LOCUS       NM_007932               3433 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus endoglin (Eng), transcript variant 1, mRNA.
ACCESSION   NM_007932
VERSION     NM_007932.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3433)
  AUTHORS   Dinakaran,S., Qutaina,S., Zhao,H., Tang,Y., Wang,Z., Ruiz,S.,
            Nomura-Kitabayashi,A., Metz,C.N., Arthur,H.M., Meadows,S.M.,
            Blanc,L., Faughnan,M.E. and Marambaud,P.
  TITLE     CDK6-mediated endothelial cell cycle acceleration drives
            arteriovenous malformations in hereditary hemorrhagic
            telangiectasia
  JOURNAL   Nat Cardiovasc Res 3 (11), 1301-1317 (2024)
   PUBMED   39487364
REFERENCE   2  (bases 1 to 3433)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   3  (bases 1 to 3433)
  AUTHORS   Miladinovic,O., Canto,P.Y., Pouget,C., Piau,O., Radic,N.,
            Freschu,P., Megherbi,A., Brujas Prats,C., Jacques,S., Hirsinger,E.,
            Geeverding,A., Dufour,S., Petit,L., Souyri,M., North,T.,
            Isambert,H., Traver,D., Jaffredo,T., Charbord,P. and Durand,C.
  TITLE     A multistep computational approach reveals a neuro-mesenchymal cell
            population in the embryonic hematopoietic stem cell niche
  JOURNAL   Development 151 (7) (2024)
   PUBMED   38451068
REFERENCE   4  (bases 1 to 3433)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3433)
  AUTHORS   Nikoloudaki,G. and Hamilton,D.W.
  TITLE     Assessing the fate and contribution of Foxd1-expressing embryonic
            precursors and their progeny in palatal development, homeostasis
            and excisional repair
  JOURNAL   Sci Rep 14 (1), 4969 (2024)
   PUBMED   38424240
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3433)
  AUTHORS   Hallmann,R., Mayer,D.N., Berg,E.L., Broermann,R. and Butcher,E.C.
  TITLE     Novel mouse endothelial cell surface marker is suppressed during
            differentiation of the blood brain barrier
  JOURNAL   Dev Dyn 202 (4), 325-332 (1995)
   PUBMED   7626790
REFERENCE   7  (bases 1 to 3433)
  AUTHORS   Qureshi,S.T., Gros,P., Letarte,M. and Malo,D.
  TITLE     The murine endoglin gene (Eng) maps to chromosome 2
  JOURNAL   Genomics 26 (1), 165-166 (1995)
   PUBMED   7782079
REFERENCE   8  (bases 1 to 3433)
  AUTHORS   Pilz,A., Woodward,K., Povey,S. and Abbott,C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
REFERENCE   9  (bases 1 to 3433)
  AUTHORS   Ge,A.Z. and Butcher,E.C.
  TITLE     Cloning and expression of a cDNA encoding mouse endoglin, an
            endothelial cell TGF-beta ligand
  JOURNAL   Gene 138 (1-2), 201-206 (1994)
   PUBMED   8125301
REFERENCE   10 (bases 1 to 3433)
  AUTHORS   Spies,T. and DeMars,R.
  TITLE     Restored expression of major histocompatibility class I molecules
            by gene transfer of a putative peptide transporter
  JOURNAL   Nature 351 (6324), 323-324 (1991)
   PUBMED   2034277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY226445.1, BB851508.1 and AK151302.1.
            
            On Apr 8, 2009 this sequence version replaced NM_007932.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1). This is also known
            as L-endoglin.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X77952.1, BC029080.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BY226445.1         70-71
            3-465               BB851508.1         3-465
            466-3433            AK151302.1         436-3403
FEATURES             Location/Qualifiers
     source          1..3433
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.09 cM"
     gene            1..3433
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
                     /note="endoglin"
                     /db_xref="GeneID:13805"
                     /db_xref="MGI:MGI:95392"
     exon            1..430
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..2325
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; transmembrane glycoprotein; cell surface MJ7/18
                     antigen"
                     /codon_start=1
                     /product="endoglin isoform 1 precursor"
                     /protein_id="NP_031958.2"
                     /db_xref="CCDS:CCDS15925.1"
                     /db_xref="GeneID:13805"
                     /db_xref="MGI:MGI:95392"
                     /translation="MDRGVLPLPITLLFVIYSFVPTTGLAERVGCDLQPVDPTRGEVT
                     FTTSQVSEGCVAQAANAVREVHVLFLDFPGMLSHLELTLQASKQNGTETQEVFLVLVS
                     NKNVFVKFQAPEIPLHLAYDSSLVIFQGQPRVNITVLPSLTSRKQILDWAATKGAITS
                     IAALDDPQSIVLQLGQDPKAPFLCLPEAHKDMGATLEWQPRAQTPVQSCRLEGVSGHK
                     EAYILRILPGSEAGPRTVTVMMELSCTSGDAILILHGPPYVSWFIDINHSMQILTTGE
                     YSVKIFPGSKVKGVELPDTPQGLIAEARKLNASIVTSFVELPLVSNVSLRASSCGGVF
                     QTTPAPVVTTPPKDTCSPVLLMSLIQPKCGNQVMTLALNKKHVQTLQCTITGLTFWDS
                     SCQAEDTDDHLVLSSAYSSCGMKVTAHVVSNEVIISFPSGSPPLRKKVQCIDMDSLSF
                     QLGLYLSPHFLQASNTIELGQQAFVQVSVSPLTSEVTVQLDSCHLDLGPEGDMVELIQ
                     SRTAKGSCVTLLSPSPEGDPRFSFLLRVYMVPTPTAGTLSCNLALRPSTLSQEVYKTV
                     SMRLNIVSPDLSGKGLVLPSVLGITFGAFLIGALLTAALWYIYSHTRGPSKREPVVAV
                     AAPASSESSSTNHSIGSTQSTPCSTSSMA"
     exon            431..585
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
                     /inference="alignment:Splign:2.1.0"
     exon            586..726
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
                     /inference="alignment:Splign:2.1.0"
     exon            727..892
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1058
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1179
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1354
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1497
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1635
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1674
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1791
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..2043
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2098
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2200
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..3433
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2865..2870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
                     /note="hexamer: AATAAA"
     polyA_site      2885
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
                     /note="major polyA site"
     regulatory      3405..3410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
                     /note="hexamer: AATAAA"
     polyA_site      3423
                     /gene="Eng"
                     /gene_synonym="CD105; Endo; S-endoglin"
ORIGIN      
        1 cgcatttcct gcctctctgg gccgggctgg atgagctgag ctccctgccc tgacagtcag
       61 acccctgcct tcatctgtgt cccgtcccca ggccaggacc gccgacagct gctgcccgaa
      121 agagcccagt gactctttcc caccacccag tcagctagag actcctgccc tgctgtgagt
      181 ctcgagccca cttctcctga cttctccgcc gccacctcag aaggctggag cagggacgtg
      241 gtcgctccgg ccgcctgctc ccttcggatc cccgcgcgaa cccacgcagg ccccggcgcc
      301 cgcccgcagc cttacctctg gataccggat aaggcccagc gcacagactc ccgggtggac
      361 agcatggacc gtggcgtgct ccctctgccc attaccctgc tgtttgtcat ctatagcttt
      421 gtacccacaa caggtctcgc agaaagagtc ggctgtgatc tacagcctgt ggaccccaca
      481 aggggtgagg tgacgtttac caccagccag gtctccgagg gctgtgtagc tcaggctgcc
      541 aatgctgtgc gtgaagtcca cgttctcttc ctggattttc ccggaatgct gtcacatctg
      601 gagctgactc ttcaggcatc caagcaaaat ggcacggaga cccaggaggt gttcctggtc
      661 ctcgtttcga acaaaaatgt cttcgtgaag ttccaggccc cggaaatccc attgcacttg
      721 gcctacgact ccagcctggt catcttccaa ggacagccaa gagtcaacat cacagtgcta
      781 ccatccctta cctccaggaa acagatcctc gactgggcag ccaccaaggg cgccatcacc
      841 tcgatagcag cactggatga cccccaaagc atcgtcctcc agttgggcca agacccaaag
      901 gcaccattct tgtgcttgcc agaagctcac aaggacatgg gcgccacact tgaatggcaa
      961 ccacgagccc agaccccagt ccaaagctgt cgcttggaag gtgtgtctgg ccacaaggag
     1021 gcctacatcc tgaggatcct gccaggttct gaggccgggc cccggacggt gaccgtaatg
     1081 atggaactga gttgcacatc tggggacgcc attctcatcc tgcatggtcc tccatatgtc
     1141 tcctggttca tcgacatcaa ccacagcatg cagatcttga ccacaggtga atactccgtc
     1201 aagatctttc caggaagcaa ggtcaaaggc gtggagctcc cagacacacc ccaaggcctg
     1261 atagcggagg cccgcaagct caatgccagc attgtcacct cctttgtaga gctccctctg
     1321 gtcagcaatg tctccctgag ggcctccagc tgcggtggtg tgttccagac cacccctgca
     1381 cccgttgtga ccacacctcc caaggacaca tgcagccccg tgctactcat gtccctgatc
     1441 cagccaaagt gtggcaatca ggtcatgact ctggcactca ataaaaaaca cgtgcagact
     1501 ctccagtgca ccatcacagg cctgactttc tgggactcca gctgccaggc tgaagacact
     1561 gacgaccatc ttgtcctgag tagcgcctac tccagctgcg gcatgaaagt gacagcccat
     1621 gtggtcagca atgaggtgat catcagtttc ccgtcaggct caccaccact tcggaaaaag
     1681 gtacagtgca tcgacatgga cagcctctcc ttccagctgg gcctctacct cagcccgcac
     1741 ttcctccagg catccaacac catcgaacta ggccagcagg ccttcgtaca ggtgagcgtg
     1801 tctccattga cctctgaggt cacagtccag ctagatagct gccatctgga cttggggccc
     1861 gaaggggaca tggtggaact catccagagc cgaacagcca agggcagctg tgtgaccttg
     1921 ctgtctccaa gccctgaagg tgacccacgc ttcagcttcc tcctccgggt ctacatggtg
     1981 cccacaccca ccgctggcac cctcagttgc aacttagctc tgcgccctag caccttgtcc
     2041 caggaagtct acaagacagt ctccatgcgc ctgaacatcg tcagccctga cctgtctggt
     2101 aaaggccttg tcctgccctc tgtactgggt atcacctttg gtgccttcct gattggggcc
     2161 ctgctcacag ctgcactctg gtacatctat tctcacacac gtggccccag caagcgggag
     2221 cccgtggtgg cagtggctgc cccggcctcc tctgagagca gcagtaccaa ccacagcatc
     2281 gggagcaccc agagcacccc ctgctccacc agcagcatgg cgtagtgccc agcctggagc
     2341 ctcggggagc cccccagcca gcccttgccc tgcaggagag accgagcagc cacaagctgg
     2401 aaaccaccgg ccatgaactt gtcccaggaa ccaaacacct cccctgcacc tgttcattcc
     2461 tcccagtgga gacttcagat tggaatacct tgggatctcc tcaccccact ttacagaact
     2521 gcccaatcca ggggctctgg gatatggctg cccgggatta cagaaagaca cggcactgcc
     2581 gtgcacaccc atgctgctta gaagcctaag cctctgcctt caagctggat cctgtgcagg
     2641 gtgggcaggc aagaactcag acatgcccag cctagcccag ggcggcctgc atctggcccc
     2701 agaagcctcc tcacctggac tggcacaact tcggttgggg aaacagaagc tgagggagct
     2761 tagatggggt gggggatcca agcccctccc agcccaccca ttggccaggc agcagggggg
     2821 agtggccagg cggctggttg tgggccaagt cctgcatatt cactaataaa tcagacatga
     2881 aaccagtgcc cctctgggtt gtatgggaga agaggaagat gggcaattat gtcacagaac
     2941 aagggtgcac acccctttgg tcggcatggt agcagacagc cagagcccat gtgtggagga
     3001 agtcagttct ctctgctgct tgctcatttg gtagcccaac cttgggtcag aggggacaga
     3061 aaccaaacac taaaaagccc tgtctacagt ctctgggaca cagctacccc tataaagttc
     3121 tgggttctaa tcctgtacat gactcttgtg ggcaatgagc ctgtggacag ctccaaagtc
     3181 agccaccctc cctcatctgt aagatgggcg tccaacttga atgcattgtc accaaggagg
     3241 cttgcgatgc agtgccttgg tgtgtgacac acagtgtgcc agtctttcat gacatgagag
     3301 gactaatcct aggccatact gtgttaaact ccaaccccca aatgtctgat gagggagcta
     3361 ggagaatagg agtcaatcaa aagttttgtc atttatttac aaaaaataaa aaataaaagg
     3421 gtttaaaagc ttc
//
