LOCUS       NM_134005               2815 bp    mRNA    linear   ROD 28-JUL-2024
DEFINITION  Mus musculus ectonucleotide pyrophosphatase/phosphodiesterase 3
            (Enpp3), mRNA.
ACCESSION   NM_134005 XM_125594
VERSION     NM_134005.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2815)
  AUTHORS   Mardjuki,R., Wang,S., Carozza,J., Zirak,B., Subramanyam,V.,
            Abhiraman,G., Lyu,X., Goodarzi,H. and Li,L.
  TITLE     Identification of the extracellular membrane protein ENPP3 as a
            major cGAMP hydrolase and innate immune checkpoint
  JOURNAL   Cell Rep 43 (5), 114209 (2024)
   PUBMED   38749434
  REMARK    GeneRIF: Identification of the extracellular membrane protein ENPP3
            as a major cGAMP hydrolase and innate immune checkpoint.
REFERENCE   2  (bases 1 to 2815)
  AUTHORS   Furuta,Y., Tsai,S.H., Kinoshita,M., Fujimoto,K., Okumura,R.,
            Umemoto,E., Kurashima,Y., Kiyono,H., Kayama,H. and Takeda,K.
  TITLE     E-NPP3 controls plasmacytoid dendritic cell numbers in the small
            intestine
  JOURNAL   PLoS One 12 (2), e0172509 (2017)
   PUBMED   28225814
  REMARK    GeneRIF: In Enpp3-/- mice, ATP concentrations were increased in the
            intestinal lumen. Plasmacytoid dendritic cell (pDC) numbers were
            remarkably decreased in the small intestinal lamina propria and
            Peyer's patches. Intestinal pDCs of Enpp3-/- mice showed enhanced
            cell death.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2815)
  AUTHORS   Tsai,S.H., Kinoshita,M., Kusu,T., Kayama,H., Okumura,R., Ikeda,K.,
            Shimada,Y., Takeda,A., Yoshikawa,S., Obata-Ninomiya,K.,
            Kurashima,Y., Sato,S., Umemoto,E., Kiyono,H., Karasuyama,H. and
            Takeda,K.
  TITLE     The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic
            allergic responses by basophils and mast cells
  JOURNAL   Immunity 42 (2), 279-293 (2015)
   PUBMED   25692702
  REMARK    GeneRIF: E-NPP3 decreases ATP concentration and suppresses basophil
            and mast cell activity.
REFERENCE   4  (bases 1 to 2815)
  AUTHORS   Lieben,L., Stockmans,I., Moermans,K. and Carmeliet,G.
  TITLE     Maternal hypervitaminosis D reduces fetal bone mass and mineral
            acquisition and leads to neonatal lethality
  JOURNAL   Bone 57 (1), 123-131 (2013)
   PUBMED   23895994
REFERENCE   5  (bases 1 to 2815)
  AUTHORS   Korekane,H., Park,J.Y., Matsumoto,A., Nakajima,K., Takamatsu,S.,
            Ohtsubo,K., Miyamoto,Y., Hanashima,S., Kanekiyo,K., Kitazume,S.,
            Yamaguchi,Y., Matsuo,I. and Taniguchi,N.
  TITLE     Identification of ectonucleotide pyrophosphatase/phosphodiesterase
            3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX
            (GnT-Vb)
  JOURNAL   J Biol Chem 288 (39), 27912-27926 (2013)
   PUBMED   23960081
REFERENCE   6  (bases 1 to 2815)
  AUTHORS   Villa-Bellosta,R., Wang,X., Millan,J.L., Dubyak,G.R. and
            O'Neill,W.C.
  TITLE     Extracellular pyrophosphate metabolism and calcification in
            vascular smooth muscle
  JOURNAL   Am J Physiol Heart Circ Physiol 301 (1), H61-H68 (2011)
   PUBMED   21490328
REFERENCE   7  (bases 1 to 2815)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132256.1 and BB400671.1.
            
            On Jul 31, 2007 this sequence version replaced NM_134005.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132256.1, AY630402.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2411              AK132256.1         14-2424
            2412-2603           AK132256.1         2426-2617
            2604-2813           AK132256.1         2619-2828
            2814-2815           BB400671.1         312-313
FEATURES             Location/Qualifiers
     source          1..2815
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 12.26 cM"
     gene            1..2815
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase 3"
                     /db_xref="GeneID:209558"
                     /db_xref="MGI:MGI:2143702"
     exon            1..180
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            181..256
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            257..379
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            380..505
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            506..566
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            567..664
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            665..744
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            745..864
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            865..974
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1040
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1113
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1222
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1351
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1383
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1511
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1578
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1666
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1845
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1900
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2055
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2188
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2266
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2399
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2556
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2815
                     /gene="Enpp3"
                     /gene_synonym="CD203c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagtcacag ctggggcagg caggacagtt cctttttccc tccccagagg gaagaaagag
       61 ccttattttc tggctagaca ggtttacaca gctacgggaa caatggattc caggctagca
      121 ttagccacag aggagcccat taagaaagac agtctcaaga aatacaagat cctttgtgtg
      181 gttcttcttg ctttgttggt gattgtatcg cttggattgg ggctgggact gggactcagg
      241 aaacctgaag aacaaggcag ctgcaggaaa aaatgctttg actcatcgca cagaggactg
      301 gagggctgcc gctgtgactc gggatgcaca ggacgaggag actgctgctg ggactttgaa
      361 gatacctgtg tgaaatcaac tcaaatatgg acgtgcaatt tattccgttg tggggagaac
      421 agactggaga cagccctctg ttcctgtgcg gatgactgtc tacagaggaa ggactgctgt
      481 gctgactaca agactgtgtg ccaaggcgaa agcccatggg tgacagaagc ctgtgcctca
      541 tcccaggagc cccagtgtcc accagggttt gacctgccac cagttatctt gttctccatg
      601 gacggtttta gagctgagta tttacaaaca tggagtaccc ttttgcctaa tatcaacaaa
      661 ctgaaaacat gtggaatcca ttctaaatat atgagagcta tgtatcccac caaaaccttc
      721 ccaaatcatt ataccattgt cacgggtttg tatccggagt cacacggcat cattgacaac
      781 aacatgtatg acgtgcacct caacaagaat ttttcccttt cttcagtgga gaaaagcaat
      841 cccgcctggt ggagcgggca gccgatttgg ctaacggcaa tgtatcaagg tttaaaagct
      901 gcttgctact actggccggg atcagatgtg gctgtcaatg gctccttccc taccatctac
      961 aggaattaca gcaattctgt cccatatgaa aggaggatta caacactgtt acaatggctg
     1021 gacctgccca aagctgaccg acccagtttt tataccatct atgtggaaga gcctgattct
     1081 gcagggcatt cgagtggacc agtcagtgct ggagtaatta aagccttgca gtcagttgac
     1141 aatgcctttg gaatgttgat ggagggtctg aaacagagga atttacacaa ctgtgtcaat
     1201 ataatcgttc tggctgatca tggaatggac cagacctcct gtgatagagt ggaatacatg
     1261 acagattatt ttcctaaaat aaacttctat atgtatcaag gacctgctcc tcgaatcagg
     1321 actcgtaata tacctcagga cttctttaca tttaattctg aagagattgt caggaacctc
     1381 agttgtcgaa aacctgacca acactttaaa ccctacttga cccctgattt gccgaaacga
     1441 ctgcactacg ccaaaaatgt cagaattgac aaagctcatc tcatggtgga tcggcaatgg
     1501 ctggctttca ggagcaaagg gagttccaat tgtggtggag gaacacatgg ctacaacaat
     1561 gagttcaaga gcatggaggc aatctttttg gcacatggac ccagctttat agagaagact
     1621 gttattgaac catttgaaaa tattgaagtc tataatctac tgtgtgatct tctgcacatt
     1681 gaaccagcac caaacaacgg tactcatggc agtctgaatc atcttctgaa gacaccgttt
     1741 tacaagccat cacatgcagg agagttgtca acgcctgctg actgtggttt tactactccc
     1801 ctgcctacag acccactaga ctgctcatgc cctgcactac agaatacgcc tggtctagaa
     1861 gagcaagcaa accaaaggct aaatcttagc gaaggcgagg ttgcagcaac ggtgaaagca
     1921 aatttgccat ttgggaggcc cagggtgatg cagaagaacg gagaccactg tctcctttac
     1981 cacagggact acatcagtgg gtacggcaaa gctatgaaga tgcccatgtg gagttcatac
     2041 accgttctca agccgggaga cacatcatct cttcctccca cagttccaga ctgtctgcgg
     2101 gctgatgtca gggttgctcc ttctgagagc caaaaatgtt ccttctattt agcagacaag
     2161 aatatcaccc atggcttcct ctatcctgca atcaaaggaa ctaatgagag tcgatatgat
     2221 gccttaatta caagtaattt ggtcccaatg tataaagaat tcaaaaaaat gtgggactac
     2281 ttccatgagg ttcttcttat aaaatatgct atagaaagaa atggactgaa tgtggttagt
     2341 ggacccatct ttgattataa ttatgatggc cattttgatg ctccggatga aatcacacaa
     2401 tatgtagctg gcactgatgt ccctatccca acacactact ttgtggtgct gacaagttgt
     2461 aaagaccaaa cccacacacc cgacagctgc cctgggtggc tggatgtcct gcccttcatc
     2521 gtccctcacc ggcccaccaa catagaaagc tgttctgaaa acaagaccga ggacctttgg
     2581 gttgaagaga ggttccaagc acacgccgcc cgggtccgag atgtggagct cctcactggc
     2641 cttgactttt atcaggagaa agcacagccc gtctctcaga ttttgcaact aaagacgtat
     2701 ctgcccacgt ttgaaaccat tatttgaatg aatggatgta taaagccatt tgacaaaatg
     2761 gggacatttc ctgtcaaaaa aaaaagttat aaaataaaat tttctatttt tcctt
//
