LOCUS       NM_175009               3019 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ENY2 transcription and export complex 2 subunit
            (Eny2), transcript variant 1, mRNA.
ACCESSION   NM_175009
VERSION     NM_175009.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3019)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3019)
  AUTHORS   Dames,P., Weise,M., Puff,R., Goke,B., Parhofer,K.G., Seissler,J.
            and Lechner,A.
  TITLE     Suppression of the nuclear factor Eny2 increases insulin secretion
            in poorly functioning INS-1E insulinoma cells
  JOURNAL   Exp Diabetes Res 2012, 460869 (2012)
   PUBMED   22649445
  REMARK    GeneRIF: there is a link between the nuclear protein Eny2 and
            insulin secretion
REFERENCE   3  (bases 1 to 3019)
  AUTHORS   Nagy,Z., Riss,A., Romier,C., le Guezennec,X., Dongre,A.R.,
            Orpinell,M., Han,J., Stunnenberg,H. and Tora,L.
  TITLE     The human SPT20-containing SAGA complex plays a direct role in the
            regulation of endoplasmic reticulum stress-induced genes
  JOURNAL   Mol Cell Biol 29 (6), 1649-1660 (2009)
   PUBMED   19114550
REFERENCE   4  (bases 1 to 3019)
  AUTHORS   Zhao,Y., Lang,G., Ito,S., Bonnet,J., Metzger,E., Sawatsubashi,S.,
            Suzuki,E., Le Guezennec,X., Stunnenberg,H.G., Krasnov,A.,
            Georgieva,S.G., Schule,R., Takeyama,K., Kato,S., Tora,L. and
            Devys,D.
  TITLE     A TFTC/STAGA module mediates histone H2A and H2B deubiquitination,
            coactivates nuclear receptors, and counteracts heterochromatin
            silencing
  JOURNAL   Mol Cell 29 (1), 92-101 (2008)
   PUBMED   18206972
REFERENCE   5  (bases 1 to 3019)
  AUTHORS   Kurshakova,M., Maksimenko,O., Golovnin,A., Pulina,M., Georgieva,S.,
            Georgiev,P. and Krasnov,A.
  TITLE     Evolutionarily conserved E(y)2/Sus1 protein is essential for the
            barrier activity of Su(Hw)-dependent insulators in Drosophila
  JOURNAL   Mol Cell 27 (2), 332-338 (2007)
   PUBMED   17643381
  REMARK    GeneRIF: E(y)2/Sus1, is recruited to the Su(Hw) insulators via
            binding to the zinc-finger domain of Su(Hw).
REFERENCE   6  (bases 1 to 3019)
  AUTHORS   Diaz,E., Yang,Y.H., Ferreira,T., Loh,K.C., Okazaki,Y.,
            Hayashizaki,Y., Tessier-Lavigne,M., Speed,T.P. and Ngai,J.
  TITLE     Analysis of gene expression in the developing mouse retina
  JOURNAL   Proc Natl Acad Sci U S A 100 (9), 5491-5496 (2003)
   PUBMED   12702772
REFERENCE   7  (bases 1 to 3019)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
REFERENCE   8  (bases 1 to 3019)
  AUTHORS   Georgieva,S., Nabirochkina,E., Dilworth,F.J., Eickhoff,H.,
            Becker,P., Tora,L., Georgiev,P. and Soldatov,A.
  TITLE     The novel transcription factor e(y)2 interacts with TAF(II)40 and
            potentiates transcription activation on chromatin templates
  JOURNAL   Mol Cell Biol 21 (15), 5223-5231 (2001)
   PUBMED   11438676
REFERENCE   9  (bases 1 to 3019)
  AUTHORS   Brand,M., Moggs,J.G., Oulad-Abdelghani,M., Lejeune,F.,
            Dilworth,F.J., Stevenin,J., Almouzni,G. and Tora,L.
  TITLE     UV-damaged DNA-binding protein in the TFTC complex links DNA damage
            recognition to nucleosome acetylation
  JOURNAL   EMBO J 20 (12), 3187-3196 (2001)
   PUBMED   11406595
REFERENCE   10 (bases 1 to 3019)
  AUTHORS   Brand,M., Yamamoto,K., Staub,A. and Tora,L.
  TITLE     Identification of TATA-binding protein-free TAFII-containing
            complex subunits suggests a role in nucleosome acetylation and
            signal transduction
  JOURNAL   J Biol Chem 274 (26), 18285-18289 (1999)
   PUBMED   10373431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127312.4.
            
            On Mar 24, 2023 this sequence version replaced NM_175009.3.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032957.1, SRR17784649.410496.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               AC127312.4         88543-88693
            152-228             AC127312.4         90011-90087
            229-299             AC127312.4         92889-92959
            300-374             AC127312.4         94350-94424
            375-3019            AC127312.4         96063-98707
FEATURES             Location/Qualifiers
     source          1..3019
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 16.91 cM"
     gene            1..3019
                     /gene="Eny2"
                     /gene_synonym="1810057B09Rik; 6720481I12; DC6; Ey2"
                     /note="ENY2 transcription and export complex 2 subunit"
                     /db_xref="GeneID:223527"
                     /db_xref="MGI:MGI:1919286"
     exon            1..151
                     /gene="Eny2"
                     /gene_synonym="1810057B09Rik; 6720481I12; DC6; Ey2"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..451
                     /gene="Eny2"
                     /gene_synonym="1810057B09Rik; 6720481I12; DC6; Ey2"
                     /note="isoform 1 is encoded by transcript variant 1; e(y)2
                     protein; enhancer of yellow 2 transcription factor
                     homolog; enhancer of yellow eye homolog; e(y)2 homolog;
                     transcription and mRNA export factor ENY2; enhancer of
                     yellow 2 homolog"
                     /codon_start=1
                     /product="transcription and mRNA export factor ENY2
                     isoform 1"
                     /protein_id="NP_778174.1"
                     /db_xref="CCDS:CCDS27456.1"
                     /db_xref="GeneID:223527"
                     /db_xref="MGI:MGI:1919286"
                     /translation="MVVSKMNKDAQMRAAINQKLIETGERERLKELLRAKLIECGWKD
                     QLKAHCKEVIKEKGLEHVTVDDLVAEITPKGRALVPDSVKKELLQRIRTFLAQHASL"
     exon            152..228
                     /gene="Eny2"
                     /gene_synonym="1810057B09Rik; 6720481I12; DC6; Ey2"
                     /inference="alignment:Splign:2.1.0"
     exon            229..299
                     /gene="Eny2"
                     /gene_synonym="1810057B09Rik; 6720481I12; DC6; Ey2"
                     /inference="alignment:Splign:2.1.0"
     exon            300..374
                     /gene="Eny2"
                     /gene_synonym="1810057B09Rik; 6720481I12; DC6; Ey2"
                     /inference="alignment:Splign:2.1.0"
     exon            375..3019
                     /gene="Eny2"
                     /gene_synonym="1810057B09Rik; 6720481I12; DC6; Ey2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      528..533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eny2"
                     /gene_synonym="1810057B09Rik; 6720481I12; DC6; Ey2"
                     /note="hexamer: AATAAA"
     polyA_site      554
                     /gene="Eny2"
                     /gene_synonym="1810057B09Rik; 6720481I12; DC6; Ey2"
                     /note="major polyA site"
     regulatory      611..616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eny2"
                     /gene_synonym="1810057B09Rik; 6720481I12; DC6; Ey2"
                     /note="hexamer: AATAAA"
     polyA_site      630
                     /gene="Eny2"
                     /gene_synonym="1810057B09Rik; 6720481I12; DC6; Ey2"
                     /note="major polyA site"
     polyA_site      657
                     /gene="Eny2"
                     /gene_synonym="1810057B09Rik; 6720481I12; DC6; Ey2"
     regulatory      2999..3004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eny2"
                     /gene_synonym="1810057B09Rik; 6720481I12; DC6; Ey2"
                     /note="hexamer: AATAAA"
     polyA_site      3019
                     /gene="Eny2"
                     /gene_synonym="1810057B09Rik; 6720481I12; DC6; Ey2"
ORIGIN      
        1 ggaaatgcgt ggtctagctt tctgtgtgct taggtgcccg agctactgag ggtctaagtc
       61 cgggcagccg aagagtgtgg taggtaacgg tcgtcagcgc aagggtcatt tcgtcgctgg
      121 gaagggacgg ccctcgcccg cggtgatggt ggttagcaag atgaacaaag atgcgcagat
      181 gagagcagcg attaaccaaa agttaataga aactggagaa agagaacgcc tcaaagagtt
      241 gctgagagct aaattaattg agtgcggctg gaaggatcag ctaaaggcac actgtaaaga
      301 ggtaattaaa gaaaaaggac tagaacacgt tactgttgat gacttggtgg ctgaaatcac
      361 tccaaaaggc agagccctgg tacctgacag tgtaaagaag gagctcctac agagaataag
      421 aacattcctt gctcagcatg ccagccttta agggtgaatt agaatgtgtt ggtctgtgga
      481 tttatttctg aaagtaaaac ttgccataat tagaaattga tttcccaaat aaagtccttt
      541 tttgtatgat ggtatacagt tttcagtaat gtatacattg tattgatttt ttccctaaat
      601 gtgttatttt aataaatatc tcatgaatga gtttcaattt ttttattttg gaataaatgg
      661 gactctgttt attactgatt gcctagaaat gttgagataa aaaatgccag caattactat
      721 tatccagtat ttatatgtgt gattctctgt gctaacgtct gagacgcctt tctgggttgt
      781 ctacaaatgg tttgttcctc ttttgattcc tcacatttga taactgtgat gctccatctt
      841 tgtactgtag gttgtctatt tctttgttac aaattctgag tgttaggact gggtcttact
      901 taatctgtat gtgccttcct tatgcttcaa agaaattacc atctagtgga agacagaaca
      961 tttccaagct gactgaacac cacattttct actcatctga actttgaaag cagaatctct
     1021 aaattgcatc cccatattct gaggtcaaga aagaactcta atgggaaata atctctacca
     1081 attagcttta ctctgacatc aatcaggatt accagatcta atggactctt gtctatcagt
     1141 gtgacctttg acgcagagtg attatgttgg ccacccttcc acttggaact ttgcatcccc
     1201 tcctcacact gcttcctacc attggaagtc ctttctggct ttttgtggag tactttttgc
     1261 tgtatgtaac ttttaagtaa tgttttgttg gactttcttc tgagtcctct gattaataat
     1321 atgttttccc tggttgaatc ccaggaggtg agtctgccat gtttcaaata tcaacagatt
     1381 gatatatgct gaacattctc acaaccagac ttaattctag cctcactgcc catatgccca
     1441 ccagtgggtc tacttccttg gatagttcac aaacaccttt aaatgaccat actttaacag
     1501 taagattctc ccctattaac tacctgtgtt ttagtcctta ttcatggggt ctctcagaca
     1561 caagtgactc aagatgaata ttaatgctat ttttcggagg gaaaaaacaa gactacttgt
     1621 gaaacatcct tagttttgtg tttgtgttac tgctgctgat tggttgaggg ccagctataa
     1681 acttggatta tcatttgtgg ccctcctaag cccaagtgat tgcagtgact cctctgtgcc
     1741 tccactatct tcctcatcgt ttccctgcct atgtggcctt atgaaattca agtctggtca
     1801 tttatttccc ctacttgaaa tgtttcaata ctggatgaaa ttcaaactca gcatactagc
     1861 taggcccctc taaatctagc acgtatttct atctctgcag tctgtaaaaa aaaaaaaatt
     1921 gttccatctc ttagtacctc tcaaaaatca taacatctag gaagcccttt aagtcatcat
     1981 gttactactt tcccttcaga gttcagcttg agtttttaaa tgttctgaca gtctcatgat
     2041 ttcaattcct tgtcactgat ttctttttgg atttttgagg taggctgtcc ctccatcagt
     2101 cagctagcct cacactggcc ttgagcatga atcctgagac ctgggagcac agggatgtta
     2161 gcccatctgg aggggaggga acaaattcat tgtatgattc tcatttctga aagaatggat
     2221 aaggcagtga ctgaactgag tgagcactac aggagcacgt gataaagtcc taatatatag
     2281 gtacagttga gaaaagggtt catcgtccac actacattaa gtttaaatgt cattgagtca
     2341 tttacagaat tatatatttg gatcttgaga tatgtacacc caaaatctcg cccaaagtaa
     2401 tattttcagt ttcattatgt tctaaatagg aattttcatt ttgttaccaa ttataaaaaa
     2461 aaagtagtct tacatggtac acagaaagta ttaaaaataa ggggtggttc ttcataattc
     2521 tgtatataga aacaaactga aaaggcttat aaagatatta ttttaatatc ccaaaagatt
     2581 taaaaaatgg catttggaaa ctccttgaca atgagaaaaa taaccaagtt taaaatgctt
     2641 tgtagaaatt taaggtgaga gcatagattc ggtttttgga gggttttttt gttttgtttt
     2701 taatggtatt tttggcctct ttccctcccc ccccccagcc ccccgcccac cccggtttgt
     2761 tttgagacag ggtcacatgt agtccaggct ttctctgtac ttgctatgta gcctaggtaa
     2821 gtcttgaata cctgatcctc ctacctctac ctcccaagtg ctgggaagac aggtgtgtgc
     2881 cacctctggg gcccataaca gcctagattt aaaacaatgc taagactccc ctaccacctt
     2941 tctctttggc atcttataaa tgtcttgtag attgaatcta gaatcactgg tatttgtaaa
     3001 taaatcaact ttgtgaaca
//
