LOCUS       NM_001359574            1958 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ectonucleotide pyrophosphatase/phosphodiesterase 7
            (Enpp7), mRNA.
ACCESSION   NM_001359574
VERSION     NM_001359574.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1958)
  AUTHORS   Tian,Y., Li,X., Wang,X., Pei,S.T., Pan,H.X., Cheng,Y.Q., Li,Y.C.,
            Cao,W.T., Petersen,J.D. and Zhang,P.
  TITLE     Alkaline sphingomyelinase deficiency impairs intestinal mucosal
            barrier integrity and reduces antioxidant capacity in dextran
            sulfate sodium-induced colitis
  JOURNAL   World J Gastroenterol 30 (10), 1405-1419 (2024)
   PUBMED   38596488
  REMARK    GeneRIF: Alkaline sphingomyelinase deficiency impairs intestinal
            mucosal barrier integrity and reduces antioxidant capacity in
            dextran sulfate sodium-induced colitis.
REFERENCE   2  (bases 1 to 1958)
  AUTHORS   Alyamani,M., Kadivar,M., Erjefalt,J., Johansson-Lindbom,B.,
            Duan,R.D., Nilsson,A. and Marsal,J.
  TITLE     Alkaline sphingomyelinase (NPP7) impacts the homeostasis of
            intestinal T lymphocyte populations
  JOURNAL   Front Immunol 13, 1050625 (2023)
   PUBMED   36741374
  REMARK    GeneRIF: Alkaline sphingomyelinase (NPP7) impacts the homeostasis
            of intestinal T lymphocyte populations.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1958)
  AUTHORS   Zhang,P., Chen,Y., Zhang,T., Zhu,J., Zhao,L., Li,J., Wang,G.,
            Li,Y., Xu,S., Nilsson,A. and Duan,R.D.
  TITLE     Deficiency of alkaline SMase enhances dextran sulfate
            sodium-induced colitis in mice with upregulation of autotaxin
  JOURNAL   J Lipid Res 59 (10), 1841-1850 (2018)
   PUBMED   30087205
  REMARK    GeneRIF: Deficiency of alkaline SMase enhances dextran sulfate
            sodium-induced colitis in mice with upregulation of autotaxin
REFERENCE   4  (bases 1 to 1958)
  AUTHORS   Chen,Y., Zhang,P., Xu,S.C., Yang,L., Voss,U., Ekblad,E., Wu,Y.,
            Min,Y., Hertervig,E., Nilsson,A. and Duan,R.D.
  TITLE     Enhanced colonic tumorigenesis in alkaline sphingomyelinase (NPP7)
            knockout mice
  JOURNAL   Mol Cancer Ther 14 (1), 259-267 (2015)
   PUBMED   25381265
  REMARK    GeneRIF: Results provides convincing evidence that alk-SMase is a
            physiologic factor that counteracts both initiation and malignant
            transformation of tumorigenesis in the colon.
REFERENCE   5  (bases 1 to 1958)
  AUTHORS   Zhang,P., Chen,Y., Cheng,Y., Hertervig,E., Ohlsson,L., Nilsson,A.
            and Duan,R.D.
  TITLE     Alkaline sphingomyelinase (NPP7) promotes cholesterol absorption by
            affecting sphingomyelin levels in the gut: A study with NPP7
            knockout mice
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 306 (10), G903-G908 (2014)
   PUBMED   24650549
  REMARK    GeneRIF: Alkaline sphingomyelinase (NPP7) is a physiological factor
            promoting cholesterol absorption by reducing sphingomyelin levels
            in the intestinal lumen.
REFERENCE   6  (bases 1 to 1958)
  AUTHORS   Zhang,Y., Cheng,Y., Hansen,G.H., Niels-Christiansen,L.L.,
            Koentgen,F., Ohlsson,L., Nilsson,A. and Duan,R.D.
  TITLE     Crucial role of alkaline sphingomyelinase in sphingomyelin
            digestion: a study on enzyme knockout mice
  JOURNAL   J Lipid Res 52 (4), 771-781 (2011)
   PUBMED   21177474
REFERENCE   7  (bases 1 to 1958)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 1958)
  AUTHORS   Duan,R.D.
  TITLE     Alkaline sphingomyelinase: an old enzyme with novel implications
  JOURNAL   Biochim Biophys Acta 1761 (3), 281-291 (2006)
   PUBMED   16631405
  REMARK    Review article
REFERENCE   9  (bases 1 to 1958)
  AUTHORS   Duan,R.D., Bergman,T., Xu,N., Wu,J., Cheng,Y., Duan,J.,
            Nelander,S., Palmberg,C. and Nilsson,A.
  TITLE     Identification of human intestinal alkaline sphingomyelinase as a
            novel ecto-enzyme related to the nucleotide phosphodiesterase
            family
  JOURNAL   J Biol Chem 278 (40), 38528-38536 (2003)
   PUBMED   12885774
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC141245.1 and AK144474.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849377,
                              SAMN00849378 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BC141245.1         79-83
            6-1958              AK144474.1         2-1954
FEATURES             Location/Qualifiers
     source          1..1958
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.33 cM"
     gene            1..1958
                     /gene="Enpp7"
                     /gene_synonym="Alk-SMase; E-NPP 7; Gm254; NPP-7"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase 7"
                     /db_xref="GeneID:238011"
                     /db_xref="MGI:MGI:3027917"
     exon            1..280
                     /gene="Enpp7"
                     /gene_synonym="Alk-SMase; E-NPP 7; Gm254; NPP-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1356
                     /gene="Enpp7"
                     /gene_synonym="Alk-SMase; E-NPP 7; Gm254; NPP-7"
                     /EC_number="3.1.4.12"
                     /note="intestinal alkaline sphingomyelinase; alkaline
                     sphingomyelin phosphodiesterase; ectonucleotide
                     pyrophosphatase/phosphodiesterase family member 7"
                     /codon_start=1
                     /product="ectonucleotide pyrophosphatase/phosphodiesterase
                     family member 7 precursor"
                     /protein_id="NP_001346503.1"
                     /db_xref="CCDS:CCDS88293.1"
                     /db_xref="GeneID:238011"
                     /db_xref="MGI:MGI:3027917"
                     /translation="MGHSAVLLCVALAILPACVTGAPVQRQHKLLLVSFDGFRWNYDQ
                     DVDTPNLDSMAQEGVKAQYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMFYNTTSTV
                     RLPYHATLGIQRWWDNGSIPIWITAQRQGLKTGSFFYPGGNVTYQGEAVTMSRKEGVL
                     HNYKNETEWRGNVDTVMKWFLEEDVSLVTLYFGEPDSTGHKYGPESQERKDMVKQVDR
                     TVGYLRDSIKRHHLSDSLNLIITSDHGMTTVNKKASDLVEFHKFSNFTFQDIQFELLD
                     YGPIGMLIPKEGMLEKVYSVLKDAHPRLHVYKKEDFPKNFHYANNPRITPLLMYSDLG
                     YVIHGRVNVQFNNGEHGFNNQDMDMKTIFRAVGPSFKAGLEVEPFESVHVYELMCQLL
                     GIVPEPNDGNPGILRPMLRSGSASLLSSQHHLVALLVGILTCLAKVL"
     exon            281..426
                     /gene="Enpp7"
                     /gene_synonym="Alk-SMase; E-NPP 7; Gm254; NPP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            427..1053
                     /gene="Enpp7"
                     /gene_synonym="Alk-SMase; E-NPP 7; Gm254; NPP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1273
                     /gene="Enpp7"
                     /gene_synonym="Alk-SMase; E-NPP 7; Gm254; NPP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1958
                     /gene="Enpp7"
                     /gene_synonym="Alk-SMase; E-NPP 7; Gm254; NPP-7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctccactcc tggcctgagc cgcctgagag ccggtcatgg gacactcagc tgtccttctc
       61 tgtgtggctc tggccattct tccagcttgt gtcactgggg cccctgtcca aagacagcat
      121 aagctactcc tcgtatcctt tgacggattc cgctggaact atgaccaaga cgtggacacc
      181 cccaacctgg actccatggc tcaggaaggg gtaaaagccc agtatatgac tcctgccttt
      241 gtcaccatga ccagcccctg ccactttaca ctggtcaccg gcaaatacat cgagaaccat
      301 ggggtggtcc acaacatgtt ctacaatacc accagcacgg tgaggctgcc ctaccacgcc
      361 acgctcggta tccagaggtg gtgggacaac ggcagcatac ccatctggat cacagcccag
      421 aggcagggct taaaaaccgg ctccttcttc taccccggtg ggaacgtcac ctaccaagga
      481 gaggccgtaa cgatgagccg gaaggagggc gtcttacaca attacaaaaa tgagacggag
      541 tggaggggga atgtggacac ggtgatgaag tggttcctgg aagaagatgt gtccctggtc
      601 actctctact ttggggagcc agactccact ggccacaagt atggccctga gtcccaggag
      661 aggaaggaca tggtgaagca ggtagacagg actgtgggct acctccggga cagcatcaag
      721 cgccaccacc tctccgacag cctcaacctg attatcacat cggaccacgg tatgacaacc
      781 gtcaacaaga aggctagtga tctggtggag ttccacaagt tctccaactt caccttccag
      841 gacatccagt ttgagctgtt ggactatggg cctatcggga tgctgatacc caaggaaggg
      901 atgctggaga aagtttacag tgtcctgaag gacgcccacc ccaggctgca tgtgtacaag
      961 aaggaggact tcccgaagaa ctttcactac gccaacaacc ccaggatcac acctctgctc
     1021 atgtacagtg acctcggcta tgttatccac gggagagtga atgtccagtt caacaatggt
     1081 gaacatggct tcaacaacca agacatggac atgaagacca tcttccgggc cgtgggtccc
     1141 agcttcaagg caggcttgga ggtggaaccc ttcgagagtg tccatgtgta tgagctcatg
     1201 tgccagttgc tgggcattgt gcccgagccc aacgatggga atcctggcat cctgcgaccc
     1261 atgctccggt cagggtccgc gtccttgctc agcagtcagc accacttggt ggcgttgttg
     1321 gtggggatcc taacatgtct ggccaaggtc ctataatgcc ccaccactta atccagttcc
     1381 gaggcccaga aggcagagga ggctcaaagc atgaagctga gactctgttt cctgcgtctc
     1441 agcctgaagt ttcctttccc acgaagcacc ttccagattc tcactctttc ccttccccac
     1501 ttcacccact cccacttcca gtgcaggagc cagaacacag cagcatctgg attctaccaa
     1561 gctggtgact ccaactagcc tggaagccag agaaccactc ctgaggcccc ctccagcaca
     1621 ggcttggagg acatctctgt agacaggcca tcagatccct gcaacagtca cactgcccct
     1681 cccccccaga tgcctcccta gcatctaccc agagccaccc actccttcct gccaccatcc
     1741 tccggtgcag acctcaaacc tcacgctgaa ctggtttgag aacagcaaag ctagctggtt
     1801 ctggagtgca ccaggagcca gcctcgctct gaggacaccc cagcatgact gagtgacaag
     1861 accagtctat tttgtgtcct gtgcagtctc aacccttggc cagagcagaa gaaggtcatt
     1921 ctgctcttct agaaacataa aacagctcac gcaatgcc
//
