LOCUS       NM_010136               3689 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus eomesodermin (Eomes), transcript variant 1, mRNA.
ACCESSION   NM_010136 XM_135209
VERSION     NM_010136.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3689)
  AUTHORS   Lee,A.S., Arefin,T.M., Gubanova,A., Stephen,D.N., Liu,Y., Lao,Z.,
            Krishnamurthy,A., De Marco Garcia,N.V., Heck,D.H., Zhang,J.,
            Rajadhyaksha,A.M. and Joyner,A.L.
  TITLE     Cerebellar output neurons can impair non-motor behaviors by
            altering development of extracerebellar connectivity
  JOURNAL   Nat Commun 16 (1), 1858 (2025)
   PUBMED   39984491
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3689)
  AUTHORS   Serdar,L.D., Egol,J.R., Lackford,B., Bennett,B.D., Hu,G. and
            Silver,D.L.
  TITLE     mRNA stability fine-tunes gene expression in the developing cortex
            to control neurogenesis
  JOURNAL   PLoS Biol 23 (2), e3003031 (2025)
   PUBMED   39913536
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3689)
  AUTHORS   Clemot-Dupont,S., Lourenco Fernandes,J.A., Larrigan,S., Sun,X.,
            Medisetti,S., Stanley,R., El Hankouri,Z., Joshi,S.V.,
            Picketts,D.J., Shekhar,K. and Mattar,P.
  TITLE     The chromatin remodeler ADNP regulates neurodevelopmental disorder
            risk genes and neocortical neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 122 (3), e2405981122 (2025)
   PUBMED   39808658
REFERENCE   4  (bases 1 to 3689)
  AUTHORS   Gabriel,G.C., Yagi,H., Tan,T., Bais,A., Glennon,B.J.,
            Stapleton,M.C., Huang,L., Reynolds,W.T., Shaffer,M.G.,
            Ganapathiraju,M., Simon,D., Panigrahy,A., Wu,Y.L. and Lo,C.W.
  TITLE     Mitotic block and epigenetic repression underlie neurodevelopmental
            defects and neurobehavioral deficits in congenital heart disease
  JOURNAL   Nat Commun 16 (1), 469 (2025)
   PUBMED   39774941
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3689)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3689)
  AUTHORS   Kimura,N., Nakashima,K., Ueno,M., Kiyama,H. and Taga,T.
  TITLE     A novel mammalian T-box-containing gene, Tbr2, expressed in mouse
            developing brain
  JOURNAL   Brain Res Dev Brain Res 115 (2), 183-193 (1999)
   PUBMED   10407135
REFERENCE   7  (bases 1 to 3689)
  AUTHORS   Hancock,S.N., Agulnik,S.I., Silver,L.M. and Papaioannou,V.E.
  TITLE     Mapping and expression analysis of the mouse ortholog of Xenopus
            Eomesodermin
  JOURNAL   Mech Dev 81 (1-2), 205-208 (1999)
   PUBMED   10330501
REFERENCE   8  (bases 1 to 3689)
  AUTHORS   Ciruna,B.G. and Rossant,J.
  TITLE     Expression of the T-box gene Eomesodermin during early mouse
            development
  JOURNAL   Mech Dev 81 (1-2), 199-203 (1999)
   PUBMED   10330500
REFERENCE   9  (bases 1 to 3689)
  AUTHORS   Wattler,S., Russ,A., Evans,M. and Nehls,M.
  TITLE     A combined analysis of genomic and primary protein structure
            defines the phylogenetic relationship of new members if the T-box
            family
  JOURNAL   Genomics 48 (1), 24-33 (1998)
   PUBMED   9503012
REFERENCE   10 (bases 1 to 3689)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC173340.1.
            
            On Aug 22, 2022 this sequence version replaced NM_010136.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094319.1, AK089817.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1356              AC173340.1         96185-97540
            1357-1511           AC173340.1         98461-98615
            1512-1633           AC173340.1         99259-99380
            1634-1792           AC173340.1         99983-100141
            1793-1854           AC173340.1         100227-100288
            1855-3689           AC173340.1         102268-104102
FEATURES             Location/Qualifiers
     source          1..3689
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 70.21 cM"
     gene            1..3689
                     /gene="Eomes"
                     /gene_synonym="TBR-2; Tbr2"
                     /note="eomesodermin"
                     /db_xref="GeneID:13813"
                     /db_xref="MGI:MGI:1201683"
     exon            1..1356
                     /gene="Eomes"
                     /gene_synonym="TBR-2; Tbr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             470..2593
                     /gene="Eomes"
                     /gene_synonym="TBR-2; Tbr2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     T-brain-2; T-box brain protein 2; eomesodermin homolog"
                     /codon_start=1
                     /product="eomesodermin homolog isoform 1"
                     /protein_id="NP_034266.2"
                     /db_xref="CCDS:CCDS23603.1"
                     /db_xref="GeneID:13813"
                     /db_xref="MGI:MGI:1201683"
                     /translation="MQLGEQLLVSSVNLPGAHFYSLESARGGGGGGGGGGGGGGGSVS
                     LLPGAAPSPQRLDLDKASKKFPGSLPCQAGSAEPAGAGAGAPAAMLSDADAGDTFGST
                     SAVAKPGPPDGRKGSPCAEEELPSAATAAATARYSMDSLSSERYYLPSPGPQGSELAA
                     PCSLFQYPAAAGAAHGPVYPASNGARYPYGSMLPPGGFPAAVCPPARAQFGPAAGSGS
                     GAGSSGGGAGGPGAYPYGQGSPLYGPYAGTSAAGSCGGLGGLGVPGSGFRAHVYLCNR
                     PLWLKFHRHQTEMIITKQGRRMFPFLSFNINGLNPTAHYNVFVEVVLADPNHWRFQGG
                     KWVTCGKADNNMQGNKMYVHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIVL
                     QSLHKYQPRLHIVEVTEDGVEDLNEPSKTQTFTFSETQFIAVTAYQNTDITQLKIDHN
                     PFAKGFRDNYDSMYTASENDRLTPSPTDSPRSHQIVPGGRYGVQNFFPEPFVNTLPQA
                     RYYNGERTVPQTNGLLSPQQSEEVANPPQRWLVTPVQQPVTNKLDIGSYESEYTSSTL
                     LPYGIKSLPLQTSHALGYYPDPTFPAMAGWGGRGAYQRKMAAGLPWTSRMSPPVFPED
                     QLAKEKVKEEISSSWIETPPSIKSLDSSDSGVYNSACKRKRLSPSTPSNGNSPPIKCE
                     DINTEEYSKDTSKGMGAYYAFYTSP"
     exon            1357..1511
                     /gene="Eomes"
                     /gene_synonym="TBR-2; Tbr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1633
                     /gene="Eomes"
                     /gene_synonym="TBR-2; Tbr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1792
                     /gene="Eomes"
                     /gene_synonym="TBR-2; Tbr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1854
                     /gene="Eomes"
                     /gene_synonym="TBR-2; Tbr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..3689
                     /gene="Eomes"
                     /gene_synonym="TBR-2; Tbr2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3667..3672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eomes"
                     /gene_synonym="TBR-2; Tbr2"
                     /note="hexamer: AATAAA"
     polyA_site      3689
                     /gene="Eomes"
                     /gene_synonym="TBR-2; Tbr2"
                     /note="major polyA site"
ORIGIN      
        1 ccaagcggtc aagtatgcct agagtttagc agagccagcc gagaggaaat ggctggttgc
       61 taaatgggaa ctcagagcta agtcctcttc ttccttagtg tgagtgtagg ggtcctgaga
      121 ggttagacaa ggagggaagg aagaaaagaa ggaaggaagg aaggaaggaa ggaaggaagg
      181 aaggaaggaa ggaaggaagg aaggagagag acacctacaa cccggggttt gttttcttgc
      241 ggaaggaaag gggcacctac aatcccgagt ttgttccctt gagggaagga cgctaaattg
      301 ggcgcgcgct gaagccgccc cgcaggtccg caggtgggta gcctaggcga gggaggaagg
      361 ggacattacc ttcccctcgg aagagggcgc tggctccccc aactggcctt tataaccagg
      421 ccgcgggagg cgaggaggca gccggttgcc gtctgcgatt cgctaaagca tgcagttggg
      481 agagcagctc ctggtgagct cggtgaacct gcccggcgcg cacttctact cgctggagag
      541 tgctcgcgga ggaggaggag gaggaggcgg aggaggaggg ggaggcggag ggagcgtcag
      601 cctcctcccc ggtgctgccc cctcgcccca gaggctggac ttagacaaag cgtccaagaa
      661 gtttccgggc agtctcccgt gccaggcggg gagcgcagaa cccgcaggcg ccggcgcggg
      721 ggcccccgcg gccatgctca gtgacgcgga cgctggggac accttcggga gcacctcggc
      781 ggtggccaag cccgggcccc cggacggccg caagggctcc ccgtgcgcgg aggaggagct
      841 gccctccgcc gccaccgccg cggccaccgc gcgctactcc atggacagcc tgagctccga
      901 gcgctactac ctcccgtcgc cgggaccgca gggctccgag ctcgccgcgc cctgctcgct
      961 cttccagtac ccggcggcgg ccggagcagc ccacggaccc gtgtaccccg cgtccaatgg
     1021 cgcgcgctac ccctacggct ccatgctgcc ccccggtgga ttccccgccg ccgtgtgccc
     1081 gcccgcgagg gcgcagttcg gccccgctgc gggttcgggg agcggcgctg gtagcagcgg
     1141 cggtggtgcc ggcggtcctg gcgcctatcc ctacggccag ggttctccgc tctacgggcc
     1201 atacgccgga acctcagcgg ccgggtcttg tggaggattg gggggcctag gggtgcctgg
     1261 ctccggcttc cgcgcccacg tctacctgtg caaccggccc ctatggctca aattccaccg
     1321 gcaccaaact gagatgatca tcaccaaaca gggcaggcgc atgtttcctt tcttgagctt
     1381 caacataaac ggactcaacc ccaccgccca ctacaatgtt ttcgtggaag tggttctggc
     1441 cgaccctaac cactggcgct tccagggggg caagtgggtg acctgcggca aagcggacaa
     1501 taacatgcag ggcaataaga tgtacgttca cccagaatct cctaacactg gctcccactg
     1561 gatgaggcag gagatttcct ttgggaagtt aaaactcacc aataacaaag gtgcaaacaa
     1621 caacaacaca cagatgatag tgttgcagtc tctgcacaaa taccaaccga ggctgcacat
     1681 cgtggaagtg acagaggacg gtgtggagga cttgaatgaa ccttccaaga ctcagacctt
     1741 caccttctca gagacacagt tcatcgctgt gacggcctac caaaacacgg atatcaccca
     1801 gctaaagatc gaccataacc ccttcgccaa aggcttccgg gacaactacg attccatgta
     1861 cacggcttca gaaaatgaca ggttaactcc atctcccacg gattccccta gatcccatca
     1921 gattgtccct ggaggtcggt acggcgttca aaacttcttc ccggagccct ttgtcaacac
     1981 tttgcctcaa gcccgatatt ataacggtga gagaaccgtg ccacagacca acggcctcct
     2041 ctcaccccaa cagagcgaag aggtggccaa ccctccccag cggtggcttg tcacgcctgt
     2101 ccagcaacct gtgaccaaca agctagacat cggttcttat gaatctgaat atacttccag
     2161 taccttgctc ccatatggta ttaagtcctt gcccctgcag acatcccatg ccctggggta
     2221 ttaccctgac ccgaccttcc ctgctatggc agggtgggga ggccgtggcg cttatcagag
     2281 gaagatggca gctggactac catggacatc cagaatgagc ccacctgtct tcccagaaga
     2341 tcagcttgcc aaggaaaaag ttaaagaaga gattagttcc tcctggatag agactccccc
     2401 ctccatcaag tctctagact ccagcgactc cggggtgtac aacagcgctt gcaagagaaa
     2461 gcgcctgtct cccagcaccc ccagcaatgg aaactcgccc cccataaagt gtgaggacat
     2521 taacactgaa gagtacagta aagacacctc caaaggcatg ggggcttatt atgcttttta
     2581 cacaagtccc tagagcatta ttttaacctt taacctttcc agatggacct ggtggtgttt
     2641 tgttgtgttc tttgcctagg ttaccaaaaa gacttttgcc ttccaccttt gatgtatcct
     2701 gttttgtgca attctctgag agaaggcgcc aaagctttgc cacggccgca ggtaactaaa
     2761 ctgaagcaga cctagcattg gttttaaagt gactggagga cgcaggagtg tttttaaaac
     2821 tgaaaaggtc gttcaaggtg ctggattgat tcatttatgg gaaacgagaa atgttcagaa
     2881 aaagcaggct atgaagaacg agtgcccggt gctattaaat gaatttcaaa gacaagaaaa
     2941 catgacagaa aaaaacaaaa caaaacaaac tttggctctt atttctactc ataaatcttt
     3001 aagcaaacag cagcccagag ggttaaaata tttttgcttc gggaagagaa gggttggacc
     3061 ttgagttaac agtgggctct tcacagatat cttctgccag ggcctataga ggctgagcct
     3121 gagagtcaag cggggaaaac aaacaaacaa acaaactgat gtttaagtgg ctagctagta
     3181 ctcactgcct tcaattcctt gcagaatttt ggaataaacc atttgttgta gggctggctc
     3241 tgtgtggctg ggatgacctg tagaaggcag gaggatcaga aagaaaggga gaagttaagt
     3301 gtacaattgt atgtttagac accttagaat attctggaat atattgtaca aattcaactg
     3361 cctaggtatc agataaaaat aatgtaaatt tggtgctttg gcgttgtaaa gaatttgcaa
     3421 aaccacaact gcagttaaga ggagggattc atatcttgga gatattctgt ccacttcgct
     3481 aagtactcag ctgcctccgt acttgcttct acacacttaa ggaaaaaccc tgcttaatcc
     3541 tctttccttg gtcatcccca cttccccctt cagtaaatgt gaaaaaaaaa attgcagtat
     3601 gatgtcacag ttcctatagg ctttttagag attctgaatt tttatgtaca gtcataagtc
     3661 atttttaata aatgtggttc aataaggga
//
