LOCUS       NM_178676               3467 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus ectonucleoside triphosphate diphosphohydrolase 3
            (Entpd3), mRNA.
ACCESSION   NM_178676
VERSION     NM_178676.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3467)
  AUTHORS   Sandhu,B., Perez-Matos,M.C., Tran,S., Singhal,G., Syed,I.,
            Feldbrugge,L., Mitsuhashi,S., Pelletier,J., Huang,J., Yalcin,Y.,
            Csizmadia,E., Tiwari-Heckler,S., Enjyoji,K., Sevigny,J.,
            Maratos-Flier,E., Robson,S.C. and Jiang,Z.G.
  TITLE     Global deletion of NTPDase3 protects against diet-induced obesity
            by increasing basal energy metabolism
  JOURNAL   Metabolism 118, 154731 (2021)
   PUBMED   33631144
  REMARK    GeneRIF: Global deletion of NTPDase3 protects against diet-induced
            obesity by increasing basal energy metabolism.
REFERENCE   2  (bases 1 to 3467)
  AUTHORS   Feldbrugge,L., Moss,A.C., Yee,E.U., Csizmadia,E., Mitsuhashi,S.,
            Longhi,M.S., Sandhu,B., Stephan,H., Wu,Y., Cheifetz,A.S.,
            Muller,C.E., Sevigny,J., Robson,S.C. and Jiang,Z.G.
  TITLE     Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2
            and -3 in the Enteric Nervous System Affects Inflammation in
            Experimental Colitis and Crohn's Disease
  JOURNAL   J Crohns Colitis 11 (9), 1113-1123 (2017)
   PUBMED   28472257
  REMARK    GeneRIF: NTPDase2 and -3 are ecto-enzymes expressed in the enteric
            nervous system. Both enzymes confer protection against gut
            inflammation in experimental colitis and exhibit alterations in
            Crohn's disease. These observations suggest that purinergic
            signalling modulated by E-NTPDases governs neuro-immune
            interactions that are relevant in Crohn's disease.
REFERENCE   3  (bases 1 to 3467)
  AUTHORS   Ma,L., Trinh,T., Ren,Y., Dirksen,R.T. and Liu,X.
  TITLE     Neuronal NTPDase3 Mediates Extracellular ATP Degradation in
            Trigeminal Nociceptive Pathway
  JOURNAL   PLoS One 11 (10), e0164028 (2016)
   PUBMED   27706204
  REMARK    GeneRIF: Results identified the expression of ecto-NTPDase3 in
            trigeminal nociceptive neurons and demonstrated the presence of
            functional ecto-ATPase activity in trigeminal nerves and
            established that ecto-NTPDase3mediates extracellularATP degradation
            in the nociceptive lamina on the brainstem.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3467)
  AUTHORS   Armfield,B.A., Seifert,A.W., Zheng,Z., Merton,E.M., Rock,J.R.,
            Lopez,M.C., Baker,H.V. and Cohn,M.J.
  TITLE     Molecular Characterization of the Genital Organizer: Gene
            Expression Profile of the Mouse Urethral Plate Epithelium
  JOURNAL   J Urol 196 (4), 1295-1302 (2016)
   PUBMED   27173853
REFERENCE   5  (bases 1 to 3467)
  AUTHORS   Oliveira,S.D., Oliveira,N.F., Meyer-Fernandes,J.R., Savio,L.E.,
            Ornelas,F.G., Ferreira,Z.S., Coutinho-Silva,R. and Silva,C.L.
  TITLE     Increased expression of NTPDases 2 and 3 in mesenteric endothelial
            cells during schistosomiasis favors leukocyte adhesion through P2Y1
            receptors
  JOURNAL   Vascul Pharmacol 82, 66-72 (2016)
   PUBMED   26924460
  REMARK    GeneRIF: Mesenteric endothelial cells are primed by schistosomiasis
            to a pro-inflammatory phenotype characterized by an increased
            expression of NTPDases 2 and 3, favoring ADP accumulation and
            mononuclear cell adhesion, possibly contributing to mesenteric
            inflammation and schistosomiasis morbidity via P2Y1 receptor
            signaling.
REFERENCE   6  (bases 1 to 3467)
  AUTHORS   Lavoie,E.G., Gulbransen,B.D., Martin-Satue,M., Aliagas,E.,
            Sharkey,K.A. and Sevigny,J.
  TITLE     Ectonucleotidases in the digestive system: focus on NTPDase3
            localization
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 300 (4), G608-G620 (2011)
   PUBMED   21233276
  REMARK    GeneRIF: the specific localization of NTPDase3 in the digestive
            system suggests functional roles of the enzyme, in association with
            NTPDase2 and ecto-5'-nucleotidase, in epithelial functions such as
            secretion and in enteric neurotransmission.
REFERENCE   7  (bases 1 to 3467)
  AUTHORS   Munkonda,M.N., Kauffenstein,G., Kukulski,F., Levesque,S.A.,
            Legendre,C., Pelletier,J., Lavoie,E.G., Lecka,J. and Sevigny,J.
  TITLE     Inhibition of human and mouse plasma membrane bound NTPDases by P2
            receptor antagonists
  JOURNAL   Biochem Pharmacol 74 (10), 1524-1534 (2007)
   PUBMED   17727821
REFERENCE   8  (bases 1 to 3467)
  AUTHORS   Kukulski,F., Levesque,S.A., Lavoie,E.G., Lecka,J., Bigonnesse,F.,
            Knowles,A.F., Robson,S.C., Kirley,T.L. and Sevigny,J.
  TITLE     Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3
            and 8
  JOURNAL   Purinergic Signal 1 (2), 193-204 (2005)
   PUBMED   18404504
  REMARK    Erratum:[Purinergic Signal. 2005 Jul 29;1(3):293]
REFERENCE   9  (bases 1 to 3467)
  AUTHORS   Lavoie,E.G., Kukulski,F., Levesque,S.A., Lecka,J. and Sevigny,J.
  TITLE     Cloning and characterization of mouse nucleoside triphosphate
            diphosphohydrolase-3
  JOURNAL   Biochem Pharmacol 67 (10), 1917-1926 (2004)
   PUBMED   15130768
REFERENCE   10 (bases 1 to 3467)
  AUTHORS   Chadwick,B.P. and Frischauf,A.M.
  TITLE     The CD39-like gene family: identification of three new human
            members (CD39L2, CD39L3, and CD39L4), their murine homologues, and
            a member of the gene family from Drosophila melanogaster
  JOURNAL   Genomics 50 (3), 357-367 (1998)
   PUBMED   9676430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB580245.1, AK046218.1, BY595885.1 and AI854406.1.
            
            [WARNING] On Oct 10, 2024 this sequence was replaced by
            NM_178676.6.
            
            On Aug 21, 2018 this sequence version replaced NM_178676.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046218.1, AK032057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BB580245.1         1-25
            26-3444             AK046218.1         2-3420
            3445-3446           BY595885.1         469-470
            3447-3467           AI854406.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..3467
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.71 cM"
     gene            1..3467
                     /gene="Entpd3"
                     /gene_synonym="Cd39l3; HB6; NTPDase-3"
                     /note="ectonucleoside triphosphate diphosphohydrolase 3"
                     /db_xref="GeneID:215446"
                     /db_xref="MGI:MGI:1321386"
     exon            1..66
                     /gene="Entpd3"
                     /gene_synonym="Cd39l3; HB6; NTPDase-3"
                     /inference="alignment:Splign:2.1.0"
     exon            67..118
                     /gene="Entpd3"
                     /gene_synonym="Cd39l3; HB6; NTPDase-3"
                     /inference="alignment:Splign:2.1.0"
     exon            119..246
                     /gene="Entpd3"
                     /gene_synonym="Cd39l3; HB6; NTPDase-3"
                     /inference="alignment:Splign:2.1.0"
     exon            247..364
                     /gene="Entpd3"
                     /gene_synonym="Cd39l3; HB6; NTPDase-3"
                     /inference="alignment:Splign:2.1.0"
     exon            365..515
                     /gene="Entpd3"
                     /gene_synonym="Cd39l3; HB6; NTPDase-3"
                     /inference="alignment:Splign:2.1.0"
     exon            516..675
                     /gene="Entpd3"
                     /gene_synonym="Cd39l3; HB6; NTPDase-3"
                     /inference="alignment:Splign:2.1.0"
     exon            676..909
                     /gene="Entpd3"
                     /gene_synonym="Cd39l3; HB6; NTPDase-3"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1182
                     /gene="Entpd3"
                     /gene_synonym="Cd39l3; HB6; NTPDase-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1293
                     /gene="Entpd3"
                     /gene_synonym="Cd39l3; HB6; NTPDase-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1431
                     /gene="Entpd3"
                     /gene_synonym="Cd39l3; HB6; NTPDase-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..3453
                     /gene="Entpd3"
                     /gene_synonym="Cd39l3; HB6; NTPDase-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2922..2927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Entpd3"
                     /gene_synonym="Cd39l3; HB6; NTPDase-3"
                     /note="hexamer: AATAAA"
     polyA_site      2939
                     /gene="Entpd3"
                     /gene_synonym="Cd39l3; HB6; NTPDase-3"
                     /note="major polyA site"
ORIGIN      
        1 tcctggactc ccgcacccca gaggcgcctc cgcttttcag caacccgcag cgaaagcagc
       61 gcccagcccg gagagaagat gtttaccgtg atgacccgcc agccatgtga acaggcaggc
      121 ttcagggccc tctcgaggac tcctgccatc gtcaccttgg tggtcctgct tgtgagcatt
      181 gtggtacttg tgacacttac actcatccag atccgccacc cacaggttct ccctccgggg
      241 ctgaagtatg gcgtcgtgct cgatgctggc tcttccagaa ccactgtcta cgtgtatcag
      301 tggccggcag agaaggagaa taacacagga gtggtcagcc aaactttcag atgcagtgtg
      361 aaaggctctg ggatctccag ctatgagaat aacccccaag atgcccccaa agcctttgag
      421 gactgtatac taaaggtcaa ggaacaggtc ccagagcacc tccacggatc cacccgcatt
      481 tacctgggag ctacagctgg gatgcgcttg ctgaggttgc agaatgagac agcagctcgt
      541 gaagtccttg agagcatcca aagctacttc aagtcccagc cttttgattt taggggtgct
      601 caaatcattt ctgggcaaga ggaaggggtg tatggatgga ttacagccaa ctatataatg
      661 ggaaatttcc tggagaagaa cctgtggcac atgtgggtgc acccgcacgg agtcgacacc
      721 acaggagccc tggatttagg tggcgcctcc acccagatat ccttcgtggc cggggagaag
      781 atggagccga acgccagcga cacggtgcag gtgtctctgt acggctacac gtacactctc
      841 tacacacaca gcttccagtg ctatggccag aatgaagcag agaagaagtt cctggccatg
      901 cttctacaga gcccttccac ggaagccaac atcagcaacc cctgctaccc tcagggctac
      961 agtaccgcct tcaccttggg ccatgtgttt ggcagcctgt gcacagagaa gcagaggcca
     1021 gagagctaca actccagtaa gagcgtcacc ttcatgggaa ctggtgaccc acgactgtgc
     1081 agggagaagg tggcttctgt gtttgacttc aatgcttgcc aagagcaaga cgcctgttcc
     1141 tttgatggca tttaccagcc caaggttcaa gggccatttg tggcgttcgc aggcttctac
     1201 tacacagcca gtgcgctaaa cctctcagga agcttctccc ttacctcctt caatgacagc
     1261 agctgggact tctgcagaca cacttggagc gagctcccag ccctgctctc cagatttgat
     1321 gagacgtatg cccggtccta ctgcttctca gcccactaca tctaccactt gctcgtaaat
     1381 ggatacaagt tcactgagga gacttggcct cagatacgct ttgaaaaaga agtggggaac
     1441 agcagcatcg cctggtccct tggctacatg ctcagcttga ccaaccagat cccagctgga
     1501 agtcccctga tccatctacc catacagcca ccggtgttta tgggagtcct ggccttcttc
     1561 acagctatcg ccttgctgtg cctggcattt cttctgtatc tatgttcatc attcaggaca
     1621 aaggagcgct ctgagaatgc cttcgaccaa gcagtggatt ctgattgagc cttccaagca
     1681 gcacctgtca ccccaggctg ccagaaccca ccagagtgac accacacagt gtgagtgaag
     1741 tggctgccac caggacctgt cccgtgctta aatgccaagg tcatgtgcct ctcagccact
     1801 gattcctgcc agagcacctc ctgggagtcc ctcatccacc cagtggggac tgcctttgca
     1861 atcctcccta cctgcttgct gatccactgg gaatcaagga gacactggct gttggtgtca
     1921 ggggcttcac tctgtctact ccagaggaag ttgagaatat aatttaatgc agaagaattg
     1981 accacgggct cggtttccct tttctctccc tccgtgctct tcctagcaag ctgcccatga
     2041 aggctccgac tctgatactt caccccaccc tgtggctttg acctagagtt cctttgcaag
     2101 accttcctgt attttagttg agtcgagccc tatctcaagt cactaatgct ttttttttag
     2161 caatctcata agcattaagc tccctgactg gtagctagta gcatttagtg gggaagatga
     2221 tggcattttg agacagtttc atggagccca tgctagcttc ctgcccacta tgtagccaag
     2281 agcagccttg atatctgttc ttttcctgag ggcagggatt atgggttgtg aggtcctcgg
     2341 ggtggaaccc cagagcttca tgcattctag gcaactattt gaccaaccga gtcacacgcc
     2401 cagcctaaga agattcagcc tcaaggacag atggcctatg tcatgtaggc agacctgaag
     2461 cacaaagaca cacagaagtc cctaaataca gagtccctat tcttattttg gagtgcccac
     2521 ttggagctct ggtcatgagg ttgctactag gcatgtgtcc tccttgtgta actgtctccc
     2581 tgctgtgtcc tcttgtaaat cacacccagt atggactgta ctgggggggg gggcagtgag
     2641 gggatctcat tgacccggca gagctcctgc tcagggtgcc tttgggctat aaacatgggg
     2701 tgtgcttttt tccccactgc tcccacaggt atacaggatc ctgtccaaag acatccctac
     2761 atttctccct gcagagttgc tacacatctt gactttggga aaagagaagg cagtctcagg
     2821 aatatttgcc tccaaagtgg gatgggaaag gtcttcaagt tcagtagcta caagctacaa
     2881 atcaatgctg tgtctcatgg ctgtttgctg gctccatatg gaataaattc ttatttttat
     2941 tttgcagcgt gtatttgtta acttaaatat gatgcccttt ctcctaagga cacaaggtgg
     3001 tatttttaaa aggaagaaag attctcactg tatagctttg tctctgcctc ctccgggctg
     3061 ggattccatg ttttatttat ttattgactg acatgagttc tgggtcatga attcagcctt
     3121 gcatgtttct tactgactga ctggccatcg ccccagcctt tgttttggtt ttgagagaag
     3181 gtcttgcaaa aactcaccaa gatgcataag tcagaaataa aaataggggt tggaaagatg
     3241 gatcactggc taagagtact ggctgctctt ctatgggatc tgggttcagt tccccgcata
     3301 agtatggcag ctcaaaacag cttgtggctc ttctagcctt ctccagcact gaatgcatgt
     3361 gctacacagc cagacatgca agcaaaatgc ccatagacat aaaagttatg gaatagattt
     3421 taaatagaag taaaataaat ctttaaaaac aaaaaaaaaa aaaaaaa
//
