LOCUS       NM_053103               6050 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ectonucleoside triphosphate diphosphohydrolase 7
            (Entpd7), mRNA.
ACCESSION   NM_053103
VERSION     NM_053103.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6050)
  AUTHORS   Kusu,T., Kayama,H., Kinoshita,M., Jeon,S.G., Ueda,Y., Goto,Y.,
            Okumura,R., Saiga,H., Kurakawa,T., Ikeda,K., Maeda,Y.,
            Nishimura,J., Arima,Y., Atarashi,K., Honda,K., Murakami,M.,
            Kunisawa,J., Kiyono,H., Okumura,M., Yamamoto,M. and Takeda,K.
  TITLE     Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17
            cell responses through regulation of luminal ATP in the small
            intestine
  JOURNAL   J Immunol 190 (2), 774-783 (2013)
   PUBMED   23241884
  REMARK    GeneRIF: ENTPDase7 controls the luminal ATP level and, thereby,
            regulates Th17 cell development in the small intestine.
REFERENCE   2  (bases 1 to 6050)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   3  (bases 1 to 6050)
  AUTHORS   Shi,J.D., Kukar,T., Wang,C.Y., Li,Q.Z., Cruz,P.E.,
            Davoodi-Semiromi,A., Yang,P., Gu,Y., Lian,W., Wu,D.H. and She,J.X.
  TITLE     Molecular cloning and characterization of a novel mammalian
            endo-apyrase (LALP1)
  JOURNAL   J Biol Chem 276 (20), 17474-17478 (2001)
   PUBMED   11278936
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY773413.1, AK147401.1 and AC141888.4.
            
            On Oct 22, 2009 this sequence version replaced NM_053103.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147401.1, AK081564.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               BY773413.1         2-137
            137-2431            AK147401.1         2-2296
            2432-6050           AC141888.4         102152-105770       c
FEATURES             Location/Qualifiers
     source          1..6050
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 36.67 cM"
     gene            1..6050
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
                     /note="ectonucleoside triphosphate diphosphohydrolase 7"
                     /db_xref="GeneID:93685"
                     /db_xref="MGI:MGI:2135885"
     exon            1..216
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
                     /inference="alignment:Splign:2.1.0"
     exon            217..319
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..2132
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
                     /EC_number="3.6.1.15"
                     /note="lysosomal apyrase-like 2; NTPDase 7; lysosomal
                     apyrase-like protein 1"
                     /codon_start=1
                     /product="ectonucleoside triphosphate diphosphohydrolase
                     7"
                     /protein_id="NP_444333.3"
                     /db_xref="CCDS:CCDS29835.1"
                     /db_xref="GeneID:93685"
                     /db_xref="MGI:MGI:2135885"
                     /translation="MARISFSYLCPASWYFTVPTVSPFLRQRVAFLGLFFIPCVLLLL
                     LIMDLRHWATSLPRDRQYERYLARVGDLEATNTEDPNLNYGLVVDCGSSGSRIFVYFW
                     PRHNGNPHDLLDIKQMRDRNSQPVVKKIKPGISAMADTPEHASDYLRPLLSFAAAHVP
                     VKKHRETPLYILCTAGMRLLPERQQLAILADLVKDLPLEFDFLFSQSQAEVISGKQEG
                     VYAWIGINFVLGRFDHEDESDSDTSVDSAAGRRRTVGILDMGGASLQIAYEVPTSASD
                     LPPKQEEAAKILLAEFNLGCDVQHTEHVYRVYVTTFLGFGGNFARQRYEDLVLNETLN
                     KNRLLGQKTGLSPDNPFLDPCLPVGLTDMVKRNNQVLHFRGKGDWASCRTLLSPLLAR
                     SNTSQASLNGIYQSPIDFNNSEFYGFSEFFYCTEDVLRIGGHYHGPTFAKAAQDYCGM
                     AWPVLAQRFKNGLFSSHADEHRLKYQCFKSAWMYEVLHEGFHFPYDYPNLQTAQLVYD
                     REVQWTLGAILYKTRFLPLRDLRQGQGGVRPAHGSWLRLSFVYNHYLFFACTLVVLLA
                     IVLYLLRIHRIHRRQTRASAPLDLLWIEQVVPMIGVQVGP"
     exon            320..502
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
                     /inference="alignment:Splign:2.1.0"
     exon            503..708
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
                     /inference="alignment:Splign:2.1.0"
     exon            709..859
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
                     /inference="alignment:Splign:2.1.0"
     exon            860..963
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1020
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1154
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1321
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1646
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1732
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1894
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..6050
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3114..3119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
                     /note="hexamer: AATAAA"
     polyA_site      3133
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
                     /note="major polyA site"
     regulatory      4856..4861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
                     /note="hexamer: AATATA"
     polyA_site      4879
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
                     /note="major polyA site"
     regulatory      5870..5875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
                     /note="hexamer: AATAAA"
     polyA_site      5898
                     /gene="Entpd7"
                     /gene_synonym="1810012B13Rik; 1810020C02Rik;
                     2810003F23Rik; LALP1; Lysal2"
ORIGIN      
        1 agtttgtgac cgccgcggct tcgccggtgg ctccggctgc gcgcagggcg ggcctctccg
       61 ggtcccctgc agtcattggc tcggtgcggt ttccttgggg acgtggcgcc gccggaggcc
      121 gggcctcctt ccggctgtgt tgggagccac tgggaaccgc tgaggaccag gaccaggccg
      181 ggctgtgcag agggacgagc gggcctcggg attcccgctg caggcttagg agatgcctgg
      241 gactaggagg ccaccctctc aaagcaaaag gaaacggagg tgacagacgt cgagaccact
      301 gaagggaacc catggctagg atcagttttt cctacctctg cccagcctcc tggtacttca
      361 ctgtgcccac agtgagcccg tttctccgtc agcgggtggc attcctggga ctcttcttta
      421 taccctgtgt ccttttactt cttttaatca tggatttacg acactgggcc acttcgttac
      481 cacgggacag gcagtatgag aggtatttgg ctcgggtagg agacctggaa gccaccaaca
      541 cggaagaccc aaatctgaat tatggactcg tggtggactg tggtagcagc ggctcccgga
      601 tttttgttta cttctggcca aggcataatg ggaaccccca tgacttgctg gacatcaaac
      661 agatgagaga ccggaacagc cagcccgtgg ttaagaaaat aaagccaggg atctccgcaa
      721 tggcagacac tccggaacat gctagcgatt accttcgacc tctgctgagc ttcgctgctg
      781 ctcatgtgcc cgtgaagaag cacagggaga cgccccttta catcctctgc actgcgggca
      841 tgaggctgct ccctgagagg caacagttgg ctatcttggc agatttagtg aaagatttgc
      901 cgttggagtt tgacttcctc ttttcacagt ctcaggccga agtgatctct gggaaacagg
      961 aaggagttta tgcatggatc ggaatcaact ttgttctggg aagatttgac catgaagatg
     1021 agtcagactc ggacacctct gtggactcag cagcaggccg caggaggaca gtgggaatcc
     1081 tggacatggg aggagcctct ctccaaattg cctacgaagt tcctacctca gcctccgacc
     1141 ttcctcccaa acaggaagaa gctgccaaga tcctgctggc cgagttcaac ctgggctgtg
     1201 acgtgcagca cacggagcac gtgtacaggg tttatgtcac caccttcctg ggctttgggg
     1261 gcaactttgc ccggcagcgc tatgaagatc tcgtgctgaa tgaaacgctt aacaaaaaca
     1321 gactgctggg ccagaagaca ggcctgagtc ctgacaatcc ctttctggac ccctgcctgc
     1381 ctgtgggact cacagatatg gtgaagagga acaaccaggt ccttcacttc cgaggaaagg
     1441 gagactgggc cagttgtcgg acattgctga gccccctgct ggcccgctcc aacaccagcc
     1501 aggcctcact gaacggtatt taccagtctc caatcgactt caacaacagc gagttctatg
     1561 gcttctcaga gttcttctac tgcaccgaag atgtgctgcg catcggtggc cactaccacg
     1621 ggcccacatt tgccaaggct gctcaggatt actgtggcat ggcgtggccg gtgctagccc
     1681 agagattcaa gaacggcctc ttttcttcac acgcagacga gcatcgactc aagtatcagt
     1741 gttttaagtc cgcttggatg tacgaagtcc tgcacgaggg gttccacttc ccctacgact
     1801 acccaaacct gcagacagcg cagctggtgt atgaccgaga ggtgcagtgg acgctgggag
     1861 caattctgta taaaacccga ttcctgcctc tcagggacct tcggcaggga cagggaggag
     1921 tccggccagc ccacggcagc tggctccgcc tttcctttgt ctacaaccac tatctcttct
     1981 ttgcttgtac cctggtggtg cttctggcca tcgtcctgta ccttctgcgc atccacagaa
     2041 ttcaccgcag acaaacccga gcctcggctc ctctggacct gctgtggatc gagcaagtgg
     2101 tgccgatgat tggggtccag gtggggccgt gaggctggag cggaagtgga gaacctccca
     2161 ttccttcgga ttgctgctgc tgctgctgct gactgaattc ctccactttc tcgaactggc
     2221 ctccgatgct gctttggcct gcgaatttct acttattcac tttgatttct ttttggtgcc
     2281 caggacggga cctcttctca gaagtcgcaa tttaacttcg aggaactaaa tgtcgagagg
     2341 ctggtgctaa gcttagccca aatgaagcat gcttctcctt tatctcagaa atttgatctg
     2401 tttctgggat gtagcatccc cccccccccc ccgccccttg ctgaagcaag tttttgattg
     2461 ggcaaccgga ggcgtggttg aaatcagctt ggattgactg ctacaaagcc agagacattc
     2521 cagcaagtgc agttgcccct gttttctctg taacagagag atccttatgt ggaagatcca
     2581 cagccttgaa tagggaccta agatctctga ggttcagtgg accagatttc aaggcaacca
     2641 aaacgataca acttccttgc ttacttgaca agccattgtg gatgtgctcg gagattcacc
     2701 cccccccccc ccccgcagtg tttctgattt tgttatatag atctgaaagg ttagagcgcc
     2761 tttgaaatgg atgacttatt gaagatctga cagtatttta tctgatactt ggtctgacca
     2821 gtatagaaaa cattttcatg tctatgtgcc tcacaaggct gcttgggcat taatattgcc
     2881 ttttgagcct taagtgtgct tatagattgg agaaaccgtg atgggaacag gacctagttt
     2941 tgcctgtttt ggttacggcc tcacaggcat atagcgtgta gaagattcaa agtgacttcc
     3001 ctcatttcac tcctaagatc ttatatatat atattgggaa ggaatgtact tgttttgttt
     3061 ataaattatg ttttgtttta agaaagaata gcatcaggag agtgggcaaa ggcaataaaa
     3121 tccaaggttt tgatttttgt ttttgttttt tgtttgtttg ttttttgttt tgttttgttt
     3181 agtttttttg agacagggtc tctgtagctc tggctgtcct ggaggaattt gctctataga
     3241 ccaggctggc cttgaactca aactcacaga gacctgcatc ttcctcccga tcactgggat
     3301 taaaggcatg agccagcatg cctggcttaa agtcaaagat cttacttttt tttttttttt
     3361 tttttttttg agatgctcaa aagacagcaa attctaaact ttggaataac tagataaatc
     3421 tgccatggag caacctggcc actttctgga tgtctgtcac aaatagctct cccactagcg
     3481 gggagaggaa agccatattc ccgatgttct cacctactgc ctctcagacg gccttctctg
     3541 cagccagcct ttcatactgt agtcctccat cgtcagctcc tccctgcccc cacctgggat
     3601 tgttcccagg gccgaagcag gagtttgatt tcttcttttg gggagtaagg caggtctcct
     3661 gagcccagtt ttctaggtcg ccaaggccag ccttgaagcc ctgatatccc tgcctctgtg
     3721 tctttgtagc gctggcttca aggagagcat caccaacctg gctcattttc tcttcatttt
     3781 gccaaagcct tttatctcta gtgttggagt tcagaagaaa aaaaaaagag tctaaaggaa
     3841 taaaaatgaa tttctttgat aataaattcc tcctgggaac agaaggaaat gaaatgattt
     3901 atgaaataga gaaaaaagtc aagatggtct tagggaggaa gccaacgtga ggatgagtgt
     3961 gttgacttag cagttaggca aggctgcaat taccatcatc tcctccctct tcctccccct
     4021 cctccctctc tctcctcgcc ccctctctct tcttccttct cctttccctt tcctcccctt
     4081 ccctcttctt cctcctcctc ctcccccttc ctccttttct tccttttctt ccccctccct
     4141 cccctctccc tcccctcccc ctcctctttt cttttctttt cttttttttt tttttgaggc
     4201 cgagtgggtg tcactaagta actcaggctg gcctggttct cagtggtcct cctgccacag
     4261 cctcctgagt gctgtgatta cagatgtgtg ccaccatgcg tgcacattag atacgtgcac
     4321 acctagcaaa gaattctttc atgtcatcta cttttcatta gggctgtgag gttgacatct
     4381 taggacttct cagttgtctc ccttctccat cattctaatt tttatgtcct gtgagtgagc
     4441 ctctgctttt tttttttaat gttgctataa aatgctctta ccagccattt gcttcctcag
     4501 ggaacattta gcttcatctt ggtttctata tagctgtctt ggtgtgttga gagatctagt
     4561 cagaagtccc tgggcaggtt aacagtggcc atgttcatgg gctccaattg agactggagg
     4621 agggaggtgg taatggtctg gttgtaaagc tctcattact gatcttcctc tttgtcctga
     4681 tgctactaga agcttccatc tgtcaagcac ttatttgtat ccctcttaat gttgtgttct
     4741 ttactatata tcatttaatc attacggcag cctttcggat tgatacccct acattctttt
     4801 tatagtttgg aaaaaaaaaa tctcaggata cctatcttta tcatttctca atataaatat
     4861 atttcttaat ttattttaat tagtctttga gtttctgttt ggtgcattgt atcctgttta
     4921 ttgctttcgt attatggggt ccagacttcc cttccttaca gtaaggcttc ccggagttcc
     4981 ataggttaag aactctgtta tatggagctg aggacattgc tctcaactca tccctgaggg
     5041 tagacttcaa atgggatctc attagccaag ttttcgctgc atctgtttta gtatttaaaa
     5101 tacttttggt tttatgttta agccattagc ttaactttgc acaatttttt tcttacccac
     5161 aacattccaa taattacaat ctgaatgaag gtacaaatgc ataatagaga tatctacctc
     5221 attatggaat aggtggcgat tcttgggaag tttctagact gggatttgta tgtgacttca
     5281 ttttagctgg actaggaatt aagtaggaac agcattggct gtttcagagt ctcttaaatc
     5341 ggtctcttag tttatgtttt accctccgtc tttgctgtgg ggaaggtaga cttctgccaa
     5401 actcgtgaag attttgctgg cattataaaa attagtatgt tcaaaaatga ggactaagaa
     5461 ccaagttttg gcacctttga ctaacaatac agaataacaa atatttttgt aaaccatgat
     5521 tgcaaaacaa tgattgaaat caaatacttt taggtaatgg tctgtatggt gggtggctct
     5581 gtccttgacc ttcaccctcc tcctaacttg gatgtgatcg aactggaaaa gctgttgtac
     5641 cctgcgtggg ttcctgtcca ttccaggctt tctgttttgg tgggaggctt gttaaggttc
     5701 tattttaagc cagctttgtc ttgttttata tccccatcgg ctgtctttga agggtttcat
     5761 atttcccctt ggcctagtag ttcattattt ttgtttgtta atactatcat tagaaggaca
     5821 gaggagaacc acacaccagc agaccatttt catttctgga aatcggagca ataaaaagac
     5881 tttttttata ttgtaaaatg gaattattgc tcatgctata agggcttcca gtttttcaaa
     5941 tatgaaccag gccattgctt ccatggcatg aaaacttgag ttgaaaatgt tctgagtcat
     6001 aggctgttta accatgcctg catgtcagac aagcttgaag atgtgtctat
//
