LOCUS       NM_026421               1844 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus enolase-phosphatase 1 (Enoph1), transcript variant 1,
            mRNA.
ACCESSION   NM_026421
VERSION     NM_026421.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1844)
  AUTHORS   Yang,D., Su,L., Li,X., Xie,C. and Zhang,Y.
  TITLE     Evidence that enolase-phosphatase 1 exacerbates early cerebral
            ischemia injury and blood-brain barrier breakdown by enhancing
            extracellular matrix destruction and inhibiting the interaction
            between ADI1 and MT1-MMP
  JOURNAL   Exp Neurol 365, 114410 (2023)
   PUBMED   37075968
  REMARK    GeneRIF: Evidence that enolase-phosphatase 1 exacerbates early
            cerebral ischemia injury and blood-brain barrier breakdown by
            enhancing extracellular matrix destruction and inhibiting the
            interaction between ADI1 and MT1-MMP.
REFERENCE   2  (bases 1 to 1844)
  AUTHORS   Barth,A., Bilkei-Gorzo,A., Drews,E., Otte,D.M., Diaz-Lacava,A.,
            Varadarajulu,J., Turck,C.W., Wienker,T.F. and Zimmer,A.
  TITLE     Analysis of quantitative trait loci in mice suggests a role of
            Enoph1 in stress reactivity
  JOURNAL   J Neurochem 128 (6), 807-817 (2014)
   PUBMED   24236849
  REMARK    GeneRIF: Our result suggests a significant role for enoph1 and
            polyamines in anxiety and depression-related behaviors.
REFERENCE   3  (bases 1 to 1844)
  AUTHORS   Ditzen,C., Varadarajulu,J., Czibere,L., Gonik,M., Targosz,B.S.,
            Hambsch,B., Bettecken,T., Kessler,M.S., Frank,E., Bunck,M.,
            Teplytska,L., Erhardt,A., Holsboer,F., Muller-Myhsok,B.,
            Landgraf,R. and Turck,C.W.
  TITLE     Proteomic-based genotyping in a mouse model of trait anxiety
            exposes disease-relevant pathways
  JOURNAL   Mol Psychiatry 15 (7), 702-711 (2010)
   PUBMED   19139748
  REMARK    GeneRIF: both single-nucleotide polymorphisms were significantly
            associated with locomotion-independent trait anxiety, further
            supporting a functional role of EP for this phenotype.
REFERENCE   4  (bases 1 to 1844)
  AUTHORS   Kim,S., Zhang,S., Choi,K.H., Reister,R., Do,C., Baykiz,A.F. and
            Gershenfeld,H.K.
  TITLE     An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger
            41, is a candidate gene for anxiety-like behavior and
            beta-carboline-induced seizures
  JOURNAL   Biol Psychiatry 65 (5), 425-431 (2009)
   PUBMED   18986647
REFERENCE   5  (bases 1 to 1844)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK167575.1, AK079062.1 and BE995909.1.
            
            On Jul 8, 2009 this sequence version replaced NM_026421.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 both encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167575.1, AK079062.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1003              AK167575.1         12-1014
            1004-1824           AK079062.1         998-1818
            1825-1844           BE995909.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1844
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 48.46 cM"
     gene            1..1844
                     /gene="Enoph1"
                     /gene_synonym="2310057D15Rik"
                     /note="enolase-phosphatase 1"
                     /db_xref="GeneID:67870"
                     /db_xref="MGI:MGI:1915120"
     exon            1..309
                     /gene="Enoph1"
                     /gene_synonym="2310057D15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..999
                     /gene="Enoph1"
                     /gene_synonym="2310057D15Rik"
                     /EC_number="3.1.3.77"
                     /note="MASA homolog;
                     2,3-diketo-5-methylthio-1-phosphopentane phosphatase"
                     /codon_start=1
                     /product="enolase-phosphatase E1"
                     /protein_id="NP_080697.2"
                     /db_xref="CCDS:CCDS39183.1"
                     /db_xref="GeneID:67870"
                     /db_xref="MGI:MGI:1915120"
                     /translation="MVVVSVPAEVTVILLDIEGTTTPIAFVKDVLFPYIKENVKEYLQ
                     THWEEEECQQDVSLLRKQAEEDAHLDGAVPIPVASGSDLQQMIQAVVDNVYWQMSHDR
                     KTTALKQLQGHMWKAAFTAGRMKAEFFADVVPAVRRWREAGMKVYIYSSGSVEAQKLL
                     FGHSTEGDILELIDGHFDTKIGHKVDSESYRKIADSIGCSTNNILFLTDVTVEASAAE
                     EADVHVAVVVRPGNAGLTDDEKTYYNLITSFSELYLPST"
     exon            310..411
                     /gene="Enoph1"
                     /gene_synonym="2310057D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            412..605
                     /gene="Enoph1"
                     /gene_synonym="2310057D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            606..738
                     /gene="Enoph1"
                     /gene_synonym="2310057D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            739..862
                     /gene="Enoph1"
                     /gene_synonym="2310057D15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1829
                     /gene="Enoph1"
                     /gene_synonym="2310057D15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1805..1810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Enoph1"
                     /gene_synonym="2310057D15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1825
                     /gene="Enoph1"
                     /gene_synonym="2310057D15Rik"
                     /note="major polyA site"
ORIGIN      
        1 tccggctgcc cacgtggtcc gggcctgcgc ggctcgcctg ctcgtcgggt gtagtaccct
       61 aggcggcttc ctctgcaact gcgggtccca gctctgtctc tgagcccctg gtcgttcgct
      121 gtcgccagcg cctcggttgt tgctgggccc tcgggagctc aagacgcgca ggcggtgttg
      181 ccctccttaa ccaaggccga gcccgtggta gcatccggca gggaaatggt cgtggtttcc
      241 gtgcccgccg aagtcaccgt aatcctgtta gatatcgaag gtaccacaac cccgattgct
      301 ttcgtgaagg atgttttatt tccgtacatc aaagaaaatg tcaaggagta cctgcagacc
      361 cactgggagg aggaggagtg tcagcaggac gtcagcctgc tgaggaaaca ggccgaggaa
      421 gatgcacatc tggacggggc tgttccgata cccgtggctt ctggcagtga tctgcagcag
      481 atgatccagg ctgtggtgga caacgtgtac tggcagatgt cccatgaccg aaagaccaca
      541 gcgctcaaac agctgcaagg ccacatgtgg aaggcagctt tcacggctgg ccgcatgaag
      601 gcagagttct ttgcagatgt ggttcctgca gtcagaaggt ggagagaggc tgggatgaag
      661 gtatacatct attcttcagg gagcgtggag gcacagaagc tgctcttcgg ccattccaca
      721 gagggagaca ttcttgagct catcgacggt cactttgaca ccaagattgg acacaaagtg
      781 gacagtgaga gttaccggaa gattgctgat agcatcggtt gttcaaccaa caacatcctg
      841 tttctcacgg atgtcaccgt agaggccagt gctgctgagg aggcggacgt gcacgtggct
      901 gtggtggtgc gacctggcaa cgcggggctc actgacgacg agaagacata ctacaacctc
      961 atcacgtcct tcagcgagct ctacctgccg tccacctaga gccaggtctg aggaagaatt
     1021 gccgtcccct agtgtctagc tttattctaa ctgtaaaagt aacgtactta tgtgtgcaca
     1081 cagacatgtg caagggtata tacatggaca tgtgctcaga ttagtttcca tgggcacata
     1141 atgtgagaaa agttgtccgt tccatgaaga ccaaattcat gtaaagacac tttatgtgta
     1201 gaccataaat ctgtcttacc aagcccgggg tgtatttgaa actgcaaaat actaatcaaa
     1261 tttgtgatgt ttatcaaatt gtttaccaag tggaaagcta gttctgagaa attattatcc
     1321 agagcctgtg ttattttaaa gactggactt gcttcaaagg tacccatacg aggagcccac
     1381 cgtccctgtc cctcgaggtc acgtcccacc gctgcactaa ggactcacgg cccagcgtcc
     1441 acaagactga ggccctgtcc ctgctcagag aacagatccg gagcaggtgg tctggtcagt
     1501 caggatggaa cagtgctaca agcaccagcc tgcctctgag cagtgctcgg aacagctgag
     1561 gccgtggcgg gctccactaa cccccagtgt tatcgtgttt tatagctgcc tttctgtgtc
     1621 ttacacagtt tgagagtata tgttaatgac tatttttttt aaaaatgttc tattgaaacc
     1681 agtgtaacag cacaaagagc tctaatgtgt aacacttcct ctgaaatgga tataaagatg
     1741 taaattttat aacagcactg tttattctga tgcattctga tgggtcagtg tcgtgtcatt
     1801 aattaataaa ggcattttct tctcatacaa aaaaaaaaaa aaaa
//
