcttttg
     4261 actctatgta tagttatgac ggcagattag atttatgtca gcttcaagtt gtattaaata
     4321 ttttgcttta tgtaatactg ttataaaata aaagtttgtt tattcta
//
