LOCUS       NM_027147               1264 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus energy homeostasis associated (Enho), mRNA.
ACCESSION   NM_027147 XM_001473388 XM_001478385 XM_912979
VERSION     NM_027147.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1264)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1264)
  AUTHORS   Tripathi,S., Maurya,S. and Singh,A.
  TITLE     Adropin may promote insulin stimulated steroidogenesis and
            spermatogenesis in adult mice testes
  JOURNAL   J Exp Zool A Ecol Integr Physiol 341 (1), 86-98 (2024)
   PUBMED   37902254
REFERENCE   3  (bases 1 to 1264)
  AUTHORS   Maurya,S., Tripathi,S. and Singh,A.
  TITLE     Ontogeny of adropin and its receptor expression during postnatal
            development and its pro-gonadal role in the ovary of pre-pubertal
            mouse
  JOURNAL   J Steroid Biochem Mol Biol 234, 106404 (2023)
   PUBMED   37743028
  REMARK    GeneRIF: Ontogeny of adropin and its receptor expression during
            postnatal development and its pro-gonadal role in the ovary of
            pre-pubertal mouse.
REFERENCE   4  (bases 1 to 1264)
  AUTHORS   Liu,Q., Zhang,S., Liu,G., Zhou,H., Guo,Y., Gao,F. and Weng,S.
  TITLE     Adropin deficiency worsens TNBS-induced colitis
  JOURNAL   Int Immunopharmacol 124 (Pt A), 110891 (2023)
   PUBMED   37688913
REFERENCE   5  (bases 1 to 1264)
  AUTHORS   Ding,F., Liu,G., Gao,F., Zheng,Z., Hong,Y., Chen,Y. and Weng,S.
  TITLE     Adropin attenuates pancreatitis-associated lung injury through
            PPARgamma phosphorylation-related macrophage polarization
  JOURNAL   Int J Mol Med 52 (4) (2023)
   PUBMED   37654184
  REMARK    GeneRIF: Adropin attenuates pancreatitis-associated lung injury
            through PPARgamma phosphorylation-related macrophage polarization.
REFERENCE   6  (bases 1 to 1264)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 1264)
  AUTHORS   Ganesh Kumar,K., Zhang,J., Gao,S., Rossi,J., McGuinness,O.P.,
            Halem,H.H., Culler,M.D., Mynatt,R.L. and Butler,A.A.
  TITLE     Adropin deficiency is associated with increased adiposity and
            insulin resistance
  JOURNAL   Obesity (Silver Spring) 20 (7), 1394-1402 (2012)
   PUBMED   22318315
REFERENCE   8  (bases 1 to 1264)
  AUTHORS   Lovren,F., Pan,Y., Quan,A., Singh,K.K., Shukla,P.C., Gupta,M.,
            Al-Omran,M., Teoh,H. and Verma,S.
  TITLE     Adropin is a novel regulator of endothelial function
  JOURNAL   Circulation 122 (11 Suppl), S185-S192 (2010)
   PUBMED   20837912
  REMARK    GeneRIF: a potential endothelial protective role of adropin that is
            likely mediated via upregulation of endothelial NO synthase
            expression through the VEGFR2-phosphatidylinositol 3-kinase-Akt and
            VEGFR2-extracellular signal regulated kinase 1/2 pathways.
            GeneRIF: Adropin has an endothelial protective function mediated
            via upregulation of eNOS expression through the VEGFR2-PI3K-Akt and
            VEGFR2-ERK1/2 pathways. Adropin therapy may thus be useful for
            limiting diseases characterized by endothelial dysfunction.
REFERENCE   9  (bases 1 to 1264)
  AUTHORS   Kumar,K.G., Trevaskis,J.L., Lam,D.D., Sutton,G.M., Koza,R.A.,
            Chouljenko,V.N., Kousoulas,K.G., Rogers,P.M., Kesterson,R.A.,
            Thearle,M., Ferrante,A.W. Jr., Mynatt,R.L., Burris,T.P., Dong,J.Z.,
            Halem,H.A., Culler,M.D., Heisler,L.K., Stephens,J.M. and
            Butler,A.A.
  TITLE     Identification of adropin as a secreted factor linking dietary
            macronutrient intake with energy homeostasis and lipid metabolism
  JOURNAL   Cell Metab 8 (6), 468-481 (2008)
   PUBMED   19041763
  REMARK    GeneRIF: Adropin regulated expression of hepatic lipogenic genes
            and adipose tissue peroxisome proliferator-activated receptor
            gamma, a major regulator of lipogenesis.
            GeneRIF: Adropin is the name given to the secreted peptide encoded
            by human C9orf165. In mice, it is abundant in liver where it is
            regulated by dietary macronutrients. Adropin regulates expression
            of genes involved in lipogenesis and adipogenesis.
REFERENCE   10 (bases 1 to 1264)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ554924.1, AK050496.1 and BQ030577.1.
            
            On or before Aug 22, 2008 this sequence version replaced
            XM_912979.2, XM_001473388.1, XM_001478385.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009710.1, AK050496.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               BQ554924.1         26-492
            468-1122            AK050496.1         267-921
            1123-1264           BQ030577.1         1-142               c
FEATURES             Location/Qualifiers
     source          1..1264
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 21.8 cM"
     gene            1..1264
                     /gene="Enho"
                     /gene_synonym="1110065P19Rik; 2310040A07Rik"
                     /note="energy homeostasis associated"
                     /db_xref="GeneID:69638"
                     /db_xref="MGI:MGI:1916888"
     exon            1..389
                     /gene="Enho"
                     /gene_synonym="1110065P19Rik; 2310040A07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            390..1247
                     /gene="Enho"
                     /gene_synonym="1110065P19Rik; 2310040A07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             549..779
                     /gene="Enho"
                     /gene_synonym="1110065P19Rik; 2310040A07Rik"
                     /note="adropin; energy homeostasis-associated protein"
                     /codon_start=1
                     /product="adropin precursor"
                     /protein_id="NP_081423.1"
                     /db_xref="CCDS:CCDS59655.1"
                     /db_xref="GeneID:69638"
                     /db_xref="MGI:MGI:1916888"
                     /translation="MGAAISQGALIAIVCNGLVGFLLLLLWVILCWACHSRSADVDSL
                     SESSPNSSPGPCPEKAPPPQKPSHEGSYLLQP"
     regulatory      1158..1163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Enho"
                     /gene_synonym="1110065P19Rik; 2310040A07Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1179
                     /gene="Enho"
                     /gene_synonym="1110065P19Rik; 2310040A07Rik"
                     /note="major polyA site"
ORIGIN      
        1 agccgactcc ctcccgccgt agccgagccc agccgaacgc agccgagccc agccgaactc
       61 ctcgacgctc ctgccgccgc cgcccgagtg ctgccgagcg agagagcgag cgagcgagcg
      121 agctagcggc cccggccgcg gaggaggcgc cgccccaggg ggaggaggtg cccgctctcc
      181 gcagaccgcc cgcggcagag gccggcccgg tcgcgccccg gcgggagcgg ccggcggagg
      241 ctgcgcggcc cagggggagg gcccggggag tggacgtcgc ccctgcccgc ctctcgccgc
      301 cccccgcccg caggctctgg agcctcagtc ggcgctgagc atcccgttgt cccggaccct
      361 ctcgcgggcg cgcaccgggc tcaactcagg cccaggactg caggtgggca tcttccctgc
      421 caagaagtcg ctgtgtgtgg acaggacagc caccttggat ggttggccac cccagagttg
      481 tgcctcggca tgggccttgc cgctgaggca gctccactgt ctgcgctggc ctgagggtgc
      541 tgtctgtcat gggggcagcc atctcccaag gggctctcat cgccatcgtc tgcaatggcc
      601 tcgtaggctt cttgctgcta ctgctctggg tcattctctg ctgggcctgc cattctcgat
      661 ctgctgacgt cgattctctc tcggaatcca gtcccaactc cagccctggc ccctgtcctg
      721 agaaggcgcc accaccccag aagcccagcc atgaaggcag ctacctgctg cagccctgaa
      781 gggctctggc ctagcctgga gtcctggacc tgagtatacc tgagtcagag cgtggaatcg
      841 gatccaagaa gtcagtcggc ctggggtcca gtcgatttga cactggaccc agcagcctag
      901 attgtagcca gcctggctcc aagagaggcc tgagtggccc tagagagaaa ggcctggagg
      961 gggggttagg agttggtgct agggccaggg ccatctggac tctgctccat cccaagggcc
     1021 aagggctgag tccatgcctt ccctaggctc agcacatctg ggctccctag gttggggagc
     1081 aaacgggaac cccatggcaa taatgggagg gtgtccaggc tgggcccctt ctctggtcct
     1141 cccactgttt gttgggtaat aaatggaact atggcttgcc ccgagatttc tttttttagg
     1201 ggctgtgtgg tagaacagaa aacaaataaa ggtaggaggt gagtgtcaaa aaaaaaaaaa
     1261 aaaa
//
