LOCUS       NM_198299               1317 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus enkurin domain containing 1 (Enkd1), mRNA.
ACCESSION   NM_198299 XM_134532
VERSION     NM_198299.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1317)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1317)
  AUTHORS   Zhong,T., Wu,X., Xie,W., Luo,X., Song,T., Sun,S., Luo,Y., Li,D.,
            Liu,M., Xie,S. and Zhou,J.
  TITLE     ENKD1 promotes epidermal stratification by regulating spindle
            orientation in basal keratinocytes
  JOURNAL   Cell Death Differ 29 (9), 1719-1729 (2022)
   PUBMED   35197565
  REMARK    GeneRIF: ENKD1 promotes epidermal stratification by regulating
            spindle orientation in basal keratinocytes.
REFERENCE   3  (bases 1 to 1317)
  AUTHORS   Song,T., Yang,Y., Zhou,P., Ran,J., Zhang,L., Wu,X., Xie,W.,
            Zhong,T., Liu,H., Liu,M., Li,D., Zhao,H. and Zhou,J.
  TITLE     ENKD1 promotes CP110 removal through competing with CEP97 to
            initiate ciliogenesis
  JOURNAL   EMBO Rep 23 (5), e54090 (2022)
   PUBMED   35301795
  REMARK    GeneRIF: ENKD1 promotes CP110 removal through competing with CEP97
            to initiate ciliogenesis.
REFERENCE   4  (bases 1 to 1317)
  AUTHORS   Sigg,M.A., Menchen,T., Lee,C., Johnson,J., Jungnickel,M.K.,
            Choksi,S.P., Garcia,G. 3rd, Busengdal,H., Dougherty,G.W.,
            Pennekamp,P., Werner,C., Rentzsch,F., Florman,H.M., Krogan,N.,
            Wallingford,J.B., Omran,H. and Reiter,J.F.
  TITLE     Evolutionary Proteomics Uncovers Ancient Associations of Cilia with
            Signaling Pathways
  JOURNAL   Dev Cell 43 (6), 744-762 (2017)
   PUBMED   29257953
REFERENCE   5  (bases 1 to 1317)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1317)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: E130303B06Rik is most abundantly expressed in tissues rich
            in highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
REFERENCE   7  (bases 1 to 1317)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   8  (bases 1 to 1317)
  AUTHORS   Keegan,C.E., Hutz,J.E., Else,T., Adamska,M., Shah,S.P., Kent,A.E.,
            Howes,J.M., Beamer,W.G. and Hammer,G.D.
  TITLE     Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd)
            mice is caused by a splicing mutation in a novel telomeric
            regulator
  JOURNAL   Hum Mol Genet 14 (1), 113-123 (2005)
   PUBMED   15537664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152826.2.
            
            On Aug 15, 2018 this sequence version replaced NM_198299.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052498.1, SRR5189685.149908.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC152826.2         125886-125937
            53-152              AC152826.2         126171-126270
            153-347             AC152826.2         126351-126545
            348-520             AC152826.2         127356-127528
            521-646             AC152826.2         129334-129459
            647-810             AC152826.2         129580-129743
            811-947             AC152826.2         129845-129981
            948-1317            AC152826.2         130073-130442
FEATURES             Location/Qualifiers
     source          1..1317
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..1317
                     /gene="Enkd1"
                     /gene_synonym="E130303B06Rik"
                     /note="enkurin domain containing 1"
                     /db_xref="GeneID:102124"
                     /db_xref="MGI:MGI:2142593"
     exon            1..52
                     /gene="Enkd1"
                     /gene_synonym="E130303B06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            53..152
                     /gene="Enkd1"
                     /gene_synonym="E130303B06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1108
                     /gene="Enkd1"
                     /gene_synonym="E130303B06Rik"
                     /codon_start=1
                     /product="enkurin domain-containing protein 1"
                     /protein_id="NP_938041.1"
                     /db_xref="CCDS:CCDS22610.1"
                     /db_xref="GeneID:102124"
                     /db_xref="MGI:MGI:2142593"
                     /translation="MCEGPSRISGPIPPDPTLCPDYYRRPASAQGRLEGNALKLDLLT
                     SGRDLDSSPPRGPRIRPEAREILERGQRGVGDVLLQLGCISLGSGVSPKRKNPKDHEK
                     ENLRRIKEIQRRFQDQERSREQGQPKPLKALWRSPKYDNVESRVKARMKELGPTSVTE
                     PAHFLRAHSRCGPGLPPSRASSPQLALPGPQAKGPGLGVDFISRNALAAKRAPRRHSR
                     SLQVLAQVQEQQRQAQERYNATQKGHVPHYLLERRDLWRKEAEARQRSQPDPSMPPGH
                     TLMPENQRLETLNNLLQSQSQLLRELVLLPAGADSLRAQGHRAELDRKLVQIEEAIKI
                     FSRPKVFVKMDT"
     exon            153..347
                     /gene="Enkd1"
                     /gene_synonym="E130303B06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            348..520
                     /gene="Enkd1"
                     /gene_synonym="E130303B06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            521..646
                     /gene="Enkd1"
                     /gene_synonym="E130303B06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            647..810
                     /gene="Enkd1"
                     /gene_synonym="E130303B06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            811..947
                     /gene="Enkd1"
                     /gene_synonym="E130303B06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1317
                     /gene="Enkd1"
                     /gene_synonym="E130303B06Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcaacagc aactcctacc ggcttgcaac agttggcggt aaaactgctc caggctgcgg
       61 taggatcatg tgcgagggcc cgtcccgcat ctctggaccc atccccccag accccactct
      121 ctgcccggac tactaccggc ggccggcctc ggcccaagga cgcctggaag gaaacgcgtt
      181 gaagctggac ctgctgactt caggtcggga cctggactcc agtcctcctc gtggccctcg
      241 catcaggcct gaagcccgag agatcctaga gcgtggccag cgaggcgtgg gggacgtgct
      301 gctgcaactg gggtgcatct ccctcggttc gggggtctct cctaagagga agaatccaaa
      361 ggaccatgag aaggaaaact tgaggcggat caaagagatt cagaggcgct tccaagacca
      421 ggaacgcagc cgggaacagg gtcagcctaa gccactgaag gcactgtggc gctcacccaa
      481 gtatgacaat gtggagtctc gagtcaaggc caggatgaag gagcttggcc ccacctctgt
      541 gacagaacct gcccactttc tgcgggcaca ctcccgctgt ggccctgggc tcccaccatc
      601 ccgtgcctcc agtcctcagc tcgcccttcc aggtccccaa gctaagggac ccggcctagg
      661 cgtggatttc attagtcgca acgccctagc tgccaagaga gccccccggc gccactcccg
      721 ctccctgcag gtccttgcac aggttcagga acagcagcgc caagcccagg agcgctacaa
      781 cgccacgcag aaaggccatg tgccccatta cttgttggaa cgcagggacc tgtggcggaa
      841 ggaagcggaa gctcgccagc gtagccagcc agacccgtcc atgcccccgg gccacacact
      901 catgcctgag aatcagcggc tggagaccct gaacaatctg ctacaaagcc agagccagct
      961 gctacgtgag ctagtactat tacctgctgg ggcagactcg ctgagagccc agggtcatcg
     1021 tgctgaactg gaccggaagt tggtgcaaat agaagaggct atcaagatct tttcccgacc
     1081 caaagtcttt gtgaagatgg atacctagtc cttccccgct tggtacccac caagagtaac
     1141 agggagatat gtgtgcggat caccacgtgg ctgccaaggg cagactcaag ccctgtcata
     1201 gctcaaagac aggagcgttg gggtgggcag aatcgaaagc acttcttagt caccaggggc
     1261 tgcagaaggg ccaccagcct cccaacttct ctgtcaaaat taaacctttt gtacaca
//
