LOCUS       NM_001409688            3219 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus enolase 2, gamma neuronal (Eno2), transcript variant
            6, mRNA.
ACCESSION   NM_001409688
VERSION     NM_001409688.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3219)
  AUTHORS   Matsumoto,M., Matsushita,K., Hane,M., Wen,C., Kurematsu,C., Ota,H.,
            Bang Nguyen,H., Quynh Thai,T., Herranz-Perez,V., Sawada,M.,
            Fujimoto,K., Garcia-Verdugo,J.M., Kimura,K.D., Seki,T., Sato,C.,
            Ohno,N. and Sawamoto,K.
  TITLE     Neuraminidase inhibition promotes the collective migration of
            neurons and recovery of brain function
  JOURNAL   EMBO Mol Med 16 (6), 1228-1253 (2024)
   PUBMED   38789599
REFERENCE   2  (bases 1 to 3219)
  AUTHORS   Misawa,H., Kamishima,K., Koyama,T., Ohgaki,L., Morisaki,Y.,
            Yamanaka,T., Itohara,S., Sawano,S., Mizunoya,W. and Ogihara,N.
  TITLE     Type selective ablation of postnatal slow and fast
            fatigue-resistant motor neurons in mice induces late onset kinetic
            and postural tremor following fiber-type transition and myopathy
  JOURNAL   Exp Neurol 376, 114772 (2024)
   PUBMED   38599366
REFERENCE   3  (bases 1 to 3219)
  AUTHORS   Nakajima,C., Sawada,M., Umeda,E., Takagi,Y., Nakashima,N.,
            Kuboyama,K., Kaneko,N., Yamamoto,S., Nakamura,H., Shimada,N.,
            Nakamura,K., Matsuno,K., Uesugi,S., Veprek,N.A., Kullmer,F.,
            Nasufovic,V., Uchiyama,H., Nakada,M., Otsuka,Y., Ito,Y.,
            Herranz-Perez,V., Garcia-Verdugo,J.M., Ohno,N., Arndt,H.D.,
            Trauner,D., Tabata,Y., Igarashi,M. and Sawamoto,K.
  TITLE     Identification of the growth cone as a probe and driver of neuronal
            migration in the injured brain
  JOURNAL   Nat Commun 15 (1), 1877 (2024)
   PUBMED   38461182
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3219)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3219)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   6  (bases 1 to 3219)
  AUTHORS   Compagnone,N.A., Bulfone,A., Rubenstein,J.L. and Mellon,S.H.
  TITLE     Steroidogenic enzyme P450c17 is expressed in the embryonic central
            nervous system
  JOURNAL   Endocrinology 136 (11), 5212-5223 (1995)
   PUBMED   7588260
REFERENCE   7  (bases 1 to 3219)
  AUTHORS   Scott,H.C., Zoeller,R.T. and Rudeen,P.K.
  TITLE     Acute prenatal ethanol exposure and luteinizing hormone-releasing
            hormone messenger RNA expression in the fetal mouse brain
  JOURNAL   Alcohol Clin Exp Res 19 (1), 153-159 (1995)
   PUBMED   7771642
REFERENCE   8  (bases 1 to 3219)
  AUTHORS   Narisawa,S., Hasegawa,H., Watanabe,K. and Millan,J.L.
  TITLE     Stage-specific expression of alkaline phosphatase during neural
            development in the mouse
  JOURNAL   Dev Dyn 201 (3), 227-235 (1994)
   PUBMED   7533563
REFERENCE   9  (bases 1 to 3219)
  AUTHORS   Kaghad,M., Dumont,X., Chalon,P., Lelias,J.M., Lamande,N., Lucas,M.,
            Lazar,M. and Caput,D.
  TITLE     Nucleotide sequences of cDNAs alpha and gamma enolase mRNAs from
            mouse brain
  JOURNAL   Nucleic Acids Res 18 (12), 3638 (1990)
   PUBMED   2362815
REFERENCE   10 (bases 1 to 3219)
  AUTHORS   Lazar,M., Lucas,M., Lamande,N., Bishop,J.G., Gros,F. and
            Legault-Demare,L.
  TITLE     Isolation of murine neuron-specific and non-neuronal enolase cDNA
            clones
  JOURNAL   Biochem Biophys Res Commun 141 (1), 271-277 (1986)
   PUBMED   3801001
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164157.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363658.5204771.1,
                                           SRR17784648.636273.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               AC164157.3         165121-165398       c
            279-761             AC164157.3         164110-164592       c
            762-857             AC164157.3         163573-163668       c
            858-916             AC164157.3         163412-163470       c
            917-986             AC164157.3         162905-162974       c
            987-1120            AC164157.3         162403-162536       c
            1121-1343           AC164157.3         161977-162199       c
            1344-1541           AC164157.3         159599-159796       c
            1542-1743           AC164157.3         158877-159078       c
            1744-1852           AC164157.3         158525-158633       c
            1853-1911           AC164157.3         157520-157578       c
            1912-3219           AC164157.3         155927-157234       c
FEATURES             Location/Qualifiers
     source          1..3219
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.17 cM"
     gene            1..3219
                     /gene="Eno2"
                     /gene_synonym="D6Ertd375e; Eno-2; NSE"
                     /note="enolase 2, gamma neuronal"
                     /db_xref="GeneID:13807"
                     /db_xref="MGI:MGI:95394"
     exon            1..278
                     /gene="Eno2"
                     /gene_synonym="D6Ertd375e; Eno-2; NSE"
                     /inference="alignment:Splign:2.1.0"
     exon            279..761
                     /gene="Eno2"
                     /gene_synonym="D6Ertd375e; Eno-2; NSE"
                     /inference="alignment:Splign:2.1.0"
     CDS             677..1981
                     /gene="Eno2"
                     /gene_synonym="D6Ertd375e; Eno-2; NSE"
                     /EC_number="4.2.1.11"
                     /note="isoform 1 is encoded by transcript variant 6;
                     gamma-enolase; neural enolase; neuron-specific enolase;
                     2-phospho-D-glycerate hydro-lyase"
                     /codon_start=1
                     /product="gamma-enolase isoform 1"
                     /protein_id="NP_001396617.1"
                     /db_xref="GeneID:13807"
                     /db_xref="MGI:MGI:95394"
                     /translation="MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIY
                     EALELRDGDKQRYLGKGVLKAVDHINSRIAPALISSGISVVEQEKLDNLMLELDGTEN
                     KSKFGANAILGVSLAVCKAGAAERDLPLYRHIAQLAGNSDLILPVPAFNVINGGSHAG
                     NKLAMQEFMILPVGAESFRDAMRLGAEVYHTLKGVIKDKYGKDATNVGDEGGFAPNIL
                     ENSEALELVKEAIDKAGYTEKMVIGMDVAASEFYRDGKYDLDFKSPADPSRYITGDQL
                     GALYQDFVRNYPVVSIEDPFDQDDWAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEE
                     KACNCLLLKVNQIGSVTEAIQACKLAQENGWGVMVSHRSGETEDTFIADLVVGLCTGQ
                     IKTGAPCRSERLAKYNQLMRIEEELGDEARFAGHNFRNPSVL"
     exon            762..857
                     /gene="Eno2"
                     /gene_synonym="D6Ertd375e; Eno-2; NSE"
                     /inference="alignment:Splign:2.1.0"
     exon            858..916
                     /gene="Eno2"
                     /gene_synonym="D6Ertd375e; Eno-2; NSE"
                     /inference="alignment:Splign:2.1.0"
     exon            917..986
                     /gene="Eno2"
                     /gene_synonym="D6Ertd375e; Eno-2; NSE"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1120
                     /gene="Eno2"
                     /gene_synonym="D6Ertd375e; Eno-2; NSE"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1343
                     /gene="Eno2"
                     /gene_synonym="D6Ertd375e; Eno-2; NSE"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1541
                     /gene="Eno2"
                     /gene_synonym="D6Ertd375e; Eno-2; NSE"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1743
                     /gene="Eno2"
                     /gene_synonym="D6Ertd375e; Eno-2; NSE"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1852
                     /gene="Eno2"
                     /gene_synonym="D6Ertd375e; Eno-2; NSE"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1911
                     /gene="Eno2"
                     /gene_synonym="D6Ertd375e; Eno-2; NSE"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..3219
                     /gene="Eno2"
                     /gene_synonym="D6Ertd375e; Eno-2; NSE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2888..2893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eno2"
                     /gene_synonym="D6Ertd375e; Eno-2; NSE"
                     /note="hexamer: ATTAAA"
     polyA_site      2910
                     /gene="Eno2"
                     /gene_synonym="D6Ertd375e; Eno-2; NSE"
                     /note="major polyA site"
     regulatory      3200..3205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eno2"
                     /gene_synonym="D6Ertd375e; Eno-2; NSE"
                     /note="hexamer: ATTAAA"
     polyA_site      3219
                     /gene="Eno2"
                     /gene_synonym="D6Ertd375e; Eno-2; NSE"
                     /note="major polyA site"
ORIGIN      
        1 actcctgctc tctctgcgcc gccgccgtca ccaccgccac tgccaccgcc accgccgcca
       61 acgccaccga ctgagtctgc agtcctcgag gtgaggcccg tatcgggccg catcccctta
      121 ctcgctcctt gccgcctcca ctccccgttg tcctgggctt agcgacccgg gcgggtgacg
      181 ctgcatacct gactgtcacc tgccttccct ggcaccctcc atctctggcc ttcccggaca
      241 gctcccggct ttctggctgt cacctcctcc tggtttagat ccaagggaaa aaatgccagt
      301 ctggcagcca tcccgcctgg ggaagtctag gggaacccca ctggtcggtg aagctgctga
      361 ggggcgaaga aatcgctgct tgcccctccc ctcatcactg cggtgttctc ccatcttgtc
      421 atgagatgta ctccgcccct actgcagtga cctccccttc ctcactgcat tgaccttctc
      481 ctctctccac ggggaaggga gaaccccttc tacagtgcct gattgcagcc cgctcctccc
      541 caccccctac ccactgcagt aacctctttg ccagccctcc cagcctctgg cccctcccac
      601 tggcctcagg ctccaccctt ctaagcctct tatctttctc cttcctccac ttccacccaa
      661 ggagatccca gccatcatgt ctatagagaa gatttgggcc cgagagatct tggactcccg
      721 tgggaatccc accgtggagg tggatctcta tactgccaaa ggtcttttcc gggctgcagt
      781 ccccagtgga gcctccaccg gcatctatga ggccctggaa ctaagggatg gggacaaaca
      841 gcgttactta ggcaaaggtg tcctgaaggc agtggaccac atcaacagca ggattgcacc
      901 agccctcatc agctcaggta tctccgtggt ggagcaggag aaactggaca acctgatgtt
      961 ggaactggat gggactgaga ataaatccaa gtttggggcc aatgccatcc tgggtgtgtc
     1021 cctggccgtg tgtaaggctg gggcagctga gagggacttg cccctctatc gccacattgc
     1081 tcagctagct gggaactccg acctcatcct gcctgtgccg gcctttaatg tgatcaatgg
     1141 tggctctcat gctgggaaca agttggccat gcaggagttc atgatcctcc cagtgggtgc
     1201 tgagagcttt cgggatgcca tgcgacttgg ggcagaggtg taccacaccc tcaagggggt
     1261 catcaaggac aagtatggca aggatgccac taacgtgggg gatgaaggcg gctttgcccc
     1321 caatatcctg gagaacagcg aagccttgga gctggtgaag gaagccatcg acaaggctgg
     1381 ctacacggaa aagatggtga tcggtatgga tgtggctgcc tctgagtttt accgcgatgg
     1441 caaatacgac ttggatttca agtctcccgc tgatccttcc cgatacatca ctggggacca
     1501 gctgggggca ctctaccagg actttgtccg gaactatcct gtggtctcca ttgaagaccc
     1561 atttgaccag gacgactggg cagcttggtc caagttcaca gccaacgtcg gcatccagat
     1621 agtgggcgat gacctgacgg tgaccaaccc caagcgcatc gagcgggcag tggaggagaa
     1681 ggcctgcaac tgtttgctgc tcaaggtcaa tcagatcggc tcggtcacag aagccatcca
     1741 agcgtgcaag ctggcccagg agaatggctg gggggttatg gtgagccatc gctctggaga
     1801 aacggaggac acgttcattg ctgatcttgt cgtcggactg tgtacaggcc agatcaagac
     1861 tggcgcccca tgcagatctg aacgtctggc gaagtacaac cagctcatga gaattgagga
     1921 agagctgggg gacgaagctc gcttcgcggg acataatttc cgaaatccca gtgtgctgtg
     1981 atccccttcc cccaaccccg cttgcctgaa cgcgggaaca tctcattctc ctggagcctc
     2041 tttcttgctg ccctgacctg ccatagtcac tctgataccc tgagccccaa gtcacccaga
     2101 acacctcgac tcaccgctcc tgctgttctt ggcttccaca accccccttg ctctctctgc
     2161 tcttcctcct ctctgggccc catttttggg gggattcagt cttcccactt tcccttctat
     2221 tctctcttct ctttaaaaaa aaattatgaa gattagaagg gggtccacag aagaatcctc
     2281 agtgtctgac aggagcttca ggattggtgt gttggggtgt ttaaagtggg gtcacgggca
     2341 tgagtgtttc agtgcttacc atggtgtgta taagccttga actatgcata gaactggagt
     2401 ttggggagtg ctggatgtgt ggtcatgctt ggttgaggct ttagtgtatg tgtttacata
     2461 cacaagcaca gtttgtttgt ttgcttattt atttatttat ttatttattt atttatttat
     2521 ttatttattt ctcagctggt cagtcagcca tctcctgtaa ctctccagtc tgaaagtgac
     2581 ctaacttgac aggactaggc acccctattc catgtggctt cattccaaga tgacccagga
     2641 tggggatttt gctagcatgg gaaggggaac agaaaagggc cttagcaatt gcttcattcg
     2701 gtgcactaac cgaagctcgg aactttacag aatggggctg tggacctggg gaggcttttc
     2761 tcctctaacc ctctccccag ccctaggctc ctccgtcttt ctccggctgc accagagcgc
     2821 tgcctcactc ccctgcgcca tgtcccacag ttgccaccat ctccgtggct ttgaaatgac
     2881 caccaccatt aaagtctgaa tcacagcgca ccaccccttg tctgaggact cttactctct
     2941 gctccatgtg agaggacgaa gagaaacgac tggatattgg cgatcctagg tagcagatca
     3001 ggggagggct caaaaagcgg caagccactg aactcatgac caagtttgca gcattgctgg
     3061 tgatgtggga tccgtggggt ttttgtttcc caagacaggg tttctacgtg tagccctggc
     3121 tgtcctggaa ctcactctgt agaccaggct ggctccaagt ttacagagat ccgcctgctt
     3181 ctgcctcccg agtgctggga ttaaaagctt gtaccacca
//
