LOCUS       NM_009848               4221 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus ectonucleoside triphosphate diphosphohydrolase 1
            (Entpd1), transcript variant 2, mRNA.
ACCESSION   NM_009848
VERSION     NM_009848.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4221)
  AUTHORS   Bessoles,S., Chiron,A., Sarrabayrouse,G., De La Grange,P.,
            Abina,A.M. and Hacein-Bey-Abina,S.
  TITLE     Erythropoietin induces tumour progression and CD39 expression on
            immune cells in a preclinical model of triple-negative breast
            cancer
  JOURNAL   Immunology 173 (2), 360-380 (2024)
   PUBMED   38953295
  REMARK    GeneRIF: Erythropoietin induces tumour progression and CD39
            expression on immune cells in a preclinical model of
            triple-negative breast cancer.
REFERENCE   2  (bases 1 to 4221)
  AUTHORS   Isaacs,J.F., Degefu,H.N., Chen,T., Kleist,S.A., Musial,S.C.,
            Ford,M.A., Searles,T.G., Lin,C.C., Skorput,A.G.J., Shirai,K.,
            Turk,M.J., Zanazzi,G.J. and Rosato,P.C.
  TITLE     CD39 Is Expressed on Functional Effector and Tissue-resident Memory
            CD8+ T Cells
  JOURNAL   J Immunol 213 (5), 588-599 (2024)
   PUBMED   38975728
  REMARK    GeneRIF: CD39 Is Expressed on Functional Effector and
            Tissue-resident Memory CD8+ T Cells.
REFERENCE   3  (bases 1 to 4221)
  AUTHORS   Araujo Furlan,C.L., Boccardo,S., Rodriguez,C., Mary,V.S.,
            Gimenez,C.M.S., Robson,S.C., Gruppi,A., Montes,C.L. and Acosta
            Rodriguez,E.V.
  TITLE     CD39 expression by regulatory T cells participates in CD8+ T cell
            suppression during experimental Trypanosoma cruzi infection
  JOURNAL   PLoS Pathog 20 (4), e1012191 (2024)
   PUBMED   38683845
  REMARK    GeneRIF: CD39 expression by regulatory T cells participates in CD8+
            T cell suppression during experimental Trypanosoma cruzi infection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4221)
  AUTHORS   Aoki,T., Wong,V., Yin,T., Nakamura,E., Endo,Y., Hayashida,K.,
            Robson,S.C., Nandurkar,H., Diamond,B., Kim,S.J., Murao,A., Wang,P.,
            Becker,L.B. and Shinozaki,K.
  TITLE     Immune cell expression patterns of CD39/CD73 ectonucleotidases in
            rodent models of cardiac arrest and resuscitation
  JOURNAL   Front Immunol 15, 1362858 (2024)
   PUBMED   38545102
  REMARK    GeneRIF: Immune cell expression patterns of CD39/CD73
            ectonucleotidases in rodent models of cardiac arrest and
            resuscitation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4221)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 4221)
  AUTHORS   Mizumoto,N., Kumamoto,T., Robson,S.C., Sevigny,J., Matsue,H.,
            Enjyoji,K. and Takashima,A.
  TITLE     CD39 is the dominant Langerhans cell-associated ecto-NTPDase:
            modulatory roles in inflammation and immune responsiveness
  JOURNAL   Nat Med 8 (4), 358-365 (2002)
   PUBMED   11927941
REFERENCE   7  (bases 1 to 4221)
  AUTHORS   Goepfert,C., Sundberg,C., Sevigny,J., Enjyoji,K., Hoshi,T.,
            Csizmadia,E. and Robson,S.
  TITLE     Disordered cellular migration and angiogenesis in cd39-null mice
  JOURNAL   Circulation 104 (25), 3109-3115 (2001)
   PUBMED   11748109
REFERENCE   8  (bases 1 to 4221)
  AUTHORS   Enjyoji,K., Sevigny,J., Lin,Y., Frenette,P.S., Christie,P.D.,
            Esch,J.S. 2nd, Imai,M., Edelberg,J.M., Rayburn,H., Lech,M.,
            Beeler,D.L., Csizmadia,E., Wagner,D.D., Robson,S.C. and
            Rosenberg,R.D.
  TITLE     Targeted disruption of cd39/ATP diphosphohydrolase results in
            disordered hemostasis and thromboregulation
  JOURNAL   Nat Med 5 (9), 1010-1017 (1999)
   PUBMED   10470077
REFERENCE   9  (bases 1 to 4221)
  AUTHORS   Schoenborn,M.A., Jenkins,N.A., Copeland,N.G., Gilbert,D.J.,
            Gayle,R.B. 3rd and Maliszewski,C.R.
  TITLE     Gene structure and chromosome location of mouse Cd39 coding for an
            ecto-apyrase
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 287-289 (1998)
   PUBMED   9730622
REFERENCE   10 (bases 1 to 4221)
  AUTHORS   Maliszewski,C.R., Delespesse,G.J., Schoenborn,M.A., Armitage,R.J.,
            Fanslow,W.C., Nakajima,T., Baker,E., Sutherland,G.R.,
            Poindexter,K., Birks,C. et al.
  TITLE     The CD39 lymphoid cell activation antigen. Molecular cloning and
            structural characterization
  JOURNAL   J Immunol 153 (8), 3574-3583 (1994)
   PUBMED   7930580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN696192.1 and AK030601.1.
            
            On Feb 6, 2015 this sequence version replaced NM_009848.3.
            
            Transcript Variant: This variant (2) contains an alternate exon in
            the 5' coding region and uses an alternate start codon, compared to
            variant 1. It encodes isoform 2 which has a shorter and distinct
            N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030601.1, SRR1660815.136988.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                CN696192.1         1-24
            25-4221             AK030601.1         2-4198
FEATURES             Location/Qualifiers
     source          1..4221
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 34.25 cM"
     gene            1..4221
                     /gene="Entpd1"
                     /gene_synonym="2610206B08Rik; ATP-DPH; Cd39;
                     E130009M23Rik; NTPDase-1"
                     /note="ectonucleoside triphosphate diphosphohydrolase 1"
                     /db_xref="GeneID:12495"
                     /db_xref="MGI:MGI:102805"
     exon            1..131
                     /gene="Entpd1"
                     /gene_synonym="2610206B08Rik; ATP-DPH; Cd39;
                     E130009M23Rik; NTPDase-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1648
                     /gene="Entpd1"
                     /gene_synonym="2610206B08Rik; ATP-DPH; Cd39;
                     E130009M23Rik; NTPDase-1"
                     /EC_number="3.6.1.5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     NTPDase 1; ecto-ATPase 1; ecto-ATPDase 1; ecto-ATP
                     diphosphohydrolase 1; lymphoid cell activation antigen;
                     ectoapyrase; CD39 antigen; NTPDase1; nucleoside
                     triphosphate diphosphohydrolase 1"
                     /codon_start=1
                     /product="ectonucleoside triphosphate diphosphohydrolase 1
                     isoform 2"
                     /protein_id="NP_033978.1"
                     /db_xref="CCDS:CCDS50434.1"
                     /db_xref="GeneID:12495"
                     /db_xref="MGI:MGI:102805"
                     /translation="MEDIKDSKVKRFCSKNILIILGFTSILAVIALIAVGLTQNKPLP
                     ENVKYGIVLDAGSSHTNLYIYKWPAEKENDTGVVQQLEECQVKGPGISKYAQKTDEIG
                     AYLAECMELSTELIPTSKHHQTPVYLGATAGMRLLRMESEQSADEVLAAVSTSLKSYP
                     FDFQGAKIITGQEEGAYGWITINYLLGRFTQEQSWLSLISDSQKQETFGALDLGGAST
                     QITFVPQNSTIESPENSLQFRLYGEDYTVYTHSFLCYGKDQALWQKLAKDIQVSSGGV
                     LKDPCFNPGYEKVVNVSELYGTPCTKRFEKKLPFDQFRIQGTGDYEQCHQSILELFNN
                     SHCPYSQCAFNGVFLPPLHGSFGAFSAFYFVMDFFKKVAKNSVISQEKMTEITKNFCS
                     KSWEETKTSYPSVKEKYLSEYCFSGAYILSLLQGYNFTDSSWEQIHFMGKIKDSNAGW
                     TLGYMLNLTNMIPAEQPLSPPLPHSTYIGLMVLFSLLLVAVAITGLFIYSKPSYFWKE
                     AV"
     exon            132..259
                     /gene="Entpd1"
                     /gene_synonym="2610206B08Rik; ATP-DPH; Cd39;
                     E130009M23Rik; NTPDase-1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..377
                     /gene="Entpd1"
                     /gene_synonym="2610206B08Rik; ATP-DPH; Cd39;
                     E130009M23Rik; NTPDase-1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..528
                     /gene="Entpd1"
                     /gene_synonym="2610206B08Rik; ATP-DPH; Cd39;
                     E130009M23Rik; NTPDase-1"
                     /inference="alignment:Splign:2.1.0"
     exon            529..688
                     /gene="Entpd1"
                     /gene_synonym="2610206B08Rik; ATP-DPH; Cd39;
                     E130009M23Rik; NTPDase-1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..925
                     /gene="Entpd1"
                     /gene_synonym="2610206B08Rik; ATP-DPH; Cd39;
                     E130009M23Rik; NTPDase-1"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1186
                     /gene="Entpd1"
                     /gene_synonym="2610206B08Rik; ATP-DPH; Cd39;
                     E130009M23Rik; NTPDase-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1306
                     /gene="Entpd1"
                     /gene_synonym="2610206B08Rik; ATP-DPH; Cd39;
                     E130009M23Rik; NTPDase-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1441
                     /gene="Entpd1"
                     /gene_synonym="2610206B08Rik; ATP-DPH; Cd39;
                     E130009M23Rik; NTPDase-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..4221
                     /gene="Entpd1"
                     /gene_synonym="2610206B08Rik; ATP-DPH; Cd39;
                     E130009M23Rik; NTPDase-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2398..2403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Entpd1"
                     /gene_synonym="2610206B08Rik; ATP-DPH; Cd39;
                     E130009M23Rik; NTPDase-1"
                     /note="hexamer: AATATA"
     polyA_site      2415
                     /gene="Entpd1"
                     /gene_synonym="2610206B08Rik; ATP-DPH; Cd39;
                     E130009M23Rik; NTPDase-1"
                     /note="major polyA site"
     polyA_site      3485
                     /gene="Entpd1"
                     /gene_synonym="2610206B08Rik; ATP-DPH; Cd39;
                     E130009M23Rik; NTPDase-1"
     regulatory      3925..3930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Entpd1"
                     /gene_synonym="2610206B08Rik; ATP-DPH; Cd39;
                     E130009M23Rik; NTPDase-1"
                     /note="hexamer: AATAAA"
     polyA_site      3948
                     /gene="Entpd1"
                     /gene_synonym="2610206B08Rik; ATP-DPH; Cd39;
                     E130009M23Rik; NTPDase-1"
     regulatory      4194..4199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Entpd1"
                     /gene_synonym="2610206B08Rik; ATP-DPH; Cd39;
                     E130009M23Rik; NTPDase-1"
                     /note="hexamer: AATAAA"
     polyA_site      4220
                     /gene="Entpd1"
                     /gene_synonym="2610206B08Rik; ATP-DPH; Cd39;
                     E130009M23Rik; NTPDase-1"
ORIGIN      
        1 ctctgaaccg tgagtacctc tctcgcagaa agccaccaca gcaagcagag acagcaaaaa
       61 caaaaaacac ccaagacaga cgagggaaga ggaaggaaac aaaaagctgc cccttatgga
      121 agatataaag gattctaagg tgaagagatt ttgctccaaa aatattctga tcatccttgg
      181 tttcacctct atcttggctg tgatagcttt gattgctgtg ggactgaccc agaacaaacc
      241 tttgccagaa aatgttaagt atgggattgt gttggatgcg gggtcatctc acaccaacct
      301 gtacatctac aagtggccgg ccgagaagga gaatgacaca ggggtggtgc agcagttaga
      361 ggaatgccaa gtgaaaggtc ctggaatctc aaaatatgct cagaaaacag atgaaatcgg
      421 tgcgtacctg gccgaatgca tggaactgtc caccgaactg ataccaacat ccaagcatca
      481 ccagactcct gtctacctgg gagccacagc aggcatgcgc ttgcttagaa tggaaagcga
      541 acaatcggca gacgaggtcc tggctgcagt gtcaacaagc cttaagagct acccctttga
      601 cttccagggt gccaagatca tcactggaca agaggaaggt gcctatgggt ggattactat
      661 taactatctg ctgggcagat tcactcagga acagagttgg ctaagcctca tctcagacag
      721 tcagaaacag gaaacctttg gcgctttgga tctcggcgga gcctccacac agatcacctt
      781 cgtgccccaa aacagcacta tagagtcccc agaaaactct ctgcaattcc gtctctatgg
      841 cgaggactat actgtgtaca cacacagctt cctgtgctat gggaaggatc aggctctctg
      901 gcagaaactg gccaaggaca ttcaggtttc aagtggtggc gtccttaagg acccatgctt
      961 taacccagga tacgagaagg ttgtgaatgt aagtgagctc tatggcactc cctgcaccaa
     1021 aagattcgaa aagaagctac catttgatca gtttcgaatc cagggcactg gagactacga
     1081 acagtgccac cagagcatcc ttgagctctt caacaacagc cactgccctt actcccagtg
     1141 tgccttcaat ggcgtcttcc tgccacctct ccatgggagt tttggggcgt tttctgcttt
     1201 ctactttgtg atggattttt ttaagaaggt agcgaaaaac agtgtcatct ctcaggagaa
     1261 aatgaccgag ataacaaaaa atttttgctc aaaatcttgg gaagagacaa agacatctta
     1321 tccttcagta aaggagaagt acctgagtga gtactgcttc tcgggcgcct acatcctctc
     1381 tctcctgcaa ggctataact tcacagacag ctcctgggaa cagattcatt ttatgggcaa
     1441 gatcaaagac agcaacgcgg ggtggacttt gggctacatg ctgaacttga ccaacatgat
     1501 cccagctgaa cagccgttgt ccccgcctct ccctcactcc acctacatcg gcctcatggt
     1561 tctcttctcc ctgctcttgg ttgctgtggc catcacaggc ctgttcatct atagcaagcc
     1621 ttcatatttc tggaaagagg cagtatagca ggagcggctg aaatgtgctg gctggagaga
     1681 gaaaacaacc tgcccaggag gcgggctccg ccctgcagga agggaggccg gagtcaccct
     1741 ttcctgctta cccgggacag tctagaccag cacgaagctt ctgaggctgc ctggagcctt
     1801 tccttggggt cactcaacac cctcttcctc aaggacttct tggtgatact ctcttgtctt
     1861 ttccagttac cctcttcctc ctttgtcctc tgtgcttggg ctcacaactc tcatggcctg
     1921 tacttcataa aagaacaatg tcaactttgt cctgagtgcc accctgccca agctgagctg
     1981 gctggaagag gaaacttgga aactatctca gccatggctt tgggacgctc cccccttccc
     2041 catgtctcct aataaagcca tgcagtgcct ttggagagaa gagacacaaa cccagtccaa
     2101 gcctgccctt tggataggag agttttctaa agtagataaa tatgtgctaa agccaaagag
     2161 tccttgccaa ggagcttatg tgctcgtgca gctaatgtga ctcagcatct gctgagaata
     2221 agagtggaga caaacacatt gtatgttccc gcgtgatgcc aaaatgctac caagtgcaac
     2281 acaaaggcca gagatttctg cagagtggat gcacatgtag gcattcaggg catagcatgt
     2341 gacagtagta tacacaacta ggaagaaagc tacagatacc acccagaatt ggaaaaaaat
     2401 atatcatcta atgcatcttt tagcgttttg tgtggtttta tatgttaaaa cacacataaa
     2461 cataaatttc accacattta catgcagctc agtatggaat cttagtacat ttacaaagtt
     2521 atacaacaat cactatattg acgatttgga caaagttata caacaatcac tatattgacg
     2581 atttggacaa agttatacaa caatcactat attgacgatt tggctttcag ttatgtgtgt
     2641 atgtgtgggt ctgtgcacat gagtacaggg aacatggtgg ccagaagagg gcgtcagtct
     2701 ttccaagctg gagttttaag caaccaggta tgaggtgtcc agtgtgggtg ctgggaatca
     2761 acttgggccc tctgctctta acctctgagt taggaggttg agttaacctc tccagcctct
     2821 ataccactat tatataacat tctattacca agaacttggc aggggacaag accatacatt
     2881 tgttttctca aaccacaaat ctttccactg atggtcaaac agactctaca acacagagat
     2941 agctcactgg gtttgaaagc cacaccacat cttattgtcc caagactttg tttagtgagg
     3001 ggaggcaggc ttttgctctg ccatggtatt tatacatcag gtgttgctgc tcctcctcat
     3061 gtgttatgca aacacaagcc ttatttcctt gtttcatgaa gtgttttgtg gataatgaat
     3121 aagtggctat ggacttttat tatggaaatg taaagagatt ttgtatcttt cctaccagta
     3181 ttgccgaaag aagtaactgt cgggagaatt gagcactatt gtattctcgc cctaactcaa
     3241 gctgtctatc cttctctgat ctggggactg actacttagg aaaatctcct gcaagctaga
     3301 agccaagtgt cctgaatctc ttgagtagtc aagtcatttt tccttctgat gtgtctcttc
     3361 tgctattcac agttggacat gctggctaag ttgtggtagc tgctgctggc tgagcgtctg
     3421 tggtcatgtg ctatgcttag gcacactgta tcttctgttc tcatagcagt ctccactcaa
     3481 actcacatct gtctcgagtc ttttttttcc tttgtttttt tatttttgtt tttgttatag
     3541 ttcttttcaa gataggactt cactgtgaag ttctggctgt cctgaaactc actataaata
     3601 aataccaggc tggcctcaaa ctcagagatc cacctgtgct aggattataa gcatgtacca
     3661 ccccatctgg tcattttatt ttattttctt aaacaccctt ccaccaccac tgctgccaat
     3721 atgttggaaa tcaaaattat aagtttcctt tggagaacaa aaatattttt aattacattt
     3781 ttatcttgtt gcccaagttt ttgaccaacc aaacaaaacg tccaacatct caatggagac
     3841 aattaggcac cacctaatct caattctatt ggacagaaga ttaatccagg ggtcatcttt
     3901 gggtcttctg ggtggaacat gtcaaataaa atgagccact actttcaatg ttgggttgcc
     3961 cattggttat agttaattat tattcatctg tagactttca ttcaggactc agaggctggt
     4021 tctgctaacc ttgttccttc aaaagtcggt gatttttttt ttctacgaac ctactacaag
     4081 ggcaacctta atcagcataa atggtttcat ttgcatataa aaatgaaact atagaactag
     4141 gctttgtgta tgcacatgga tgtgtatgag agagaaaagt ttcaattcat ctaaataaac
     4201 gagtaagaaa tgtaacgtga t
//
