LOCUS       NM_001168693            2405 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus endonuclease, polyU-specific (Endou), transcript
            variant 2, mRNA.
ACCESSION   NM_001168693
VERSION     NM_001168693.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2405)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2405)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2405)
  AUTHORS   Paikari,A., D Belair,C., Saw,D. and Blelloch,R.
  TITLE     The eutheria-specific miR-290 cluster modulates placental growth
            and maternal-fetal transport
  JOURNAL   Development 144 (20), 3731-3743 (2017)
   PUBMED   28935707
REFERENCE   4  (bases 1 to 2405)
  AUTHORS   Poe,J.C., Kountikov,E.I., Lykken,J.M., Natarajan,A., Marchuk,D.A.
            and Tedder,T.F.
  TITLE     EndoU is a novel regulator of AICD during peripheral B cell
            selection
  JOURNAL   J Exp Med 211 (1), 57-69 (2014)
   PUBMED   24344237
  REMARK    GeneRIF: EndoU is a critical regulator of an RNA-dependent pathway
            controlling peripheral B cell survival and antigen responsiveness
            that may contribute to peripheral B cell tolerance.
REFERENCE   5  (bases 1 to 2405)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2405)
  AUTHORS   Kingsmore,S.F., Bieniarz,M.C., Watson,M.L. and Seldin,M.F.
  TITLE     Genetic mapping of Pp11r, a thymocyte gene expressed during
            apoptosis, to mouse chromosome 15
  JOURNAL   Mamm Genome 4 (8), 459-460 (1993)
   PUBMED   8104059
  REMARK    Review article
REFERENCE   7  (bases 1 to 2405)
  AUTHORS   Baughman,G., Lesley,J., Trotter,J., Hyman,R. and Bourgeois,S.
  TITLE     Tcl-30, a new T cell-specific gene expressed in immature
            glucocorticoid-sensitive thymocytes
  JOURNAL   J Immunol 149 (5), 1488-1496 (1992)
   PUBMED   1506680
REFERENCE   8  (bases 1 to 2405)
  AUTHORS   Baughman,G., Harrigan,M.T., Campbell,N.F., Nurrish,S.J. and
            Bourgeois,S.
  TITLE     Genes newly identified as regulated by glucocorticoids in murine
            thymocytes
  JOURNAL   Mol Endocrinol 5 (5), 637-644 (1991)
   PUBMED   2072923
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA119943.1, AK132616.1 and AC104225.18.
            
            Transcript Variant: This variant (2) contains different segments
            for its 5' UTR and coding region, compared to variant 1. The
            predicted protein (isoform 2) results from translation initiation
            at an upstream AUG and has a shorter N-terminus, when it is
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132616.1, SRR5189673.74937.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AA119943.1         19-84
            67-890              AK132616.1         8-831
            891-1004            AC104225.18        76421-76534
            1005-1526           AK132616.1         946-1467
            1527-2405           AC104225.18        79133-80011
FEATURES             Location/Qualifiers
     source          1..2405
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 53.7 cM"
     gene            1..2405
                     /gene="Endou"
                     /gene_synonym="Pp11r; Tcl-30"
                     /note="endonuclease, polyU-specific"
                     /db_xref="GeneID:19011"
                     /db_xref="MGI:MGI:97746"
     exon            1..191
                     /gene="Endou"
                     /gene_synonym="Pp11r; Tcl-30"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1375
                     /gene="Endou"
                     /gene_synonym="Pp11r; Tcl-30"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; poly(U)-specific endoribonuclease; protein
                     endoU; PP11-related protein; T-cell-specific protein 30;
                     uridylate-specific endoribonuclease; placental protein
                     11-related protein; placental protein 11 related"
                     /codon_start=1
                     /product="uridylate-specific endoribonuclease isoform 2
                     precursor"
                     /protein_id="NP_001162164.1"
                     /db_xref="CCDS:CCDS49712.1"
                     /db_xref="GeneID:19011"
                     /db_xref="MGI:MGI:97746"
                     /translation="MKARVPFIVAMLCGLAWAGNLESCASRCHEKFNRDAVCQCDRRC
                     PQHDDCCDDYEHLCTAEEGPPEPEAFLDPEDKIPTSHLYSAPSSCQGRCREAYDKHHP
                     CHCNDRCPEFGNCCEDFDSLCGGDHEGFSHSSDAVTKEELESISETIYRVDTNKAQKE
                     DIVLNSQNRISPSETGNQVDRSPEPLFTYVNEKLFSKPTYAAFINLLNNYQRATGHGE
                     HFSAQQLEEQGVFLREVMKTAVMKELYSFLHHQNRYSSEQEFVDDLKNMWFGLYSRGN
                     DEGDSSGFEHVFSGEVKKGKVTGFHNWIRFYLQEKEGLLDYYSHNYDGPWDSYPDVLA
                     MQFNWDGYYKEVGSVFIGSSPEFEFALYSLCFITRPGKKCHLSLGGYPLAIQTYTWDK
                     TTYGNGKKYIATAYVVSSSQ"
     exon            192..314
                     /gene="Endou"
                     /gene_synonym="Pp11r; Tcl-30"
                     /inference="alignment:Splign:2.1.0"
     exon            315..377
                     /gene="Endou"
                     /gene_synonym="Pp11r; Tcl-30"
                     /inference="alignment:Splign:2.1.0"
     exon            378..518
                     /gene="Endou"
                     /gene_synonym="Pp11r; Tcl-30"
                     /inference="alignment:Splign:2.1.0"
     exon            519..690
                     /gene="Endou"
                     /gene_synonym="Pp11r; Tcl-30"
                     /inference="alignment:Splign:2.1.0"
     exon            691..890
                     /gene="Endou"
                     /gene_synonym="Pp11r; Tcl-30"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1004
                     /gene="Endou"
                     /gene_synonym="Pp11r; Tcl-30"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1111
                     /gene="Endou"
                     /gene_synonym="Pp11r; Tcl-30"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1254
                     /gene="Endou"
                     /gene_synonym="Pp11r; Tcl-30"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..2405
                     /gene="Endou"
                     /gene_synonym="Pp11r; Tcl-30"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatccagcca caccagatcc acaagtcctg gtgtctttaa aaggatcggc ctgagggata
       61 cggctcatct gggcactgtg acgttcatct tgattgtggt gggaagtcca acggccgctc
      121 tgctgcaggt ggcatcatga aggcccgtgt tccttttata gtggctatgc tctgtggtct
      181 agcctgggct ggaaacctgg agtcgtgcgc atctcgctgt catgagaaat ttaaccggga
      241 tgctgtctgc cagtgtgatc gccggtgtcc ccagcatgat gactgctgtg acgactatga
      301 acatctgtgc actgctgaag aaggaccccc agagccagag gcattcctgg atccagagga
      361 caagatccca accagccacc tctactccgc accgagctcc tgccagggcc gctgccggga
      421 agcctacgac aagcaccacc cttgccactg taatgaccgc tgcccagagt ttggaaactg
      481 ctgtgaggat tttgacagtc tgtgtggtgg tgatcatgag ggtttctccc acagcagcga
      541 tgccgtcact aaggaggagc ttgagagcat ctccgagacc atctacaggg tagataccaa
      601 caaagcccag aaggaagaca ttgtgctcaa cagtcagaac cggatctccc catcagagac
      661 ggggaaccaa gtggatcgaa gcccagagcc gctcttcact tacgtcaacg agaagctgtt
      721 ctccaagcct acctatgcag cctttatcaa cttactcaac aattaccagc gggccacagg
      781 ccacggggag catttcagtg cccagcaact ggaggagcag ggtgtcttcc tcagggaggt
      841 catgaagacg gctgtcatga aggaactcta tagctttctc catcaccaaa accgttacag
      901 ctcagaacaa gagtttgtgg acgatttgaa gaacatgtgg tttgggctgt actcgagagg
      961 caatgatgaa ggggactcga gtggctttga acatgtcttc tctggcgaag tgaagaaagg
     1021 caaggtcact ggctttcata actggatccg cttctacctg caggagaagg agggtctgct
     1081 ggactactac agtcacaact acgacgggcc ctgggactcc taccccgatg tcctggccat
     1141 gcagttcaat tgggatggct actacaaaga agtgggctcg gtcttcattg gcagcagccc
     1201 tgagttcgag tttgcccttt actctctgtg cttcatcacc aggccaggca aaaagtgcca
     1261 tctgagcctg ggtggctatc ctctggccat ccagacctac acctgggata agaccaccta
     1321 cggaaatggc aagaagtaca ttgccacagc ctacgtggtg tcttcttccc aatagagcct
     1381 gcagccagct ggggtcctga gggcagaggg acaagcaggg tcctggtgct atttgctcct
     1441 tactggggag gggagggagg agtctgggag gaatcccaga gctcagtttt gtaaaaggaa
     1501 tctcgaatct agaaatgccc acttgggaga gagaaaaaaa aaaagaagaa aaagatataa
     1561 ttagaaaaat gcagagaatc agccaaacct ttgtctctct gtattttggc aacatgaact
     1621 gggaaacaga gctctctctg cctagagaaa ggagcggccc tcaagatctc tttgccgagt
     1681 ttgggagcca tgagcaagtc cttggctcca tacttccctc taatgtgaag gggaggggtc
     1741 tgccctttcc ctccttgggg ctgggggttg gggggggggg ctgaaggtat tatgactgta
     1801 aaggtgtctt cagttgtttt tagggagaac aggtagtaga aattcaggat taccaagtgg
     1861 ccaccagtgc acacactccg cagctgtgac tcagccttgt gtagggtccc aaagaagcaa
     1921 gccttagaac cgagcaggtg aatcttagag agtcagccaa ggacagtgca gagtcacggg
     1981 ttgggaggta tgtgggctag ggtatgtggt ttcctcagtc ctaaacgtct gtgtggccaa
     2041 ctcagcatct gcttccagaa gtttcccact tgcagatgtt cagtgcagtt acagacatgc
     2101 gtttgattcc acagttttgt ttcatttcaa aagaattccc ctcacaggag gatggctgag
     2161 catcaaagga ggacaaccat ctataacttg gtgtcattga caactatatt aatgtttatc
     2221 cagctgccgt agtttgaaac attctgggct gggagaagag ggaccccggg gtttctaatt
     2281 tcaaccccaa atgacatgtt tatttgcacc tgatgctcag gagccagatg tggaccctgc
     2341 agagccaggc ttgtaccaca gctcagaggc gtcaagtttc caattaaagc cactggagaa
     2401 aacct
//
