LOCUS       NM_001136062            1494 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus enolase 3, beta muscle (Eno3), transcript variant 2,
            mRNA.
ACCESSION   NM_001136062
VERSION     NM_001136062.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1494)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1494)
  AUTHORS   Cai,S., Si,N., Wang,Y. and Yin,N.
  TITLE     Transcriptomic analysis of the upper lip and primary palate
            development in mice
  JOURNAL   Front Genet 13, 1039850 (2023)
   PUBMED   36685938
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1494)
  AUTHORS   Sakamoto,T., Matsuura,T.R., Wan,S., Ryba,D.M., Kim,J.U., Won,K.J.,
            Lai,L., Petucci,C., Petrenko,N., Musunuru,K., Vega,R.B. and
            Kelly,D.P.
  TITLE     A Critical Role for Estrogen-Related Receptor Signaling in Cardiac
            Maturation
  JOURNAL   Circ Res 126 (12), 1685-1702 (2020)
   PUBMED   32212902
REFERENCE   4  (bases 1 to 1494)
  AUTHORS   Huang,J., Du,J., Lin,W., Long,Z., Zhang,N., Huang,X., Xie,Y.,
            Liu,L. and Ma,W.
  TITLE     Regulation of lactate production through p53/beta-enolase axis
            contributes to statin-associated muscle symptoms
  JOURNAL   EBioMedicine 45, 251-260 (2019)
   PUBMED   31201144
  REMARK    GeneRIF: The in vitro evidence revealed that statins increased the
            expression of muscle specific glycolytic enzyme b-enolase through
            promoting the degradation of basal p53 proteins, resulting in
            increased of lactate production...  Elevated lactate production by
            statins through the p53/b-enolase axis contributes to
            Statin-associated muscle symptoms (SAMS)
REFERENCE   5  (bases 1 to 1494)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   6  (bases 1 to 1494)
  AUTHORS   Lucas,M., Goblet,C., Keller,A., Lamande,N., Gros,F., Whalen,R.G.
            and Lazar,M.
  TITLE     Modulation of embryonic and muscle-specific enolase gene products
            in the developing mouse hindlimb
  JOURNAL   Differentiation 51 (1), 1-7 (1992)
   PUBMED   1280607
REFERENCE   7  (bases 1 to 1494)
  AUTHORS   Keller,A., Ott,M.O., Lamande,N., Lucas,M., Gros,F., Buckingham,M.
            and Lazar,M.
  TITLE     Activation of the gene encoding the glycolytic enzyme beta-enolase
            during early myogenesis precedes an increased expression during
            fetal muscle development
  JOURNAL   Mech Dev 38 (1), 41-54 (1992)
   PUBMED   1525038
REFERENCE   8  (bases 1 to 1494)
  AUTHORS   Peterson,C.A., Cho,M., Rastinejad,F. and Blau,H.M.
  TITLE     Beta-enolase is a marker of human myoblast heterogeneity prior to
            differentiation
  JOURNAL   Dev Biol 151 (2), 626-629 (1992)
   PUBMED   1339335
REFERENCE   9  (bases 1 to 1494)
  AUTHORS   Barbieri,G., De Angelis,L., Feo,S., Cossu,G. and Giallongo,A.
  TITLE     Differential expression of muscle-specific enolase in embryonic and
            fetal myogenic cells during mouse development
  JOURNAL   Differentiation 45 (3), 179-184 (1990)
   PUBMED   2090519
REFERENCE   10 (bases 1 to 1494)
  AUTHORS   Lamande,N., Mazo,A.M., Lucas,M., Montarras,D., Pinset,C., Gros,F.,
            Legault-Demare,L. and Lazar,M.
  TITLE     Murine muscle-specific enolase: cDNA cloning, sequence, and
            developmental expression
  JOURNAL   Proc Natl Acad Sci U S A 86 (12), 4445-4449 (1989)
   PUBMED   2734297
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY784892.1, AK002485.1 and
            AI841640.1.
            
            [WARNING] On Jun 17, 2024 this sequence was replaced by
            NM_001136062.3.
            
            On Jan 24, 2013 this sequence version replaced NM_001136062.1.
            
            Summary: This gene encodes one of the three enolase isoenzymes
            found in vertebrates. Enolase is a dimeric enzyme that converts
            2-phosphoglycerate to phosphoenolpyruvate as part of the glycolytic
            pathway. This isozyme is found in skeletal muscle where it is
            involved in muscle development and regeneration. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jan 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002485.1, X57747.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BY784892.1         4-33
            31-1419             AK002485.1         3-1391
            1420-1494           AI841640.1         1-75                c
FEATURES             Location/Qualifiers
     source          1..1494
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 43.21 cM"
     gene            1..1494
                     /gene="Eno3"
                     /gene_synonym="Eno-3; MSE"
                     /note="enolase 3, beta muscle"
                     /db_xref="GeneID:13808"
                     /db_xref="MGI:MGI:95395"
     exon            1..92
                     /gene="Eno3"
                     /gene_synonym="Eno-3; MSE"
                     /inference="alignment:Splign:2.1.0"
     exon            93..179
                     /gene="Eno3"
                     /gene_synonym="Eno-3; MSE"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1399
                     /gene="Eno3"
                     /gene_synonym="Eno-3; MSE"
                     /EC_number="4.2.1.11"
                     /note="muscle-specific enolase; skeletal muscle enolase;
                     2-phospho-D-glycerate hydro-lyase"
                     /codon_start=1
                     /product="beta-enolase"
                     /protein_id="NP_001129534.1"
                     /db_xref="CCDS:CCDS24961.1"
                     /db_xref="GeneID:13808"
                     /db_xref="MGI:MGI:95395"
                     /translation="MAMQKIFAREILDSRGNPTVEVDLHTAKGRFRAAVPSGASTGIY
                     EALELRDGDKARYLGKGVLKAVEHINKTLGPALLEKKLSVVDQEKVDKFMIELDGTEN
                     KSKFGANAILGVSLAVCKAGAAEKGVPLYRHIADLAGNPDLVLPVPAFNVINGGSHAG
                     NKLAMQEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKYGKDATNVGDEGGFAPNIL
                     ENNEALELLKTAIQAAGYPDKVVIGMDVAASEFYRNGKYDLDFKSPDDPARHISGEKL
                     GELYKNFIQNYPVVSIEDPFDQDDWATWTSFLSGVDIQIVGDDLTVTNPKRIAQAVEK
                     KACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQ
                     IKTGAPCRSERLAKYNQLMRIEEALGDKAVFAGRKFRNPKAK"
     exon            180..275
                     /gene="Eno3"
                     /gene_synonym="Eno-3; MSE"
                     /inference="alignment:Splign:2.1.0"
     exon            276..334
                     /gene="Eno3"
                     /gene_synonym="Eno-3; MSE"
                     /inference="alignment:Splign:2.1.0"
     exon            335..404
                     /gene="Eno3"
                     /gene_synonym="Eno-3; MSE"
                     /inference="alignment:Splign:2.1.0"
     exon            405..538
                     /gene="Eno3"
                     /gene_synonym="Eno-3; MSE"
                     /inference="alignment:Splign:2.1.0"
     exon            539..761
                     /gene="Eno3"
                     /gene_synonym="Eno-3; MSE"
                     /inference="alignment:Splign:2.1.0"
     exon            762..959
                     /gene="Eno3"
                     /gene_synonym="Eno-3; MSE"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1161
                     /gene="Eno3"
                     /gene_synonym="Eno-3; MSE"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1270
                     /gene="Eno3"
                     /gene_synonym="Eno-3; MSE"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1329
                     /gene="Eno3"
                     /gene_synonym="Eno-3; MSE"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1480
                     /gene="Eno3"
                     /gene_synonym="Eno-3; MSE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1460..1465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eno3"
                     /gene_synonym="Eno-3; MSE"
                     /note="hexamer: AATAAA"
     polyA_site      1480
                     /gene="Eno3"
                     /gene_synonym="Eno-3; MSE"
                     /note="major polyA site"
ORIGIN      
        1 aaatgcccag tctgagaggg ggtgaactga cactgtccca gctgctacct agaggagaca
       61 ctccactcaa agttccaagg aaggctttcc agccatggcc atgcaaaaaa tcttcgcccg
      121 ggaaatcctg gactccaggg gcaaccccac ggtggaggtg gacctgcaca cagccaaggg
      181 tcgattccga gcagctgtgc ccagtggagc ttccacgggt atctatgaag cactggaact
      241 ccgagatgga gacaaagcac gatacctggg gaaaggagtg ctgaaggctg tggaacacat
      301 caacaagact ctaggtcctg ctctgctgga aaagaaacta agtgttgtgg atcaagaaaa
      361 agttgacaag ttcatgattg agctggacgg gaccgagaat aagtccaagt ttggggccaa
      421 cgccatcctg ggtgtgtccc tggctgtctg caaggctgga gcagctgaga aaggggtccc
      481 tctctaccga cacatcgcag atcttgcagg caatcccgac ctcgtactcc ctgtgcctgc
      541 ctttaatgtg atcaacggcg gctctcatgc tggaaacaag ctggccatgc aggagttcat
      601 gattctgcca gtgggagcca gctctttcaa ggaagccatg cgcatcggcg ctgaggtcta
      661 ccaccacctc aagggggtca tcaaggccaa gtatgggaag gacgccacca acgtggggga
      721 tgagggtggc tttgcaccca acatcctgga gaacaatgag gccctggagc tgctaaagac
      781 agccatccag gcagccggtt acccggacaa ggtggtgatc ggcatggatg tagctgcgtc
      841 tgaattctac cgcaacggca agtatgatct ggacttcaag tcacccgatg accctgccag
      901 gcacatcagt ggggagaagc ttggggagct gtacaagaac ttcatccaga actatcccgt
      961 ggtctccatt gaggacccct ttgaccagga tgactgggcc acatggacct cattcctctc
     1021 tggggtggac atccagattg tgggagatga cctcacggta accaacccca agaggattgc
     1081 tcaggctgtg gagaagaagg cctgcaattg cctgctcctg aaggtcaacc agatcggctc
     1141 cgtgacggag tccatccagg cctgtaaact tgcacaatct aatggctggg gagtgatggt
     1201 gagccaccgc tctggggaga ccgaagacac tttcatcgct gaccttgtgg tgggactctg
     1261 cacaggacag atcaagactg gtgctccctg ccgttcagag cgtctggcaa aatacaacca
     1321 gcttatgagg attgaggagg ctcttgggga caaagctgtc tttgctggaa gaaagttccg
     1381 taatccaaag gccaaatgag gagctggaga ctccaggctt tcacaggaaa gacacaggcc
     1441 ttcaagccct tctcccagaa ataaacactg ccaaaccaga aaaaaaaaaa aaaa
//
