LOCUS       NM_177821               8749 bp    mRNA    linear   ROD 30-OCT-2023
DEFINITION  Mus musculus E1A binding protein p300 (Ep300), mRNA.
ACCESSION   NM_177821 XM_484488
VERSION     NM_177821.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8749)
  AUTHORS   Liu J, Meng F, Wang W, Wu M, Zhang Y, Cui M, Qiu C, Hu F, Zhao D,
            Wang D, Liu C, Liu D, Xu Z, Wang Y, Li W and Li C.
  TITLE     Medial prefrontal cortical PPM1F alters depression-related
            behaviors by modifying p300 activity via the AMPK signaling pathway
  JOURNAL   CNS Neurosci Ther 29 (11), 3624-3643 (2023)
   PUBMED   37309288
  REMARK    GeneRIF: Medial prefrontal cortical PPM1F alters depression-related
            behaviors by modifying p300 activity via the AMPK signaling
            pathway.
REFERENCE   2  (bases 1 to 8749)
  AUTHORS   Lee SY, Park SY, Lee SH, Kim H, Kwon JH, Yoo JY, Kim K, Park MS,
            Lee CG, Elias JA, Sohn MH, Shim HS and Yoon HG.
  TITLE     The deubiquitinase UCHL3 mediates p300-dependent chemokine
            signaling in alveolar type II cells to promote pulmonary fibrosis
  JOURNAL   Exp Mol Med 55 (8), 1795-1805 (2023)
   PUBMED   37524875
  REMARK    GeneRIF: The deubiquitinase UCHL3 mediates p300-dependent chemokine
            signaling in alveolar type II cells to promote pulmonary fibrosis.
REFERENCE   3  (bases 1 to 8749)
  AUTHORS   Zhou P, VanDusen NJ, Zhang Y, Cao Y, Sethi I, Hu R, Zhang S, Wang
            G, Ye L, Mazumdar N, Chen J, Zhang X, Guo Y, Li B, Ma Q, Lee JY, Gu
            W, Yuan GC, Ren B, Chen K and Pu WT.
  TITLE     Dynamic changes in P300 enhancers and enhancer-promoter contacts
            control mouse cardiomyocyte maturation
  JOURNAL   Dev Cell 58 (10), 898-914 (2023)
   PUBMED   37071996
  REMARK    GeneRIF: Dynamic changes in P300 enhancers and enhancer-promoter
            contacts control mouse cardiomyocyte maturation.
REFERENCE   4  (bases 1 to 8749)
  AUTHORS   de Thonel A, Ahlskog JK, Daupin K, Dubreuil V, Berthelet J, Chaput
            C, Pires G, Leonetti C, Abane R, Barris LC, Leray I, Aalto AL,
            Naceri S, Cordonnier M, Benasolo C, Sanial M, Duchateau A,
            Vihervaara A, Puustinen MC, Miozzo F, Fergelot P, Lebigot E,
            Verloes A, Gressens P, Lacombe D, Gobbo J, Garrido C, Westerheide
            SD, David L, Petitjean M, Taboureau O, Rodrigues-Lima F, Passemard
            S, Saberan-Djoneidi D, Nguyen L, Lancaster M, Sistonen L and Mezger
            V.
  TITLE     CBP-HSF2 structural and functional interplay in Rubinstein-Taybi
            neurodevelopmental disorder
  JOURNAL   Nat Commun 13 (1), 7002 (2022)
   PUBMED   36385105
  REMARK    Erratum:[Nat Commun. 2023 Sep 28;14(1):6067. PMID: 37770591]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8749)
  AUTHORS   Lv W, Jiang W, Luo H, Tong Q, Niu X, Liu X, Miao Y, Wang J, Guo Y,
            Li J, Zhan X, Hou Y, Peng Y, Wang J, Zhao S, Xu Z and Zuo B.
  TITLE     Long noncoding RNA lncMREF promotes myogenic differentiation and
            muscle regeneration by interacting with the Smarca5/p300 complex
  JOURNAL   Nucleic Acids Res 50 (18), 10733-10755 (2022)
   PUBMED   36200826
REFERENCE   6  (bases 1 to 8749)
  AUTHORS   Mutoh H, Naya FJ, Tsai MJ and Leiter AB.
  TITLE     The basic helix-loop-helix protein BETA2 interacts with p300 to
            coordinate differentiation of secretin-expressing enteroendocrine
            cells
  JOURNAL   Genes Dev 12 (6), 820-830 (1998)
   PUBMED   9512516
REFERENCE   7  (bases 1 to 8749)
  AUTHORS   Lill NL, Grossman SR, Ginsberg D, DeCaprio J and Livingston DM.
  TITLE     Binding and modulation of p53 by p300/CBP coactivators
  JOURNAL   Nature 387 (6635), 823-827 (1997)
   PUBMED   9194565
REFERENCE   8  (bases 1 to 8749)
  AUTHORS   Yao TP, Ku G, Zhou N, Scully R and Livingston DM.
  TITLE     The nuclear hormone receptor coactivator SRC-1 is a specific target
            of p300
  JOURNAL   Proc Natl Acad Sci U S A 93 (20), 10626-10631 (1996)
   PUBMED   8855229
REFERENCE   9  (bases 1 to 8749)
  AUTHORS   Arany,Z., Sellers,W.R., Livingston,D.M. and Eckner,R.
  TITLE     E1A-associated p300 and CREB-associated CBP belong to a conserved
            family of coactivators
  JOURNAL   Cell 77 (6), 799-800 (1994)
   PUBMED   8004670
REFERENCE   10 (bases 1 to 8749)
  AUTHORS   Missero C, Serra C, Stenn K and Dotto GP.
  TITLE     Skin-specific expression of a truncated E1a oncoprotein binding to
            p105-Rb leads to abnormal hair follicle maturation without
            increased epidermal proliferation
  JOURNAL   J Cell Biol 121 (5), 1109-1120 (1993)
   PUBMED   7684738
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY076076.1, AK042627.1, AK139715.1, CN535246.1, CD348567.1,
            BU701221.1 and AC102262.10.
            
            [WARNING] On Jan 9, 2024 this sequence was replaced by NM_177821.7.
            
            On Jan 19, 2007 this sequence version replaced NM_177821.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144976.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                BY076076.1         2-78
            78-2549             AK042627.1         74-2545
            2550-3673           AK139715.1         1043-2166
            3674-4218           CN535246.1         192-736
            4219-4864           CD348567.1         12-657
            4865-5499           BU701221.1         73-707
            5500-8749           AC102262.10        110990-114239
FEATURES             Location/Qualifiers
     source          1..8749
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.16 cM"
     gene            1..8749
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /note="E1A binding protein p300"
                     /db_xref="GeneID:328572"
                     /db_xref="MGI:MGI:1276116"
     exon            1..509
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            510..1147
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1324
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1586
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1700
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1946
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2040
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2178
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2296
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2471
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2549
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2659
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2797
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..3229
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3409
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..3554
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            3555..3673
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            3674..3913
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            3914..4002
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            4003..4083
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            4084..4140
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            4141..4218
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            4219..4286
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            4287..4437
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            4438..4584
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            4585..4698
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            4699..4864
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            4865..5029
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            5030..5191
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            5192..5473
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
     exon            5474..8749
                     /gene="Ep300"
                     /gene_synonym="A430090G16; A730011L11; KAT3B; p300; p300
                     HAT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaggaggag gacagcgccg aggaggaaga agctgatggc ggcggcggag ctccgagaga
       61 cctcggctgg gcaggggctc gccgtggcgg gctggggact gcgtctgtag agctgtgagt
      121 tcccgagaat tcgctgcagc ggacgtgctc gtgggatcag tgttgctgta ccctcctccc
      181 ggcctggttt aggcccggcc cctcgcactt gcccctacca tttctgttga gtccgcatcc
      241 ctctccggcc accgcaacca ggcgaagaga aaaaggaact tccccccacc cctgttgggt
      301 ggcggcggag ctccggagcc cacccttagg agcggggcgg ggaccccgtt tcggagaaga
      361 gatttcctca ggattctcgt ttttttcctc ggttgtatct ccgaaagaat taaaaatggc
      421 cgagaatgtg gtggaacccg ggccgccttc agccaagcgg cctaaactct catctccggc
      481 cctctcggcg tccgccagcg atggcacaga ttttggttca ctgtttgacc tggaacatga
      541 cttaccagat gaattaatca actctacaga attgggacta accaatggtg gcgatatcag
      601 tcagcttcag acaagtcttg gcatagtaca agatgcagcc tcgaaacata aacagctgtc
      661 agaactgctg aggtctggta gctccccaaa cctcaacatg ggagtcggtg gcccaggcca
      721 agcgatggcc agccaggccc aacagaacag ccctggatta agtttgataa atagcatggt
      781 caaaagccca atggcacaga caggcttgac ttctccaaac atggggattg gcagtagtgg
      841 accaaatcag ggtcctactc agtccccagc aggtatgatg aacagtccag tgaaccagcc
      901 tgccatggga atgaacacag ggatgaatgc tggcatgaat cctggaatgt tggctgcagg
      961 caatggacaa gggataatgc ccaatcaagt catgaacggt tccattggag caggccgggg
     1021 acggccaaac atgcagtacc caaatgcagg catgggcaat gctggcagtt tattgactga
     1081 gccactacag cagggctctc ctcagatggg aggacagcca ggattgagag gcccccaacc
     1141 acttaagatg ggaatgatga acaatcccag tccttatggt tcaccataca ctcagaattc
     1201 tggacagcag attggagcaa gtggccttgg tctccaaatt cagacaaaga ctgttctacc
     1261 aaataactta tctccatttg caatggacaa aaaggcagtt cctggtgggg gaatgcccag
     1321 tatgggccag cagcctaccc catcggtcca gcagccaggc ctggtgactc cagttgccgc
     1381 aggaatgggt tctggagcac acacagctga tccagagaag cgcaagctca tccagcagca
     1441 gcttgttctc cttttacatg ctcacaagtg ccagcgccgg gagcaagcta atggggaagt
     1501 gaggcagtgc aaccttcctc actgtcgtac catgaaaaat gtcctaaacc atatgacaca
     1561 ttgccagtca ggcaaatcct gccaagtggc acattgtgca tcttctcgac aaatcatttc
     1621 acactggaaa aattgcacaa ggcatgattg tcctgtgtgt cttcctctca aaaatgctgg
     1681 ggataagcga aatcaacagt caattttgac tggagcacca gttgggcttg gaaaccctag
     1741 ctctctagga gtggggcagc agtccactcc tagcctaagc actgttagtc agattgaccc
     1801 cagctctata gagcgagctt acgctgctct tggactaccc tatcaagtaa accagattcc
     1861 accacaaccc caggtacaag caaagaatca acaaagccag ccatctggac agtctcccca
     1921 gggcatgcgg tctgtgaaca acatgagtgc tagtcctatg ggtgtaaatg gaggtgttgg
     1981 ggttcagacg ccaaatcttc tttctgactc catgttgcat tcaactataa attctcaaaa
     2041 cccaatgatg agtgaaaatg ctggtgtggc ctccctgggt cctttgccaa cagcagctca
     2101 gccatctagt actggaattc gaaaacagtg gcatgaagat attactcagg atcttcgaaa
     2161 ccaccttgtt cataaacttg ttcaagccat atttcccact ccggatcctg ctgctttaaa
     2221 agaccgacgg atggaaaatc ttgttgcata tgctcgtaaa gtggaagggg acatgtatga
     2281 atctgcaaac aatagagcgg aatactatca cctcctagcc gagaagatct ataagatcca
     2341 gaaggaacta gaagagaaac gaaggactag actacagaaa cagaacatgc taccgaatgc
     2401 tcctggcatg ggtccagttc ctatgaatac tgggtcgaac atggggcagc aaccaacagg
     2461 aatgactacc aatggtcctg tacctgaccc gtctatgatc cgtggcagtg tgccgaacca
     2521 catgatgcct cggatgactc cacagcctgg tttgaatcaa tttgggcaga tgaatatgcc
     2581 acagccccct attggacccc ggcaaccctc tcctcttcag caccatggac aattggctca
     2641 gtctgggtca ctcaatccgc ctatgggcta tggacctcgc atgcagcagg cttccggcca
     2701 gaaccagttc ctctcccaga ctcagttcac atcccaagga atgaatgtaa caaacatgcc
     2761 tttggctcca tccagcggtc aagcaccagt gtctcaagca caaatgtcca gttcttcttg
     2821 cccagtgaac tctcctataa tgcctccagg gtctcaaggg agccacattc actgtcctac
     2881 tctgcctcaa caagctcatc agaattcacc ttctcctgtt cctagccgca cccctactcc
     2941 tcatcatacc cccccaagca tagggaatca accaccacca gcaacagcaa ttccaacacc
     3001 tgttcctaca cctcctgcca taccacctgg accacagccc ccatctctgc atccctcatc
     3061 tagacaaaca cctacaccac caacacatct gcctccccaa gtgcagcctt cacttcctgc
     3121 tgctccttct gctgaccagt cccagcaaca gcctcggtca cagcagagca cagcagtttc
     3181 tgttcctacc ccaacagcac cattgctgcc tcctcagcct tccactccgc tttctcagcc
     3241 agctgtgagc attgaaggcc aggtctcaaa ccctccatct actagtagca ccgaagtgaa
     3301 ttctcagacc attcctgaga agcagccttc acaggaagtg aaaatggagt ctaaaatgga
     3361 ggtggataag ccagaaccag cagatgctca acctgaggat acaaaggagg ctaaaggtga
     3421 ggatgttaaa gtagaaccta cagaaatgga ggagagaggc cctgagttaa aaactgatgg
     3481 gaaagaggag gaagaacagc caagcacctc tgctacccag tcctccccag ctcctggaca
     3541 gtcaaagaag aagattttca aaccagagga attacgacag gctctgatgc caacattgga
     3601 ggcactttac cggcaggacc cagaatctct tccctttcgt cagcctgtgg acccgcagct
     3661 tctaggaatc cctgattact ttgatattgt gaagagcccc atggatcttt ctacaatcaa
     3721 gaggaagtta gatactggac aataccaaga gccctggcaa tatatagatg atatttggct
     3781 tatgttcaac aatgcctggt tatataaccg taaaacttca agggtataca aatattgctc
     3841 taaactttct gaagtatttg aacaagaaat tgaccctgtc atgcaaagcc ttggatactg
     3901 ttgtggcaga aagttggagt tttctccaca gactctttgt tgctatggga aacagttatg
     3961 cacaatcccc cgtgatgcta cttactacag ttaccagaac aggtatcatt tctgtgagaa
     4021 gtgtttcaat gaaatccaag gggagagcgt ttctttgggt gatgaccctt cccaacctca
     4081 aactacaata aataaagaac agttttccaa gagaaaaaat gacacgttgg atcctgaact
     4141 gtttgttgag tgcacagagt gtggaagaaa gatgcaccag atctgtgtcc ttcaccacga
     4201 gatcatctgg ccatctgggt ttgtctgtga tggctgttta aagaaaactg cacgaactag
     4261 gaaagaaaat aagctttctg ctaaaagatt gccatctacc agacttggga cctttctgga
     4321 gaatcgagtg aatgactttc tgaggcgaca aaatcaccct gaatcaggag aggtcactgt
     4381 tcgggttgtt catgcttctg acaaaactgt ggaagtgaaa ccaggcatga aagcaaggtt
     4441 tgtagatagt ggagagatgg cagaatcttt tccataccga acaaaggccc tgtttgcctt
     4501 tgaagaaatt gatggtgttg acttgtgttt cttcggcatg catgttcaag aatatggctc
     4561 tgactgcccc cctcccaacc agaggagggt atacatatct tacctcgata gtgttcattt
     4621 cttccgtcct aaatgcttgc ggactgcagt ctatcatgaa attctaattg gatatttgga
     4681 atatgtcaag aaattaggat acacaacagg gcacatctgg gcctgtccac ccagtgaagg
     4741 ggatgactat atcttccatt gccatccacc tgatcagaag ataccaaagc ccaagcgcct
     4801 gcaagaatgg tacaaaaaga tgcttgacaa ggctgtatca gaacgtattg tccatgacta
     4861 caaggatatt ttaaaacaag ctactgaaga tcgattaaca agtgcaaagg aactacccta
     4921 ctttgaaggt gatttctggc ccaatgttct agaagaaagc atcaaggagc ttgaacagga
     4981 agaggaagag aggaaacggg aagagaacac cagcaacgag agtactgatg taacaaaagg
     5041 agacagcaaa aatgctaaga agaagaataa caagaaaacc agcaaaaaca agagcagcct
     5101 gagtaggggc aataagaaga agcctggtat gcccaatgtg tctaatgacc tttctcagaa
     5161 actgtatgcc accatggaaa agcataaaga ggttttcttt gtgatccgcc tcatcgcttg
     5221 tcctgctccc aattccctgc ctcccattgt tgatcctgac cctctcatcc cctgtgacct
     5281 gatggacggt agagatgcat ttctcaccct tgcaagggac aagcacctgg agttctcttc
     5341 acttcgaaga gcccagtggt ctaccatgtg catgctggtg gagctccata cacagagtca
     5401 ggatcgcttt gtctacacct gcaacgagtg caagcaccac gtggagacac gctggcattg
     5461 cactgtgtgt gaggattatg acctgtgcat cacttgttat aacactaaaa atcatgacca
     5521 caaaatggag aaactaggcc ttggcttaga tgatgagagc aataaccagc aagctgcagc
     5581 tacacagagc ccaggagact cccgccgcct gagcatccaa cgctgcatcc agtctctggt
     5641 gcatgcctgt cagtgccgca acgccaactg ctccctgcct tcctgccaga agatgaagag
     5701 ggttgtgcag cacaccaaag gctgcaaacg gaaaaccaat ggtgggtgcc ccatttgcaa
     5761 acagcttatt gccctctgct gctatcatgc caagcactgc caggagaaca agtgcccggt
     5821 gccattttgc ctcaacatca agcaaaagct ccggcagcaa cagctgcagc accggctcca
     5881 acaggctcag atgctccgta ggaggatggc cagcatgcaa cgaactggtg tggcggggca
     5941 gcagcagggc ctgccgtccc caactcctgc tacaccaact acccctactg gccaacagcc
     6001 agccacccca cagacacccc agccccaacc cacctctcaa ccacagccca ctcctcccaa
     6061 caacatgaca ccctacttac ccaggactca gactactggc cctgtgtccc agggtaaggc
     6121 accaggccag gtgaccccac ctaccccacc tcagactgct caggcccccc ttccagggcc
     6181 tccacctgca gcagtagaaa tggcaatgca aattcagagg gcagcagaga cacagcgcca
     6241 gatggcccat gtacagattt tccaaaggcc aatccagcac cagatgcccc agatgtcacc
     6301 catggcccct atgggcatga acccacctcc tatggccaga ggtcctggtg ggcatttgga
     6361 tccaggaata ggtccagcag gaatgcagca acagccacct tgggcccaag gaggaatgcc
     6421 tcagccccag cagatgcagt cagggatgcc aaggccagcc atgatgtcag tggcccagca
     6481 tggtcagcct ttaaacatgg ctccacaacc aggattgggc caagtgggtg tgagccctct
     6541 caagccaggc actgtgtctc aacaagcctt acaaaacctt ttgcggactc tcaggtctcc
     6601 cagttctccc ttacagcagc aacaggtgct tagtatcctt catgccaacc cccaactgtt
     6661 ggctgcattc atcaagcagc gggctgccaa gtatgccaac cctaatccac agcctctccc
     6721 tggacagcct ggcatgaccc agggacagcc agggctgcag ccacctacca tgcctggcca
     6781 gcaaggtgtc cactccaacc cagccttgca gaacatgaat cctctgcagg caggtgtcca
     6841 gagagctggc ctgccccagc agcagccgca gcagcagctc cagccaccca tgggagcaat
     6901 gagtccccaa gctcagcaaa tgaacatgaa tcacaatacc atgccttcac agttcagaga
     6961 catcttaaga cggcagatga tgcaacagca gggagcaggg ccaggaatcg gccctggaat
     7021 ggccaaccag ttccagcagc cccaaggaat tggctatcca ccgcagcagc agcagcagca
     7081 gcgaatgcag catcacatgc agcaaatgca gcaaggaaat atgggacaaa tgggtcagct
     7141 tccccaggct ctgggggctg aggcaggagc cagtctacag gcctatcagc agcgacttct
     7201 tcaacaacag atggggtctc ctgctcagcc caaccctatg agcccacagc agcacatgct
     7261 cccaaatcag gcacagtccc cacacctaca aggtcaacaa atccctaatt ctctctccaa
     7321 tcaagtgcgc tctccccagc ctgtcccttc tcctcgacca cagtctcagc ccccccattc
     7381 cagcccatct ccgaggatgc agcctcagcc ttctccacac catgtttctc cacagaccag
     7441 ttccccacat cctggactgg tagctgccca ggctgccaac cctatggaac aagggcattt
     7501 tgccagccca gaccagaatt caatgctttc acagctcgct agcaatcctg gcatggcaaa
     7561 cctccacggg gcaagtgcca cggacctggg actgagcagc gataatgcag acttgaattc
     7621 aaacctctca cagagtacac tagacataca ctagagacac cttgtagtat tttggaagca
     7681 aaagattatt ttctcttaac aagacttttt gtactgaaaa caattttttt gaatctttct
     7741 tagcctaaaa gacccatttt ccttggaaca tgtaagaact gtgcagtagc catttatggt
     7801 ttaaagtaaa caggccagat gaacctgagg gataatagat tacaaagaat atatttttgt
     7861 tatggctggt taccccagct ctttttcccc ttgtgtgtgt ggttcaagtg tgcactggga
     7921 ggcaactgag gtctgaagcc aaccatatgc tcctgccttg ccgataggtt ttattatttt
     7981 ttttaaatta atgaaaatat gtaatattaa tagttattat ttactggtgc agatggttga
     8041 catttttccc tattttcctc actttatgaa agaatttaaa taaaaaaaaa gaacatttct
     8101 aaaaccagag gacaaaaggg gttaatgtta cgtaaaatta cattatatat atatatatat
     8161 ataaatatat ataaatatat taaaatacca atttttttct ctgggtgcaa agatgttcat
     8221 tcttttaaaa acatttaaaa aataaaataa aaagcctcct ctttccatcc ctcaagtcaa
     8281 cttttgtgct ccagaaaatt ttctattctg taagtctaag ggtaaaactt caagtattaa
     8341 gataatttgt acatgtagag aaaaaaatga ctttttcata atatacaggg gcagctgcca
     8401 aattgatgta ttataatatt gtggtttctg tttcttgaga aaaatttttt gttattttta
     8461 catctaacag aggaaaaaaa atttaaaaag agggtaagaa atgactccag tggggtgatt
     8521 ttaacatgca aatgtctgag atttcttcac ttgctttctt ccttactctg ccccacacac
     8581 gtacactttc tgtaaaactt gaaaatagaa agcaaaaacc ctcaactgtt gtaaatcatg
     8641 caattaaggt tgattactta taaatatgaa ctttggatca ctgtatagac tgttaaattt
     8701 gatttcttat tacctattgt taaataaact gtgtgagaca gacacctga
//
