LOCUS       NM_007930               4752 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus ectodermal-neural cortex 1 (Enc1), mRNA.
ACCESSION   NM_007930
VERSION     NM_007930.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4752)
  AUTHORS   Schott,M., Leon-Perinan,D., Splendiani,E., Strenger,L., Licha,J.R.,
            Pentimalli,T.M., Schallenberg,S., Alles,J., Samut Tagliaferro,S.,
            Boltengagen,A., Ehrig,S., Abbiati,S., Dommerich,S., Pagani,M.,
            Ferretti,E., Macino,G., Karaiskos,N. and Rajewsky,N.
  TITLE     Open-ST: High-resolution spatial transcriptomics in 3D
  JOURNAL   Cell 187 (15), 3953-3972 (2024)
   PUBMED   38917789
REFERENCE   2  (bases 1 to 4752)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4752)
  AUTHORS   Puelles,L. and Hidalgo-Sanchez,M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4752)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   5  (bases 1 to 4752)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   6  (bases 1 to 4752)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 4752)
  AUTHORS   Hernandez,M., Andres-Barquin,P.J. and Israel,M.A.
  TITLE     Assignment of the ectodermal-neural cortex 1 gene (Enc1) to mouse
            chromosome band 13D1 by fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 158-159 (2000)
   PUBMED   10965111
REFERENCE   8  (bases 1 to 4752)
  AUTHORS   Morrisey,E.E., Tang,Z., Sigrist,K., Lu,M.M., Jiang,F., Ip,H.S. and
            Parmacek,M.S.
  TITLE     GATA6 regulates HNF4 and is required for differentiation of
            visceral endoderm in the mouse embryo
  JOURNAL   Genes Dev 12 (22), 3579-3590 (1998)
   PUBMED   9832509
REFERENCE   9  (bases 1 to 4752)
  AUTHORS   Kim,T.A., Lim,J., Ota,S., Raja,S., Rogers,R., Rivnay,B., Avraham,H.
            and Avraham,S.
  TITLE     NRP/B, a novel nuclear matrix protein, associates with p110(RB) and
            is involved in neuronal differentiation
  JOURNAL   J Cell Biol 141 (3), 553-566 (1998)
   PUBMED   9566959
REFERENCE   10 (bases 1 to 4752)
  AUTHORS   Hernandez,M.C., Andres-Barquin,P.J., Martinez,S., Bulfone,A.,
            Rubenstein,J.L. and Israel,M.A.
  TITLE     ENC-1: a novel mammalian kelch-related gene specifically expressed
            in the nervous system encodes an actin-binding protein
  JOURNAL   J Neurosci 17 (9), 3038-3051 (1997)
   PUBMED   9096139
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132173.1 and AV465735.1.
            
            On Oct 20, 2009 this sequence version replaced NM_007930.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132173.1, BC058098.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4736              AK132173.1         1-4736
            4737-4752           AV465735.1         348-363
FEATURES             Location/Qualifiers
     source          1..4752
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 50.66 cM"
     gene            1..4752
                     /gene="Enc1"
                     /gene_synonym="Nrpb; PIG10"
                     /note="ectodermal-neural cortex 1"
                     /db_xref="GeneID:13803"
                     /db_xref="MGI:MGI:109610"
     exon            1..425
                     /gene="Enc1"
                     /gene_synonym="Nrpb; PIG10"
                     /inference="alignment:Splign:2.1.0"
     exon            426..2239
                     /gene="Enc1"
                     /gene_synonym="Nrpb; PIG10"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..2208
                     /gene="Enc1"
                     /gene_synonym="Nrpb; PIG10"
                     /note="ENC-1"
                     /codon_start=1
                     /product="ectoderm-neural cortex protein 1"
                     /protein_id="NP_031956.3"
                     /db_xref="CCDS:CCDS26710.1"
                     /db_xref="GeneID:13803"
                     /db_xref="MGI:MGI:109610"
                     /translation="MSVSVHENRKSRASSGSINIYLFHKSSYADSVLTHLNLLRQQRL
                     FTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLL
                     DYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQ
                     CTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAMNWI
                     SYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKI
                     LQNDGVVTSLCARPRKTGHALFLLGGQTFMCDKLYLVDQKAKEIIPKADIPSPRKEFS
                     ACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYV
                     VGGHTAATGCLPASPSVSLKQVEQYDPTTNKWTMVAPLREGVSNAAVVSAKLKLFAFG
                     GTSVSHDKLPKVQCYDQCENRWSVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSACSA
                     YKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWN
                     SITTVPYSLIPTAFVSTWKHLPS"
     exon            2240..4743
                     /gene="Enc1"
                     /gene_synonym="Nrpb; PIG10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4717..4722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Enc1"
                     /gene_synonym="Nrpb; PIG10"
                     /note="hexamer: AATAAA"
     polyA_site      4743
                     /gene="Enc1"
                     /gene_synonym="Nrpb; PIG10"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcagct cccgcagcct cagagccagc ggcgcgacgg aggcgctgca gagacccgga
       61 gccgacgcca ggcggccgcc agcgctcacg ccgcaacccc gttccctccc cctgcgtgca
      121 gaccgccttc ctccgcggcg cggccgccgc aggctcactc tcccctggct aggcgcgcgc
      181 cggcagacgc ttggcccggc cggggcgcca ggtccgtagc agcagatccg gagaccgagg
      241 tcagctgcct gccgaaacca gcccgggagc cactaccccg gacgctatcg cctcccttcc
      301 cagcgctcct ttctccccgg cgatcgccac cgcttcctgg aacagagacg cccttcgtcg
      361 gctccctgcg ggtgaccgag gcaagaaccg cagccggttg tgtgcagagg ccagccgcca
      421 ctactgagtt gaaacaaaat gtcagtcagt gtgcatgaga accgcaagtc cagggccagc
      481 agtggctcca tcaacatcta cctgtttcat aagtcctcct acgcggacag cgttctcact
      541 cacctgaacc ttctgcgtca gcagcggctc ttcacagatg tccttctcca tgcgggaaac
      601 aggaccttcc cttgccaccg ggcagtgctg gctgcgtgca gccgctactt cgaagccatg
      661 ttcagtggtg gcctgaaaga gagccaggac agtgaggtga acttcgacaa ttccatccac
      721 ccagaagtct tagagctgct tctagactac gcatactcct cccgggtcat tatcaatgaa
      781 gaaaatgctg agtcgctcct ggaggctggt gacatgctgg agttccagga catcagagat
      841 gcgtgtgcag aatttctaga gaagaacctg catcccacca actgcctggg tatgctgctg
      901 ttgtctgatg cccaccagtg caccaagctg tacgaactct cctggagaat gtgtctcagc
      961 aacttccaaa ccattcggaa gaacgaagat ttcctccagt tgccccagga catggttgtg
     1021 cagctgctgt ccagtgaaga actggagacg gaagacgaaa ggctggtgta tgagtctgcg
     1081 atgaactgga tcagctatga cctgaagaag cgctactgtt acctcccgga actgttgcag
     1141 acagtgaggc tggccctcct tcctgccatc tatctcatgg agaacgtggc gatggaagaa
     1201 ctcatcacca agcagagaaa gagtaaggag atcgtggaag aggccatcag gtgcaaacta
     1261 aaaatcttac agaatgacgg cgtggtcacc agtctctgtg ctcgtcctcg gaaaactggc
     1321 catgccctgt tcctcctggg agggcagact ttcatgtgtg acaaactgta cttggtagac
     1381 cagaaggcta aagaaatcat tcccaaggct gacattccca gcccgaggaa agagttcagc
     1441 gcatgtgcaa ttggctgcaa agtatatatt actggggggc ggggatcaga gaacggagtc
     1501 tcaaaagatg tctgggttta cgataccctg catgaggagt ggtccaaggc tgcccccatg
     1561 ctggtggcca ggtttggcca tggatctgct gaactgaagc actgcctcta tgtagtcggt
     1621 gggcacacag ctgcaactgg ctgcctccca gcctccccct cggtctccct aaagcaagta
     1681 gaacagtatg accccacaac caacaaatgg accatggtag ccccactccg cgaaggtgtc
     1741 agcaatgctg ctgtagtgag tgccaaactt aagctgtttg ctttcggggg taccagtgtg
     1801 agccacgaca agctgcccaa ggttcagtgt tacgatcaat gcgagaacag atggtcagtg
     1861 ccggccacct gtccccagcc ctggcgttac acagccgcag ctgtgctggg aaaccagatt
     1921 tttatcatgg gtggagatac agagttctct gcctgctccg cttacaaatt caatagtgag
     1981 acttaccagt ggaccaaggt gggagatgtg acagccaagc gcatgagctg ccacgccgtg
     2041 gcgtccggga acaagcttta cgtagttgga gggtacttcg gcattcagcg ctgcaagact
     2101 ttggactgtt acgacccaac tttagatgtg tggaacagca taaccactgt tccctactct
     2161 ctgatcccta ctgcattcgt cagcacctgg aaacacctgc cttcctaatg tagagcatcc
     2221 taaagaaagc acgcatgagc tcattctgat gcacggcgag atgagatgtc atttctgctt
     2281 tggagaaggc aagtttaatg aagagaaaga aaaacaggag cagttgctac tgagactcct
     2341 cgaataccat cggctgcacc ttgcaaacac tctcaagtgg acatgaagga aggggtgggg
     2401 ggaggggcgg gttttttttt tttcaatata agtagcacat ggtttaaata tgaatgactg
     2461 aacttgtgat ctagtccttg tctggtaatt gtggattaat gtcagcgtta atcagcccct
     2521 caaagggaga gaaaagctgg gcttttccct tgctgtacct cattcagctt ttgatttcca
     2581 tggccccacc atttatgtgc aagatttgca atggttgtca gcttcctctg aagaccgagc
     2641 ttgacgcctc catgccagct gccgttggag acgcaaagcc aagcaagggt caggagggaa
     2701 gctggcccgg ctgactggag aatgggaacc ccaggactct ccactcatct cgaagggttg
     2761 tggtcccccc aggaaagtct cgagacaatg gggacattgt tggtagctgt tcggtagatg
     2821 ctctttgcta tttataagtg actttaaacc ttctcttggc tgttaagaaa tgtgttctag
     2881 atttagctat ttattgtttg cggcctgcat gctgaaacag tgcttacgtt gtctccatgt
     2941 gtacggggcc tgtgtggatg gtcgtatgtt ttgcacattt tgtagttgtt ggtgtgcttc
     3001 gccgcacaca aaaaaagaag actttggggc tgtaatttgg aggataagta gagggtgggt
     3061 ggggggaggg gtacattttt gaagtgtcgg gacagagaca gattccaaga ctggaaactt
     3121 caattacatc cagaggcaga gaaacctttc ctcgaccact ctttattgag gtaccctggt
     3181 cacactgatg gcaggacaca caagagcagg gtattggtct gcccttcttc ctcctgtccg
     3241 tctgatttac ctaactttgg tctcggctgc tgactcttgg agaggaccaa attactttgt
     3301 agtatttccc ccgtttgtgt aatgtcctga aaccttggag aggttccaga atacttctgt
     3361 atatagggca caggtgaaga cattgtccaa agcttattta tttatctatt tatttaccct
     3421 gggcgagtaa ccacaccagt gggggggaaa aaactaaaat gtgtggagtg taaacaaact
     3481 cactgaccac gtggctcttg gaccttgatt tagaaaggct catactccca ggaaaacacc
     3541 cattttgata caatgtaaac gttcgtgttc acccttggat acatgttgaa agagctcttt
     3601 ggtacacgga agtgacatct ttggggtcag tgttacgagg tggcctgtgg aggtcttccg
     3661 gtcctgttgg gatcatttgt gaatacattc tttgctcctc ttaagtgctt gtttcctaac
     3721 cgtgcagtgg taggtattag tacactgggc acttccccag ggatctgggg aagaccagag
     3781 cttgcagctc tgcctgcttt gatccatatt tctcacagtg ctgtattaaa aaatagaacc
     3841 taaggcagat agccaccttt acattgtgag tgtgtttacc ttgtctaatg acggataatt
     3901 ccttaacatt tctctccacc ttagtacttt aggctaatta tacacgtctg tctgtgccat
     3961 gagtaagtgg actgtagttg gaccaaaaaa acaaatgagc cgttggacca tttgagcagt
     4021 cagtttctgg tccttagatg tattctaagc agtgtaagtg tctgattgta ccctggtggc
     4081 atgatcagtt gtcttgtagc tgtcccccgc tccatagttt acaatgcaaa tctgtctcaa
     4141 gatcttcact tcgctgctgc tgagagcagg agaattttct gcagctgttt caaagttgtg
     4201 gcctggcctt gaatcctcta ttaattactg tgtgagccag agggaactgc cctgcaaggg
     4261 tgggccccca gccggcaggg gaactttcta gactcccgct cattcaattg atctaggcat
     4321 ttgggcttgc tacttgacca ttctcgccct gtgaaatgtc ccacactttg aagcaaatac
     4381 aattcacagc acagtacaca caaaaaccct ggcataagac ggggaggttc ttcttatttt
     4441 gtgagccggt tgccctggaa acggataaca aagggcagcc ttccacttct ggtataatgg
     4501 gggagcctct tttctcaggc ttgacacctg tctgaataag agtgattaga gccgcataat
     4561 atccctctct tggctattga ataagtggtt cacataccca accctgtaga agttagaaga
     4621 tggtcggtca tgtctgtatg ttcttgtttg catctactac atttttaagg ttttgtaaaa
     4681 ctgttatttt tttttcacga tgtgaaactg aaggtcaata aattattaga gattttctct
     4741 tcaaaaaaaa aa
//
