LOCUS       NM_001026214            4987 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus ectonucleoside triphosphate diphosphohydrolase 5
            (Entpd5), transcript variant 2, mRNA.
ACCESSION   NM_001026214
VERSION     NM_001026214.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4987)
  AUTHORS   Xu,L., Zhou,Y., Wang,G., Bo,L., Jin,B., Dai,L., Lu,Q., Cai,X.,
            Hu,L., Liu,L., Wu,Y., Chang,X., Huang,Y., Song,L., Zhang,T.,
            Wang,Y., Xiao,Y., Zhang,F., Liu,L., Shi,M., Wang,T. and Guo,B.
  TITLE     The UDPase ENTPD5 regulates ER stress-associated renal injury by
            mediating protein N-glycosylation
  JOURNAL   Cell Death Dis 14 (2), 166 (2023)
   PUBMED   36849424
  REMARK    GeneRIF: The UDPase ENTPD5 regulates ER stress-associated renal
            injury by mediating protein N-glycosylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4987)
  AUTHORS   Walsh,J., Jenkins,R.E., Wong,M., Olayanju,A., Powell,H., Copple,I.,
            O'Neill,P.M., Goldring,C.E., Kitteringham,N.R. and Park,B.K.
  TITLE     Identification and quantification of the basal and inducible
            Nrf2-dependent proteomes in mouse liver: biochemical,
            pharmacological and toxicological implications
  JOURNAL   J Proteomics 108 (100), 171-187 (2014)
   PUBMED   24859727
  REMARK    GeneRIF: Six proteins were regulated at both basal and inducible
            levels exhibiting the largest dynamic range of Nrf2 regulation:
            cytochrome CYP2A5, GSTM3, GSTM1, ENTPD5,UDPGDH, and EPHX1.
REFERENCE   3  (bases 1 to 4987)
  AUTHORS   Georgas,K.M., Chiu,H.S., Lesieur,E., Rumballe,B.A. and Little,M.H.
  TITLE     Expression of metanephric nephron-patterning genes in
            differentiating mesonephric tubules
  JOURNAL   Dev Dyn 240 (6), 1600-1612 (2011)
   PUBMED   21491542
REFERENCE   4  (bases 1 to 4987)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4987)
  AUTHORS   Fang,M., Shen,Z., Huang,S., Zhao,L., Chen,S., Mak,T.W. and Wang,X.
  TITLE     The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg
            effect, and proliferation in the PTEN pathway
  JOURNAL   Cell 143 (5), 711-724 (2010)
   PUBMED   21074248
  REMARK    GeneRIF: During a study using the embryonic fibroblasts from the
            PTEN null mice ENTPD5, is found to be upregulated by AKT
            activation; this enzyme seems to mediate many of the observed
            cancer-related phenotypes associated with AKT activation.
REFERENCE   6  (bases 1 to 4987)
  AUTHORS   Braun,N., Fengler,S., Ebeling,C., Servos,J. and Zimmermann,H.
  TITLE     Sequencing, functional expression and characterization of rat
            NTPDase6, a nucleoside diphosphatase and novel member of the
            ecto-nucleoside triphosphate diphosphohydrolase family
  JOURNAL   Biochem J 351 Pt 3 (Pt 3), 639-647 (2000)
   PUBMED   11042118
REFERENCE   7  (bases 1 to 4987)
  AUTHORS   Recio,J.A., Zambrano,N., de La Pena,L., Powers,C., Siwarski,D.,
            Huppi,K. and Notario,V.
  TITLE     cDNA isolation, expression, and chromosomal localization of the
            mouse pcph proto-oncogene
  JOURNAL   Mol Carcinog 26 (2), 130-136 (1999)
   PUBMED   10506756
REFERENCE   8  (bases 1 to 4987)
  AUTHORS   Trombetta,E.S. and Helenius,A.
  TITLE     Glycoprotein reglucosylation and nucleotide sugar utilization in
            the secretory pathway: identification of a nucleoside diphosphatase
            in the endoplasmic reticulum
  JOURNAL   EMBO J 18 (12), 3282-3292 (1999)
   PUBMED   10369669
REFERENCE   9  (bases 1 to 4987)
  AUTHORS   Chadwick,B.P. and Frischauf,A.M.
  TITLE     The CD39-like gene family: identification of three new human
            members (CD39L2, CD39L3, and CD39L4), their murine homologues, and
            a member of the gene family from Drosophila melanogaster
  JOURNAL   Genomics 50 (3), 357-367 (1998)
   PUBMED   9676430
REFERENCE   10 (bases 1 to 4987)
  AUTHORS   Chadwick,B.P., Williamson,J., Sheer,D. and Frischauf,A.M.
  TITLE     cDNA cloning and chromosomal mapping of a mouse gene with homology
            to NTPases
  JOURNAL   Mamm Genome 9 (2), 162-164 (1998)
   PUBMED   9457681
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY049870.1, AK081435.1, AK160950.1 and CD775710.1.
            
            On Oct 29, 2013 this sequence version replaced NM_001026214.1.
            
            Transcript Variant: This variant (2) encodes the predominant
            protein (isoform b). Variants 2, 3 and 4 encode the same isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036641.1, AK081435.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BY049870.1         2-37
            37-1822             AK081435.1         2-1787
            1823-4400           AK160950.1         1644-4221
            4401-4987           CD775710.1         1-587               c
FEATURES             Location/Qualifiers
     source          1..4987
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.18 cM"
     gene            1..4987
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /note="ectonucleoside triphosphate diphosphohydrolase 5"
                     /db_xref="GeneID:12499"
                     /db_xref="MGI:MGI:1321385"
     exon            1..60
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            61..130
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            131..203
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            204..483
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..1553
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /EC_number="3.6.1.6"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; NTPDase 5; nucleoside diphosphatase; GDPase
                     ENTPD5; UDPase ENTPD5; uridine-diphosphatase ENTPD5;
                     guanosine-diphosphatase ENTPD5; CD39 antigen-like 4"
                     /codon_start=1
                     /product="ectonucleoside triphosphate diphosphohydrolase 5
                     isoform b precursor"
                     /protein_id="NP_001021385.1"
                     /db_xref="CCDS:CCDS26045.1"
                     /db_xref="GeneID:12499"
                     /db_xref="MGI:MGI:1321385"
                     /translation="MATSWGAVFMLIIACVGSTVFYREQQTWFEGVFLSSMCPINVSA
                     GTFYGIMFDAGSTGTRIHVYTFVQKTAGQLPFLEGEIFDSVKPGLSAFVDQPKQGAET
                     VQELLEVAKDSIPRSHWERTPVVLKATAGLRLLPEQKAQALLLEVEEIFKNSPFLVPD
                     GSVSIMDGSYEGILAWVTVNFLTGQLHGRGQETVGTLDLGGASTQITFLPQFEKTLEQ
                     TPRGYLTSFEMFNSTFKLYTHSYLGFGLKAARLATLGALEAKGTDGHTFRSACLPRWL
                     EAEWIFGGVKYQYGGNQEGEMGFEPCYAEVLRVVQGKLHQPEEVRGSAFYAFSYYYDR
                     AADTHLIDYEKGGVLKVEDFERKAREVCDNLGSFSSGSPFLCMDLTYITALLKDGFGF
                     ADGTLLQLTKKVNNIETGWALGATFHLLQSLGITS"
     exon            484..563
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            564..707
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            708..783
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            784..819
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            820..908
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            909..988
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1050
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1152
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1293
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1350
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1466
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..4972
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2143..2148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /note="hexamer: AATAGA"
     polyA_site      2171
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /note="major polyA site"
     regulatory      4949..4954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /note="hexamer: AATAAA"
     polyA_site      4972
                     /gene="Entpd5"
                     /gene_synonym="Cd39l4; ER-UDPase; mNTPase; NTPDase-5;
                     NTPDase5; Pcph"
                     /note="major polyA site"
ORIGIN      
        1 gaggggcggg gcggagatcg ctccgaggcg gcgggcgtcc gcgccagggc ggcgcgcgcg
       61 ttcttggttg acacaggaat gaagagtgta ttggctgaat cttcaagcag aggcgatcat
      121 tatgaccctg ctttttaaat tggcctgcgt gacccgccca cttggtgtaa aagaagaacc
      181 ggccaaaggg agggcctgaa ggacctccac aggagtgtga gcagcactgc ttcagcaaca
      241 aagcctcagg tccacatctt gggaagaata tggccacttc ctggggggct gtcttcatgc
      301 tgatcatagc ctgcgttggc agcactgtct tctacagaga acagcagacc tggtttgaag
      361 gtgtcttctt gtcttccatg tgccccatta atgtcagtgc cggcaccttt tatggaatta
      421 tgtttgatgc gggcagcact ggaactcgga ttcatgttta cacttttgtg cagaaaacag
      481 caggacagct cccctttctg gaaggtgaaa tttttgattc tgtgaagccg ggactttctg
      541 cttttgtgga tcagcccaaa cagggtgctg agactgtcca ggagctcttg gaggtggcca
      601 aagactcgat ccccagaagc cactgggaaa ggaccccggt ggttctgaaa gcaacggccg
      661 gactccgttt gctgcctgag cagaaagccc aggctctgct cttggaggta gaggagatct
      721 tcaagaattc acctttcctg gtcccagatg gcagcgttag catcatggat gggtcctatg
      781 aaggcatact agcctgggtt accgtgaact ttctaacagg tcagctgcat ggtcgtggcc
      841 aggagactgt ggggaccctt gacctggggg gtgcctccac ccaaatcacg tttctacccc
      901 agtttgagaa aaccctggaa caaacaccta ggggctacct cacttccttt gagatgttta
      961 acagcacttt taagctctat acacatagtt acttgggatt tggactgaaa gctgcaagac
     1021 tggcaactct gggagccctg gaagcaaaag ggactgatgg acatacgttt cgaagtgcct
     1081 gtttaccaag atggttggaa gcagagtgga tctttggggg tgtgaaatac cagtatggtg
     1141 gtaaccaaga aggggagatg ggctttgaac cctgctatgc ggaagtgctg agggtagtac
     1201 aggggaaact tcaccagcca gaagaagtcc gaggaagcgc cttctacgct ttctcttact
     1261 actacgatcg agccgctgac acacacttga tcgattatga aaagggcggg gttttaaaag
     1321 ttgaagattt tgaaagaaaa gccagagaag tgtgtgacaa cttggggagc ttctcctcgg
     1381 gcagtccttt cctctgcatg gacctcactt acatcacagc cctgttgaaa gatggttttg
     1441 gctttgccga cggcaccctc ttacagctca caaagaaagt gaacaacata gagactggtt
     1501 gggccttggg ggccaccttt cacctgctcc agtctctggg catcaccagc tgaggccaag
     1561 ctccacctct gaagcctgca tttctgaaca gttttctcac aggaaggcgt ggactcagag
     1621 acattttctg acctctctgg aaaagcctgg cccgaaaccc gttaactggt tttataagga
     1681 gggaggggtt tttagatgag tcttgctctt gagcctagtg atttgggctt caatgatttg
     1741 cacatctaat gtgaatagct cctaaccact tggtgggtgc atggctggca ccagactgta
     1801 aatcttttgg gattctttgt tacagagtcc tgcaaaggaa aaaagagaaa aggtttggaa
     1861 ctccatgcta gattgcgagt tcagagacag gtccctgggg accaaagaac aatctcgttt
     1921 caacccttgg atgcctcatt gctttgaatg gattcatttt tgcttataag ctgatttact
     1981 gaaatcccat aacccatcaa tgctgttaat ttttttcttc ctacccttat tacattccct
     2041 accctaaaag cctgggggaa atacctggtt ttgcttccca tctataattg agaaagaggg
     2101 gggaaaagat actgtattag aatttgtgtg atcctgtggc acaatagatc aaccaaccca
     2161 tttaaagctt agagctgtcc tcagtatttt atttttagac aagggctgtg ttgtgtttgt
     2221 tgttcaggct ggcctggaac tcagtatgta acccaggttg ccttgaatta ccaattctcc
     2281 cgcctcagcc tcctgaacct tgggcttgca ggagtgagct gttatgctca tgtcatggcc
     2341 catcttagca agacggagag agtagctctt aactgcctag agtataagca aggagaccgt
     2401 cgggtctcaa gggatagctg ttgccactct ggacgtaatg aacattccgc cctggagatg
     2461 cgtgcctatc cagtgtcagt cagcactgcc tcccaagccc atgtgtttat agaattaaac
     2521 acagccctaa actgtgtgcc tttgtatttc cgtgaagtac aaatgtgccc ttgttttcgc
     2581 tctgcagtta gaagttaatg cgtgagctct ttgtgtctaa agattaccaa tgctttcagt
     2641 tgtcctttgg ggggttgagg tgtggaaagt gctgggaatc gaacccagga cttcttgaat
     2701 gttaagcaca atgtgctagc actatgcttg tatagtcctg ctttcctgcc taggcccctg
     2761 ctgaatttgg ctattttctg aattcgttgt ctagctcagg atctcagaac ccctttccag
     2821 tgatacccaa atttggtttg gttggctatt ttggtccata ttggtacagg tcaggacagt
     2881 gagtagcatt agagaaccat gttttctctc tcaggacgtt ttctgggttg tggttgaaca
     2941 caggtcatgc atgcgaggca tgggtactca ctctactgca ttatttagct ctttaaagtc
     3001 attacctgaa agatcttaaa cttctgtcac tatgtcgttt ctagtattac atcactggcc
     3061 acagggtctc ctgtcgcttg gctcctgtca cagcactttg ccctcctctt ctctttccag
     3121 cccaggaagt tttcatctcc cctaatgtaa tttttggcca cctacttttc cttctgctct
     3181 tcacaaagga tgtgactatg cctgggccca tggtagtccc tggggaacct tgttttttaa
     3241 gccattacat cgagtcaata atataaagaa aaaggtattc gaccagtcat agtccactaa
     3301 atgctatcac agttgtgaga aaccaagctg tctccccaag agtaagcaag caatgctcat
     3361 taagatgcct ttataacagg ccttatggcg caggcctgta atcctagcta ccttgaagct
     3421 gaggcaggag gactgcaagt tataggcttg ctgtgggcaa ctcagtgcaa cactcaacaa
     3481 attttaaaag ggatgagtta gaagacagtg ttcagtggca aagctagttg gcatgccagg
     3541 ccctagattc agtccccagc actaaagaca aagcagacta ctgctctcta cacagctggt
     3601 ctctgacacc tcagacacag gggccctagc tataaagtgt gtattgttcc acagacacct
     3661 atggttacct tggatactgc cagaactcct aaatacatga acttttacct cagaaattta
     3721 tctgcttatg tcctgttaat cttcaaggct ttttgtttgt tcttttggag acagggtttc
     3781 tgtctgtgta gctctggttg ccctagagtg ggtctctgta gaccaggctg gcctcaaact
     3841 catagatctg tctctgcctc tctagtatta gaatgaaagg tgtgcaccac cactacccgg
     3901 caacgtacac cttttttatt aaggggcttc tattgtgttc tgaagttcca tctctgtgac
     3961 aacattaata tactttaaat acctgggatg tggtctggta catacatggt ggatgctgtg
     4021 tgtgtattat atatactact atattatgaa cacctgagtc atggaagtcc ttgcaaagtg
     4081 tgccttaaaa tcctcaacct ttttaacttt tctcatacat cgaagtcagt attcttatga
     4141 aggcccccat attgaaaaaa gtcaccttgt cctgagaggt tgtagccatc atcattttcc
     4201 agcggctgcc atcttttatt ctgggaacgt tttctgggtt cactgacatc attactttgt
     4261 actaagtttt cctcgttgct taaaaggctg ctctgtagca acaactgtct catcccttca
     4321 aagcttttcc aaagcagttt agcttatttg aaaagggggc tttcttactt catcttttca
     4381 aaataaactg ctgggcatgc cgtttctgta gtgttgttat ctaacacagc tcagggtctc
     4441 ttctggaggc ctctttggca ctttgcagta cacacacact tcaaaacccc aaataatgaa
     4501 gcactcagcc acacaaggag gacctgtgca gcagctgagc cccttctgac tggttgctga
     4561 ggcctctgca gctgtgcgtg cgatgagatc gtgtattgtt ttattactgg acagagaatg
     4621 gtatcccaga gaggagccat aaataaaact gaactgtgga gccgtgataa ggaaggagaa
     4681 atagcagtac taataagatc tggctgttat ttatcttcgt gtccccctta aatccagtgt
     4741 actttgtcaa agcaatttgt atttaactgg catgccagtg ttaattttaa aacaacagtc
     4801 taacaaaaat gtatcaggta tttctaattc ttactctgtc aagataatta tataaattta
     4861 tgaccagcat ttaagtactt tatttagaaa ggtctgttgc caagtgaagt gagggagaac
     4921 atcttggaga ttcctttgtt tgtgtagtaa taaaaagctc cttttaatta aaaaaaaaaa
     4981 aaaaaaa
//
