LOCUS       NM_026174               3084 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus ectonucleoside triphosphate diphosphohydrolase 4
            (Entpd4), transcript variant 1, mRNA.
ACCESSION   NM_026174 XM_913933
VERSION     NM_026174.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3084)
  AUTHORS   Boschen,K.E., Ptacek,T.S., Berginski,M.E., Simon,J.M. and
            Parnell,S.E.
  TITLE     Transcriptomic analyses of gastrulation-stage mouse embryos with
            differential susceptibility to alcohol
  JOURNAL   Dis Model Mech 14 (6) (2021)
   PUBMED   34137816
REFERENCE   2  (bases 1 to 3084)
  AUTHORS   Xiao,J., Vemula,S.R., Xue,Y., Khan,M.M., Kuruvilla,K.P.,
            Marquez-Lona,E.M., Cobb,M.R. and LeDoux,M.S.
  TITLE     Motor phenotypes and molecular networks associated with germline
            deficiency of Ciz1
  JOURNAL   Exp Neurol 283 (Pt A), 110-120 (2016)
   PUBMED   27163549
REFERENCE   3  (bases 1 to 3084)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   4  (bases 1 to 3084)
  AUTHORS   Cui,C.Y., Kunisada,M., Esibizione,D., Grivennikov,S.I., Piao,Y.,
            Nedospasov,S.A. and Schlessinger,D.
  TITLE     Lymphotoxin-beta regulates periderm differentiation during
            embryonic skin development
  JOURNAL   Hum Mol Genet 16 (21), 2583-2590 (2007)
   PUBMED   17673451
REFERENCE   5  (bases 1 to 3084)
  AUTHORS   Corbo,J.C. and Cepko,C.L.
  TITLE     A hybrid photoreceptor expressing both rod and cone genes in a
            mouse model of enhanced S-cone syndrome
  JOURNAL   PLoS Genet 1 (2), e11 (2005)
   PUBMED   16110338
  REMARK    Erratum:[PLoS Genet. 2008 Jan;4(1):e18]
REFERENCE   6  (bases 1 to 3084)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   7  (bases 1 to 3084)
  AUTHORS   Biederbick,A., Kosan,C., Kunz,J. and Elsasser,H.P.
  TITLE     First apyrase splice variants have different enzymatic properties
  JOURNAL   J Biol Chem 275 (25), 19018-19024 (2000)
   PUBMED   10858452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY276189.1, AK004761.1 and AK031065.1.
            
            On Mar 24, 2009 this sequence version replaced NM_026174.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1). This locus is
            contained within a tandem segmental duplication. This sequence
            aligns equally well to ectonucleoside triphosphate
            diphosphohydrolase 4B.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045342.1, AK004761.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BY276189.1         2-35
            35-3029             AK004761.1         2-2996
            3030-3084           AK031065.1         2171-2225
FEATURES             Location/Qualifiers
     source          1..3084
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.05 cM"
     gene            1..3084
                     /gene="Entpd4"
                     /gene_synonym="1200014F22Rik; 4930513O14Rik;
                     A430102M06Rik; Lysal1; mKIAA0392"
                     /note="ectonucleoside triphosphate diphosphohydrolase 4"
                     /db_xref="GeneID:67464"
                     /db_xref="MGI:MGI:1914714"
     exon            1..138
                     /gene="Entpd4"
                     /gene_synonym="1200014F22Rik; 4930513O14Rik;
                     A430102M06Rik; Lysal1; mKIAA0392"
                     /inference="alignment:Splign:2.1.0"
     exon            139..247
                     /gene="Entpd4"
                     /gene_synonym="1200014F22Rik; 4930513O14Rik;
                     A430102M06Rik; Lysal1; mKIAA0392"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..2081
                     /gene="Entpd4"
                     /gene_synonym="1200014F22Rik; 4930513O14Rik;
                     A430102M06Rik; Lysal1; mKIAA0392"
                     /EC_number="3.6.1.6"
                     /EC_number="3.6.1.15"
                     /EC_number="3.6.1.42"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lysosomal apyrase-like 1; UDPase; NTPDase 4;
                     uridine-diphosphatase; lysosomal apyrase-like protein of
                     70 kDa"
                     /codon_start=1
                     /product="ectonucleoside triphosphate diphosphohydrolase 4
                     isoform 1"
                     /protein_id="NP_080450.1"
                     /db_xref="CCDS:CCDS27240.1"
                     /db_xref="GeneID:67464"
                     /db_xref="MGI:MGI:1914714"
                     /translation="MGRIGISCLFPASWHFSISPVGCPRILNTNLRQIVVISILAAAV
                     SLLYFSVVIIRSKYGWLSKDKKFQRYLARVTDVEATDTNNPSVNYGIVVDCGSSGSRI
                     FVYCWPRHNGNPHDLLDIRQMRDKNRKPVVMKIKPGISEFATSPEKVSDYISPLLSFA
                     AEHVPRAKHKETPLYILCTAGMRVLPESQQKAILEDLLTDIPVHYDFLFSDSHAEVIS
                     GKQEGVYAWIGINFVLGRFEHIEEDDEAVVEVNIPGSESSEAIVRKRTAGVLDMGGVS
                     TQIAYEVPQTVSFASSQQEEVAKNLLAEFNLGCDVHQTEHVYRVYVATFLGFGGNAAR
                     QRYEDRLFASTVQKNRLLGKQTGLTPDAPLLDPCLPLDIKDEIQQNGQTLYLQGTGDF
                     DLCRETLQPFMNKTNETQTSLNGVYQPPIHFQNSEFYGFSEFYYCTEDVLRMGGDYNA
                     ARFTQAAKDYCATKWSILRERFDRGLYASHADLHRLKYQCFKSAWMFEVFHKGFSFPV
                     TYKNLKTALQVYDKEVQWTLGAILYRTRFLPLRDIRQEVFRAGHAHWRGVSFVYNHYL
                     FSGCFLVVLLSILLYLLRLRRIHRRAPRTGSLWMEEGLPSQKGPGPL"
     exon            248..445
                     /gene="Entpd4"
                     /gene_synonym="1200014F22Rik; 4930513O14Rik;
                     A430102M06Rik; Lysal1; mKIAA0392"
                     /inference="alignment:Splign:2.1.0"
     exon            446..651
                     /gene="Entpd4"
                     /gene_synonym="1200014F22Rik; 4930513O14Rik;
                     A430102M06Rik; Lysal1; mKIAA0392"
                     /inference="alignment:Splign:2.1.0"
     exon            652..802
                     /gene="Entpd4"
                     /gene_synonym="1200014F22Rik; 4930513O14Rik;
                     A430102M06Rik; Lysal1; mKIAA0392"
                     /inference="alignment:Splign:2.1.0"
     exon            803..906
                     /gene="Entpd4"
                     /gene_synonym="1200014F22Rik; 4930513O14Rik;
                     A430102M06Rik; Lysal1; mKIAA0392"
                     /inference="alignment:Splign:2.1.0"
     exon            907..966
                     /gene="Entpd4"
                     /gene_synonym="1200014F22Rik; 4930513O14Rik;
                     A430102M06Rik; Lysal1; mKIAA0392"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1121
                     /gene="Entpd4"
                     /gene_synonym="1200014F22Rik; 4930513O14Rik;
                     A430102M06Rik; Lysal1; mKIAA0392"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1288
                     /gene="Entpd4"
                     /gene_synonym="1200014F22Rik; 4930513O14Rik;
                     A430102M06Rik; Lysal1; mKIAA0392"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1613
                     /gene="Entpd4"
                     /gene_synonym="1200014F22Rik; 4930513O14Rik;
                     A430102M06Rik; Lysal1; mKIAA0392"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1699
                     /gene="Entpd4"
                     /gene_synonym="1200014F22Rik; 4930513O14Rik;
                     A430102M06Rik; Lysal1; mKIAA0392"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1861
                     /gene="Entpd4"
                     /gene_synonym="1200014F22Rik; 4930513O14Rik;
                     A430102M06Rik; Lysal1; mKIAA0392"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..3084
                     /gene="Entpd4"
                     /gene_synonym="1200014F22Rik; 4930513O14Rik;
                     A430102M06Rik; Lysal1; mKIAA0392"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcgagct gtgacgtgac gttggcgggc gcgcgccgcg tggctcccgg aaaggagccg
       61 aacctccgga aagctggtgg ccgggatgcg gggcgctagt ggccgcccgc ccccccggag
      121 ccgcggcccg cccagcaggg tggccctgac tccatgaagg ccccagctct gattctgtca
      181 ttgtggatga cgaggactga ctcccaccat atcgcctgga ccttgcttgc cctttcagta
      241 tggggaggat tggcatttcc tgtctctttc ctgcctcttg gcattttagc atctctccag
      301 tgggctgtcc tcgaattctg aacaccaatt tacgacaaat cgttgtcatt agcatcctgg
      361 ctgcagctgt ctccctttta tacttctctg ttgtcataat ccgcagcaag tatgggtggc
      421 tgtcaaagga caagaaattt caaaggtact tggcccgagt cacagacgtt gaggccacag
      481 acaccaacaa ccccagcgtg aactatggca tcgtggtgga ctgcggcagc agtgggtctc
      541 ggatatttgt ctactgctgg cctcggcaca atggcaaccc tcacgatctg ctggacatca
      601 gacagatgag ggacaaaaac cggaagccag tggtgatgaa gattaagccc ggcatctcag
      661 agtttgctac ctctccagaa aaagtcagcg actacatttc tccgcttctg agctttgctg
      721 cagaacatgt gcctcgggca aaacacaaag agacacctct ctacattctc tgcacagctg
      781 gaatgagagt ccttcctgaa agccagcaga aagccatcct agaggacctc ctgaccgaca
      841 tccctgtgca ctatgatttc ctgttttctg actcccatgc cgaagtcatc tcaggaaaac
      901 aagaaggtgt gtatgcttgg atcggcatta attttgtcct cggacggttt gagcatattg
      961 aggaggatga cgaggcggtt gtggaagtca acattccggg cagcgagagc agcgaggcca
     1021 tcgtgcggaa aaggacagct ggtgtcctcg acatgggagg cgtgtctacc cagatagcgt
     1081 acgaagtccc ccaaactgta agctttgcct cctcgcagca ggaagaagta gctaaaaacc
     1141 tgttagctga attcaacctg gggtgcgatg tccaccagac tgagcatgtg taccgcgtct
     1201 acgtggccac gtttcttggg tttggtggta atgctgcccg gcagagatat gaagaccgac
     1261 tatttgccag cacagttcag aaaaacaggc tcctgggtaa acagactggt ctgactcctg
     1321 atgctccact actggatccc tgcttgcctc tggacattaa agatgagatc cagcaaaacg
     1381 ggcagaccct gtaccttcag gggacaggag actttgacct gtgtcgagag accctgcagc
     1441 ctttcatgaa caaaaccaat gagacccaga cttccctcaa tggcgtctac cagcctccaa
     1501 tccacttcca gaacagtgaa ttctacggct tctctgagtt ctactactgc accgaggatg
     1561 tcttgcgaat ggggggagac tacaatgctg ctagattcac tcaagctgcc aaggattact
     1621 gtgcaacaaa gtggtcgatc ctgcgggaac gctttgaccg aggactctat gcctctcatg
     1681 ccgacctcca tcgactgaag tatcagtgtt tcaaatcagc ctggatgttc gaggtgttcc
     1741 acaaaggctt ctcctttcct gtcacctaca aaaacctgaa gacggccttg caggtgtatg
     1801 acaaggaagt acagtggacc ctgggggcca tcctttaccg gacccgcttc ctgcccttga
     1861 gagacatccg gcaggaggtg ttccgagctg gccacgcgca ctggcggggc gtgtccttcg
     1921 tctacaacca ctatctgttc tccggttgct tcctggtcgt ccttctgtcc atccttctct
     1981 acctgctgcg gctgcggcgc atccaccgca gggcgccccg cactggctct ctgtggatgg
     2041 aggaaggcct gccctcccag aagggccctg ggcccttgtg acagacactg cgtcagcctg
     2101 aagaagactc tacaggaaaa gccattttca cctcagggtt tcttgtatgc tcagacggtt
     2161 ttgtttgccc ctttcctttc tgttacaaaa accctctgat tgtaagccct gctgtctgga
     2221 gggactacca ttgtgaacac agctttaaca ggaggggtgg gaataggaag ttcactctgc
     2281 cacacatcag cactttcagc acacgcactt gaatgcagtg ccaaggggac agtggcaggt
     2341 tcccatcagc atgggtggca cttcagagtg tcctgggaca gaaccaagcc gtgagttaga
     2401 ccctctttcc tctccaaaca cctcaaccta gaagggaggc gtttggtttt atttgctgct
     2461 caggtccatc accatcggtg ttttcttgac agatgtaaga ctttagtctt tcataggaaa
     2521 aatcaacaag atggtggcac agggaggtga cactgaagag tggtcagtga tgagagctcc
     2581 agaggcgagc cacgctctgc cgcagacaag cacacacctg caaagcagcc gcgcttgtcc
     2641 tgtgctgaga atctctgtgg ccctctcaga gcagccttgg ggtttgtttg agtgctcatt
     2701 tgttttgttt gtttgttttt aaaccagaaa gttcttaaag ttcccctggt ccagtggtct
     2761 gagagagagc tgagtgtgcc ctacaggtgc ccagcgcctc tgagccgaag gtctgtgctg
     2821 ttgagctagc tgctccaggc tcttcctctt ctgagctgtc gtcccactgt tcagatctct
     2881 tcactgtttt tcttcaggac accccacaca ttgcttgaca gtccttgttg tcacgctgtg
     2941 gttgcagctg tcgttggcaa tgccactgta agcccacacc gtggaagagc ctgaatttaa
     3001 aataagaaat aaatgcacac gttgaaaaca gacttgacat tttaaacaga aacctgaaaa
     3061 ggacaaccag ggacatgcga ggct
//
