LOCUS       NM_007931               1019 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus endonuclease G (Endog), transcript variant 1, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_007931
VERSION     NM_007931.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1019)
  AUTHORS   Zhu,C., Fan,F., Li,C.Y., Xiong,Y. and Liu,X.
  TITLE     Caspase-3 promotes oncogene-induced malignant transformation via
            EndoG-dependent Src-STAT3 phosphorylation
  JOURNAL   Cell Death Dis 15 (7), 486 (2024)
   PUBMED   38977663
  REMARK    GeneRIF: Caspase-3 promotes oncogene-induced malignant
            transformation via EndoG-dependent Src-STAT3 phosphorylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1019)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1019)
  AUTHORS   Wang,W., Tan,J., Liu,X., Guo,W., Li,M., Liu,X., Liu,Y., Dai,W.,
            Hu,L., Wang,Y., Lu,Q., Lee,W.X., Tang,H.W. and Zhou,Q.
  TITLE     Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver
            disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress
  JOURNAL   Nat Commun 14 (1), 6201 (2023)
   PUBMED   37794041
  REMARK    GeneRIF: Cytoplasmic Endonuclease G promotes nonalcoholic fatty
            liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress.
            Erratum:[Nat Commun. 2024 Aug 21;15(1):7167. doi:
            10.1038/s41467-024-51312-x.. PMID: 39168977]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1019)
  AUTHORS   Wang,W., Li,J., Tan,J., Wang,M., Yang,J., Zhang,Z.M., Li,C.,
            Basnakian,A.G., Tang,H.W., Perrimon,N. and Zhou,Q.
  TITLE     Endonuclease G promotes autophagy by suppressing mTOR signaling and
            activating the DNA damage response
  JOURNAL   Nat Commun 12 (1), 476 (2021)
   PUBMED   33473107
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1019)
  AUTHORS   Park,K.H., Yoon,S.M., Song,H.N., Yang,J.H., Ryu,S.E. and Woo,E.J.
  TITLE     Crystal structure of the mouse endonuclease G
  JOURNAL   Biochem Biophys Res Commun 526 (1), 35-40 (2020)
   PUBMED   32192768
  REMARK    GeneRIF: Crystal structure of the mouse endonuclease G.
REFERENCE   6  (bases 1 to 1019)
  AUTHORS   Irvine,R.A., Adachi,N., Shibata,D.K., Cassell,G.D., Yu,K.,
            Karanjawala,Z.E., Hsieh,C.L. and Lieber,M.R.
  TITLE     Generation and characterization of endonuclease G null mice
  JOURNAL   Mol Cell Biol 25 (1), 294-302 (2005)
   PUBMED   15601850
  REMARK    GeneRIF: endonuclease G is essential for embryonic survival, but
            not through a mitochondrial or apoptosis function
REFERENCE   7  (bases 1 to 1019)
  AUTHORS   Zhang,J., Dong,M., Li,L., Fan,Y., Pathre,P., Dong,J., Lou,D.,
            Wells,J.M., Olivares-Villagomez,D., Van Kaer,L., Wang,X. and Xu,M.
  TITLE     Endonuclease G is required for early embryogenesis and normal
            apoptosis in mice
  JOURNAL   Proc Natl Acad Sci U S A 100 (26), 15782-15787 (2003)
   PUBMED   14663139
  REMARK    GeneRIF: EndoG is essential during early embryogenesis and plays a
            critical role in normal apoptosis and nuclear DNA fragmentation
REFERENCE   8  (bases 1 to 1019)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 1019)
  AUTHORS   Meiss,G., Gimadutdinow,O., Haberland,B. and Pingoud,A.
  TITLE     Mechanism of DNA cleavage by the DNA/RNA-non-specific Anabaena sp.
            PCC 7120 endonuclease NucA and its inhibition by NuiA
  JOURNAL   J Mol Biol 297 (2), 521-534 (2000)
   PUBMED   10715218
REFERENCE   10 (bases 1 to 1019)
  AUTHORS   Prats,E., Noel,M., Letourneau,J., Tiranti,V., Vaque,J., Debon,R.,
            Zeviani,M., Cornudella,L. and Ruiz-Carrillo,A.
  TITLE     Characterization and expression of the mouse endonuclease G gene
  JOURNAL   DNA Cell Biol 16 (9), 1111-1122 (1997)
   PUBMED   9324313
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845258.5.
            
            On Mar 18, 2023 this sequence version replaced NM_007931.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB012108.1, AK144459.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-554               AL845258.5         57862-58415
            555-664             AL845258.5         59191-59300
            665-1019            AL845258.5         60040-60394
FEATURES             Location/Qualifiers
     source          1..1019
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.29 cM"
     gene            1..1019
                     /gene="Endog"
                     /note="endonuclease G"
                     /db_xref="GeneID:13804"
                     /db_xref="MGI:MGI:1261433"
     exon            1..554
                     /gene="Endog"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..947
                     /gene="Endog"
                     /note="endonuclease G, mitochondrial; endo G"
                     /codon_start=1
                     /product="endonuclease G, mitochondrial precursor"
                     /protein_id="NP_031957.1"
                     /db_xref="CCDS:CCDS15872.1"
                     /db_xref="GeneID:13804"
                     /db_xref="MGI:MGI:1261433"
                     /translation="MRALRAGLTLALGAGLGAAAEHWRRREGKAPGLLGRVPLLPVVA
                     ADLPALPGGPAGGTGELAKYGLPGVAQLRSRESYVLSYDPRTRGALWVLEQLRPERLR
                     GDGDRSACDFREDDSVHAYHRATNADYRGSGFDRGHLAAAANHRWSQRAMDDTFYLSN
                     VAPQVPHLNQNAWNNLERYSRSLTRTYQNVYVCTGPLFLPRTEADGKSYVKYQVIGKN
                     HVAVPTHFFKVLILEAAGGQIELRSYVMPNAPVDETIPLERFLVPIESIERASGLLFV
                     PNILARAGNLKAITAGSK"
     exon            555..664
                     /gene="Endog"
                     /inference="alignment:Splign:2.1.0"
     exon            665..1019
                     /gene="Endog"
                     /inference="alignment:Splign:2.1.0"
     regulatory      993..998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Endog"
                     /note="hexamer: ATTAAA"
     polyA_site      1019
                     /gene="Endog"
                     /note="major polyA site"
ORIGIN      
        1 acgccagcac aggctccttc actctgtgct aacatcagta gcgtccttgt cctccggtag
       61 gcatgcgcgc gctgcgggcc ggcctgaccc tagcgctggg cgcggggctg ggcgccgcgg
      121 cagagcattg gcggcggcgg gagggcaaag cgccggggct gctgggccga gtgccattgt
      181 tgccggtggt cgcggccgat cttcccgcgc tgccgggggg accggcgggc ggcaccgggg
      241 aactggccaa gtacgggctg cccggcgtgg cgcagctccg gagccgcgag tcctacgtgc
      301 ttagctacga cccgcgcacg cgcggtgcgc tctgggtgtt ggagcagctg aggccagagc
      361 ggctccgtgg cgacggggac cgtagcgcct gcgacttccg cgaggatgac tctgtgcacg
      421 cgtaccaccg cgccaccaat gcggactacc gcggcagtgg ctttgaccgc ggccatttgg
      481 ccgccgccgc caaccaccgc tggagtcagc gggccatgga cgacaccttc tacctgagca
      541 acgtagcgcc tcaggtgcca cacctcaacc agaatgcctg gaacaacctt gagaggtaca
      601 gccgcagctt gacgcgaact taccaaaatg tctatgtctg cacggggccg cttttcctgc
      661 ccaggaccga ggctgatggg aagtcctatg tgaagtacca ggttattggg aagaaccacg
      721 tggcagtgcc cacacacttc ttcaaggtgc tgatcctgga ggcagccggt gggcagatcg
      781 agctacgttc ctacgtgatg cccaatgccc ccgtggatga gaccatccct ctggagcggt
      841 tcctggtgcc catcgagagc atcgagcggg cctcgggatt gctcttcgtg cccaatattc
      901 tggctcgagc tggaaacctc aaggctatca ctgctggcag caagtgatgg tggaggactc
      961 actggagccc ctggggagat gggctgactc acattaaagg cagttatttt tggagagaa
//
