LOCUS       NM_007934               4208 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus glutamyl aminopeptidase (Enpep), mRNA.
ACCESSION   NM_007934
VERSION     NM_007934.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4208)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4208)
  AUTHORS   Valverde,A., Dunys,J., Lorivel,T., Debayle,D., Gay,A.S.,
            Lacas-Gervais,S., Roques,B.P., Chami,M. and Checler,F.
  TITLE     Aminopeptidase A contributes to biochemical, anatomical and
            cognitive defects in Alzheimer's disease (AD) mouse model and is
            increased at early stage in sporadic AD brain
  JOURNAL   Acta Neuropathol 141 (6), 823-839 (2021)
   PUBMED   33881611
  REMARK    GeneRIF: Aminopeptidase A contributes to biochemical, anatomical
            and cognitive defects in Alzheimer's disease (AD) mouse model and
            is increased at early stage in sporadic AD brain.
REFERENCE   3  (bases 1 to 4208)
  AUTHORS   Marahrens,B., Schulze,A., Wysocki,J., Lin,M.H., Ye,M., Kanwar,Y.S.,
            Bader,M., Velez,J.C.Q., Miner,J.H. and Batlle,D.
  TITLE     Knockout of aminopeptidase A in mice causes functional alterations
            and morphological glomerular basement membrane changes in the
            kidneys
  JOURNAL   Kidney Int 99 (4), 900-913 (2021)
   PUBMED   33316280
  REMARK    GeneRIF: Knockout of aminopeptidase A in mice causes functional
            alterations and morphological glomerular basement membrane changes
            in the kidneys.
REFERENCE   4  (bases 1 to 4208)
  AUTHORS   Mace,C., Del Nogal Avila,M., Marshall,C.B., Kharlyngdoh,J., Das,R.,
            Molina-Jijon,E., Donoro Blazquez,H., Shastry,S., Soria,E.,
            Wetzels,J., Dijkman,H., Avila-Casado,C., Clement,L.C. and
            Chugh,S.S.
  TITLE     The zinc fingers and homeoboxes 2 protein ZHX2 and its interacting
            proteins regulate upstream pathways in podocyte diseases
  JOURNAL   Kidney Int 97 (4), 753-764 (2020)
   PUBMED   32059999
REFERENCE   5  (bases 1 to 4208)
  AUTHORS   Chen,L., Toke,N.H., Luo,S., Vasoya,R.P., Aita,R., Parthasarathy,A.,
            Tsai,Y.H., Spence,J.R. and Verzi,M.P.
  TITLE     HNF4 factors control chromatin accessibility and are redundantly
            required for maturation of the fetal intestine
  JOURNAL   Development 146 (19) (2019)
   PUBMED   31345929
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4208)
  AUTHORS   Lin,Q., Taniuchi,I., Kitamura,D., Wang,J., Kearney,J.F.,
            Watanabe,T. and Cooper,M.D.
  TITLE     T and B cell development in BP-1/6C3/aminopeptidase A-deficient
            mice
  JOURNAL   J Immunol 160 (10), 4681-4687 (1998)
   PUBMED   9590213
REFERENCE   7  (bases 1 to 4208)
  AUTHORS   Wang,J., Walker,H., Lin,Q., Jenkins,N., Copeland,N.G., Watanabe,T.,
            Burrows,P.D. and Cooper,M.D.
  TITLE     The mouse BP-1 gene: structure, chromosomal localization, and
            regulation of expression by type I interferons and interleukin-7
  JOURNAL   Genomics 33 (2), 167-176 (1996)
   PUBMED   8660964
REFERENCE   8  (bases 1 to 4208)
  AUTHORS   Wenger,R.H., Kopf,M., Nitschke,L., Lamers,M.C., Kohler,G. and
            Nielsen,P.J.
  TITLE     B-cell maturation in chimaeric mice deficient for the heat stable
            antigen (HSA/mouse CD24)
  JOURNAL   Transgenic Res 4 (3), 173-183 (1995)
   PUBMED   7795661
REFERENCE   9  (bases 1 to 4208)
  AUTHORS   Li,L., Wang,J. and Cooper,M.D.
  TITLE     cDNA cloning and expression of human glutamyl aminopeptidase
            (aminopeptidase A)
  JOURNAL   Genomics 17 (3), 657-664 (1993)
   PUBMED   8244382
REFERENCE   10 (bases 1 to 4208)
  AUTHORS   Wu,Q., Lahti,J.M., Air,G.M., Burrows,P.D. and Cooper,M.D.
  TITLE     Molecular cloning of the murine BP-1/6C3 antigen: a member of the
            zinc-dependent metallopeptidase family
  JOURNAL   Proc Natl Acad Sci U S A 87 (3), 993-997 (1990)
   PUBMED   1689065
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY311350.1, AK146808.1, BC064061.1 and AK031439.1.
            
            On Jan 30, 2007 this sequence version replaced NM_007934.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128975.1, M29961.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BY311350.1         12-40
            30-3741             AK146808.1         2-3713
            3742-3770           BC064061.1         1475-1503
            3771-4208           AK031439.1         2804-3241
FEATURES             Location/Qualifiers
     source          1..4208
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 57.92 cM"
     gene            1..4208
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /note="glutamyl aminopeptidase"
                     /db_xref="GeneID:13809"
                     /db_xref="MGI:MGI:106645"
     exon            1..888
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..3106
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /EC_number="3.4.11.7"
                     /note="EAP; AP-A; BP-1/6C3 antigen; aminopeptidase A"
                     /codon_start=1
                     /product="glutamyl aminopeptidase"
                     /protein_id="NP_031960.1"
                     /db_xref="CCDS:CCDS17831.1"
                     /db_xref="GeneID:13809"
                     /db_xref="MGI:MGI:106645"
                     /translation="MNFAEEEPSKKYCIKGKHVAIICGVVVAVGLIVGLSVGLTRSCE
                     QDTTPAPSQPPPEASTALPPQDQNVCPDSEDESGEWKNFRLPDFINPVHYDLEVKALM
                     EEDRYTGIVTISVNLSKPTRDLWLHIRETKITKLPELRRPSGEQVPIRRCFEYKKQEY
                     VVIQAAEDLAATSGDSVYRLTMEFKGWLNGSLVGFYKTTYMEDGQIRSIAATDHEPTD
                     ARKSFPCFDEPNKKSTYSISIIHPKEYSALSNMPEEKSEMVDDNWKKTTFVKSVPMST
                     YLVCFAVHRFTAIERKSRSGKPLKVYVQPNQKETAEYAANITQAVFDYFEDYFAMEYA
                     LPKLDKIAIPDFGTGAMENWGLVTYRETNLLYDPLLSASSNQQRVASVVAHELVHQWF
                     GNTVTMDWWDDLWLNEGFASFFEFLGVNHAEKDWQMLSQVLLEDVFPVQEDDSLMSSH
                     PVVVTVSTPAEITSVFDGISYSKGASILRMLQDWITPEKFQKGCQIYLKKFQFANAKT
                     SDFWDSLQEASNLPVKEVMDTWTSQMGYPVVTVSGRQNITQKRFLLDSKADPSQPPSE
                     LGYTWNIPVRWADNDNSRITVYNRLDKGGITLNANLSGDAFLKINPDHIGFYRVNYEG
                     GTWDWIAEALSSNHTRFSAADRSSFIDDAFALARAQLLNYKIALNLTMYLKSEEDFLP
                     WERVISSVSYIISMFEDDRELYPMIETYFQGQVKPVADLLGWQDTGSHITKLLRASIL
                     GFACKMGDREALGNASQLFDSWLKGSASIPVNLRLLVYRYGMQNSGNEAAWNYTLEQY
                     QKTSLAQEKEKLLYGLASVKDVKLLARYLEMLKDPNIIKTQDVFTVIRYISYNSYGKT
                     MAWNWIQLNWDYLVSRFTINDRYLGRIVTIAEPFNTELQLWQMQSFFAKYPNAGAGAK
                     PREQVLETVKNNIEWLNVNRQSIREWFASLP"
     exon            889..1030
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1162
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1283
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1438
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1552
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1687
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1753
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1819
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1971
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2051
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2185
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2241
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2392
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2466
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2571
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2742
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2883
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..2962
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..4208
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3743..3748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /note="hexamer: AATAAA"
     polyA_site      3772
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /note="major polyA site"
     regulatory      4185..4190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
                     /note="hexamer: AATAAA"
     polyA_site      4203
                     /gene="Enpep"
                     /gene_synonym="6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51"
ORIGIN      
        1 ttatatagcg ctgagccaac attctcatca gtcctcctcc ttcaagtcag cttctcttct
       61 gcgtctccat cctactcctt ggtctccgca ttcatcctgg agtggccggt ggggacgagc
      121 aggaccggga agagggagag gtgtgggaaa gcgaagccaa gctgccaggg atcggacgcc
      181 ttccaattga aaagggaagt cagctgacaa ggaaagttag ttaaatttaa catcctttca
      241 tgtgtaacat ctgacttcgg gggagaaaat gaactttgca gaggaagagc cctccaagaa
      301 atactgcatt aaaggcaaac acgtggccat catctgtgga gtagtggtgg cagttggatt
      361 aatagtggga ctttctgtgg gtttgaccag gtcgtgtgag caggacacaa ccccagctcc
      421 ttcccaacct cctccggaag ccagcactgc cctccctcct caggaccaga atgtctgccc
      481 tgacagtgaa gatgaaagcg gagaatggaa aaacttcagg ctgcctgact tcatcaatcc
      541 agttcactac gacctggagg tgaaggccct gatggaggaa gacaggtaca cgggaatagt
      601 gaccatctct gtcaacttga gcaaacccac tcgtgaccta tggctccaca tcagggagac
      661 caagatcacc aagctgccgg agctaaggag gccctctggg gagcaggtac caattcgacg
      721 gtgcttcgag tataagaagc aggagtacgt ggtgatccag gctgcagaag accttgcggc
      781 caccagtggg gacagtgtct atcggctgac catggagttt aaaggctggc tgaacggttc
      841 ccttgtgggt ttttacaaaa ccacctacat ggaggacggg caaatcagga gcatagctgc
      901 cactgaccat gaaccaacag atgccaggaa gtccttccct tgtttcgacg aacccaacaa
      961 gaagtcaact tacagtatat ccatcatcca cccaaaagaa tactcagcac tttctaatat
     1021 gccagaagag aaatcagaga tggtggatga caactggaag aaaaccactt ttgtgaagtc
     1081 tgtcccaatg agcacttacc tggtgtgctt tgctgtgcat cggttcactg ctatagagag
     1141 aaaatccagg agcggcaaac cactcaaggt ctatgtccag cccaatcaga aggagacagc
     1201 agagtatgcg gcaaacataa cccaagctgt atttgattac ttcgaagact acttcgctat
     1261 ggagtatgcg cttcctaaac tggataaaat tgctattcca gattttggca ccggcgccat
     1321 ggaaaattgg ggacttgtca cttaccgaga aacaaacctg ctttacgacc ccctactatc
     1381 ggcctcatct aaccagcaga gagtggccag cgtggttgcc cacgaacttg tacaccagtg
     1441 gtttggaaat actgtgacca tggactggtg ggacgacttg tggctaaatg aaggatttgc
     1501 ttcgttcttc gagttcttgg gagtaaacca cgcagaaaaa gactggcaga tgctcagtca
     1561 ggtgctgctt gaagatgtgt tccccgtgca agaggacgac tccctgatgt cttcacatcc
     1621 agtggtcgtc accgtgtcca cgccagctga aataacatct gtgtttgatg ggatatcata
     1681 cagcaaggga gcttctattc tgagaatgct ccaagactgg ataacaccag agaaattcca
     1741 aaaaggctgt cagatttact tgaaaaaatt ccagttcgcg aatgcaaaaa cttccgactt
     1801 ttgggattca ctgcaagagg caagcaatct gccagtgaaa gaagtgatgg acacctggac
     1861 tagccagatg ggttatcctg tggtcactgt gagtggaagg cagaacatca cccagaaacg
     1921 ctttctgttg gactccaaag ctgatccttc gcagccaccg tcagagctcg gttacacatg
     1981 gaatattcca gtcagatggg ctgataatga caactcaagg atcaccgtgt acaataggtt
     2041 agacaaagga ggaatcactc tgaatgctaa tcttagcgga gatgcttttc tcaaaatcaa
     2101 cccagatcac attgggtttt atcgtgtaaa ttatgaagga ggaacgtggg attggatagc
     2161 cgaggctctc tcctcaaacc acacgagatt ctccgctgct gaccggtcaa gttttattga
     2221 tgatgctttt gctttggcaa gagctcaact tctgaattat aaaatagctc tgaacttgac
     2281 catgtatctc aaatcagaag aggatttcct accatgggag agagtcattt catctgtaag
     2341 ctacatcatt agcatgtttg aagatgacag agagctgtac cccatgatag agacgtactt
     2401 tcaaggccaa gtgaagcccg ttgcagattt gctgggatgg caggataccg gaagccacat
     2461 cacaaagtta ctccgggcct ctatcttagg attcgcatgc aagatggggg acagagaagc
     2521 cttgggcaat gcttcccagt tatttgactc ctggctgaaa gggagcgcaa gtattccggt
     2581 aaacctcagg ctgcttgtgt accgctatgg aatgcagaac tctggcaatg aggcagcgtg
     2641 gaactatacc ctagagcagt atcagaaaac atcgcttgcc caagagaaag aaaaactgct
     2701 ctatgggtta gcttcagtga aggatgttaa actcttggca aggtatctgg aaatgctcaa
     2761 agaccccaat attattaaaa ctcaggatgt atttaccgtc atccgctaca tctcctacaa
     2821 cagttatggg aagacaatgg cctggaattg gatacaactc aactgggact atctggtcag
     2881 cagatttaca atcaatgaca gataccttgg ccggatcgtc accatagctg agcccttcaa
     2941 cactgaactg cagctctggc agatgcagag cttttttgca aaatatccaa atgctggcgc
     3001 tggagcaaaa cctagagagc aagtgctgga gacggtgaag aacaacatcg agtggctaaa
     3061 cgtgaacaga cagtccatca gagagtggtt cgctagcctg ccgtaggacg gacagtgaaa
     3121 acacgtgcaa gggtgaaggc acgtcatctg tgcctctgct gcaccgtggg cggagcctga
     3181 gatggcctgt tttacagacc gcagagggga gcctttgaaa ccagttctgc ttttgctaag
     3241 tactgtattt atgtcacgca aagcttttaa attattcctc tttgtttttg caggaagata
     3301 ctaatagagt atttaatata ctcagggatt tctgctaagt gttcttcatg ggaaagtctt
     3361 tacaaactga agggtttaat agtcacatta atgtctttaa tatcattcct tgtatcttag
     3421 atctgtgaaa atggagcaat ttggtcctag ctttacattt ttagtaccaa agaaacacca
     3481 cttaatcttc tctcttgatt gatttttaaa gtttaaatac cagtacttgc agggtgtatt
     3541 gccatcttaa tctttatttt attattcaga attacataga cctaatatca ttttattcac
     3601 aaatgtctca ctgctttaaa tcctaccaaa gtaaccttgg cttaagtttt gatcaaggat
     3661 tgaaggaatg agccaaagaa atgactgact gttgcctttg gtcttacaaa atcagacaat
     3721 gctgtattct tttttttttt taaataaatt taaattatta ccttgaaaaa cacattgttt
     3781 cccagtatca ccttactcct gagtgaatgt gacggcacca ttccccaaat aatttagcac
     3841 attacaagtg tgcttcaaga gcctgacctt ggtcacgcat gatgcactgc tgtctctcct
     3901 gatgcgtgca aagttccctt caaatgagct atgaaattag tgggcatggg ggcgcttaac
     3961 tgcgctccat ggatttttat agggaagaat gaaagtaatt ggaaactgtt caggaaggag
     4021 agaaggcgga tttaaattta actttgccct ccctagcagc aaaagtgtga aaatggagaa
     4081 agttgaggtt gtcctccagc aaagctgcac atctaaggat atgtcttctt atagataaat
     4141 tttatatata cacctttaaa tgtaaaccaa tatagaagac cactaataaa aattatatat
     4201 gtagactg
//
