LOCUS       NM_001357996            4507 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ectonucleotide pyrophosphatase/phosphodiesterase 4
            (Enpp4), transcript variant 2, mRNA.
ACCESSION   NM_001357996 XM_006524130
VERSION     NM_001357996.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4507)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4507)
  AUTHORS   Yan,D., Han,W., Dong,Z., Liu,Q., Jin,Z., Chu,D., Tian,Y., Zhang,J.,
            Song,D., Wang,D. and Zhu,X.
  TITLE     Homology modeling and docking studies of ENPP4: a BCG activated
            tumoricidal macrophage protein
  JOURNAL   Lipids Health Dis 15, 19 (2016)
   PUBMED   26823374
  REMARK    GeneRIF: These results indicate that zinc remains inside the ENPP4
            protein, a Bacillus Calmette-Guerin activated tumoricidal
            macrophage protein, throughout the simulation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4507)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   4  (bases 1 to 4507)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   5  (bases 1 to 4507)
  AUTHORS   Lemon,W.J., Bernert,H., Sun,H., Wang,Y. and You,M.
  TITLE     Identification of candidate lung cancer susceptibility genes in
            mouse using oligonucleotide arrays
  JOURNAL   J Med Genet 39 (9), 644-655 (2002)
   PUBMED   12205107
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030230.13 and AI854294.1.
            
            [WARNING] On Jul 30, 2024 this sequence was replaced by
            NM_001357996.2.
            
            On Nov 14, 2017 this sequence version replaced XM_006524130.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157622.1, SRR9219379.7741.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                CT030230.13        43279-43377         c
            100-957             CT030230.13        39375-40232         c
            958-1128            CT030230.13        38879-39049         c
            1129-4490           CT030230.13        33884-37245         c
            4491-4507           AI854294.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..4507
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 20.34 cM"
     gene            1..4507
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase 4"
                     /db_xref="GeneID:224794"
                     /db_xref="MGI:MGI:2682634"
     exon            1..99
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /inference="alignment:Splign:2.1.0"
     exon            100..957
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1493
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /EC_number="3.6.1.29"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase
                     family member 4; NPP-4; E-NPP4; AP3Aase; AP3A hydrolase;
                     bis(5'-adenosyl)-triphosphatase enpp4"
                     /codon_start=1
                     /product="bis(5'-adenosyl)-triphosphatase enpp4 precursor"
                     /protein_id="NP_001344925.1"
                     /db_xref="CCDS:CCDS28803.1"
                     /db_xref="GeneID:224794"
                     /db_xref="MGI:MGI:2682634"
                     /translation="MFNMKILVIPLFWGLVTGYKGNSSDSSAPRLLLVSFDGFRADYL
                     KSYDLPHLQNFIKEGVLVEHVKNVFITKTFPNHYSIVTGLYEESHGIVANSMYDSVTK
                     KHFSESNDKDPFWWNGAEPIWVTNQLQENRSSAAAMWPGTDVPIHNITASYFMNYSSS
                     VSFKERLGNVTTWLSSSNPPVTFAALYWEEPDVSGHKYGPEDKENMRRVLKEVDDLIG
                     DIVLKLKVLGLWDSLNVIITSDHGMAQCSKNRLIDLDSCIDRSNYSVIDLTPVAAILP
                     KINVTEVYDKLKRCNPHMNVYLKEAIPNRFYYQHSSRIQPIILVAEEGWTITLNKSSF
                     KLGDHGYDNSLPSMHPFLAAHGPAFRKGYRQSTINTVDIYPMMCHILGLKPHPNNGTL
                     SHTKCLLVDQWCINLPEAIGIVVSALLVLTMLTGLMIFMRSRASTSRPFSRLQLQEDD
                     DDPLID"
     exon            958..1128
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..4497
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4477..4482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /note="hexamer: AATAAA"
     polyA_site      4497
                     /gene="Enpp4"
                     /gene_synonym="4933413N07Rik; E-NPP 4; Gm90"
                     /note="major polyA site"
ORIGIN      
        1 cgcgctccgc ccgcgtccgc cgaccagata gtggccggga gcgcggggtt ccgctagcgc
       61 tgagttccgc gcgccagacc gaagtggcgg tggaggcggg ggccctagct gctgtgtgca
      121 acatgttcaa tatgaagata ttagtaattc ctttgttttg gggacttgtc actggctata
      181 aagggaactc ttccgatagc tcagcacctc ggttacttct ggtatccttt gacggcttta
      241 gagctgacta cctgaagagc tatgaccttc ctcacctcca gaactttatc aaagaaggtg
      301 tcttggtgga acatgttaaa aatgttttta tcaccaaaac ttttccaaac cactacagca
      361 ttgtgacggg cttatatgag gaaagccatg gcatcgtggc caactccatg tatgacagtg
      421 tcacaaagaa acatttttct gaatccaatg ataaggatcc gttttggtgg aatggagcgg
      481 agcctatttg ggtgaccaat cagcttcagg aaaacaggtc aagcgctgcc gctatgtggc
      541 ctggcactga tgtgcccatt cacaatatca cagcttccta ttttatgaac tatagcagct
      601 ccgtgtcctt taaggaaaga ctgggtaacg ttaccacatg gctcagcagt tccaacccac
      661 cagtcacctt tgcagcgctc tattgggaag aaccagatgt aagcggccac aagtatgggc
      721 ctgaagataa agaaaacatg cgccgggtat tgaaagaagt agatgacctt attggtgata
      781 ttgtcctaaa gctcaaggtg ttaggactat gggacagcct taatgtgatc attacaagcg
      841 atcatgggat ggctcagtgt tctaagaaca gactgataga tttggattcc tgcatcgacc
      901 gttcaaacta cagtgttata gacttgaccc ctgtggctgc gattcttccc aaaataaatg
      961 taacagaggt ttatgacaaa ctgaaacgct gtaaccctca catgaatgtt tatctcaaag
     1021 aagctatccc taacagattt tactaccaac acagcagtcg aattcagccc attattttgg
     1081 ttgctgagga aggctggaca atcaccctga acaagtcatc atttaaatta ggtgaccatg
     1141 gctatgataa ttccctgcct agtatgcacc cgtttcttgc tgcccacgga cctgccttta
     1201 gaaaaggtta caggcagagc accatcaaca ctgtggatat ttatccaatg atgtgccaca
     1261 tcctgggact aaaaccacat cccaataatg gaaccctcag tcataccaag tgcttgttgg
     1321 tggaccagtg gtgcattaat ctcccagaag ccattggaat tgttgttagt gcactattgg
     1381 tattaaccat gctaacaggc ctcatgatat tcatgcggag cagagcatcc acatcccgtc
     1441 cattctcccg tcttcagctg caggaagatg acgatgaccc tttaattgat taattcacca
     1501 tgtcttatta atttcaaaac taaggatcca tgcaaggagt ggtgttacag ccataaaaaa
     1561 ggtatatttc aaaagacaag acacacatgg caaaattact ctggggtgtg tgtgtgtgtg
     1621 tgtgtgtgtg tgtgtgtgtg ccctgttttg gtgtgttgcc tgatgcaaat aaccctgatg
     1681 gtatttaatt gctggtaaat cagttcaaac cactaatgtc cctagcaaga ctagcctttg
     1741 agaaaaaaca aaacaaaaca aaaaaacaaa acaaaacttg agtccttctt ccttctttcc
     1801 ttccttcctt ctttctttcc ttccttcctt ctttccatta ttcttccttt cttctttctt
     1861 tactttcaat gaaatatatc tttaagtgaa aatataccag aatttaatag gcatgctttt
     1921 ctaacaagtt tatatatttg taaatgacac aaaactattt atgtaatttg tgcattttgt
     1981 gtaccctaga gaaaaagttg catatatttt tatatttgtc tttagttagt gtgtgtccca
     2041 agaaaaccct tgagatagga aattctgtga tagttaataa aaccgattag ccacagggca
     2101 taactgtagc atacaaagaa actgttttaa ataaagctgc taaaaacaat caaaacccaa
     2161 ggaagactat gtgatgtaga gcccgagctt agtaagaccc gtcagctgtt gacacctcag
     2221 aagctgagtc tggggctggg cacagtggtg cacacaagta ggaaagatga ggcagaggcc
     2281 ttgagatgga gtccagcttg gttacatagc aataccttgg ggttttgttt gttcatctgt
     2341 ttgttttagt tacatttttg gatactattg tttataagaa gtttcaaaga gcatagagaa
     2401 aaattcttct ctgtttgtgt ttaacgtctc tgagcaagtt gtgtgtgcca gtgtgtttgt
     2461 atgagtgaat gtgcagaggt catgtgacat gtgaaaggga catgtgccag aacacagctg
     2521 tcgaggaagg ttcggctcaa ggaaaggcta cttcttgcag actttatgcg catactttta
     2581 ccaactcata acttaatatc actattaaaa ataccatatt tttgttataa ttttcaattc
     2641 tcatgtttat tggaagtgtt caatgctgta ggaaaaaaaa tatgacgaga gtataaagct
     2701 gcaaggtcag ggttttgaac ttgacctttg tggctcttga atgtgccttc tgtgcagtcg
     2761 agtggtcagc catgtaaaat ggagttgagt gtcttctgcc ctggcagcag ctgcgtgcta
     2821 agggcagagc agctccagcc ctgctactgc tcgcttgctc gcctgactca tcataactcc
     2881 gagaaccaga gagttgttgg gaagcactgt catcattcac tccctccaca gctgggtcct
     2941 cagagccaga gctatcaaaa cagcctacat gatgtccatt ggacaacaga ccactgcttc
     3001 ctggtactgg ggtgatctcc cgcattctga caacgtaaag caaacttgat tattgctctt
     3061 gagacgcaag atgggtctaa agtatgcagt gcaggtagac accgatgatc cgtgatgact
     3121 ctcgacactt gtcagtcatc ttagatttat tgcgctgaac tggctcactg tgaatttcct
     3181 taaagtttga tgtctggagc ctcattgtat ttgggttttg agaggcattt ctgtactgcg
     3241 tacataatct atgctcttgg tcacagaatg gatgttttaa gaacaggata ggaatgattt
     3301 tgttcataag tgttctgatt tattttgtta catgcagtag agatactaaa ggttgaaggg
     3361 ttgatcaagt aaaacaatag agaaatctct gcttatttca atttccattt aagaaagtaa
     3421 caaactgcaa tattcgcttt gagaagaagt aggtgggcac ttaggacttg tctccagcag
     3481 agttgaagac agtttagctc ccacagtgct gcggatccca gcacaatccc agtgcggtct
     3541 ccttcccctg gctgcacctt acacttggtg tccatgtgta gaacagactt ttataaaggc
     3601 tgggatggga agggatgctc tgccagtgtc ttagtccttg cagcacatgg atttattttg
     3661 tattttattc tgttctcaga atactaaaac tagttaaaat gttataaagt gcttattcag
     3721 gagacaagaa tagtatttgt ttaatcaagt atattatcat attgaacttt ctgctagttc
     3781 gtttgtatcc ttgaaaaaca aaaactaaag cccctggctg tagttttgct ctgagaaaac
     3841 cttcttagta aagataggct ttgacatgga gatttagtgt ttgtgttagc taaacctgct
     3901 ctgctttctg ttcaggagaa aatatttggc ttccaaaata tttagctctt ggtgatagta
     3961 cccaaagata atgggaacgt gtttgtctgt gtacttgttg gtaattgcac tagtcagctc
     4021 agaatttagt accttgactc tctagtagag gtccaggtgt gttcctgtta gccacctatc
     4081 atgtgtgctc ttctgtaaaa gcagtagggt atggcaaagg cgtgctggca gtgctgccca
     4141 gaaggtttcc tttaagaacc cacaggtaaa gccttgggat attaaaggct ctgcctttgc
     4201 actggtcttg gatgtatccc tctctgccca cctgggaagc tttaaggctt gttggcttta
     4261 attctttttg tgaagagtgg ctcatttcat ttttaattta taacattaca aaagaaggac
     4321 aaagattagg tgtagagtat gtatttattg tcagttctca aacagcatgt aaatatagtg
     4381 agtgtgctat aaggaagttt gcagtgcctt aagttaaagg gagtacattg tttcaacttg
     4441 tagataatga ctttgcttat gattaaaatg tatgtaaata aagtctaccc aaacaaaaaa
     4501 aaaaaaa
//
