LOCUS       NM_199016               4558 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ectonucleotide pyrophosphatase/phosphodiesterase 4
            (Enpp4), transcript variant 1, mRNA.
ACCESSION   NM_199016 XM_128689
VERSION     NM_199016.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4558)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4558)
  AUTHORS   Yan,D., Han,W., Dong,Z., Liu,Q., Jin,Z., Chu,D., Tian,Y., Zhang,J.,
            Song,D., Wang,D. and Zhu,X.
  TITLE     Homology modeling and docking studies of ENPP4: a BCG activated
            tumoricidal macrophage protein
  JOURNAL   Lipids Health Dis 15, 19 (2016)
   PUBMED   26823374
  REMARK    GeneRIF: These results indicate that zinc remains inside the ENPP4
            protein, a Bacillus Calmette-Guerin activated tumoricidal
            macrophage protein, throughout the simulation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4558)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   4  (bases 1 to 4558)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   5  (bases 1 to 4558)
  AUTHORS   Lemon,W.J., Bernert,H., Sun,H., Wang,Y. and You,M.
  TITLE     Identification of candidate lung cancer susceptibility genes in
            mouse using oligonucleotide arrays
  JOURNAL   J Med Genet 39 (9), 644-655 (2002)
   PUBMED   12205107
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ182752.1, CAAA01049488.1, CB723093.1 and CO044941.1.
            
            [WARNING] On Jul 30, 2024 this sequence was replaced by
            NM_199016.3.
            
            On Jan 13, 2006 this sequence version replaced NM_199016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090098.1, BC027749.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-415               CJ182752.1         1-415
            416-709             CAAA01049488.1     22153-22446         c
            710-1186            CB723093.1         159-635
            1187-1819           CO044941.1         3-635               c
            1820-4558           CAAA01049488.1     16346-19084         c
FEATURES             Location/Qualifiers
     source          1..4558
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 20.34 cM"
     gene            1..4558
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase 4"
                     /db_xref="GeneID:224794"
                     /db_xref="MGI:MGI:2682634"
     exon            1..160
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /inference="alignment:Splign:2.1.0"
     exon            161..1018
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1554
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /EC_number="3.6.1.29"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase
                     family member 4; NPP-4; E-NPP4; AP3Aase; AP3A hydrolase;
                     bis(5'-adenosyl)-triphosphatase enpp4"
                     /codon_start=1
                     /product="bis(5'-adenosyl)-triphosphatase enpp4 precursor"
                     /protein_id="NP_950181.2"
                     /db_xref="CCDS:CCDS28803.1"
                     /db_xref="GeneID:224794"
                     /db_xref="MGI:MGI:2682634"
                     /translation="MFNMKILVIPLFWGLVTGYKGNSSDSSAPRLLLVSFDGFRADYL
                     KSYDLPHLQNFIKEGVLVEHVKNVFITKTFPNHYSIVTGLYEESHGIVANSMYDSVTK
                     KHFSESNDKDPFWWNGAEPIWVTNQLQENRSSAAAMWPGTDVPIHNITASYFMNYSSS
                     VSFKERLGNVTTWLSSSNPPVTFAALYWEEPDVSGHKYGPEDKENMRRVLKEVDDLIG
                     DIVLKLKVLGLWDSLNVIITSDHGMAQCSKNRLIDLDSCIDRSNYSVIDLTPVAAILP
                     KINVTEVYDKLKRCNPHMNVYLKEAIPNRFYYQHSSRIQPIILVAEEGWTITLNKSSF
                     KLGDHGYDNSLPSMHPFLAAHGPAFRKGYRQSTINTVDIYPMMCHILGLKPHPNNGTL
                     SHTKCLLVDQWCINLPEAIGIVVSALLVLTMLTGLMIFMRSRASTSRPFSRLQLQEDD
                     DDPLID"
     exon            1019..1189
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..4558
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4538..4543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /note="hexamer: AATAAA"
     polyA_site      4558
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /note="major polyA site"
ORIGIN      
        1 gcgctccgcc cgcgtccgcc gaccagatag tggccgggag cgcggggttc cgctagcgct
       61 gagttccgcg cgccagaccg aagtggcggt ggaggcgggt gagtcccgga gggaaatgcc
      121 actcccttcc ccagctcgcc gagggcggag ggtagagacg gggccctagc tgctgtgtgc
      181 aacatgttca atatgaagat attagtaatt cctttgtttt ggggacttgt cactggctat
      241 aaagggaact cttccgatag ctcagcacct cggttacttc tggtatcctt tgacggcttt
      301 agagctgact acctgaagag ctatgacctt cctcacctcc agaactttat caaagaaggt
      361 gtcttggtgg aacatgttaa aaatgttttt atcaccaaaa cttttccaaa ccactacagc
      421 attgtgacgg gcttatatga ggaaagccat ggcatcgtgg ccaactccat gtatgacagt
      481 gtcacaaaga aacatttttc tgaatccaat gataaggatc cgttttggtg gaatggagcg
      541 gagcctattt gggtgaccaa tcagcttcag gaaaacaggt caagcgctgc cgctatgtgg
      601 cctggcactg atgtgcccat tcacaatatc acagcttcct attttatgaa ctatagcagc
      661 tccgtgtcct ttaaggaaag actgggtaac gttaccacat ggctcagcag ttccaaccca
      721 ccagtcacct ttgcagcgct ctattgggaa gaaccagatg taagcggcca caagtatggg
      781 cctgaagata aagaaaacat gcgccgggta ttgaaagaag tagatgacct tattggtgat
      841 attgtcctaa agctcaaggt gttaggacta tgggacagcc ttaatgtgat cattacaagc
      901 gatcatggga tggctcagtg ttctaagaac agactgatag atttggattc ctgcatcgac
      961 cgttcaaact acagtgttat agacttgacc cctgtggctg cgattcttcc caaaataaat
     1021 gtaacagagg tttatgacaa actgaaacgc tgtaaccctc acatgaatgt ttatctcaaa
     1081 gaagctatcc ctaacagatt ttactaccaa cacagcagtc gaattcagcc cattattttg
     1141 gttgctgagg aaggctggac aatcaccctg aacaagtcat catttaaatt aggtgaccat
     1201 ggctatgata attccctgcc tagtatgcac ccgtttcttg ctgcccacgg acctgccttt
     1261 agaaaaggtt acaggcagag caccatcaac actgtggata tttatccaat gatgtgccac
     1321 atcctgggac taaaaccaca tcccaataat ggaaccctca gtcataccaa gtgcttgttg
     1381 gtggaccagt ggtgcattaa tctcccagaa gccattggaa ttgttgttag tgcactattg
     1441 gtattaacca tgctaacagg cctcatgata ttcatgcgga gcagagcatc cacatcccgt
     1501 ccattctccc gtcttcagct gcaggaagat gacgatgacc ctttaattga ttaattcacc
     1561 atgtcttatt aatttcaaaa ctaaggatcc atgcaaggag tggtgttaca gccataaaaa
     1621 aggtatattt caaaagacaa gacacacatg gcaaaattac tctggggtgt gtgtgtgtgt
     1681 gtgtgtgtgt gtgtgtgtgt gccctgtttt ggtgtgttgc ctgatgcaaa taaccctgat
     1741 ggtatttaat tgctggtaaa tcagttcaaa ccactaatgt ccctagcaag actagccttt
     1801 gagaaaaaac aaaacaaaac aaaaaaacaa aacaaaactt gagtccttct tccttctttc
     1861 cttccttcct tctttctttc cttccttcct tctttccatt attcttcctt tcttctttct
     1921 ttactttcaa tgaaatatat ctttaagtga aaatatacca gaatttaata ggcatgcttt
     1981 tctaacaagt ttatatattt gtaaatgaca caaaactatt tatgtaattt gtgcattttg
     2041 tgtaccctag agaaaaagtt gcatatattt ttatatttgt ctttagttag tgtgtgtccc
     2101 aagaaaaccc ttgagatagg aaattctgtg atagttaata aaaccgatta gccacagggc
     2161 ataactgtag catacaaaga aactgtttta aataaagctg ctaaaaacaa tcaaaaccca
     2221 aggaagacta tgtgatgtag agcccgagct tagtaagacc cgtcagctgt tgacacctca
     2281 gaagctgagt ctggggctgg gcacagtggt gcacacaagt aggaaagatg aggcagaggc
     2341 cttgagatgg agtccagctt ggttacatag caataccttg gggttttgtt tgttcatctg
     2401 tttgttttag ttacattttt ggatactatt gtttataaga agtttcaaag agcatagaga
     2461 aaaattcttc tctgtttgtg tttaacgtct ctgagcaagt tgtgtgtgcc agtgtgtttg
     2521 tatgagtgaa tgtgcagagg tcatgtgaca tgtgaaaggg acatgtgcca gaacacagct
     2581 gtcgaggaag gttcggctca aggaaaggct acttcttgca gactttatgc gcatactttt
     2641 accaactcat aacttaatat cactattaaa aataccatat ttttgttata attttcaatt
     2701 ctcatgttta ttggaagtgt tcaatgctgt aggaaaaaaa atatgacgag agtataaagc
     2761 tgcaaggtca gggttttgaa cttgaccttt gtggctcttg aatgtgcctt ctgtgcagtc
     2821 gagtggtcag ccatgtaaaa tggagttgag tgtcttctgc cctggcagca gctgcgtgct
     2881 aagggcagag cagctccagc cctgctactg ctcgcttgct cgcctgactc atcataactc
     2941 cgagaaccag agagttgttg ggaagcactg tcatcattca ctccctccac agctgggtcc
     3001 tcagagccag agctatcaaa acagcctaca tgatgtccat tggacaacag accactgctt
     3061 cctggtactg gggtgatctc ccgcattctg acaacgtaaa gcaaacttga ttattgctct
     3121 tgagacgcaa gatgggtcta aagtatgcag tgcaggtaga caccgatgat ccgtgatgac
     3181 tctcgacact tgtcagtcat cttagattta ttgcgctgaa ctggctcact gtgaatttcc
     3241 ttaaagtttg atgtctggag cctcattgta tttgggtttt gagaggcatt tctgtactgc
     3301 gtacataatc tatgctcttg gtcacagaat ggatgtttta agaacaggat aggaatgatt
     3361 ttgttcataa gtgttctgat ttattttgtt acatgcagta gagatactaa aggttgaagg
     3421 gttgatcaag taaaacaata gagaaatctc tgcttatttc aatttccatt taagaaagta
     3481 acaaactgca atattcgctt tgagaagaag taggtgggca cttaggactt gtctccagca
     3541 gagttgaaga cagtttagct cccacagtgc tgcggatccc agcacaatcc cagtgcggtc
     3601 tccttcccct ggctgcacct tacacttggt gtccatgtgt agaacagact tttataaagg
     3661 ctgggatggg aagggatgct ctgccagtgt cttagtcctt gcagcacatg gatttatttt
     3721 gtattttatt ctgttctcag aatactaaaa ctagttaaaa tgttataaag tgcttattca
     3781 ggagacaaga atagtatttg tttaatcaag tatattatca tattgaactt tctgctagtt
     3841 cgtttgtatc cttgaaaaac aaaaactaaa gcccctggct gtagttttgc tctgagaaaa
     3901 ccttcttagt aaagataggc tttgacatgg agatttagtg tttgtgttag ctaaacctgc
     3961 tctgctttct gttcaggaga aaatatttgg cttccaaaat atttagctct tggtgatagt
     4021 acccaaagat aatgggaacg tgtttgtctg tgtacttgtt ggtaattgca ctagtcagct
     4081 cagaatttag taccttgact ctctagtaga ggtccaggtg tgttcctgtt agccacctat
     4141 catgtgtgct cttctgtaaa agcagtaggg tatggcaaag gcgtgctggc agtgctgccc
     4201 agaaggtttc ctttaagaac ccacaggtaa agccttggga tattaaaggc tctgcctttg
     4261 cactggtctt ggatgtatcc ctctctgccc acctgggaag ctttaaggct tgttggcttt
     4321 aattcttttt gtgaagagtg gctcatttca tttttaattt ataacattac aaaagaagga
     4381 caaagattag gtgtagagta tgtatttatt gtcagttctc aaacagcatg taaatatagt
     4441 gagtgtgcta taaggaagtt tgcagtgcct taagttaaag ggagtacatt gtttcaactt
     4501 gtagataatg actttgctta tgattaaaat gtatgtaaat aaagtctacc caaacaaa
//
