LOCUS       NM_001357997            4604 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ectonucleotide pyrophosphatase/phosphodiesterase 4
            (Enpp4), transcript variant 3, mRNA.
ACCESSION   NM_001357997 XM_006524134
VERSION     NM_001357997.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4604)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4604)
  AUTHORS   Yan,D., Han,W., Dong,Z., Liu,Q., Jin,Z., Chu,D., Tian,Y., Zhang,J.,
            Song,D., Wang,D. and Zhu,X.
  TITLE     Homology modeling and docking studies of ENPP4: a BCG activated
            tumoricidal macrophage protein
  JOURNAL   Lipids Health Dis 15, 19 (2016)
   PUBMED   26823374
  REMARK    GeneRIF: These results indicate that zinc remains inside the ENPP4
            protein, a Bacillus Calmette-Guerin activated tumoricidal
            macrophage protein, throughout the simulation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4604)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   4  (bases 1 to 4604)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   5  (bases 1 to 4604)
  AUTHORS   Lemon,W.J., Bernert,H., Sun,H., Wang,Y. and You,M.
  TITLE     Identification of candidate lung cancer susceptibility genes in
            mouse using oligonucleotide arrays
  JOURNAL   J Med Genet 39 (9), 644-655 (2002)
   PUBMED   12205107
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030230.13 and AI854294.1.
            
            [WARNING] On Jul 30, 2024 this sequence was replaced by
            NM_001357997.2.
            
            On Nov 14, 2017 this sequence version replaced XM_006524134.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219383.121237.1,
                                           SRR1660817.74988.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               CT030230.13        43182-43377         c
            197-1054            CT030230.13        39375-40232         c
            1055-1225           CT030230.13        38879-39049         c
            1226-4538           CT030230.13        33933-37245         c
            4539-4604           AI854294.1         1-66                c
FEATURES             Location/Qualifiers
     source          1..4604
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 20.34 cM"
     gene            1..4604
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase 4"
                     /db_xref="GeneID:224794"
                     /db_xref="MGI:MGI:2682634"
     exon            1..196
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /inference="alignment:Splign:2.1.0"
     exon            197..1054
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1590
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /EC_number="3.6.1.29"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase
                     family member 4; NPP-4; E-NPP4; AP3Aase; AP3A hydrolase;
                     bis(5'-adenosyl)-triphosphatase enpp4"
                     /codon_start=1
                     /product="bis(5'-adenosyl)-triphosphatase enpp4 precursor"
                     /protein_id="NP_001344926.1"
                     /db_xref="CCDS:CCDS28803.1"
                     /db_xref="GeneID:224794"
                     /db_xref="MGI:MGI:2682634"
                     /translation="MFNMKILVIPLFWGLVTGYKGNSSDSSAPRLLLVSFDGFRADYL
                     KSYDLPHLQNFIKEGVLVEHVKNVFITKTFPNHYSIVTGLYEESHGIVANSMYDSVTK
                     KHFSESNDKDPFWWNGAEPIWVTNQLQENRSSAAAMWPGTDVPIHNITASYFMNYSSS
                     VSFKERLGNVTTWLSSSNPPVTFAALYWEEPDVSGHKYGPEDKENMRRVLKEVDDLIG
                     DIVLKLKVLGLWDSLNVIITSDHGMAQCSKNRLIDLDSCIDRSNYSVIDLTPVAAILP
                     KINVTEVYDKLKRCNPHMNVYLKEAIPNRFYYQHSSRIQPIILVAEEGWTITLNKSSF
                     KLGDHGYDNSLPSMHPFLAAHGPAFRKGYRQSTINTVDIYPMMCHILGLKPHPNNGTL
                     SHTKCLLVDQWCINLPEAIGIVVSALLVLTMLTGLMIFMRSRASTSRPFSRLQLQEDD
                     DDPLID"
     exon            1055..1225
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..4594
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4574..4579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /note="hexamer: AATAAA"
     polyA_site      4594
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /note="major polyA site"
ORIGIN      
        1 cgcgctccgc ccgcgtccgc cgaccagata gtggccggga gcgcggggtt ccgctagcgc
       61 tgagttccgc gcgccagacc gaagtggcgg tggaggcggg tgagtcccgg agggaaatgc
      121 cactcccttc cccagctcgc cgagggcgga gggtagagac ggtgagagct tctggttcct
      181 tcttctccac ccgcgggggc cctagctgct gtgtgcaaca tgttcaatat gaagatatta
      241 gtaattcctt tgttttgggg acttgtcact ggctataaag ggaactcttc cgatagctca
      301 gcacctcggt tacttctggt atcctttgac ggctttagag ctgactacct gaagagctat
      361 gaccttcctc acctccagaa ctttatcaaa gaaggtgtct tggtggaaca tgttaaaaat
      421 gtttttatca ccaaaacttt tccaaaccac tacagcattg tgacgggctt atatgaggaa
      481 agccatggca tcgtggccaa ctccatgtat gacagtgtca caaagaaaca tttttctgaa
      541 tccaatgata aggatccgtt ttggtggaat ggagcggagc ctatttgggt gaccaatcag
      601 cttcaggaaa acaggtcaag cgctgccgct atgtggcctg gcactgatgt gcccattcac
      661 aatatcacag cttcctattt tatgaactat agcagctccg tgtcctttaa ggaaagactg
      721 ggtaacgtta ccacatggct cagcagttcc aacccaccag tcacctttgc agcgctctat
      781 tgggaagaac cagatgtaag cggccacaag tatgggcctg aagataaaga aaacatgcgc
      841 cgggtattga aagaagtaga tgaccttatt ggtgatattg tcctaaagct caaggtgtta
      901 ggactatggg acagccttaa tgtgatcatt acaagcgatc atgggatggc tcagtgttct
      961 aagaacagac tgatagattt ggattcctgc atcgaccgtt caaactacag tgttatagac
     1021 ttgacccctg tggctgcgat tcttcccaaa ataaatgtaa cagaggttta tgacaaactg
     1081 aaacgctgta accctcacat gaatgtttat ctcaaagaag ctatccctaa cagattttac
     1141 taccaacaca gcagtcgaat tcagcccatt attttggttg ctgaggaagg ctggacaatc
     1201 accctgaaca agtcatcatt taaattaggt gaccatggct atgataattc cctgcctagt
     1261 atgcacccgt ttcttgctgc ccacggacct gcctttagaa aaggttacag gcagagcacc
     1321 atcaacactg tggatattta tccaatgatg tgccacatcc tgggactaaa accacatccc
     1381 aataatggaa ccctcagtca taccaagtgc ttgttggtgg accagtggtg cattaatctc
     1441 ccagaagcca ttggaattgt tgttagtgca ctattggtat taaccatgct aacaggcctc
     1501 atgatattca tgcggagcag agcatccaca tcccgtccat tctcccgtct tcagctgcag
     1561 gaagatgacg atgacccttt aattgattaa ttcaccatgt cttattaatt tcaaaactaa
     1621 ggatccatgc aaggagtggt gttacagcca taaaaaaggt atatttcaaa agacaagaca
     1681 cacatggcaa aattactctg gggtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgccc
     1741 tgttttggtg tgttgcctga tgcaaataac cctgatggta tttaattgct ggtaaatcag
     1801 ttcaaaccac taatgtccct agcaagacta gcctttgaga aaaaacaaaa caaaacaaaa
     1861 aaacaaaaca aaacttgagt ccttcttcct tctttccttc cttccttctt tctttccttc
     1921 cttccttctt tccattattc ttcctttctt ctttctttac tttcaatgaa atatatcttt
     1981 aagtgaaaat ataccagaat ttaataggca tgcttttcta acaagtttat atatttgtaa
     2041 atgacacaaa actatttatg taatttgtgc attttgtgta ccctagagaa aaagttgcat
     2101 atatttttat atttgtcttt agttagtgtg tgtcccaaga aaacccttga gataggaaat
     2161 tctgtgatag ttaataaaac cgattagcca cagggcataa ctgtagcata caaagaaact
     2221 gttttaaata aagctgctaa aaacaatcaa aacccaagga agactatgtg atgtagagcc
     2281 cgagcttagt aagacccgtc agctgttgac acctcagaag ctgagtctgg ggctgggcac
     2341 agtggtgcac acaagtagga aagatgaggc agaggccttg agatggagtc cagcttggtt
     2401 acatagcaat accttggggt tttgtttgtt catctgtttg ttttagttac atttttggat
     2461 actattgttt ataagaagtt tcaaagagca tagagaaaaa ttcttctctg tttgtgttta
     2521 acgtctctga gcaagttgtg tgtgccagtg tgtttgtatg agtgaatgtg cagaggtcat
     2581 gtgacatgtg aaagggacat gtgccagaac acagctgtcg aggaaggttc ggctcaagga
     2641 aaggctactt cttgcagact ttatgcgcat acttttacca actcataact taatatcact
     2701 attaaaaata ccatattttt gttataattt tcaattctca tgtttattgg aagtgttcaa
     2761 tgctgtagga aaaaaaatat gacgagagta taaagctgca aggtcagggt tttgaacttg
     2821 acctttgtgg ctcttgaatg tgccttctgt gcagtcgagt ggtcagccat gtaaaatgga
     2881 gttgagtgtc ttctgccctg gcagcagctg cgtgctaagg gcagagcagc tccagccctg
     2941 ctactgctcg cttgctcgcc tgactcatca taactccgag aaccagagag ttgttgggaa
     3001 gcactgtcat cattcactcc ctccacagct gggtcctcag agccagagct atcaaaacag
     3061 cctacatgat gtccattgga caacagacca ctgcttcctg gtactggggt gatctcccgc
     3121 attctgacaa cgtaaagcaa acttgattat tgctcttgag acgcaagatg ggtctaaagt
     3181 atgcagtgca ggtagacacc gatgatccgt gatgactctc gacacttgtc agtcatctta
     3241 gatttattgc gctgaactgg ctcactgtga atttccttaa agtttgatgt ctggagcctc
     3301 attgtatttg ggttttgaga ggcatttctg tactgcgtac ataatctatg ctcttggtca
     3361 cagaatggat gttttaagaa caggatagga atgattttgt tcataagtgt tctgatttat
     3421 tttgttacat gcagtagaga tactaaaggt tgaagggttg atcaagtaaa acaatagaga
     3481 aatctctgct tatttcaatt tccatttaag aaagtaacaa actgcaatat tcgctttgag
     3541 aagaagtagg tgggcactta ggacttgtct ccagcagagt tgaagacagt ttagctccca
     3601 cagtgctgcg gatcccagca caatcccagt gcggtctcct tcccctggct gcaccttaca
     3661 cttggtgtcc atgtgtagaa cagactttta taaaggctgg gatgggaagg gatgctctgc
     3721 cagtgtctta gtccttgcag cacatggatt tattttgtat tttattctgt tctcagaata
     3781 ctaaaactag ttaaaatgtt ataaagtgct tattcaggag acaagaatag tatttgttta
     3841 atcaagtata ttatcatatt gaactttctg ctagttcgtt tgtatccttg aaaaacaaaa
     3901 actaaagccc ctggctgtag ttttgctctg agaaaacctt cttagtaaag ataggctttg
     3961 acatggagat ttagtgtttg tgttagctaa acctgctctg ctttctgttc aggagaaaat
     4021 atttggcttc caaaatattt agctcttggt gatagtaccc aaagataatg ggaacgtgtt
     4081 tgtctgtgta cttgttggta attgcactag tcagctcaga atttagtacc ttgactctct
     4141 agtagaggtc caggtgtgtt cctgttagcc acctatcatg tgtgctcttc tgtaaaagca
     4201 gtagggtatg gcaaaggcgt gctggcagtg ctgcccagaa ggtttccttt aagaacccac
     4261 aggtaaagcc ttgggatatt aaaggctctg cctttgcact ggtcttggat gtatccctct
     4321 ctgcccacct gggaagcttt aaggcttgtt ggctttaatt ctttttgtga agagtggctc
     4381 atttcatttt taatttataa cattacaaaa gaaggacaaa gattaggtgt agagtatgta
     4441 tttattgtca gttctcaaac agcatgtaaa tatagtgagt gtgctataag gaagtttgca
     4501 gtgccttaag ttaaagggag tacattgttt caacttgtag ataatgactt tgcttatgat
     4561 taaaatgtat gtaaataaag tctacccaaa caaaaaaaaa aaaa
//
