LOCUS       NM_172117               2500 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ectonucleoside triphosphate diphosphohydrolase 6
            (Entpd6), transcript variant 1, mRNA.
ACCESSION   NM_172117
VERSION     NM_172117.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2500)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2500)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2500)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   4  (bases 1 to 2500)
  AUTHORS   Chadwick,B.P. and Frischauf,A.M.
  TITLE     The CD39-like gene family: identification of three new human
            members (CD39L2, CD39L3, and CD39L4), their murine homologues, and
            a member of the gene family from Drosophila melanogaster
  JOURNAL   Genomics 50 (3), 357-367 (1998)
   PUBMED   9676430
REFERENCE   5  (bases 1 to 2500)
  AUTHORS   Chadwick,B.P., Williamson,J., Sheer,D. and Frischauf,A.M.
  TITLE     cDNA cloning and chromosomal mapping of a mouse gene with homology
            to NTPases
  JOURNAL   Mamm Genome 9 (2), 162-164 (1998)
   PUBMED   9457681
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845174.4.
            
            On Oct 24, 2007 this sequence version replaced NM_172117.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.142801.1,
                                           SRR1660817.289446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AL845174.4         193462-193614
            154-477             AL845174.4         197391-197714
            478-554             AL845174.4         200424-200500
            555-698             AL845174.4         203124-203267
            699-774             AL845174.4         204484-204559
            775-810             AL845174.4         205614-205649
            811-899             AL845174.4         206757-206845
            900-979             AL845174.4         207947-208026
            980-1044            AL845174.4         208496-208560
            1045-1146           AL845174.4         209831-209932
            1147-1284           AL845174.4         211340-211477
            1285-1341           AL845174.4         213246-213302
            1342-1454           AL845174.4         214673-214785
            1455-2500           AL845174.4         215010-216055
FEATURES             Location/Qualifiers
     source          1..2500
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.74 cM"
     gene            1..2500
                     /gene="Entpd6"
                     /gene_synonym="2700026H11Rik; Cd39l2; NTPDase-6"
                     /note="ectonucleoside triphosphate diphosphohydrolase 6"
                     /db_xref="GeneID:12497"
                     /db_xref="MGI:MGI:1202295"
     exon            1..153
                     /gene="Entpd6"
                     /gene_synonym="2700026H11Rik; Cd39l2; NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            154..477
                     /gene="Entpd6"
                     /gene_synonym="2700026H11Rik; Cd39l2; NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1553
                     /gene="Entpd6"
                     /gene_synonym="2700026H11Rik; Cd39l2; NTPDase-6"
                     /EC_number="3.6.1.6"
                     /note="isoform 1 is encoded by transcript variant 1; CD39
                     antigen-like 2; NTPDase 6"
                     /codon_start=1
                     /product="ectonucleoside triphosphate diphosphohydrolase 6
                     isoform 1"
                     /protein_id="NP_742115.2"
                     /db_xref="CCDS:CCDS16861.1"
                     /db_xref="GeneID:12497"
                     /db_xref="MGI:MGI:1202295"
                     /translation="MRKIPNHGTLRMTKVAYPLGLCVGLFIYVAYIKWHRASAAQAFF
                     TIAGAASGARWTQQAFSSPGSAARGHEVFYGIMFDAGSTGTRIHVFQFARPPGETPTL
                     THETFKALKPGLSAYADDVEKSAQGIQELLNVAKQHIPYDFWKATPLVLKATAGLRLL
                     PGEKAQKLLQKVKEVFKASPFLVGDDCVSIMNGTDEGVSAWITVNFLTGSLKTPGSSS
                     VGMLDLGGGSTQITFLPRVEGTLQASPPGHLTALQMFNRTYKLYSYSYLGLGLMSARL
                     AILGGVEGKPAENDKELVSPCLSPRFRGEWEHAEVTYRISGQKAVGLYELCASRVSEV
                     LRNKVHRTEEAQHVDFYAFSYYYDLAASFGLIDAEKGGSLVVGDFEIAAKYVCRTLET
                     QPPSSPFACMDLTYISLLLHEFGFPGDKVLKLARKIDNVETSWALGAIFHYIDSLKRQ
                     KVPAL"
     exon            478..554
                     /gene="Entpd6"
                     /gene_synonym="2700026H11Rik; Cd39l2; NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            555..698
                     /gene="Entpd6"
                     /gene_synonym="2700026H11Rik; Cd39l2; NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            699..774
                     /gene="Entpd6"
                     /gene_synonym="2700026H11Rik; Cd39l2; NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            775..810
                     /gene="Entpd6"
                     /gene_synonym="2700026H11Rik; Cd39l2; NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            811..899
                     /gene="Entpd6"
                     /gene_synonym="2700026H11Rik; Cd39l2; NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            900..979
                     /gene="Entpd6"
                     /gene_synonym="2700026H11Rik; Cd39l2; NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1044
                     /gene="Entpd6"
                     /gene_synonym="2700026H11Rik; Cd39l2; NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1146
                     /gene="Entpd6"
                     /gene_synonym="2700026H11Rik; Cd39l2; NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1284
                     /gene="Entpd6"
                     /gene_synonym="2700026H11Rik; Cd39l2; NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1341
                     /gene="Entpd6"
                     /gene_synonym="2700026H11Rik; Cd39l2; NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1454
                     /gene="Entpd6"
                     /gene_synonym="2700026H11Rik; Cd39l2; NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..2500
                     /gene="Entpd6"
                     /gene_synonym="2700026H11Rik; Cd39l2; NTPDase-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2480..2485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Entpd6"
                     /gene_synonym="2700026H11Rik; Cd39l2; NTPDase-6"
                     /note="hexamer: AATAAA"
     polyA_site      2499
                     /gene="Entpd6"
                     /gene_synonym="2700026H11Rik; Cd39l2; NTPDase-6"
                     /note="major polyA site"
ORIGIN      
        1 gacagcttct cggcgtctgc tggggtttgc ttccacgcgt taaggctctg ttgacgcgga
       61 ccggcgctgg agagctgggc gcgcggtgtg tggtcgctgt ctgcctccgg ctacgccact
      121 acctctcctg cggggccgag ggagccgtgc aggcagcggc tgcgtagttc ccagcagact
      181 gagaaatgag aaaaatacca aaccatggga ccctgcggat gacgaaggtg gcatatcccc
      241 tgggactgtg cgtgggcctg ttcatctatg ttgcctatat caagtggcac cgggcctctg
      301 ctgcccaggc cttcttcacc attgctgggg ctgcctcggg ggcacggtgg acccagcagg
      361 ccttcagctc cccaggctca gctgcacgtg gtcatgaggt cttctatggg atcatgtttg
      421 acgctgggag caccggcacc cgcatccacg tcttccagtt cgcccggcca cctggagaaa
      481 ctcccacctt gacccatgaa accttcaaag cactgaagcc tgggctttct gcttacgctg
      541 atgatgttga aaagagtgct caggggatcc aggagcttct gaatgttgct aagcaacaca
      601 ttccttatga tttctggaag gctacccctc tggttctcaa ggccacagct ggtttgcgcc
      661 tgctgccagg agaaaaggct cagaagttgc tgcaaaaggt gaaggaggtg ttcaaggcat
      721 cacccttcct tgtcggggat gactgtgttt ccatcatgaa cggcacagac gaaggtgttt
      781 cggcctggat cactgtcaac ttcctgacag gcagtctgaa gaccccagga agcagcagtg
      841 tgggcatgct ggatttgggc ggaggatcca ctcagatcac tttcctccca cgtgtcgagg
      901 gtaccctgca ggcctccccg cccggccacc tgacggcgct gcagatgttt aacaggactt
      961 acaagctgta ctcctacagc tacctggggc tgggactgat gtcggcacgg ctggctatct
     1021 tgggcggtgt ggaggggaaa cctgctgaga atgacaagga actggtcagc ccctgtctgt
     1081 ctccccggtt ccgaggagag tgggagcatg cggaggtcac ctatagaatt tcaggacaga
     1141 aggcagtggg cctctatgag ctgtgtgcca gtagagtatc agaagtcctc cgaaataaag
     1201 tacacaggac ggaagaggca cagcacgtgg acttctatgc gttttcctac tactatgacc
     1261 ttgcagccag ctttggtctt atagatgcag agaaaggagg cagccttgta gttggagact
     1321 ttgagatagc agccaagtac gtgtgccgca ctctggagac acagccgccg agcagcccct
     1381 ttgcctgcat ggacctcacc tacatcagcc tactgctcca cgagtttggt tttcccgggg
     1441 acaaggtgct gaagctggct cggaaaattg acaatgttga aaccagctgg gctctgggag
     1501 ctatttttca ttacatcgac tccctgaaga gacagaaggt tcctgccttg tagcagctga
     1561 gccctagtcc ctgcctcaac cagaattcca aggctcccaa ctccatggac ccctctgtct
     1621 tggaagtgac accatccttg aggagcctgc atctggctga gaccctctgt gcctgcagtg
     1681 tcatctgcag atttgcctgg gacatggccc atgtactagc cctgctacac cacactagct
     1741 ggggcagggc cagggtagga atgctgcttg gcctgaggcc atctccctgc cttacttacc
     1801 tccaagtggg cagggagcca ggtggggccc agggcacatg cagccctgtt cttattccat
     1861 ccctgtgcag gattgtggct gcttttatgt gtttctgtga cgtgagtctt gttttgtctc
     1921 ccagcccctg ttccctcatg agccaggcct ctctgccttc ccagagttgt gggagttgaa
     1981 gtaacctgac cttgccacag tgcaacctcg aggggagcac atcttgaatg tggccatctc
     2041 ttcctcggga cagacatgtg aaatcacctg gagatttgct gtcccacctt tgaatggtat
     2101 agcattaact gatgtgggga cactgagtag gaagaagatg gcccagtgcc tctttacaga
     2161 cccagcgtgc cgcctttgca gagaatgtgg gtgtgagcag agctgtgaga atgttcaggg
     2221 ccgttgctca agtactacct tgtgagctgt gagtgcttta tgttaaaact gagcccctct
     2281 tctggacaca actatgtccc agtgaatgta ttcctgctat gagccacttg cagaccagtg
     2341 gggcggatga gaaagctcag ccctgaacca tactacccct taccccaccc tcctcactcg
     2401 gctgcagctg gcttccccat ggtcccctca gtgaatgtac agttcataaa ataagctgag
     2461 ccaccactgt tcaactcaaa ataaaggttt acaagggttt
//
