LOCUS       NM_175313               4128 bp    mRNA    linear   ROD 21-MAY-2024
DEFINITION  Mus musculus EGF domain specific O-linked N-acetylglucosamine
            transferase (Eogt), mRNA.
ACCESSION   NM_175313
VERSION     NM_175313.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4128)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4128)
  AUTHORS   Nauman,M., Varshney,S., Choi,J., Augenlicht,L.H. and Stanley,P.
  TITLE     EOGT enables residual Notch signaling in mouse intestinal cells
            lacking POFUT1
  JOURNAL   Sci Rep 13 (1), 17473 (2023)
   PUBMED   37838775
  REMARK    GeneRIF: EOGT enables residual Notch signaling in mouse intestinal
            cells lacking POFUT1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4128)
  AUTHORS   Tanwar,A. and Stanley,P.
  TITLE     Synergistic regulation of Notch signaling by different O-glycans
            promotes hematopoiesis
  JOURNAL   Front Immunol 14, 1097332 (2023)
   PUBMED   37795096
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4128)
  AUTHORS   Alam,S.M.D., Tsukamoto,Y., Ogawa,M., Senoo,Y., Ikeda,K.,
            Tashima,Y., Takeuchi,H. and Okajima,T.
  TITLE     N-Glycans on EGF domain-specific O-GlcNAc transferase (EOGT)
            facilitate EOGT maturation and peripheral endoplasmic reticulum
            localization
  JOURNAL   J Biol Chem 295 (25), 8560-8574 (2020)
   PUBMED   32376684
  REMARK    GeneRIF: N-Glycans on EGF domain-specific O-GlcNAc transferase
            (EOGT) facilitate EOGT maturation and peripheral endoplasmic
            reticulum localization.
REFERENCE   5  (bases 1 to 4128)
  AUTHORS   Chal,J., Al Tanoury,Z., Oginuma,M., Moncuquet,P., Gobert,B.,
            Miyanari,A., Tassy,O., Guevara,G., Hubaud,A., Bera,A., Sumara,O.,
            Garnier,J.M., Kennedy,L., Knockaert,M., Gayraud-Morel,B.,
            Tajbakhsh,S. and Pourquie,O.
  TITLE     Recapitulating early development of mouse musculoskeletal
            precursors of the paraxial mesoderm in vitro
  JOURNAL   Development 145 (6) (2018)
   PUBMED   29555813
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4128)
  AUTHORS   Shaheen,R., Aglan,M., Keppler-Noreuil,K., Faqeih,E., Ansari,S.,
            Horton,K., Ashour,A., Zaki,M.S., Al-Zahrani,F.,
            Cueto-Gonzalez,A.M., Abdel-Salam,G., Temtamy,S. and Alkuraya,F.S.
  TITLE     Mutations in EOGT confirm the genetic heterogeneity of
            autosomal-recessive Adams-Oliver syndrome
  JOURNAL   Am J Hum Genet 92 (4), 598-604 (2013)
   PUBMED   23522784
REFERENCE   7  (bases 1 to 4128)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   8  (bases 1 to 4128)
  AUTHORS   Sakaidani,Y., Ichiyanagi,N., Saito,C., Nomura,T., Ito,M.,
            Nishio,Y., Nadano,D., Matsuda,T., Furukawa,K. and Okajima,T.
  TITLE     O-linked-N-acetylglucosamine modification of mammalian Notch
            receptors by an atypical O-GlcNAc transferase Eogt1
  JOURNAL   Biochem Biophys Res Commun 419 (1), 14-19 (2012)
   PUBMED   22310717
  REMARK    GeneRIF: the characterization of A130022J15Rik, a mouse gene
            homolog of Drosophila Eogt (Eogt 1), was reported.
REFERENCE   9  (bases 1 to 4128)
  AUTHORS   Sewell,W., Sparrow,D.B., Smith,A.J., Gonzalez,D.M., Rappaport,E.F.,
            Dunwoodie,S.L. and Kusumi,K.
  TITLE     Cyclical expression of the Notch/Wnt regulator Nrarp requires
            modulation by Dll3 in somitogenesis
  JOURNAL   Dev Biol 329 (2), 400-409 (2009)
   PUBMED   19268448
REFERENCE   10 (bases 1 to 4128)
  AUTHORS   Loebel,D.A., O'Rourke,M.P., Steiner,K.A., Banyer,J. and Tam,P.P.
  TITLE     Isolation of differentially expressed genes from wild-type and
            Twist mutant mouse limb buds
  JOURNAL   Genesis 33 (3), 103-113 (2002)
   PUBMED   12124942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155727.6.
            
            On May 29, 2018 this sequence version replaced NM_175313.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK037507.1, SRR9219382.133417.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC155727.6         2636-2690
            56-437              AC155727.6         3264-3645
            438-494             AC155727.6         4071-4127
            495-718             AC155727.6         6038-6261
            719-819             AC155727.6         7482-7582
            820-928             AC155727.6         8588-8696
            929-1023            AC155727.6         16252-16346
            1024-1128           AC155727.6         17139-17243
            1129-1235           AC155727.6         20064-20170
            1236-1339           AC155727.6         25899-26002
            1340-1432           AC155727.6         30718-30810
            1433-1504           AC155727.6         31307-31378
            1505-1591           AC155727.6         31473-31559
            1592-1660           AC155727.6         32573-32641
            1661-1722           AC155727.6         35460-35521
            1723-1842           AC155727.6         37560-37679
            1843-1945           AC155727.6         38739-38841
            1946-4128           AC155727.6         39316-41498
FEATURES             Location/Qualifiers
     source          1..4128
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 44.88 cM"
     gene            1..4128
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /note="EGF domain specific O-linked N-acetylglucosamine
                     transferase"
                     /db_xref="GeneID:101351"
                     /db_xref="MGI:MGI:2141669"
     exon            1..55
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /inference="alignment:Splign:2.1.0"
     exon            56..437
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /inference="alignment:Splign:2.1.0"
     exon            438..494
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /inference="alignment:Splign:2.1.0"
     exon            495..718
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /inference="alignment:Splign:2.1.0"
     CDS             509..2092
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /EC_number="2.4.1.255"
                     /note="EGF domain-specific O-linked N-acetylglucosamine
                     (GlcNAc) transferase; extracellular O-linked
                     N-acetylglucosamine transferase"
                     /codon_start=1
                     /product="EGF domain-specific O-linked N-acetylglucosamine
                     transferase precursor"
                     /protein_id="NP_780522.1"
                     /db_xref="CCDS:CCDS20383.1"
                     /db_xref="GeneID:101351"
                     /db_xref="MGI:MGI:2141669"
                     /translation="MLMLLVFGVLLHEVPLSGQDKAHSEADDAPGKALYDYSSLRLPA
                     EHIPFFLHNNRHVASVCREDSHCPYKKHLENLNYCWGYEKSCAPEFRFGSPVCSYVDL
                     GWTDTLESAQDMFWRQADFGYARERLGEIRTICQPERASDSSLVCSRYLQYCRATGLY
                     LDLRNIKRNHDRFKEDFLQGGEIGGYCKLDSHALVSEGQRKSPLQSWFAELQGYTQLN
                     FRPIEDAKCDIVVEKPTYFMKLDAGINMYHHFCDFLNLYLTQHVNNSFSTDVYIVMWD
                     TSTYGYGDLFSDTWKAFTDYDVIHLKTYDSKKVCFKEAVFSLLPRMRYGLFYNTPLIS
                     GCQNTGLFRAFSQHVLHRLNITQEGPKDGKVRVTILARSTEYRKILNQDELVNALKTV
                     STFEVRVVDYKYRELGFLDQLRITHNTDIFIGMHGAGLTHLLFLPDWAAVFELYNCED
                     ERCYLDLARLRGIHYITWRKPSKVFPQDKGHHPTLGEHPKFTNYSFDVEEFMYLVLQA
                     AEHVLQHPQWPFKKKHDEL"
     exon            719..819
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /inference="alignment:Splign:2.1.0"
     exon            820..928
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1023
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1128
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1235
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1339
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1432
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1504
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1591
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1660
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1722
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1842
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1945
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..4128
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2569..2574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /note="hexamer: GATAAA"
     polyA_site      2596
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /note="major polyA site"
     regulatory      4102..4107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /note="hexamer: AATAAA"
     polyA_site      4128
                     /gene="Eogt"
                     /gene_synonym="A130022J15Rik; Aer61"
                     /note="major polyA site"
ORIGIN      
        1 gttactccca agctgccgcc actgccgccg ccgccgctcc ctagtcaagc tgcaggtccg
       61 tgaaaatcca atcaagccac acacgagtgg agcgcgattg accgttttgt gcaaaaagac
      121 gcggtagcct aacctactaa agctttcatc cctgccaagt cttgccagag aactcaactc
      181 cgggaaggct ttctgccagg ccctgaagtt gtactttcat gcaccacagg gaaccatcac
      241 ccagcatatg caagtgggta catgccctcc cttgcaaaag ccaactttct gatctgctcc
      301 tttagatttt ccccacggcc aagggttact tttttccatg aatggtcaag ttttgttaac
      361 cggcagaacg cattgcagag ctgtggattt ggatacccga aatttaggac ctagtgctcc
      421 aagccgcgac ctagaaggtt ttaggctagc caaagcatca gcagcttccg gaggggattc
      481 tgaggactaa aaaggtctgc aggttgctat gttaatgctg cttgtctttg gagtattgct
      541 tcatgaagtc ccactgagtg gccaggacaa ggctcattct gaggctgacg atgcgcctgg
      601 caaggccctg tatgactact ccagcctccg cctccctgcg gagcacattc ccttcttctt
      661 gcacaataac aggcatgttg cctctgtgtg cagggaggat tcccactgtc catataagaa
      721 acacttagaa aatctaaact actgctgggg ttatgagaag tcctgcgcac cagagtttag
      781 attcggttcc cccgtttgca gctatgtcga cttgggatgg accgatactc tggagtcagc
      841 ccaggacatg ttctggaggc aagctgactt tggatatgcg cgagagcgac tgggagagat
      901 aagaacgatc tgccagccag agagagcaag cgactcaagt ctggtttgct cccgttacct
      961 tcagtattgt agagctactg gtctatacct ggacttaaga aacatcaaga gaaaccacga
     1021 cagattcaag gaagattttc ttcagggtgg tgaaattggt ggatactgta aacttgacag
     1081 tcatgcactg gtgtctgaag ggcagcgtaa aagtcccctg cagtcttggt ttgctgagct
     1141 acaaggctac acgcagctca atttcaggcc tatagaagat gctaaatgtg acatcgttgt
     1201 tgaaaaacca acgtatttca tgaaattaga tgcaggtatt aatatgtacc accacttctg
     1261 tgacttcctg aatctctacc tcactcagca cgttaacaat tctttcagca cggacgtgta
     1321 catcgtgatg tgggacacca gcacttacgg gtatggtgac ctcttctccg atacctggaa
     1381 agcatttact gactatgacg tcatacattt gaaaacctat gattccaaaa aggtgtgttt
     1441 taaagaagcc gtgttttcgt tgctgccccg catgcggtac gggctgttct ataacacgcc
     1501 tctgatctct ggctgtcaga atacaggatt attcagagcc ttctcccagc atgtgctgca
     1561 taggctgaac atcactcaag agggacccaa ggatggcaaa gttcgagtta ccattcttgc
     1621 acgcagcaca gaataccgga aaatcctgaa ccaagacgag ctggtaaatg cactgaaaac
     1681 agtatccaca tttgaagtcc gggtggttga ttacaagtac agagaactcg ggtttttaga
     1741 tcagctcagg atcacgcaca acacggacat atttattggc atgcatggag ctggccttac
     1801 ccacttactt ttccttccgg actgggctgc tgtgttcgag ctgtacaact gtgaagatga
     1861 gcgctgctac ttagacctgg ccaggctcag aggcatccac tacatcacct ggcggaagcc
     1921 cagcaaagta tttcctcagg ataagggtca ccatccaact ctgggagaac acccgaagtt
     1981 taccaactac tcttttgatg tagaagaatt catgtacctt gtccttcagg ctgcagagca
     2041 tgtactgcag cacccacagt ggccatttaa gaagaaacat gatgagctat agaagtgttg
     2101 aggttgtttc caagagtgtt gacaccctct cacagccata gactcacaat cagaggagca
     2161 gaacagcctg tcatatccta ctgtaagagg aaacatgacg ttttacttct gaatatagct
     2221 caggctgacc ttgaactagt gatcctcttg cctgagccaa ctgagtgctc accttacagg
     2281 tgtgccccac catgcctgtc tacagagtta ctttttgtat atgaaagcac acctccagga
     2341 gatgctaagt cttccatgtg tttattgtgt ctttgctatt tatcaaaggt atttttgcac
     2401 tgaaaaaggt tacttttata gttcaaaggt gggcagatgc ccattggtgt ggcagagctc
     2461 tcctgtgggg atgcaaagtt gtcaacatcg gtggcttcag acttgatata tgtgtttgtt
     2521 aactgtaatg tgatcttgat tccagagtgt catggcttca tctatttgga taaactcatc
     2581 tatttggata aactcagaac tgttgttatt tgccattgta tgttcataaa tatggttgta
     2641 gggtctgggc acatggctta gtgtagaatg ctggccttgc atgtatgggc ctctgggttt
     2701 aatccctagc aacaccacac acacacacac acacacacac acacacacac acacacgtct
     2761 aagtctgtga ttctcaggac caaactatag gactacgtta tagaccagta attagtcaac
     2821 tccagattcc gtgcatcaag agcctgacaa agatcatgct gttgtattta ttaattttgt
     2881 ttctatatct catttcaatc atgttctccc caaatgtaat ggcagtgttg ataagagcct
     2941 gtcagaacat tctgtagtac catctccact gacgcttcag ccgtgaagac ccttcatgct
     3001 gacttggcat gaagtcttag tttccatcag gccagtgttt gtgagcacac acggctgtgt
     3061 gtatctacct ctggcagaat ggaagtaacc ctagtctctg taaaacactg ccaagtagcc
     3121 acatgaagag aagacacttt ccctgtttat ttgttttttg atttttaaaa taaggccatt
     3181 aaaaacacgg tagacctgtg aattatccaa tcaaaacaaa agccccaaga aagtggcact
     3241 gagcaaacag gatgcccagc agcaggcttc ccctggactg cctttgtttc ttactgctaa
     3301 gcacatagct caacagtcag aaaccatggg tttgttctat tgtacagtgt gatgcttgtg
     3361 tcttattaac atctgcggca tctcatttag aagctacttt taattttttt acaatgcact
     3421 tagcaaatcg cagccaagga cttcattttt taaattttag agaagcgacc tacaaaataa
     3481 aatattggtg actaacagct cctcggaggt ttgctctctt ttcctttcag gaattgttaa
     3541 aagagttgta gactttattt attaaaatac ctttcaagga aatagtggcc ctctataggc
     3601 aggacttccc tttgggtcaa aaaaattctt tggaaaacat tgtaacatga ggaattgtta
     3661 aatgacaggt ttgctgctgt tccgggtgca ggatattagg taggcagggg aagaaggggc
     3721 tgtcccacag gaaggggagg gagtggaagg atcatgttgc cccggacatc gaggacaaac
     3781 atctgagact gtgtctggaa aaccttcctt ttacctcatt tcaagctgca cagggaccta
     3841 tgtgttcaca gactaccgag gattccagaa actgaggaca ctttcatact gaaaccgtat
     3901 ttgaatattt tgcaattaga atatacttta tataaagaca gtcatttaaa attttaatta
     3961 atgggattaa cttttttatc agacttttgg tgggagcaga agatctgcag attgttgtaa
     4021 aatctaaaat gtagatatgg ccctttttta ttaagtctgt aaggagatgc atttcactgt
     4081 acattttggg tgtagctttg gaataaagtt ttctatattt catttaca
//
