LOCUS       NM_001164636            5112 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus endonuclease V (Endov), transcript variant 1, mRNA.
ACCESSION   NM_001164636
VERSION     NM_001164636.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5112)
  AUTHORS   Kong,X.Y., Vik,E.S., Nawaz,M.S., Berges,N., Dahl,T.B., Vagbo,C.,
            Suganthan,R., Segers,F., Holm,S., Quiles-Jimenez,A., Gregersen,I.,
            Fladeby,C., Aukrust,P., Bjoras,M., Klungland,A., Halvorsen,B. and
            Alseth,I.
  TITLE     Deletion of Endonuclease V suppresses chemically induced
            hepatocellular carcinoma
  JOURNAL   Nucleic Acids Res 48 (8), 4463-4479 (2020)
   PUBMED   32083667
  REMARK    GeneRIF: The data suggest that EndoV is involved in the development
            of hepatocellular carcinoma in mice.
REFERENCE   2  (bases 1 to 5112)
  AUTHORS   Nawaz,M.S., Vik,E.S., Ronander,M.E., Solvoll,A.M., Blicher,P.,
            Bjoras,M., Alseth,I. and Dalhus,B.
  TITLE     Crystal structure and MD simulation of mouse EndoV reveal wedge
            motif plasticity in this inosine-specific endonuclease
  JOURNAL   Sci Rep 6, 24979 (2016)
   PUBMED   27108838
  REMARK    GeneRIF: Mouse Endonuclease V shares substrate preferences with
            human EndoV by catalyzing cleavage at inosines in RNA and being
            inert towards inosines in DNA.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5112)
  AUTHORS   Moe,A., Ringvoll,J., Nordstrand,L.M., Eide,L., Bjoras,M.,
            Seeberg,E., Rognes,T. and Klungland,A.
  TITLE     Incision at hypoxanthine residues in DNA by a mammalian homologue
            of the Escherichia coli antimutator enzyme endonuclease V
  JOURNAL   Nucleic Acids Res 31 (14), 3893-3900 (2003)
   PUBMED   12853604
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK084233.1, BC056486.1 and AL645911.14.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK084233.1, SRR9219382.149647.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-591               AK084233.1         2-592
            592-1409            AK084233.1         594-1411
            1410-5080           BC056486.1         1382-5052
            5081-5112           AL645911.14        218369-218400
FEATURES             Location/Qualifiers
     source          1..5112
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.8 cM"
     gene            1..5112
                     /gene="Endov"
                     /gene_synonym="A730011L01Rik"
                     /note="endonuclease V"
                     /db_xref="GeneID:338371"
                     /db_xref="MGI:MGI:2444688"
     exon            1..113
                     /gene="Endov"
                     /gene_synonym="A730011L01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1074
                     /gene="Endov"
                     /gene_synonym="A730011L01Rik"
                     /EC_number="3.1.-.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative endonuclease FLJ39025 homolog; novel endonuclease
                     V protein"
                     /codon_start=1
                     /product="endonuclease V isoform 1"
                     /protein_id="NP_001158108.1"
                     /db_xref="CCDS:CCDS48999.1"
                     /db_xref="GeneID:338371"
                     /db_xref="MGI:MGI:2444688"
                     /translation="MAHTAAERPPEETLSLWKGEQARLKARVVDRDTEAWQRDPSFSG
                     LQKVGGVDVSFVKGDSVRACASLVVLSYPELKVVYEDSRMVGLKAPYVSGFLAFREVP
                     FLVELVQRLQEKEPDLMPQVVLVDGNGVLHQRGFGVACHLGVLTELPCIGVAKKLLQV
                     DGLENNALHKEKIVLLQAGGDTFPLIGSSGTVLGMALRSHDHSTKPLYVSVGHRISLE
                     VAVRLTHHCCRFRIPEPIRQADIRSREYIRRTLGQLGVAPAQRKDRSQKEQRPNACPQ
                     GGPGALADQGRPPECDGRDSSSDRKAPEPGFQEQKDQQLEGTGHQEDSDLWPPSPAWV
                     QSPP"
     exon            114..285
                     /gene="Endov"
                     /gene_synonym="A730011L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            286..420
                     /gene="Endov"
                     /gene_synonym="A730011L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            421..460
                     /gene="Endov"
                     /gene_synonym="A730011L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            461..573
                     /gene="Endov"
                     /gene_synonym="A730011L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            574..642
                     /gene="Endov"
                     /gene_synonym="A730011L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            643..771
                     /gene="Endov"
                     /gene_synonym="A730011L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            772..848
                     /gene="Endov"
                     /gene_synonym="A730011L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            849..5112
                     /gene="Endov"
                     /gene_synonym="A730011L01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1386..1391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Endov"
                     /gene_synonym="A730011L01Rik"
                     /note="hexamer: AATACA"
     polyA_site      1413
                     /gene="Endov"
                     /gene_synonym="A730011L01Rik"
                     /note="major polyA site"
     regulatory      3116..3121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Endov"
                     /gene_synonym="A730011L01Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3138
                     /gene="Endov"
                     /gene_synonym="A730011L01Rik"
                     /note="major polyA site"
     regulatory      5083..5088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Endov"
                     /gene_synonym="A730011L01Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      5103
                     /gene="Endov"
                     /gene_synonym="A730011L01Rik"
ORIGIN      
        1 aacagctcgg cgccggcgct ccggaagtga cgtcctcaaa gcctcgaggc gctagccatg
       61 gctcacacgg ccgctgagcg gccgccagag gaaaccctgt cgctgtggaa aggggaacaa
      121 gcccggctga aagcgcgcgt ggtggatcgg gacacggagg cctggcagcg ggaccccagc
      181 ttctcgggcc tgcagaaggt cgggggcgtg gatgtgtcct tcgtgaaagg ggacagtgtc
      241 cgggcctgcg cttccctggt agtgctgagc taccccgagc tcaaggtggt gtatgaggac
      301 agccgcatgg ttggcctgaa ggccccctat gtgtcaggct tcctggcctt ccgagaggtc
      361 cctttcctgg tggagttggt acagcggctg caagagaagg aaccagatct catgccccag
      421 gtcgttcttg tggatggaaa cggggtgctt caccaacgag gcttcggggt ggcctgccac
      481 cttggtgtcc ttacagagct gccatgcatc ggggtggcca agaagctcct gcaggtggat
      541 ggactggaga acaatgctct gcacaaggag aagattgtgc tcctgcaggc cggaggagac
      601 acatttcctc tgataggcag ctctgggact gtcctgggaa tggccctgag gagccatgac
      661 cacagcacca agcccctcta tgtctctgtg ggccacagaa taagcctgga ggtcgctgtg
      721 cgcctcaccc accactgctg taggttccgg atcccagaac ctatacgcca ggctgacatc
      781 cgctctcgag agtacatccg aaggactcta gggcagcttg gggtggctcc tgcacagaga
      841 aaggacagga gccagaaaga gcagaggcca aatgcatgcc cccaaggagg cccaggagca
      901 cttgcagatc aaggcaggcc tcctgaatgc gacggcagag actccagctc agaccggaaa
      961 gcccccgagc caggcttcca ggagcagaag gaccagcagt tggagggaac cgggcatcag
     1021 gaagactcgg acctctggcc tccttctcca gcctgggtac agtcaccacc ctgagaagat
     1081 gatctctagg agcagtggag acctcaccac agtcacaggt ggagcaccac accccagagg
     1141 caacagtgca tggaactcca ggaggatgca gcgggcttaa tccagcgtgg gccagtgtag
     1201 gccagtggct gccagcctcc tccatcactg gctagtcagt gtggtcacca tgccccagca
     1261 ggaccatatt ccagaccagg aagcacacac aagcaccaag agtacatgaa ggacttcagg
     1321 cctcgggtgc ccagaggccc tgcggttggc aacctgtgcc agcagctctg ccttgccctc
     1381 ttgggaatac agacctggtt cttcctggct ttaccctcat gggtcactct tacttcacca
     1441 tcccagccac gggagactgt catccgtgtc atagccaggc tgcagccccc aaggtgcctg
     1501 tcctcaagct tgtttgccgc tgagcttgag ggacctgcag ttgggaaagc ctcaatcctg
     1561 gagcaggctc aagagtgggc gatggggagt cagctgcaca gagggtgcca gatgggaagc
     1621 cggttgaggc ccatggtgag aaagccccag gctcggctcc tcactcctct tcctgccacc
     1681 ctctcaccag agagcgtcaa aatcccatcc cactaagaag gcgggtctgt tctagcctgg
     1741 tggcttcttg tctgggtggc cttgaagggg ctgctgaggc aggccaacag cagggctgca
     1801 gtgccctccc tgtcctccca cacacattct aggctcacca gagtggcatc tgagctggga
     1861 cacagagatg gcacgcctgt gacatgtctc ttgccctcac cctagtcccc agattccctg
     1921 gaggagaggt gacagatggt ggggaagcta gctactaagt cctgtggata cccacagggg
     1981 gtggtcagga tgggatgacg gtcggtgatg gggaaggaca gacgggtggt tctcctgtga
     2041 tacccaggcc catttagact cagctgggct gctgcgactc cctcctaagt cagtccatag
     2101 tgactacccc ttgggggtag gtctgctgct gctgtctctg atggagctgg tggctcatcc
     2161 ccactccctg gggtttcagg ttttggatat aaggaagata gatatgtggt tctgtcaccc
     2221 agtaaatgaa gtgtggggca ggaggcagcc tccccaccac acacctggta tgtataggcc
     2281 agcctccatg ggcaagaacc ccacggccac ccagggtgtc cgagcaggac attcctgcag
     2341 tgtccacatc cacccactgg ccctccgcag tctctcacaa acattctgtg cacacacaca
     2401 caaccacaca tacacactct ctctctctct ctcttcatat tccctgacac tcttgtggaa
     2461 gccagagctg gagggcctac agctggcccc accatctgcc ttcccaactt ccagacctct
     2521 cccttctcaa gccctgtcaa gacagagttg tggaggggga atttggaggt gggggaagga
     2581 aaaggctgaa gctcaaccac aatagctcga accattgaaa gcttagatgt gaggtgagaa
     2641 gtaaggcagc cgagcttgag ggccagcaca cagcatcctt gtttgaaggg aagctgttta
     2701 gagaagtagg gccccagagg ccaaggccat cagtccttaa gaccatcctc acagatgtgg
     2761 aggaaaacag cttacagagt cccctgtcca ggcctcacct gagcaggtag ctcctcccac
     2821 tcctgtgaga caccaaagtg tggctgggga cccagcctgg tcaccccatc tcatctgttc
     2881 aactcttaac agaagacctt ccccaagaca cagaagtcag gcctgatgct gctcagcttg
     2941 gcaccttcca acactcagac tctcctcagc ctgggcagag tagctctcca ggctgctgta
     3001 caggcagaca ctgccagggg cccactcccc acatactgag gagcagggca gaacctgaac
     3061 gtggccttct agacaacttt tatgtgattt gttctgaaag aaaatccttt cagtcattaa
     3121 aatacaattt gttttgcaca gtggagtgtc tggggagcct gagaccagag tctctgggca
     3181 tgggctcaag gcaaccctga gtaacatagg cctgaggctt tgtcacaaac aaaaaggatt
     3241 cattaccgtg tacagccatt atcacgcttg cctgcgccaa agcatttcta ttgtcccaaa
     3301 gacagccctg tactattagc ttctagtact ctcccatacc cacaagggcc tgtcagccca
     3361 gctgccccgc tgggtgtgtg tggcagccca gattttacct ggctgagctg ctacagggag
     3421 ctaagatagt gaggtgccag ggccaggggg atgcaaactg aaggagcagg gtggatagaa
     3481 catagagtgt gggcaagtct ggggtggggc gttcagacac cccagacacc ggtgcttgag
     3541 ggcagggggc cctaagtgca gtggcgtctc agctccttcc cgcagaacct taaaaatagg
     3601 gccgcagtga tgtccatctc agcagaccac agctctctag agctaagaat attcttgaac
     3661 ctcttaataa ttcaagtcag atccaaatag attttcatat tcatctgcag tttctgtgcc
     3721 ccttcccagc atccctaccc ctgtccggca gctgggagaa gttggcttcc agggggaggc
     3781 aacctaaact agctgctgtg tctgtcactc aggaccccag tcatccccat ttcctgctca
     3841 tgggacaaca agaatggtgg actgccaggg ctggagccgc ctactatgat ctagccatgg
     3901 ccaaccctga ggagagaggc ccaagccatc atggttccta cataccagac aggccaggct
     3961 agggaacctt gacccttcct caacacctca agagagccaa ttgctgtctc ctggcttctg
     4021 gggagcccat atgctcctta gaccccaatg ggagcatact gtcctgcctc ctcagaagag
     4081 tccttgaagg gctaggtctc gggttgagac ctggggattg catctgtaca gggctccagc
     4141 cccaggtctc tgttcttgaa tgctaagtgt gcctggccaa gtcactctgc ctctgggtga
     4201 ctctttcctt gatagtgaga tggtgggtgt agtgtctcca gagtcagcag gatatcagcc
     4261 tggaccacct tcccctcccg agagtgccag ggtgaacacc ccccccccaa aaacccactt
     4321 gtcagccaaa gatctggtat cgaaggtgag gagcaagcat cagcgtcgta aggtagaggc
     4381 ttacccacct ggcccactca ccccagcagc aacccaatcc agcatcccca ctgcactgcc
     4441 ctaaccaatt gattaattaa aagcagaggc acagaacagc ggcacgggac cactgacttg
     4501 cagatgaatg gcccaagaag tagtcaggtg ggtgtcgccg tggtgataga ataggactct
     4561 ggttcccatt ccccacacag agcaggcgcc cgctgctcca ggtccttaaa ggctcctggg
     4621 aaatgggaag ataaagtgca ggagccggga ctccaggcag aggcacctgg atcaggtctt
     4681 gatggagagg gtgtagtttg ggcttgggct gggattttgt cttgttttgt tttaacaggg
     4741 tctgatcaca gcagaactgg atgaccttga gcctctggtc ttccttctcc cagctcctag
     4801 cagtggggcc acattgcagg tctatgccac cacactgatg ctggagatca aagccaaggc
     4861 tctgtgcttg ctgaacaaac acgaccaact gggctggaga ggtggctcaa tggttaagag
     4921 cactgactgc tcttccagag gtcccgagtt caactcccag caaccacatg ttggctcaca
     4981 accatctgta atgggatctg ataccctctt ctggtgtgtc tgaagacagc tacagtgtgc
     5041 tcatatacat gaaataaata aatctttaaa aaaaaaaaaa gaaagaaaaa aatacactac
     5101 caactgaatg ac
//
